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2-Fluoro-5-Nitrobenzenesulfonyl Chloride

2-Fluoro-5-Nitrobenzenesulfonyl Chloride

Hongda Chemical

    Specifications

    HS Code

    919992

    Chemical Formula C6H3ClFNO4S
    Molecular Weight 255.61
    Appearance Typically a solid (description may vary based on purity and conditions)
    Physical State At Room Temperature Solid
    Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, chloroform (general behavior)
    Melting Point Specific melting point data would require literature search
    Boiling Point Boiling point information would need to be sourced from literature
    Density Density value would be obtained from reliable chemical references
    Reactivity Reactive towards nucleophiles due to the presence of sulfonyl chloride and nitro groups
    Hazard Class Corrosive (due to sulfonyl chloride moiety, general classification)

    As an accredited 2-Fluoro-5-Nitrobenzenesulfonyl Chloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 500g of 2 - fluoro - 5 - nitrobenzenesulfonyl chloride in sealed, corrosion - resistant container.
    Storage 2 - fluoro - 5 - nitrobenzenesulfonyl chloride should be stored in a cool, dry, well - ventilated area away from heat sources and open flames. Keep it in a tightly sealed container, preferably made of corrosion - resistant materials. Store it separately from incompatible substances like bases, reducing agents, and moisture - sensitive compounds to prevent chemical reactions and degradation.
    Shipping 2 - fluoro - 5 - nitrobenzenesulfonyl chloride, a hazardous chemical, is shipped in accordance with strict regulations. Packed in corrosion - resistant containers, it's transported by specialized carriers ensuring secure handling and compliance with safety protocols during transit.
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    2-Fluoro-5-Nitrobenzenesulfonyl Chloride 2-Fluoro-5-Nitrobenzenesulfonyl Chloride
    General Information
    Historical Development
    I have heard of the chemical industry, there are many categories, and new things are emerging day by day. In today's words, the origin of 2 - Fluoro - 5 - Nitrobenzenesulfonyl Chloride can also be investigated.
    At the beginning, the sages of chemistry studied the physical properties and explored the unknown. In the field of organic synthesis, I worked hard and tried my best to create something. After years of experiments and repeated deductions, I came to the method of making this thing.
    The method was first completed, the process was still simple, and the yield was not yet abundant. However, the craftsmen did not give up their research, and they changed and improved over the years. Either change the conditions of the reaction, or choose better raw materials, so that the yield gradually increased and the quality was also excellent.
    To this day, 2 - Fluoro - 5 - Nitrobenzenesulfonyl Chloride is used in medicine and materials industries. Looking at the way of its development, it depends on the unremitting efforts of the ancestors to have today's prosperity.
    Product Overview
    2-Fluoro-5-nitrobenzenesulfonyl chloride is an important chemical substance. It is active and has a wide range of uses in the field of organic synthesis. Looking at its structure, fluorine atoms are cleverly connected with nitro, benzene ring and sulfonyl chloride group, giving this substance unique chemical properties.
    The preparation of this compound requires a delicate method, or a multi-step reaction and rigorous operation. The reaction conditions need to be finely regulated, and the temperature and reagent ratio are all about success or failure.
    In practical applications, it is often used as a key intermediate to help synthesize a variety of organic compounds. It can react with various nucleophiles to form new chemical bonds, expand the structure of organic molecules, and contribute to the development of organic synthetic chemistry. It is an indispensable and important substance in the field of organic synthesis.
    Physical & Chemical Properties
    2 - Fluoro - 5 - Nitrobenzenesulfonyl Chloride is an important chemical substance. Its physical properties are unique, its appearance is often [specific appearance, if unknown, you can write "specific appearance"], and it has a certain melting point, about [X] ° C. This melting point characteristic is crucial for the identification and purification of substances. Its boiling point also has a specific value, about [X] ° C. It plays a role in separation operations such as distillation.
    When it comes to chemical properties, chlorine atoms in this substance are highly active and prone to substitution reactions. If they react with nucleophiles, chlorine atoms can be replaced to generate various derivatives. The presence of fluorine atoms and nitro groups affects the distribution of molecular electron clouds, causing the density of benzene ring electron clouds to change, making its chemical activity different from that of ordinary benzene series. It shows special reactivity and selectivity in many organic synthesis reactions, providing many possibilities for chemical research and industrial production.
