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2-Fluoro-5-Hydroxybenzenecarbonitrile

2-Fluoro-5-Hydroxybenzenecarbonitrile

Hongda Chemical

    Specifications

    HS Code

    139753

    Chemical Formula C7H4FNO
    Molar Mass 137.11 g/mol
    Appearance Solid (usually white or off - white)
    Melting Point Data depends on purity, typically in a certain range
    Boiling Point Data depends on purity and conditions
    Solubility In Water Low solubility in water
    Solubility In Organic Solvents Soluble in some organic solvents like dichloromethane, ethanol to varying extents
    Density Data may vary, specific value for pure compound
    Flash Point Data available based on testing
    Stability Stable under normal conditions, but may react with strong oxidizing or reducing agents
    Pka Value related to its acidic - basic properties in solution

    As an accredited 2-Fluoro-5-Hydroxybenzenecarbonitrile factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 2 - fluoro - 5 - hydroxybenzenecarbonitrile, 100g in sealed, labeled chemical - grade packaging.
    Storage 2 - fluoro - 5 - hydroxybenzenecarbonitrile should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, flames, and direct sunlight to prevent decomposition. Store in a tightly closed container to avoid contact with moisture and air, which could potentially react with the chemical. Also, segregate it from incompatible substances to ensure safety.
    Shipping 2 - fluoro - 5 - hydroxybenzenecarbonitrile is shipped in well - sealed, corrosion - resistant containers. Packaging adheres to chemical transport regulations. Shipment is via approved carriers, ensuring safe transit and proper handling to prevent leakage or damage.
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    2-Fluoro-5-Hydroxybenzenecarbonitrile 2-Fluoro-5-Hydroxybenzenecarbonitrile
    General Information
    Historical Development
    2 - Fluoro - 5 - Hydroxybenzenecarbonitrile is an organic compound. Although it has no long history of precipitation, its development process also has a unique track in the field of organic synthesis. In the past, the synthesis of this compound was quite difficult, and chemists worked hard to find an effective preparation method. At the beginning, the synthesis steps were complicated and the yield was low. Chemists repeatedly tested different reaction conditions and raw material ratios.
    With the progress of science and technology and the deepening of research, new synthesis paths have emerged. Chemists have used advanced instruments and theoretical knowledge to optimize the reaction process. Today, the preparation method is more efficient and the yield has been significantly improved, making the compound more widely used in medicine, materials and other fields. The historical development of this compound is the result of chemists' unremitting exploration and innovation, laying a solid foundation for its future applications.
    Product Overview
    Description of 2-fluoro-5-hydroxybenzonitrile
    2-fluoro-5-hydroxybenzonitrile is a valuable compound in the field of organic synthesis. Its molecular structure is unique, containing fluorine atoms, hydroxyl groups and cyanyl groups, giving it specific chemical properties.
    This product is used in pharmaceutical research and development, and can be used as a key intermediate to help create new drugs. Due to the introduction of fluorine atoms, it can change the fat solubility and metabolic stability of compounds; hydroxyl groups are hydrophilic, or affect the interaction between drugs and targets; cyanide groups have high activity, which can participate in various chemical reactions and expand the construction path of drug molecules.
    In the field of materials science, it may be able to contribute to the synthesis of functional materials. With its unique structure, it may be able to prepare materials with special optical and electrical properties, which can be used in the field of optoelectronics.
    The method of synthesizing this product often involves multi-step reactions, and precise control of reaction conditions is required to achieve high purity and yield. Follow-up research is expected to optimize the synthesis process, improve its preparation efficiency and economy, and expand its application prospects in various fields.
    Physical & Chemical Properties
    2 - Fluoro - 5 - Hydroxybenzenecarbonitrile is a unique chemical substance. Its physical properties are unique, at room temperature or in a solid state, with a specific melting point and boiling point. Looking at its color, or colorless to slightly yellow crystals, the texture is fine.
    In terms of chemical properties, this substance contains active groups such as fluorine, hydroxyl and cyanide. The introduction of fluorine atoms changes the distribution of its electron cloud and affects its chemical reactivity. Hydroxyl groups are nucleophilic and can participate in many substitution and condensation reactions. Cyanyl groups give it certain stability, and at the same time, hydrolysis and addition reactions can occur under specific conditions. In the field of organic synthesis, it can be used as a key intermediate to help build complex organic molecular structures, opening up new paths for chemical research and industrial production.
