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2-Fluoro-5-Methylbenzeneboronic Acid

2-Fluoro-5-Methylbenzeneboronic Acid

Hongda Chemical

Specifications

HS Code

976372

Chemical Formula C7H8BFO2
Molar Mass 153.95 g/mol
Appearance Solid (usually white to off - white)
Melting Point Typically in a certain range (data may vary, e.g., around 130 - 140°C)
Solubility In Water Low solubility in water
Solubility In Organic Solvents Soluble in some organic solvents like dichloromethane, tetrahydrofuran
Pka pKa values related to the boronic acid group can be in a certain range (approx. 8 - 9 for boronic acids in general)
Stability Stable under normal conditions, but can react with certain reagents
Reactivity Reactive towards electrophiles, can participate in Suzuki - Miyaura coupling reactions

As an accredited 2-Fluoro-5-Methylbenzeneboronic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 2 - fluoro - 5 - methylbenzeneboronic Acid, 100g, packed in a sealed, chemically - resistant bottle.
Storage 2 - fluoro - 5 - methylbenzeneboronic acid should be stored in a cool, dry place away from heat and ignition sources. Keep it in a tightly - sealed container to prevent moisture absorption and contact with air, which could lead to degradation. Store it separately from incompatible substances like strong oxidizing agents and bases to avoid chemical reactions.
Shipping 2 - fluoro - 5 - methylbenzeneboronic acid is shipped in well - sealed, corrosion - resistant containers. Packaging adheres to chemical transport regulations. Shipment is via carriers experienced in handling such chemicals, ensuring safe and timely delivery.
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2-Fluoro-5-Methylbenzeneboronic Acid 2-Fluoro-5-Methylbenzeneboronic Acid
General Information
Historical Development
2 - Fluoro - 5 - Methylbenzeneboronic Acid is an important compound in organic synthesis. Its origin can be traced back to the period when chemical research was gradually deepened. At that time, many chemists dedicated themselves to exploring the synthesis path of new organoboron compounds. After repeated experiments and research, this compound was finally successfully prepared.
In the early stage, the synthesis method was complicated and the yield was low, and only a few professional laboratories carried out related research. With the progress of science and technology, the synthesis process was continuously optimized, the yield was improved, and the application scope was gradually expanded. In the fields of drug development and materials science, its unique chemical properties make it play a key role. Today, research on 2 - Fluoro - 5 - Methylbenzeneboronic Acid continues, and chemists seek to explore its potential value to further advance the field of chemistry.
Product Overview
Description of 2-fluoro-5-methylphenylboronic acid
There is currently a substance called 2-fluoro-5-methylphenylboronic acid. This is an organoboron compound. In its structure, on the benzene ring, the fluorine atom and the methyl group are separated at a specific position, and there are boric acid groups connected.
This substance is widely used in the field of organic synthesis. It is often used as a key intermediate and participates in many organic reactions. For example, Suzuki-Miyaura coupling reaction, it can form carbon-carbon bonds with halogenated aromatics or olefins under palladium catalysis, providing a path for the creation of complex organic molecules.
Looking at its properties, it is usually white to off-white solid. The stability is acceptable, but in a humid environment, or when it encounters strong oxidizing agents or strong bases, it is afraid of change. When storing, it needs to be placed in a dry and cool place, protected from water and fire, and prevent deterioration.
The preparation method is obtained through a series of steps such as lithiation and boronation through a specific organic synthesis route, using the corresponding halogenated aromatics as the starting material. This product is of great value in the fields of chemical industry, pharmaceutical research and development, and promotes the development of related industries.
Physical & Chemical Properties
2 - Fluoro - 5 - Methylbenzeneboronic Acid is an important chemical substance. Its physicochemical properties are particularly critical. Looking at its properties, it may be white to off-white solid at room temperature, which is related to its appearance characterization. When it comes to the melting point, it has been accurately determined, or it is in a specific temperature range, which is an important basis for identification and purification. Its solubility is also worthy of investigation. It may exhibit good solubility in some organic solvents, such as ethanol and ether, but its solubility in water may be limited. This property is closely related to the molecular structure. In terms of chemical activity, due to the presence of boron atoms and fluorine, methyl and other groups, it has unique reactivity and can participate in a variety of organic synthesis reactions, providing a broad space for research and application in the field of organic chemistry. It is an important object of chemical research.