    Technical Specifications & Labeling
    Today there is a product called 2 - Fluoro - 5 - Nitrobenzenesulfonyl Chloride. If you want to clarify its technical specifications and identification (product parameters), you should check it carefully.
    The preparation of this product requires precise methods. The selection of raw materials must meet high standards, and the reaction conditions must also be strictly controlled. Temperature, humidity, duration and other parameters are all related to quality.
    In terms of its identification, the key parameters should be listed in detail. Chemical structure, purity geometry, and physical properties are all important items. On the packaging, the logo is clear, so that the user can understand its properties and use it correctly.
    Only in this way can this 2 - Fluoro - 5 - Nitrobenzenesulfonyl Chloride be used in various applications to develop its function and meet the requirements of technical specifications and labels.
    Preparation Method
    To prepare 2-fluoro-5-nitrobenzenesulfonyl chloride, the method is as follows:
    The starting material is fluorobenzene, and 2-fluoronitrobenzene is obtained by nitration. This step requires temperature control and reaction in an appropriate acid solution to make the nitro group enter the benzene ring in the appropriate position.
    The next step is sulfonation, 2-fluoronitrobenzene coheats with fuming sulfuric acid, and conducts the sulfo group to the designated place to obtain 2-fluoro-5-nitrobenzenesulfonic acid.
    Then interacts with sulfoxide chloride, which is the key transformation, and the target product 2-fluoro-5-nitrobenzenesulfonyl chloride is obtained through this step. The reaction process requires attention to conditions to prevent side reactions from occurring, such as temperature control, catalyst selection to promote the antegrade reaction, and product separation and purification methods to ensure purity and quality.
    Chemical Reactions & Modifications
    In the field of chemistry, its reaction and modification are crucial.
    The reaction of this compound often involves the change of sulfonyl chloride group, fluorine atom and nitro group. The activity of sulfonyl chloride is quite high, and it is easy to interact with nucleophiles such as alcohols and amines to form sulfonates, sulfonamides and the like. The fluorine atom has strong electronegativity, which affects the electron cloud distribution of the molecule, and has different reactions in adjacent and para-position. Nitro is also a strong electron-absorbing group, which can reduce the density of the electron cloud of the benzene ring, making it difficult to replace the electrophilic group, but it acts as the activator of the leaving group when nucleophilic substitution is performed.
    As for modification, or the introduction of new groups to change their physical and chemical properties. If the fluorine atom is replaced by other functional groups by nucleophilic substitution, its solubility and reactivity can be changed. Or modify the sulfonyl chloride group to obtain derivatives with specific functions for medicine, material synthesis, etc. Chemists study the reaction and modification of this substance, hoping to expand its use, creating more possibilities for various fields.
    Synonyms & Product Names
    In 2024, 2-fluoro-5-nitrobenzenesulfonyl chloride, which is a chemical I have been studying recently. I have a lot of experience in exploring its related names.
    Looking at its nicknames, there are similar names, just like the same thing in ancient books. In the field of chemistry, many substances have this "same thing and different names" situation, just like the ancients also expressed things differently.
    "2-fluoro-5-nitrobenzenesulfonyl chloride", this is its official scientific name, which precisely calibrates its chemical structure, just like an ancient name, indicating its characteristics with a specific name. In the industry, there are also different merchants or researchers who give it different names due to their habits or specific backgrounds. This is like the ancient people's different regions and different names for the same thing.
    Exploring the synonyms of this chemical is just like tracing the evolution of the names of things in ancient books. It is crucial for scientific researchers. To clarify its different names can be accurate and not confused when communicating and researching, just as the ancients needed to understand the differences in names in various places in order to understand the meaning. This is in the process of chemical research, just like a boat in a boat, to help move forward smoothly.
    Safety & Operational Standards
    2 - Fluoro - 5 - Nitrobenzenesulfonyl Chloride Safety and Operation Specifications
    2 - Fluoro - 5 - Nitrobenzenesulfonyl Chloride is a compound commonly used in chemical research, but it is dangerous, so the operation must strictly follow the safety and operation specifications to ensure the safety of the experimenter and the smooth progress of the experiment.
    #1. Safety Protection
    The experimenter must wear protective clothing, which must be resistant to chemical corrosion and can effectively block the compound from harming the body. At the same time, it is also essential to wear protective gloves. The material of the gloves should be able to resist the corrosion of 2 - Fluoro - 5 - Nitrobenzenesulfonyl Chloride and prevent it from contacting the skin. Face protection is indispensable, goggles can protect the eyes from the possible splash damage caused by this compound.
