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2-Fluoro-6-Formylbenzeneboronic Acid

2-Fluoro-6-Formylbenzeneboronic Acid

Hongda Chemical

Specifications

HS Code

427495

Chemical Formula C7H6BFO3
Molar Mass 167.93 g/mol
Appearance Solid (usually white or off - white)
Physical State At Room Temp Solid
Solubility In Water Moderate solubility (due to boronic acid group)
Solubility In Organic Solvents Soluble in some polar organic solvents like ethanol, acetone
Melting Point Typically in a certain range, around [specific value if known] °C
Pka Of Boronic Acid Group Around 8 - 9 (approximate for boronic acid moiety)
Reactivity Reactive towards nucleophiles, can form boronate esters

As an accredited 2-Fluoro-6-Formylbenzeneboronic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 100g of 2 - fluoro - 6 - formylbenzeneboronic Acid in a sealed chemical - grade container.
Storage 2 - fluoro - 6 - formylbenzeneboronic acid should be stored in a cool, dry place away from heat and direct sunlight. Keep it in a tightly - sealed container to prevent moisture absorption, as boronic acids can react with water. Store it separately from incompatible substances like strong oxidizing agents and bases to avoid potential chemical reactions that could degrade the compound.
Shipping 2 - fluoro - 6 - formylbenzeneboronic acid is shipped with proper chemical - resistant packaging. It's carefully labeled, following safety regulations. Shipment may be via ground or air, depending on quantity and urgency, ensuring stability during transit.
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2-Fluoro-6-Formylbenzeneboronic Acid 2-Fluoro-6-Formylbenzeneboronic Acid
General Information
Historical Development
In the past, when chemical technology was not yet developed, the study of all kinds of substances was still in ignorance. And with the gradual progress of science, everyone began to explore the secrets of substances.
2 - Fluoro - 6 - Formylbenzeneboronic Acid This thing, its beginning is also the work of many chemists. At the beginning, the method of its preparation was explored, and it went through twists and turns. In the laboratory, Xu Xian tried repeatedly to prepare various reagents and change the conditions of the reaction. Or the temperature is not good, or the proportion of reagents is poor, resulting in no reaction.
However, the determination of chemists, unremitting search. After years of work, finally a good method of preparation. Since then, the output of 2 - Fluoro - 6 - Formylbenzeneboronic Acid has gradually stabilized, and it has gradually developed its use in various fields such as medicine and materials.
Product Overview
Today there is a product called 2 - Fluoro - 6 - Formylbenzeneboronic Acid. This is a key raw material for organic synthesis, and it has extraordinary uses in the fields of medicine and materials.
Its shape is white crystalline powder, which is stable in nature. However, it encounters strong acids and alkalis, or there is a reaction change. When preparing, it must go through many complicated processes and strictly control the reaction conditions before it can be obtained.
This product is used in pharmaceutical research and development, and can be used as a key intermediate to help create new drugs or cure diseases. In the field of materials, it can improve the properties of materials and make them more suitable for diverse needs.
Although it is widely used, safety procedures must be strictly followed when operating to prevent accidents. Our chemical researchers should make full use of this material and contribute to scientific progress and people's well-being.
Physical & Chemical Properties
2 - Fluoro - 6 - Formylbenzeneboronic Acid is an organic compound. Its physicochemical properties are very important. From the perspective of physical properties, at room temperature, this substance is either in a specific form, or in a solid state, with a specific color, or in a white crystal, and has a certain melting point. This melting point is of great significance for its purification and identification. Its solubility cannot be ignored. It may have good solubility in some organic solvents, and its solubility in water may vary.
On its chemical properties, because it contains functional groups such as boron ester groups and aldehyde groups, its chemical activity is quite high. The aldehyde group can participate in many classical chemical reactions, such as oxidation reactions to form carboxylic acids, and reduction reactions can be converted into alcohols. Boroester groups are widely used in the field of organic synthesis, and can participate in the Suzuki-Miyaura coupling reaction to construct complex organic molecular structures. The physicochemical properties of this compound lay the foundation for its application in organic synthesis, drug development and other fields.
Technical Specifications & Labeling
2 - Fluoro - 6 - Formylbenzeneboronic Acid is an important chemical substance. Its process specifications and identification (product parameters) are related to the quality and application of this product.
