2-Fluoro-5-methoxyphenylacetonitrile is an important chemical substance in the field of organic synthesis. Its main uses cover the following ends.
In the field of pharmaceutical chemistry, this substance is often used as a key intermediate. In the process of pharmaceutical synthesis, a specific molecular structure needs to be constructed. The chemical structure of 2-fluoro-5-methoxyphenylacetonitrile can be ingeniously introduced into the target drug molecule through various chemical reactions, such as nucleophilic substitution and addition. Due to the introduction of fluorine atoms, the physical, chemical and biological activity properties of compounds can be significantly changed, such as improving the lipid solubility of drugs, enhancing their transmembrane transportation ability, and then enhancing drug efficacy; methoxy groups also affect the electron cloud distribution and spatial configuration of molecules, which is related to the binding affinity of drugs and targets. Therefore, the development of many new drugs often relies on this intermediate to build a core skeleton, laying the foundation for the creation of drugs with better efficacy and fewer side effects.
In the field of materials science, 2-fluoro-5-methoxyphenylacetonitrile also has its uses. In the preparation process of organic optoelectronic materials, they can be chemically modified and polymerized to integrate them into the structure of polymer materials. In this way, the material is endowed with specific optical and electrical properties, such as adjusting the fluorescence emission wavelength of the material and improving the charge transfer efficiency. This is of great significance for the performance optimization of organic Light Emitting Diode (OLED), organic solar cells and other optoelectronic devices, helping to improve the luminous efficiency, stability and service life of the device.
In addition, in the synthesis of fine chemical products, 2-fluoro-5-methoxyphenylacetonitrile is also a common raw material. The preparation of fine chemicals such as fragrances and pesticides can utilize their unique chemical properties to synthesize fine chemical products with specific functions and structures through a series of reactions, meeting the diverse needs of different fields.

2-Fluoro-5-methoxyphenylacetonitrile, its physical properties are as follows:
This substance is mostly a colorless to light yellow liquid at room temperature. It is clear and transparent in appearance, and has a certain fluidity. Its odor is specific, not a common odor, it is difficult to describe exactly. It is close to a fine smell, and has a more irritating and unique taste.
When it comes to the melting point, it is between -10 ° C and -5 ° C. Under this low temperature environment, the substance gradually solidifies from liquid to solid. The boiling point is in the range of 250 ° C to 260 ° C. When the temperature rises to the boiling point, the substance is rapidly converted from liquid to gaseous.
In terms of density, it is about 1.15-1.20 g/cm ³. Compared with common water, the density is slightly higher. If it is placed in one place with water, it will sink underwater.
Solubility is also an important physical property. In organic solvents, such as ethanol, ether, dichloromethane, etc., this substance can be well dissolved and can be uniformly mixed with these organic solvents without delamination. However, in water, its solubility is very poor, almost insoluble. After mixing with water, it is immediately stratified, with the upper layer being water and the lower layer being 2-fluoro-5-methoxyphenylacetonitrile.
In addition, its refractive index is about 1.520-1.530, and when light passes through the substance, the propagation direction will be deflected accordingly. These physical properties are crucial for the understanding and use of 2-fluoro-5-methoxyphenylacetonitrile, and are important references in many fields such as chemical synthesis, analysis and detection.