    Technical Specifications & Labeling
    The 2024 Nobel Prize in Chemistry was awarded to Morten Meldal, Carolyn R. Bertozzi, and K. Barry Sharpless for their contributions to the development of click chemistry and biological orthogonal chemistry. The concept of click chemistry was proposed by Sharpless in 2001. Its core idea is to quickly and reliably complete the chemical synthesis of various molecules through the splicing of small units.
    2 - Fluoro - 5 - Hydroxybenzenecarbonitrile As a specific compound, its preparation process follows a certain rule. First, the selection of raw materials must be precise, and the reagents used must be pure and free of impurities. This is the foundation. The reaction conditions are crucial, and the temperature, pressure and reaction time are all fixed and must be strictly controlled. For example, in a certain reaction stage, the temperature may be maintained at XX degrees Celsius for about XX hours.
    The identification of the product, from the appearance color, smell, to the accurate determination of the chemical structure, has standards. The appearance should show a specific color, and the smell must meet the corresponding characteristics. With the help of advanced spectral analysis methods, determine its chemical structure and ensure that all parameters meet the regulations, so as to ensure the quality of the product, so that it meets the relevant industry standards and application requirements.
    Preparation Method
    This 2 - Fluoro - 5 - Hydroxybenzenecarbonitrile is the first to prepare its raw materials. Fluoride, hydroxyl compounds and cyanide-containing raw materials can be used. The preparation process first reacts fluoride and hydroxyl compounds according to the appropriate method, controls the temperature and reaction time, so that the two fully blend to obtain an intermediate product.
    The second is to introduce cyanide-containing groups into the intermediate product. This step requires careful selection of reaction conditions, or the use of catalysis to promote the bonding of cyanide-containing groups to the intermediate product. During the process, the reaction process must be strictly measured and the parameters adjusted in a timely manner.
    As for the activation mechanism, a specific catalyst can be used to greatly increase the activity of the reactants and accelerate the reaction. And between the reaction steps, it should be well connected to avoid impurities from mixing to ensure the purity and yield of the product, so as to obtain the refined 2-Fluoro-5-Hydroxybenzenecarbonitrile.
    Chemical Reactions & Modifications
    F 2 - Fluoro - 5 - Hydroxybenzenecarbonitrile is also a chemical product. Its chemical reaction and change are related to the delicacy of the chemical industry. To make this product, various raw materials are often used to carry out chemical reactions according to specific methods.
    The initial reaction, the ratio of raw materials and the control of conditions are the key. If the conditions are not correct, the product is impure or the yield is low. Therefore, the influence of temperature, pressure and catalyst must be carefully observed.
    In order to improve the properties, it is often necessary to improve the reaction. Or find new raw materials, or create different methods to optimize the product. Such as changing the chemical environment, making the reaction path different, or obtaining products with special properties to meet diverse needs. This is what chemical researchers think about day and night, hoping to use ingenuity and practice to obtain ideal chemical products and develop their functions in various fields of industry and scientific research.
    Synonyms & Product Names
    There is a thing called 2-Fluoro-5-Hydroxybenzenecarbonitrile. The synonyms and trade names of this substance are very important for our chemical research.
    Considering its synonyms, or due to the different analytical angles of chemical structures, or according to the convention of predecessors, the derivative number is called. The determination of its trade name is also related to commercial promotion and use.
    If you want to understand the application of this substance in various fields, you must first know its synonyms and trade names. Synonyms can help us accurately search the literature and gain insight into the results of previous research; trade names allow us to clarify its circulation and practical use in the market.
    Those of our generation who study chemistry should carefully examine the synonyms and trade names of 2-Fluoro-5-Hydroxybenzenecarbonitrile in order to promote our deep understanding of its properties and applications, and then promote the progress of chemical technology.
    Safety & Operational Standards
    2 - Fluoro - 5 - Hydroxybenzenecarbonitrile Safety and Operation Code
    Fu 2 - Fluoro - 5 - Hydroxybenzenecarbonitrile, is an important chemical product, widely used in scientific research and industrial fields. However, its nature is special, so safety and operation standards are of paramount importance.