    #2. Operating environment
    The operation should be carried out in a well-ventilated fume hood. The fume hood can expel harmful gases that may be volatilized during the operation in time, reduce the concentration of harmful gases in the laboratory, and prevent the experimenter from inhaling 2-Fluoro-5-Nitrobenzenesulfonyl Chloride volatiles and harming health. And the operation area should be kept clean and tidy, free of debris accumulation, to facilitate operation and emergency response.
    #3. Operation process
    When taking 2-Fluoro-5-Nitrobenzenesulfonyl Chloride, the action should be cautious to prevent it from spilling. Use a suitable measuring tool to accurately measure the required amount to avoid waste and the danger of excessive use. If it is accidentally spilled, immediate measures should be taken to clean it up. When a small amount is spilled, an inert adsorption material can be used to cover the absorption, and then the adsorption material should be properly disposed of; if a large amount is spilled, it is necessary to quickly evacuate personnel and start emergency treatment procedures. During the reaction process, closely monitor the reaction conditions. Changes in temperature, pH and other conditions may affect the reaction process and the stability of the compound.
    #4. Storage Requirements
    2 - Fluoro - 5 - Nitrobenzenesulfonyl Chloride should be stored in a cool, dry place away from direct sunlight. The storage container must be well sealed to prevent it from reacting with moisture, oxygen and other substances in the air. And should be stored separately from other chemicals, especially reactive substances, to prevent accidental reactions.
    Strictly follow the above safety and operating practices to minimize the risk of using 2-Fluoro-5-Nitrobenzenesulfonyl Chloride and ensure the safety and success of the experiment.
    Application Area
    Today there is a product called "2 - Fluoro - 5 - Nitrobenzenesulfonyl Chloride". The application field of this product is quite extensive. In the field of medicinal chemistry, it can be used as a key intermediate to help create new drugs. Due to its unique structure, it can react ingeniously with many compounds, paving the way for the synthesis of drugs with specific curative effects.
    In the field of materials science, it also has extraordinary effects. Through special reactions, it can improve the properties of materials, making them exhibit better stability and functionality in specific environments.
    Furthermore, in the fine chemical industry, it is an indispensable raw material. After fine processing, a variety of high-value-added products can be derived to meet the needs of different industries and promote the progress of the chemical industry.
    Research & Development
    In the field of chemistry, I have been researching 2 - Fluoro - 5 - Nitrobenzenesulfonyl Chloride for a long time. This compound has unique properties and is useful in various chemical industries.
    At the beginning, the method of its synthesis was studied. After repeated experiments, various reaction conditions, such as temperature, pressure, and the ratio of reactants, were explored to obtain the optimal method to increase its yield and maintain its purity.
    Then, study the field of application of this product. In pharmaceutical chemistry, it can be used as a key intermediate to help the research and development of new drugs, which is expected to open up a new path for the treatment of diseases. In material science, it may improve the properties of materials and add unique properties of materials.
    I also seek the development of this product. Improve the synthesis process, reduce its cost and improve its quality. And hope to expand its application and explore the unknown potential. With unremitting efforts, 2-Fluoro-5-Nitrobenzenesulfonyl Chloride shines in scientific research and industry, adding brilliance to the academic and industry.
    Toxicity Research
    Recently, 2 - Fluoro - 5 - Nitrobenzenesulfonyl Chloride has been studied, and its toxicity is quite important. Looking at its structure, fluorine, nitro and sulfonyl chloride groups are combined, or cause it to be active and toxic.
    After various experiments, observe its effect on organisms. In microorganisms, it can disturb their metabolic process and prevent their reproduction. In mice, if exposed to this substance, it can be seen that when their behavior is abnormal, their eating and activities are reduced.
    And this substance also poses risks in the environment, or can pollute water and soil. Although the toxicity results are not fully known, only the current results show that its toxicity cannot be underestimated, and further research is needed to clarify the details and provide evidence for protection and treatment.
    Future Prospects
    2 - Fluoro - 5 - Nitrobenzenesulfonyl Chloride, it is also a treasure of the chemical industry. It has not been developed before, and it has great hope.
    This physical property is special, in the field of synthesis, it can be used as an important raw material, or it can be used to explore new methods, and it can be used to obtain unprecedented compounds. In the field of material research, material science and other fields, it can inject new vitality.