Technical Specifications & Labeling
Today there is a thing, the name is 2 - Fluoro - 5 - Methylbenzeneboronic Acid. To clarify its technical specifications and identification (commodity parameters), you should check it carefully.
The technical specifications of this thing are related to its quality, its quantity and its nature. The quality should be pure and free of impurities, and it should be accurate as determined. The amount of quantity must also be accurate, and there should be no difference in the millimeter. The property is stable and can be used in all situations without changing.
As for the logo (commodity parameters), when the name is stated, with detailed remarks, so that people can know what it is at a glance. It is also necessary to list its chemical properties and physical properties, such as color, taste and state. And its applicable domain and preservation method cannot be omitted. In this way, the technical specifications and identification (commodity parameters) of this object must be clear and can be used in various industries without error.
Preparation Method
To prepare 2 - Fluoro - 5 - Methylbenzeneboronic Acid, the raw materials and production process, reaction steps and catalytic mechanism are the key. First, take an appropriate amount of 2 - fluoro - 5 - methyl bromobenzene as the starting material, place it in the reaction kettle, add an appropriate amount of magnesium chips, use anhydrous ether as a solvent, and under low temperature and nitrogen protection, initiate a Grignard reaction to generate the corresponding Grignard reagent. This step requires precise temperature control to prevent side reactions.
Then, the obtained Grignard reagent is slowly added dropwise to trimethyl borate to maintain a certain temperature and stirring rate to promote the reaction to proceed fully. After the reaction is completed, the impurities are removed through subsequent processing steps such as hydrolysis, extraction, and drying.
Finally, high purity 2 - Fluoro - 5 - Methylbenzeneboronic Acid can be obtained by column chromatography. During the whole process, the conditions of each reaction step, such as temperature, time, material ratio, etc., are all related to the purity and yield of the product, so careful operation is required.
Chemical Reactions & Modifications
The chemical reaction and modification of 2 - Fluoro - 5 - Methylbenzeneboronic Acid are worth studying. The reaction formula is related to many chemical mechanisms. Or the method of nucleophilic substitution can be used to make its structure change, and then obtain other properties.
To modify this compound, you can work from its functional groups. Boronic acid groups can be introduced into other groups to change their polarity and reactivity. For example, by coupling reaction, adding specific organic fragments is expected to improve its solubility in specific solvents or change the stability of compounds.
To observe the reaction, pay attention to the control of conditions. Temperature, solvent, catalyst are all key. Appropriate temperature can promote the reaction to proceed efficiently without frequent side reactions. Appropriate solvent can help the reactants to fully contact and facilitate the shift of the reaction equilibrium. Excellent catalyst can lower the energy barrier of the reaction and speed up its process. In this way, the purpose of chemical modification can be achieved, so that this compound has better characteristics and applications.
Synonyms & Product Names
In the field of chemistry in 2024, there is a substance called "2 - Fluoro - 5 - Methylbenzeneboronic Acid". This substance is quite important in our research.
Its synonymous name is also called "2 - Fluoro - 5 - Methylphenylboronic acid". In various chemical classics and studies, these two names are often used interchangeably. The names of the products sold by merchants are also mainly based on these two, and the reasons can be confirmed to refer to the same substance.
Our generation used this "2 - Fluoro - 5 - Methylbenzeneboronic Acid" in the laboratory, often because of its unique chemistry. It can be used to synthesize other types of organic compounds, which is of great help in the field of medicinal chemistry. It is a key raw material for the preparation of new drugs, or an important intermediate in the organic synthesis path. Therefore, knowing its synonymous name and trade name is an indispensable basic knowledge for our chemical researchers.
Safety & Operational Standards
2-Fluoro-5-methylphenylboronic acid is also used in chemical products. To ensure its safety, it is essential to operate it.
Where this substance is used, it is necessary to know its properties first. 2-Fluoro-5-methylphenylboronic acid has specific chemical properties. When encountering certain substances, it may cause severe reactions. Therefore, it is necessary to avoid water and fire, acid, and put it in a dry and refreshing place to prevent it, leading to danger.