Process specifications need to precisely control the synthesis steps, starting from the raw material ratio, all links need to follow specific procedures. If the reaction temperature should be maintained at a certain precise range, the purity and yield of the product can be guaranteed. And the reaction time cannot be ignored. If it is too short, the reaction will not be completed, and if it is too long or side reactions will breed.
In terms of identification, the basic parameters such as product name, molecular formula and molecular weight should be clearly marked. This allows users to understand its chemical characteristics and operate reasonably according to the characteristics during storage, transportation and use. Precise process specifications and clear markings are the cornerstones of the quality and safety of 2 - Fluoro - 6 - Formylbenzeneboronic Acid applications.
Preparation Method
This 2 - Fluoro - 6 - Formylbenzeneboronic Acid is prepared. First, take 2 - fluoro - 6 - methylbenzoic acid as raw material, mix concentrated sulfuric acid with concentrated nitric acid, and nitrate it at an appropriate temperature to obtain nitrification products. Then with an appropriate reducing agent, the nitro group is reduced to an amino group to form an intermediate containing amino groups.
The second time is to make a diazonium salt from sodium nitrite and hydrochloric acid, and then react with boron reagents to obtain a boron-containing compound. After a specific oxidizing agent, the methyl group is oxidized to an aldehyde group. In this process, the reaction temperature, time and the amount of each reagent need to be precisely controlled. The reaction device needs to be well sealed to prevent impurities from invading. And after each step of the reaction, it needs to be separated and purified, such as extraction, crystallization, etc., to improve the purity of the product, then 2-Fluoro-6-Formylbenzeneboronic Acid.
Chemical Reactions & Modifications
Recently, the research on 2 - Fluoro - 6 - Formylbenzeneboronic Acid has given me a lot of thought in the study of chemical reactivity.
At the beginning of the study, according to the usual method, its reaction is not as good as the original stage. This compound has special properties, and the usual method can be used to solve it. For all kinds of things, or the degree of dissolution, or the dissolution, all get the ideal result.
However, I have not yet done it, but I think about it, and study its properties. It contains a boron aldehyde group and a fluorine atom. This group affects each other, causing its reactivity to be different.
Then the method is used, and the special dissolution and the degree of integration are different. The reaction rate is controllable, and the recovery rate has also increased.
From this, if you want to get the ideal reaction, you must study its nature deeply, and if you don't follow the usual pattern, you can get something. Make the reaction according to my requirements, and recognize its improvement.
Synonyms & Product Names
2-Fluoro-6-formylphenylboronic acid, this substance is quite important in chemical research. Its nickname and trade name have their own origins.
Looking back at the past, the name of chemical substances was first developed, depending on its nature, structure or source. 2-Fluoro-6-formylphenylboronic acid, because of the benzene ring, two fluorine atoms, hexa-formyl group, and boric acid structure, so it got this name.
As for the nickname, or according to its local structural characteristics, or because of the synthesis path. Trade names are often taken by merchants, in order to be concise and easy to remember, and to highlight product characteristics, so as to facilitate marketing activities.
Looking at this substance, it is often used as a key intermediate in the field of organic synthesis. With its special structure, it can participate in various reactions and build complex organic molecules. Many researchers have used its power to develop new synthesis methods and advance the development of chemical science.
Safety & Operational Standards
2 - Fluoro - 6 - Formylbenzeneboronic Acid Safety and Operating Practices
2 - Fluoro - 6 - Formylbenzeneboronic Acid is an important chemical substance that is widely used in research and production. However, during its use, safety and operating standards are extremely critical.
#Storage Safety
This substance should be stored in a cool, dry and well-ventilated place. Keep away from fire and heat sources and prevent direct sunlight. Due to its active chemical nature, contact with oxidants, acids, alkalis and other substances may cause dangerous reactions, so it should be stored separately and should not be mixed. The storage area should be equipped with suitable materials to contain leaks, just in case.
#Operating Specifications
When operating, it is necessary to strictly follow the standard procedures. Operators need to be specially trained and familiar with the operation points and emergency treatment methods. The operation site should be well ventilated to reduce the risk of harmful gas accumulation. When taking this substance, use appropriate tools to avoid direct contact with the skin and eyes. In case of inadvertent contact, rinse immediately with a large amount of flowing water and seek medical treatment in time.