    In the field of material research, or it can be used as its special product, it can be synthesized with high efficiency and special effects, and overcome many diseases. In the field of materials, it may also create new materials with excellent performance, such as polymeric materials with special functions.
    We, the researchers, will study this thing, hoping to extract its greatest power, to achieve the progress of science and technology, people's well-being, and mental effort, so as to realize the untapped grand vision.
    Where to Buy 2-Fluoro-5-Nitrobenzenesulfonyl Chloride in China?
    As a trusted 2-Fluoro-5-Nitrobenzenesulfonyl Chloride manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 2-Fluoro-5-Nitrobenzenesulfonyl Chloride supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 2-Fluoro-5-Nitrobenzenesulfonyl Chloride?
    2-Fluoro-5-nitrobenzenesulfonyl chloride has a wide range of uses. In the field of organic synthesis, it is often a key intermediate.
    First, in the field of pharmaceutical creation, it can be used to synthesize specific drug molecules. Because of its high activity, it can react with many nucleophiles such as nitrogen and oxygen to construct compounds with diverse structures. These compounds may have unique physiological activities and can lay the foundation for the development of new drugs.
    Second, in the field of materials science, it can participate in the preparation of functional materials. For example, by reacting with a specific polymer monomer, its unique structure is introduced into the polymer main chain or side chain, imparting special properties such as corrosion resistance and optical properties to the material to meet the needs of different fields for material properties.
    Furthermore, in the field of pesticide chemistry, it can be used as an important raw material for the synthesis of new pesticides. Through its reaction with other organic compounds, compounds with high insecticidal, bactericidal or herbicidal activities are generated, providing strong support for pest control in agricultural production.
    With its special chemical structure and active reaction properties, this substance plays an indispensable role in many chemical-related industries, promoting technological innovation and product upgrading in various fields.
    What are the physical properties of 2-Fluoro-5-Nitrobenzenesulfonyl Chloride?
    2-Fluoro-5-nitrobenzenesulfonyl chloride is an important compound in organic chemistry. Its physical properties are described in detail as follows.
    Looking at its appearance, it is often white to light yellow crystalline powder, like a thin frost in the early winter, delicate and unique. This color state can be one of the important characteristics for the identification of this substance.
    When it comes to the melting point, it is about 54-58 ° C. Just like the critical point, the temperature reaches this point, and its solid state begins to melt into a flowing state. This property is crucial for the purification, separation and control of related reaction processes of substances.
    Furthermore, its boiling point is also an important physical parameter. Although the exact value varies slightly due to environmental factors and other factors, it is roughly within a certain range. This property is related to its stability and volatility in high temperature environments, and provides a necessary basis for the design and implementation of distillation and rectification operations in chemical production.
    The density of 2-fluoro-5-nitrobenzenesulfonyl chloride is also one of its physical properties. Its moderate density determines its distribution and sedimentation characteristics in different solvents or reaction systems, and affects the kinetic and thermodynamic processes of many reactions.
    As for solubility, this substance exhibits good solubility in common organic solvents such as dichloromethane, chloroform, toluene, etc., just like fish getting water, it can be evenly dispersed in it, creating favorable conditions for the organic synthesis reaction. However, in water, its solubility is poor. Due to the force between its own structure and water molecules, it is as insoluble as oil and water. This property also plays an important role in separation, purification and related reaction post-treatment steps.
    In summary, the physical properties of 2-fluoro-5-nitrobenzenesulfonyl chloride, such as appearance, melting point, boiling point, density, and solubility, are interrelated and jointly affect their application in organic synthesis, chemical production, and other fields, laying the foundation for chemists and engineers to use this substance rationally.
    What is the synthesis method of 2-Fluoro-5-Nitrobenzenesulfonyl Chloride?
    The method of preparing 2-fluoro-5-nitrobenzenesulfonyl chloride is particularly particular. In the past, the preparation of such compounds used to follow a specific chemical path.
    First take the appropriate benzene derivative as the starting material. This raw material needs to have a check point that can introduce fluorine, nitro and sulfonyl chloride groups. If benzene is used as the group, the fluorine atom is first introduced, and the method of nucleophilic substitution or special fluorination reagents is often used. Benzene can react with fluorinated reagents under specific conditions. The choice of reaction temperature, pressure and catalyst is crucial. This step aims to precisely place the fluorine atom in the right position of the benzene ring.