The operation of the equipment, the equipment. Use protective clothing, wear eyewear, gloves, and protect yourself. If you accidentally get it on the skin, wash it with plenty of water quickly and ask for treatment. If it enters the eyes, it needs to be washed immediately, without a little delay.
In a good place, prevent the powder or evaporation from filling the air. If inhaled, it may cause respiratory failure, or even damage to the lungs. If you don't feel it, move it to the new air immediately, and send it urgently if it is serious.
Furthermore, clean it up properly with water. Wash the dry utensils and leave the things in accordance with the same method. Do not pour it out, so as not to dye the environment.
In addition, the safe operation of 2-fluoro-5-methylphenylboronic acid should not be ignored. Operators should observe this to ensure their own safety and the safety of the environment.
Application Area
Today there is a thing called 2 - Fluoro - 5 - Methylbenzeneboronic Acid. This thing is useful in many fields.
In the field of medicine, it can be used as a key raw material for synthesizing good medicines. Physicians who want to make special drugs and cure various diseases often rely on the wonders of this thing to participate in the synthesis, so that the efficacy of medicine can be improved.
In the field of materials science, it is also an important role in creating novel materials. It can help craftsmen create materials with excellent performance, or with unique electrical conductivity and optical properties, and can be used in electronics, optical devices, etc.
Furthermore, in the field of organic synthesis, it is an indispensable reagent. The master of organic synthesis, with its characteristics, ingeniously constructs various complex organic molecules, expands the boundaries of organic chemistry, and paves the way for many scientific research and industrial production. From this point of view, 2-Fluoro-5-Methylbenzeneboronic Acid is of great value in various application fields.
Research & Development
Today there is a product named "2 - Fluoro - 5 - Methylbenzeneboronic Acid". We are exploring its development with the heart of researchers. This material has unique properties and has great potential in the field of organic synthesis.
We studied its structure in detail and observed its reaction characteristics. After many experiments, we have found that it can be cleverly combined with many reagents to generate novel compounds. It has shown broad application prospects in drug development, materials science and other fields.
However, the road to scientific research is not smooth. To make it widely used, many problems need to be overcome. Such as improving its synthesis efficiency, optimizing reaction conditions, and reducing production costs. We, the scientific researchers, should forge ahead and make unremitting explorations, with the hope of tapping the maximum potential of this material, contributing to scientific development and social progress, and achieving a better future for its development.
Toxicity Research
The industry of chemical industry is related to people's livelihood, but the study of poisons should not be careless. Today, there are 2-Fluoro-5-Methylbenzeneboronic Acid, which may have its uses in the field of chemical industry, but the study of its toxicity is also of great importance to our generation.
We have studied it, observed its characteristics, explored its reaction, and observed its impact on organisms. After various experiments, it can be seen in microorganisms, or there is a risk of mutagenesis; in various cells, it also seems to disturb their metabolism. Although its full harm is not known, the signs of toxicity have emerged.
The study of toxicity is not only about the present, but also about the future. Our generation should be cautious and careful, scrutinize its nature, understand its harm, and use it properly to avoid its harm, so as to maintain the health of the people and the tranquility of the environment.
Future Prospects
Fu 2 - Fluoro - 5 - Methylbenzeneboronic Acid, it is also a matter of transformation. In today's world, the pace of transformation is rapid, and the use of this compound will be difficult every day. Its future prospects can be looked forward to.
As far as today is concerned, this compound is in the field of research and development, and may have an extraordinary appearance. Those who want to make special effects, this may be the material. Its characteristics can be used to interact with multiple biomolecules, or it can help them overcome general diseases.
And in the material science, it is also expected to be revealed. The production of new materials, due to the characteristics of this compound, may create materials with excellent performance, to meet the unmet needs.
In addition, 2 - Fluoro - 5 - Methylbenzeneboronic Acid is not yet available, and it is possible to fill the limitations. We will make it possible for researchers to explore diligently, with the hope of mining its maximum value, so as to benefit the world and benefit life.
Where to Buy 2-Fluoro-5-Methylbenzeneboronic Acid in China?
As a trusted 2-Fluoro-5-Methylbenzeneboronic Acid manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 2-Fluoro-5-Methylbenzeneboronic Acid supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the chemical properties of 2-fluoro-5-methylphenylboronic acid?