When conducting chemical reactions involving 2-Fluoro-6-Formylbenzeneboronic Acid, it is necessary to precisely control the reaction conditions, such as temperature, pressure, reaction time, etc. Closely monitor the reaction process to prevent the reaction from getting out of control. After the reaction is completed, properly dispose of the remaining substances and waste, and dispose of them harmlessly in accordance with relevant regulations. They must not be discarded at will to avoid pollution to the environment.
#Emergency Treatment
In the event of a leakage accident, personnel from the leakage contaminated area should be quickly evacuated to a safe area and quarantined, and access should be strictly restricted. Emergency personnel must wear appropriate protective equipment to avoid self-harm. In the event of a small amount of leakage, it can be absorbed by inert materials such as sand and vermiculite and collected in a closed container. In the event of a large amount of leakage, build a dike or dig a pit for containment, cover it with foam to reduce steam disasters, and then transfer it to a tanker or a special collector with a pump for recycling or transportation to a waste treatment site for disposal.
In conclusion, when using 2 - Fluoro - 6 - Formylbenzeneboronic Acid, compliance with safety and operating practices is related to personnel safety, environmental safety and the smooth progress of experiments or production, and must not be taken lightly.
Application Area
2-Fluoro-6-formylphenylboronic acid, the application field of this substance is related to many. In the field of organic synthesis, it can be used as a key intermediate. Due to its unique structure, it can participate in a variety of chemical reactions, such as Suzuki-Miyaura coupling reaction, through which the reaction can cleverly construct carbon-carbon bonds, which play a major role in the construction of complex organic molecules.
In the field of materials science, it may contribute significantly to the optimization of the performance of specific materials. For example, in optical materials, after rational use, the optical properties of materials can be improved, which will contribute to the development of materials science. Furthermore, in the field of medicinal chemistry, there is also potential application value, which may become the cornerstone of the development of new drugs and contribute to the cause of human health.
Research & Development
Today there is a thing called 2 - Fluoro - 6 - Formylbenzeneboronic Acid. As a researcher of chemistry, I have devoted myself to the research and innovation of this thing.
At the beginning, I wanted to understand its properties, so I measured it by various methods. Observe its state, explore its chemical properties, and understand its changes in different environments. And study the method of synthesis, hoping to obtain the best method, improve its yield, and reduce its cost.
In the process of research, problems frequently appear. The method of synthesis is complex or inefficient, and the material consumption is huge. However, I was not discouraged, tried new methods many times, and finally got into the territory.
Looking to the future, this product may be of great use in the fields of medicine and materials. I will continue to research it, hoping to develop its growth, add new color to the industry, and promote the progress and prosperity of this field.
Toxicity Research
The industry of chemical industry is related to people's livelihood, and the toxicity of things cannot be ignored. Today there is a substance called "2-Fluoro-6-Formylbenzeneboronic Acid", and our generation should investigate its toxicity in detail.
Husband studies the way of toxicity, the first method of experimentation. Take all kinds of creatures, such as rats and rabbits, set different doses and observe their reactions. Observe their diet, activities, and physiological changes, and remember their symptoms to judge the strength of toxicity.
It also examines its chemical structure, fluorine, boron, and other elements, which are related to toxicity. Its exposure to the environment, or its phase with other substances, must also be scrutinized in detail. Looking at its degradation, there are harmless substances, or even more toxic.
Furthermore, human contact is also important. The touch of the skin, the entry of respiration, and the intake of food can all cause toxicity. It is necessary to understand the course of its harm to determine the protection policy.
In summary, to study the toxicity of "2 - Fluoro - 6 - Formylbenzeneboronic Acid", multiple methods must be taken to fully understand its nature, so as to avoid harm and profit, and protect the safety of all beings.
Future Prospects
I try to research the chemical industry, focusing on 2 - Fluoro - 6 - Formylbenzeneboronic Acid. Looking at the current state, although it has a place for use, what I want is its future.
The properties of this thing can be further developed in the field of pharmaceutical synthesis. With precise methods, help create new drugs, and add force to the treatment of diseases and diseases. And in material science, it can turn the ordinary into magic, make the material special, and meet the needs of diversity.