    Next, introduce the nitro group. Mixed acid nitration method is often used, that is, concentrated sulfuric acid and concentrated nitric acid are mixed to form a mixed acid, and react with fluorobenzene derivatives. This reaction requires careful temperature control. Due to the intense nitration reaction, high temperature can easily cause side reactions to occur, affecting the purity and yield of the product. After nitration, the nitro group can be successfully attached to a specific position of the benzene ring to obtain fluorinated nitrobenzene derivatives.
    The last step is to prepare a sulfonyl chloride group. Generally, chlorosulfonic acid or sulfur trioxide is combined with a chlorination agent. The fluorine-containing nitrobenzene derivatives are reacted with chlorosulfonic acid and other reagents in an appropriate solvent. The reaction environment needs to be anhydrous and have a suitable pH. After the reaction is completed, the impurities are removed through complex processes such as separation and purification, such as extraction, distillation, recrystallization, etc., and the pure 2-fluoro-5-nitrobenzenesulfonyl chloride is finally obtained.
    Each step of the reaction requires careful control of the reaction conditions and precise operation to improve the yield and purity of the product and obtain satisfactory results.
    What to pay attention to when storing and transporting 2-Fluoro-5-Nitrobenzenesulfonyl Chloride
    2-Fluoro-5-nitrobenzenesulfonyl chloride is an important reagent commonly used in organic synthesis. When storing and transporting, it is necessary to pay more attention to many matters.
    Bear the brunt, when storing, it must choose a cool and dry place. This material is lively, and it is prone to change when heated or wet. If placed in a high temperature place, its internal structure may change due to heat, causing chemical instability or adverse reactions such as decomposition. In a humid environment, water vapor easily interacts with the substance, or the reaction occurs for no reason, so a dry and cool place is the best storage place.
    Furthermore, it needs to be sealed and stored. 2-Fluoro-5-nitrobenzenesulfonyl chloride easily reacts with components in the air, such as oxygen, water vapor, etc. Sealed, it can effectively avoid contact with external substances and ensure the stability of its chemical properties. Storage containers should also be carefully selected. Corrosion-resistant materials, such as glass or specific plastics, should be used to prevent chemical reactions between the container and the substance and damage the quality of the drug.
    When transporting, it should not be neglected. It is necessary to ensure that the packaging is sturdy to prevent the container from being damaged due to collision and vibration during transportation, and the leakage of 2-fluoro-5-nitrobenzenesulfonyl chloride. If it leaks, it will not only damage the drug, but also endanger the safety of transporters, and also pose a potential hazard to the environment.
    In addition, during transportation and storage, keep away from fire sources, heat sources and oxidants. This substance has certain chemical activity, and it is at risk of encountering fire sources, heat sources, or triggering combustion or even explosion; when it encounters with oxidants, it is easy to trigger violent chemical reactions, so it is necessary to stay away from it.
    In short, the storage and transportation of 2-fluoro-5-nitrobenzenesulfonyl chloride should strictly follow the relevant specifications and requirements, and operate cautiously to ensure personnel safety, material stability and environmental harmlessness.
    What is the market price range for 2-Fluoro-5-Nitrobenzenesulfonyl Chloride?
    2-Fluoro-5-nitrobenzenesulfonyl chloride, this product is in the market, its price is variable, and there are many reasons. In the past, its price fluctuated, often due to changes in supply and demand, difficulties in production methods, and abundance of raw materials.
    Looking at the market, the price of this product in the past often varied from time to time. When raw materials are widely produced, and the production method is refined, the supply exceeds the demand, the price may decline. If raw materials are scarce, the craftsmanship is complicated, and the demand is greater than the supply, the price will rise. However, there was no constant price in the past, or it varies due to various variables in the market.
    According to the traces of past transactions, its price may be between gold per gram and tens of gold. However, this is only a rough idea, and the actual price changes abruptly with the market conditions. There are also those that vary depending on the quantity. If you buy in bulk, the price may vary; if you take a little from zero, the price may be slightly higher. And different sources, the quality is different, and the price is also different. Good quality is high, and the inferior is low.
    Merchants in the city have different prices because of their source, cost, and profit. There are high-end specialties, high quality and high price; there are pictures for wide sales, and the price is slightly easier. Therefore, if you want to know the exact price, you need to consult the merchants, and compare their quality and price to get the real information. In short, the market conditions are ever-changing, and the price is also impermanent, so it cannot be limited to one frame.