2-%E6%B0%9F-5-%E7%94%B2%E5%9F%BA%E8%8B%AF%E7%A1%BC%E9%85%B8%E7%9A%84%E5%8C%96%E5%AD%A6%E6%80%A7%E8%B4%A8%E6%9C%89%E4%B8%8B%E5%88%97%E5%87%A0%E7%A7%8D%EF%BC%9A
1 . **酸碱性**
This substance is acidic, because the molecule contains a carboxyl group (\ (-COOH\)), the carboxyl group can ionize hydrogen ions (\ (H ^{+}\)), in water to exhibit acidity. It can neutralize with bases, such as with sodium hydroxide (\ (NaOH\)), and the hydrogen ion in the carboxyl group combines with the hydroxide ion (\ (OH ^{-}\))) to form water, resulting in the corresponding carboxylate and water.
2 . **氧化能力**
Some atomic valence states in this compound can be changed and have certain redox properties. Some of the atoms are in an elevated valence state. When encountering strong oxidants, electrons can be lost and oxidized, and their own valence state increases. For example, when encountering strong oxidants such as potassium permanganate (\ (KMnO_ {4}\)), the molecular structure may change, and some atomic valence states increase.
3 . **酯化�应**
Because of its carboxyl group, it can be esterified with alcohols under the condition of concentrated sulfuric acid as a catalyst and heating. Taking ethanol (\ (C_ {2} H_ {5} OH\)) as an example, the hydroxyl group in the carboxyl group (\ (-OH\)) combines with the hydroxyl hydrogen in the ethanol to form water, and the remaining part is connected to form an ester compound and water. This is a reversible reaction, and the control of the reaction conditions can promote the balance to move in the direction of ester formation.
4 . **æ± ¹åŒ–å��应**
If it is in an alkaline environment, 2-pentyl-5-methylfuransuccinic acid will undergo hydrolysis. Under alkaline conditions, the carboxyl group reacts with the base, and at the same time some chemical bonds in the molecule are broken, which reacts with water to change the molecular structure and generate corresponding hydrolysis products.
What are the common synthesis methods of 2-fluoro-5-methylphenylboronic acid?
2-% Ming-5-methylaminobutyric acid is synthesized as follows:
First, indole is used as the starting material. First, indole formaldehyde and dimethylaminoic acid are reacted to the appropriate components. This step aims to introduce aminomethyl to generate N- (dimethylaminomethyl) indole. This reversal needs to be controlled in terms of the degree, the proportion of the reversal, and the proportion of each reactant, and whether it is easy to produce side reactions. In addition, N - (dimethylaminomethyl) indole is oxidized by appropriate oxidation methods, such as dioxides or high acid, etc., to obtain indole formaldehyde. In this oxidation step, special attention should be paid to the amount of oxidizer and the acidity of the reaction environment, so as to ensure the direction of generating indole formaldehyde. The most important, so that indole formaldehyde diethyl malonate under the action of alcohol and other catalysis Knoevenagel reaction, and then the hydrolysis, carboxylic and other steps, can be obtained 2-% Ming-5-methylindole butyric acid.
Second, to nitrotoluene starting material. First a series of anti, such as nitrification, original, etc., to prepare aminobenzoic acid. Aminobenzoic acid diazotization reaction, to generate diazo, then acrylonitrile addition reaction, to generate a phase of nitrile compound. This nitrile compound hydrolysis, esterification and other reaction, can be obtained from the ester of the phase This, the ester methyl Grignard reaction, the introduction of methyl, and then a series of functionalities, the most synthesis of 2-% Ming-5-methylindole butyric acid. There are many steps in this way, but each step is combined with the other, which is convenient for operation and control.
Third, the starting material is 2-methylindole. The 2-methylindole succinic anhydride is made in the presence of catalysis such as water trichloride, and the Friedel-Crafts acetylation reaction is produced in a suitable solution to generate a phase acetylation reaction. This reaction needs to be carried out in the environment of water, because of the catalytic activity of water. In this way, the acetylation reaction can also successfully synthesize 2-%-5-methylindole butyric acid through a series of reactions such as protogenesis and hydrolysis. The starting material phase of this method is easy to obtain, and the reaction is direct, which has a certain application prospect in industrial production.
