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What are the main uses of 2-Fluoro-5-Methylbenzene-1-Sulfonyl Chloride?
2-Fluoro-5-methylbenzene-1-sulfonyl chloride is an important raw material for organic synthesis and is widely used in many fields.
First, in the field of medicinal chemistry, this compound is often used as a key intermediate. Due to its active chemical properties of sulfonyl chloride groups, it can substitution react with various nucleophiles containing nitrogen, oxygen, sulfur, etc., and then construct complex drug molecular structures. In the synthesis of many antibacterial, anti-inflammatory, anti-tumor and other drugs, 2-fluoro-5-methylbenzene-1-sulfonyl chloride plays an important role in the synthesis of compounds with specific biological activities and pharmacological properties.
Second, in the field of materials science, it also shows unique value. By reacting with different functional monomers or polymers, materials can be given special properties. For example, introducing it into polymer materials can improve the surface properties of materials, enhance their chemical stability, or give materials some special optical and electrical properties, thus preparing high-performance materials suitable for electronic devices, optical materials and other fields.
Third, in the field of pesticide chemistry, 2-fluoro-5-methylbenzene-1-sulfonyl chloride can be used to synthesize new pesticides. With its unique chemical structure, the synthesized pesticide may have the characteristics of high efficiency, low toxicity, and environmental friendliness, which helps to improve the yield and quality of crops while reducing the negative impact on the environment.
In summary, 2-fluoro-5-methylbenzene-1-sulfonyl chloride plays an important role in many fields such as medicine, materials, and pesticides due to its active chemical properties, providing a key chemical basis and synthesis means for the development of various fields.
What are the physical properties of 2-Fluoro-5-Methylbenzene-1-Sulfonyl Chloride?
2-Fluoro-5-methylbenzene-1-sulfonyl chloride, this substance is a colorless to light yellow liquid with a pungent odor and an uncomfortable smell. Its boiling point is quite high, between 270 ° C and 280 ° C, due to intermolecular forces and structural properties. At room temperature, the density is greater than that of water, about 1.45-1.55 g/cm ³. When placed in water, it will sink to the bottom.
Its solubility is unique, and it can be well miscible in organic solvents such as dichloromethane, chloroform, toluene, etc. Due to the principle of similar miscibility and molecular polarity matching; while in water, the solubility is very small, because of its molecular structure, the hydrophobic benzene ring and sulfonyl chloride groups account for a large proportion, which hinders its interaction with water to form hydrogen bonds.
2-fluoro-5-methylbenzene-1-sulfonyl chloride has active chemical properties. In the sulfonyl chloride group, the chlorine atom is highly active, and it is vulnerable to attack by nucleophiles. Substitution reactions occur, resulting in the formation of derivatives such as sulfonamides and sulfonates. It is also unstable in contact with water, slowly hydrolyzes, produces hydrogen chloride gas, and generates white fog, which is caused by the hydrolysis reaction to produce acidic substances. Although its fluorine atom is relatively stable, it can also participate in the reaction under specific conditions, affecting the overall reactivity and selectivity of the molecule.
2-Fluoro-5-Methylbenzene-1-Sulfonyl the chemistry of Chloride
2-Fluoro-5-methylbenzene-1-sulfonyl chloride is an important compound in organic chemistry. Its chemical properties are unique and valuable for investigation.
Looking at its structure, fluorine atoms and methyl are on the same benzene ring, and sulfonyl chloride groups are also connected to the benzene ring. Fluorine atoms have high electronegativity, which can affect the distribution of electron clouds in the benzene ring, causing the electron cloud density of the benzene ring to decrease, thus changing the activity of the electrophilic substitution of the benzene ring. Methyl is the power supply group, which can increase the electron cloud density of the benzene ring. The two have opposite effects and jointly affect the reactivity of the benzene ring. The sulfonyl chloride group is chemically active and easily hydrolyzed in contact with water to form the corresponding sulfonic acid and hydrogen chloride. In many organic synthesis reactions, this group is often used as an important intermediate. For example, it can react with alcohols to form sulfonates. This reaction is widely used in the synthesis of organic compounds with specific functions.