I hope that in the future, with the advance of science and technology, I will explore more possibilities for this thing. Research its new method to increase its production and improve its quality. I also hope to join hands with all the wise people to expand their use, so that 2 - Fluoro - 6 - Formylbenzeneboronic Acid will shine in the world, leaving a blessing for future generations, and becoming a bright stroke in the history of chemical industry. This is my future prospect.
Where to Buy 2-Fluoro-6-Formylbenzeneboronic Acid in China?
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Frequently Asked Questions

As a leading 2-Fluoro-6-Formylbenzeneboronic Acid supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 2-Fluoro-6-Formylbenzeneboronic Acid?
2-Fluoro-6-formylphenylboronic acid has a wide range of uses. In the field of organic synthesis, it is often used as a key intermediate to construct complex organic molecules. For example, in the construction of fluorine-containing aromatic compounds with specific structures, it can participate in diverse reactions due to its unique structure and properties, such as the Suzuki coupling reaction. In the Suzuki coupling reaction, it can form carbon-carbon bonds with halogenated aromatics under the action of suitable catalysts and bases, resulting in the efficient synthesis of a series of bioactive or material properties compounds, which is of great significance in drug development and materials science.
In the field of medicinal chemistry, the introduction of fluorine atoms can often significantly change the physical and chemical properties and biological activities of compounds. 2-fluoro-6-formylphenylboronic acid can be used as a starting material to introduce fluorine-containing structural fragments through multi-step reactions, laying the foundation for the creation of new drugs. At the same time, formyl groups also provide rich possibilities for subsequent reactions, which can be further modified by oxidation, reduction, condensation and other reactions to meet the needs of drug design.
In the field of materials science, through the organic synthesis reactions it participates in, polymers or organic semiconductor materials containing specific functional groups can be prepared. Such materials exhibit unique properties in the field of optoelectronics, such as applications in organic Light Emitting Diodes (OLEDs), organic solar cells and other devices, which are expected to improve device performance and efficiency.
In short, 2-fluoro-6-formylphenylboronic acid, with its special molecular structure, plays an indispensable role in many important fields such as organic synthesis, drug development and materials science, providing an important material basis and reaction intermediate for innovation and development in various fields.
What are the physical properties of 2-Fluoro-6-Formylbenzeneboronic Acid?
2-Fluoro-6-formylphenylboronic acid is an important reagent in the field of organic synthesis. Its physical properties are unique and deserve careful investigation.
Looking at its appearance, it usually appears white to off-white solid. This color and morphology are also common in many organic compounds, providing a basis for preliminary identification. In terms of melting point, it is roughly within a certain range, but the exact value varies slightly due to differences in preparation methods and purity. Generally speaking, the melting point is in a relatively moderate range, which is of great significance for its temperature control in the synthesis operation. If the melting point is too low, it may not be stable at room temperature; if it is too high, a higher temperature is required for melting during the reaction process, or the choice of reaction conditions is affected.
Solubility is also a key physical property. In organic solvents such as dichloromethane and tetrahydrofuran, 2-fluoro-6-formylphenylboronic acid exhibits good solubility. This property makes it convenient to participate in various organic reactions, because many organic reactions are often carried out in organic solvent systems. In water, its solubility is relatively limited, which is related to the properties of the groups contained in the molecular structure. Although the boroxy group contained has a certain polarity, the existence of fluorine atoms and hydrophobic parts such as benzene rings limits its solubility in water.
In addition, the stability of this compound also needs attention. Under normal conditions, it has certain stability, but when it encounters strong oxidizing agents, strong acids or strong bases, it is prone to chemical reactions, resulting in structural changes. Therefore, it needs to be stored in a dry, cool and away from such substances to ensure that its quality and reactivity are not affected and play its due role in organic synthesis.
What is the synthesis method of 2-Fluoro-6-Formylbenzeneboronic Acid?
The method for preparing 2-fluoro-6-formylphenylboronic acid can be performed by the following steps.
Starting material, 2-fluoro-6-methylbenzoic acid is commonly selected. First, it is converted into the corresponding acid chloride, which can be reacted with thionyl chloride ($SOCl_2 $). At an appropriate temperature (e.g. heating reflux), the benzoic acid carboxyl group is converted into an acyl chloride group to obtain 2-fluoro-6-methylbenzoyl chloride.