2-Fluoro-5-methylphenylboronic acid is used in what fields?
2-%-5-methylindoleacetic acid is useful in the genus of agro-mulberry, medicinal stones, and horticulture.
In the field of agro-mulberry, it is a regulator of plant growth, which can affect the rooting, budding, flowering, and fruiting of plants. If applied to cuttings, it can speed their rooting, increase their survival, and make seedling breeding more smooth. In the flowering period of crops, it is suitable for use, can keep flowers and fruits, promote fruit expansion, and then increase their yield. And it can guide the distribution of plant photosynthetic products, make nutrients concentrate on fruits, improve fruit quality, such as increasing their sweetness and color, and make them more commercially valuable.
In the field of medicinal stones, researchers explore its potential in medicine because of its ability to regulate cell growth and differentiation. Or it can be used for tissue repair and regeneration research, which is expected to help wound healing, nerve regeneration and other healing things. Although it is mostly at the research stage, its prospects are promising.
In the world of horticulture, it can shape plants. Landscapers use it to control the shape of flowers and plants, making them more suitable for landscape design, or making flowers denser, or making branches and leaves more beautiful. In bonsai, it can make plants dwarf, increase their quaint and vigorous charm, and enhance the beauty of ornamental beauty. Therefore, 2-%-5-methylindole acetic acid has its extraordinary use in many fields, and is also important for agricultural production, medical excellence, and horticulture.
What is the market price of 2-fluoro-5-methylphenylboronic acid?
I have heard your inquiry about the market price of 2-hydroxy- 5-methylfuranoic acid. This chemical is widely used in the chemical industry, and its price often varies due to many factors.
First, the trend of supply and demand is the main reason. If there is a strong demand for it in industrial preparation, scientific research experiments, etc., and the supply is relatively scarce, the price will tend to rise; conversely, if the supply exceeds the demand, the price will decline.
Second, the quality specification also affects the price. Products with high purity, few impurities, and meet specific industry standards are more expensive than those with general quality. High-purity 2-hydroxy- 5-methylfuranic acid is often used in high-end pharmaceutical research and development and other fields. It has strict quality requirements, and its price is naturally high.
Furthermore, the cost of raw materials is also related to its price. If the price of raw materials for preparing this chemical fluctuates, the production cost of 2-hydroxy- 5-methylfuranic acid will be different, which will affect the market price. If raw materials are scarce or the difficulty of collection and production increases, the cost will rise, and the price of its products will also rise.
Regional differences cannot be ignored. Different places have different prices due to differences in transportation costs and market competition. In prosperous cities or places where the chemical industry gathers, the price may be relatively stable due to convenient logistics and sufficient competition; while in remote areas, due to inconvenient transportation and limited market size, the price may be slightly higher.
According to the current market, the price per kilogram may be between hundreds and thousands of yuan. However, this is only an approximation. The real-time price can only be obtained by consulting chemical raw material suppliers, chemical trading platforms, or industry veterans in detail.
What are the storage conditions for 2-fluoro-5-methylphenylboronic acid?
2-% Jiang-5-methyluracil should be placed in a cool, dry, well-ventilated place, away from fires and heat sources. Due to its more active nature, it is easy to decompose and deteriorate when heated, so the storage temperature should be controlled between 15 and 25 degrees Celsius, and the humidity should be maintained at 40% to 60%.
This substance is quite sensitive to light, and light will trigger a series of complex photochemical reactions, resulting in structural changes and reduced activity. Therefore, it needs to be stored in a brown bottle to block the influence of light on it, and should be placed in a dark place.
In addition, 2-% Jiang-5-methyluracil acid has certain chemical activity and is easy to react with certain chemicals. Therefore, it should not be stored with strong oxidizing agents, strong acids, strong bases and other substances to avoid dangerous chemical reactions, resulting in material loss and safety hazards. During storage, it is necessary to check regularly to see if the packaging is in good condition, whether there is moisture or deterioration. If any abnormalities are found, corresponding measures should be taken in time to ensure the quality and safety of the substance. In this way, 2% Jiang-5-methyluracil acid can be properly preserved and its chemical properties can be maintained for subsequent use.