It can also react with amines to form sulfonamides, which is a key reaction step in the preparation of a variety of drugs and functional materials. In nucleophilic substitution reactions, the chlorine atoms in the sulfonyl chloride group are easily replaced by nucleophiles, which gives the compound great flexibility in building complex organic molecular structures. Due to its special structure, 2-fluoro-5-methylbenzene-1-sulfonyl chloride exhibits diverse and active chemical properties, which plays an indispensable role in the field of organic synthetic chemistry and provides an important way for the creation of novel organic compounds and materials.
What are the synthesis methods of 2-Fluoro-5-Methylbenzene-1-Sulfonyl Chloride?
The synthesis of 2-fluoro-5-methylbenzene-1-sulfonyl chloride often involves several methods. One is to use 2-fluoro-5-methylbenzene as the starting material and introduce a sulfonic acid group through a sulfonation reaction. This step mostly uses concentrated sulfuric acid or fuming sulfuric acid as a sulfonation reagent. At an appropriate temperature and reaction time, the hydrogen on the benzene ring is replaced by a sulfonic acid group to obtain 2-fluoro-5-methylbenzene sulfonic acid. When reacting, pay attention to the control of temperature. If it is too high, it is easy to cause side reactions, which affects the yield and purity.
Then, the obtained 2-fluoro-5-methylbenzenesulfonic acid is converted into sulfonyl chloride. Chlorination reagents are commonly used for this conversion, such as phosphorus pentachloride ($PCl_5 $), dichlorosulfoxide ($SOCl_2 $), etc. Taking dichlorosulfoxide as an example, it is co-heated with 2-fluoro-5-methylbenzenesulfonic acid, and the hydroxyl group in the sulfonic acid group is replaced by a chlorine atom to obtain the target product 2-fluoro-5-methylbenzene-1-sulfonyl chloride. In this process, sulfoxide is not only a chlorination agent, but also its by-products are gases (sulfur dioxide and hydrogen chloride), which are easy to separate, and the reaction proceeds in a positive direction.
Or from other related aromatic derivatives, a series of functional groups are converted to achieve the purpose. For example, suitable substituents are introduced first, and then the structure of the target molecule is gradually constructed through a specific reaction sequence. However, this approach may require more steps, and the optimization of the reaction conditions at each step is crucial to ensure the efficiency and selectivity of each step of the reaction, thereby improving the efficiency and yield of the overall synthesis. In the whole process of synthesis, the reaction conditions, the amount of reagents and the purification of intermediates need to be carefully controlled to obtain high-purity 2-fluoro-5-methylbenzene-1-sulfonyl chloride.
What are the precautions for 2-Fluoro-5-Methylbenzene-1-Sulfonyl Chloride in storage and transportation?
2-Fluoro-5-methylbenzene-1-sulfonyl chloride is a chemical substance. When storing and transporting, many matters must be paid attention to.
First word storage. This material is lively, and it should be placed in a cool, dry and well-ventilated place. Do not coexist with water, alkalis and other substances in the same room. Because it is easy to react in contact with water, or cause violent changes, and even dangerous. For example, if it encounters with water, it may cause a hydrolysis reaction, releasing hydrogen chloride gas, which is corrosive and harmful to human respiratory organs and the environment. And alkali substances can also react chemically with it, causing the substance to deteriorate, so it must be stored away from such items.
In addition, the storage temperature is also very important. It should be maintained at a suitable low temperature to prevent it from decomposing or accelerating deterioration due to excessive temperature. It is also necessary to ensure that the storage container is tightly closed to prevent leakage. The material of the container should also be carefully selected, and it must be able to withstand the erosion of this substance. Common containers such as glass, certain plastics or metal materials, depending on their characteristics.
As for transportation, extreme caution is also required. Packing that meets safety standards must be used and tightly sealed to prevent leakage during transportation. Transportation vehicles should also be equipped with corresponding emergency treatment equipment and protective equipment for emergencies. Transportation personnel must also be specially trained to be familiar with the characteristics of this substance and emergency treatment methods. During transportation, it is necessary to avoid it from being close to heat sources and fire sources to prevent danger. And the transportation route planning also needs to be thorough, avoiding sensitive areas such as water source reserves and densely populated areas to ensure safety. In short, the storage and transportation of 2-fluoro-5-methylbenzene-1-sulfonyl chloride must be based on safety and strictly follow relevant procedures to be safe.