Then, 2-fluoro-6-methylbenzoyl chloride is reduced to obtain 2-fluoro-6-methylbenzaldehyde. The reducing reagent can be selected from lithium aluminum hydride ($LiAlH_4 $) or sodium borohydride ($NaBH_4 $). Taking sodium borohydride as an example, in a suitable solvent such as ethanol, the reaction temperature can be controlled to reduce the acid chloride to an aldehyde group to obtain 2-fluoro-6-methylbenzaldehyde.
Then 2-fluoro-6-methylbenzaldehyde is boronized. In general, n-butyllithium ($n - BuLi $) is used in combination with borate esters (such as trimethyl borate $B (OCH_3) _3 $). First, n-butyllithium is reacted with 2-fluoro-6-methylbenzaldehyde at low temperature (such as $-78 ^ {\ circ} C $), so that the hydrogen on the methyl group is replaced by lithium to form a lithium intermediate. Then trimethyl borate is added, nucleophilic substitution occurs, and after hydrolysis, 2-fluoro-6-formylphenylboronic acid is obtained.
Another route can be started from 2-fluoro-6-bromotoluene. 2-Fluoro-6-bromotoluene was treated with n-butyllithium to form an aryl lithium reagent at low temperature, and then reacted with diisopropylformamide ($DIPF $) to introduce formyl groups to obtain 2-fluoro-6-formyltoluene. After reacting with n-butyllithium and trimethyl borate, the target product 2-fluoro-6-formylphenylboronic acid can also be obtained after hydrolysis. During the whole process, attention should be paid to the control of reaction conditions, the choice of solvent, and the separation and purification of each step of the reaction to improve the purity and yield of the product.
What are the precautions for 2-Fluoro-6-Formylbenzeneboronic Acid in storage and transportation?
2-Fluoro-6-formylphenylboronic acid, when storing and transporting, pay attention to many matters. This is a key intermediate in organic synthesis, which is active in nature, so when storing, be sure to choose a dry, cool and well-ventilated place. Because it is extremely sensitive to moisture, it is easy to hydrolyze and lose its activity, so it should be tightly moisture-proof. It can be placed in a sealed container with a desiccant to keep the environment dry.
Furthermore, temperature is also crucial. High temperature can easily cause it to deteriorate, so it should be stored in a low temperature place, usually 2-8 ° C, which can effectively extend its shelf life and ensure the stability of its chemical properties.
As for the transportation, the first heavy packaging is stable. It must be properly wrapped with suitable packaging materials to prevent collision and vibration from causing damage to the packaging and exposing the material. And during transportation, it should also maintain low temperature and dry conditions, which can be achieved by refrigerated transportation equipment.
In addition, because of its certain chemical hazards, transporters need to be familiar with relevant regulations and safety knowledge, and go through transportation procedures in accordance with regulations to ensure compliance and safety throughout the transportation process. Do not slack a little, so as not to cause harm and damage personal and environmental safety.
What is the market price range for 2-Fluoro-6-Formylbenzeneboronic Acid?
2-Fluoro-6-formylphenylboronic acid, an important organic synthesis intermediate in the field of fine chemicals, is commonly found in medicine, pesticides, and materials science. As for its market price range, it is difficult to say exactly, because it is affected by many factors.
First, the market supply and demand situation has a deep impact on prices. If the market demand for pharmaceutical products containing this compound surges, and the production and supply are difficult for a while, the price will rise; conversely, if the demand is sluggish and the supply exceeds the demand, the price will decline.
Second, the difficulty of the preparation process is closely related to the cost. If the preparation of this compound requires complicated processes, rare raw materials or special equipment, the production cost will be high, and the price will naturally not be low; if the process is simple and efficient, the cost will be reduced, and the price will be more affordable.
Third, product purity is also the key. High-purity 2-fluoro-6-formylphenylboronic acid is often used in high-end pharmaceutical research and development, and its price is often much higher than that of general purity products.
Furthermore, different suppliers have different pricing strategies, and factors such as brand, service, and logistics costs will also make prices vary.
According to past market conditions, its price may range from tens to hundreds of yuan per gram. However, this is only a rough estimate. The current exact price needs to be consulted in detail by professional chemical raw material suppliers, or by referring to real-time quotations on chemical product trading platforms.