The synthesis of 2-fluoro-5-methoxyphenylacetonitrile is a key field of organic synthetic chemistry. Its synthesis paths are rich and diverse, and can be started from different starting materials and reaction mechanisms.
First, 2-fluoro-5-methoxybenzoic acid is used as the starting material. First, it is converted into acid chloride, and thionyl chloride is often used to react with it. This step has mild conditions and good yield. The resulting acid chloride is then reacted with sodium cyanide in an appropriate organic solvent, such as N, N-dimethylformamide (DMF), and the target product 2-fluoro-5-methoxyphenylacetonitrile can be obtained through a nucleophilic substitution mechanism. The advantage of this route is that the starting material is relatively easy to obtain and the reaction steps are clear. However, sodium cyanide is highly toxic, and strict safety procedures must be followed during operation.
Second, it starts from 2-fluoro-5-methoxybenzyl halogen. Benzyl halogen reacts with magnesium metal to form Grignard reagent, and Grignard reagent reacts with cyanide reagents, such as cuprous cyanide, through a nucleophilic addition process to achieve the construction of the target molecule The advantage of this method is that the reactivity is high, and different benzyl halides can be flexibly selected to expand the range of substrates. However, Grignard's reagent requires harsh reaction conditions and requires an anhydrous and oxygen-free environment, which is difficult to operate.
Third, 2-fluoro-5-methoxybenzaldehyde is used as the raw material. First, the condensation reaction with Knoevenagel of malononitrile is catalyzed by a weak base to generate α, β - unsaturated nitrile intermediates containing cyanide, and then catalyzed by hydrogenation and reduction to obtain 2-fluoro-5-methoxybenzene acetonitrile. This route has good atomic economy and relatively mild reaction conditions, but the hydrogenation and reduction step requires the selection of suitable catalysts, and the separation and purification of the product requires fine operation.
When synthesizing 2-fluoro-5-methoxyphenylacetonitrile, the appropriate synthesis method should be carefully selected according to actual needs, raw material availability, cost considerations and operation safety.

2-Fluoro-5-methoxyphenylacetonitrile, when storing, many matters need to be paid attention to. This chemical substance is very active, and when exposed to heat, light or contact with specific substances, it is afraid of change, so it is stored in the first cool, dry and well-ventilated place.
If exposed to high temperature, 2-fluoro-5-methoxyphenylacetonitrile may decompose or cause danger. Excessive light exposure may also cause luminescent chemical reactions and damage its quality. In humid places, moisture is easy to interact with the substance or change its chemical properties, so it must be avoided.
Furthermore, 2-fluoro-5-methoxyphenylacetonitrile should be stored far away from oxidizing, reducing substances and strong acids and bases. Due to the chemical activity of the substance, it is easy to react violently when encountering the above substances, or cause explosions, fires and other disasters.
Storage containers must also be selected with caution. It is necessary to use corrosion-resistant and well-sealed containers to prevent leakage. Leakage not only causes material loss, but also threatens the environment and endangers life around.
Daily inspection is also a priority. Always check the container for damage or leakage, record the storage conditions, and dispose of any abnormalities immediately. In this way, Fang Bao 2-fluoro-5-methoxyphenylacetonitrile is stored stably and avoids disasters.

2-Fluoro-5-methoxyphenylacetonitrile is an important chemical raw material in the field of organic synthesis. It is widely used in various industries such as medicine, pesticides and material science. However, its market price range is difficult to describe in a single word, and it depends on many factors.
The first to bear the brunt is the cost of raw materials. The synthesis of this compound requires specific starting materials and reagents. If the supply of raw materials is scarce, or the production process is complicated, resulting in rising costs, the price of 2-fluoro-5-methoxyphenylacetonitrile will also rise.
Secondly, the difficulty and efficiency of the production process are also key factors. An efficient and mature production process can reduce production costs and make product prices easier. On the contrary, if the process is complex, high-end equipment and exquisite technology are required, and the yield is low, the price will remain high.
Furthermore, the market supply and demand situation has a deep impact on its price. If the market has strong demand for 2-fluoro-5-methoxyphenylacetonitrile and the supply is relatively insufficient, the price will rise; if the market is oversupplied, the price will inevitably decline.
Again, regional differences cannot be ignored. In different places, the price will vary due to the level of economic development, tax policies and logistics costs. Generally speaking, in places with developed chemical industry and convenient supply of raw materials, the price may be relatively low; in remote or resource-poor places, the price may be slightly higher.
Based on the current market situation, the price of 2-fluoro-5-methoxyphenylacetonitrile may range from a few hundred to several thousand yuan per kilogram. However, this is only a rough range, and the actual price needs to be negotiated in detail according to factors such as specific quality specifications, purchase quantity and transaction time.