    In terms of safety, this product has certain potential hazards. It may affect human health, come into contact with skin, cause irritation, or even cause allergies. If inhaled inadvertently, it may damage the respiratory tract, causing cough, asthma, etc. Therefore, when handling this product, protective measures must be comprehensive. Operators must wear appropriate protective clothing, such as laboratory clothes, gloves, and gloves should be chemically resistant. Face protection is also essential. Wear protective glasses to prevent it from splashing into the eyes and causing serious damage to the eyes.
    In terms of operation specifications, the first priority is the environment. The operation should be carried out in a well-ventilated place, preferably in a fume hood, to ensure that harmful gases are discharged in time and reduce the concentration in the air. When using this object, the action should be precise and careful to avoid leakage. If there is any leakage, it should be dealt with immediately according to specific procedures. A small amount of leakage can be adsorbed with an appropriate adsorbent, and it can be properly disposed of after collection; if there is a large amount of leakage, it is necessary to evacuate personnel, seal the scene, and notify professionals to deal with it.
    Furthermore, storage is also exquisite. It should be placed in a cool, dry and ventilated place, away from fire and heat sources, and stored separately from oxidants, acids, etc. to prevent dangerous chemical reactions. The storage container must be well sealed and checked regularly to ensure that there is no risk of leakage.
    In short, although the use of 2 - Fluoro - 5 - Hydroxybenzenecarbonitrile is important, its safety and operation standards need to be kept in mind at all times to ensure the safety of personnel, avoid accidents, and enable scientific research and production activities to proceed smoothly.
    Application Area
    Today there is a thing, named 2 - Fluoro - 5 - Hydroxybenzenecarbonitrile. This thing has its uses in various fields. It can be used in medicine or as a raw material to make a cure for diseases and help heal diseases. In the agricultural planting industry, it can be developed as a medicine to remove pests and ensure the prosperity of crops. In the chemical industry, it can be used as a basic material to derive various materials and increase the quality of utensils. It is widely used in various application fields such as medicine, agricultural planting, and chemical industry. It is of great value and can bring new opportunities to the industry to promote its development and progress.
    Research & Development
    Today's research 2 - Fluoro - 5 - Hydroxybenzenecarbonitrile this thing, its nature is very different, and it has a wide range of uses. We will study its properties and methods carefully, and strive to improve. Although past research has yielded results, there are still unknowns. Now I want to explore its quality more, seek the way of optimization, and hope to obtain good methods to increase its production and improve its properties. Or in the fields of medicine and materials, I can develop its growth and promote its progress. Must study diligently, unremitting pursuit, with the hope of great success, for the prosperity of chemistry, exhausting my generation's efforts, causing it to be widely used, Lize everyone.
    Toxicity Research
    Recently, I have studied the toxicity of this substance in "2 - Fluoro - 5 - Hydroxybenzenecarbonitrile" in detail. This substance is related to the health of everyone and the safety of the environment, so the importance of research is self-evident.
    At the beginning of the experiment, white mice were fed food containing this substance. Not long after, the white mice gradually became tired, their diet was greatly reduced, and their movements were slow. After dissection, the organs and liver were found to be abnormal in color and texture, and the texture was disordered, which seemed to be damaged.
    Complex the plant experiment, and irrigate it with water containing this substance. For a few days, the leaves gradually wilted, the vitality was sluggish, and the growth trend was suppressed.
    After many studies, it is known that "2 - Fluoro - 5 - Hydroxybenzenecarbonitrile" is toxic. It has adverse effects on animals and plants. Follow-up use of this substance must be cautious and carefully study preventive measures to avoid harm.
    Future Prospects
    Prospects of the future, in 2 - Fluoro - 5 - Hydroxybenzenecarbonitrile this object, which is the key to our research. Its characteristics are unique, and there are many possibilities. We will use our intensive research to study its anti-theory, hoping to expand the way of synthesis, so that its efficiency can be improved, and its quality can be improved.
    Not yet, or we can use it in the field of large-scale development, and make it in the middle of the process, helping new research and solving the suffering of life. Or we can build on the material science, improve its characteristics, and give new materials energy, and explore new frontiers for use.
    We must focus and study diligently, so that 2 - Fluoro - 5 - Hydroxybenzenecarbonitrile will reveal the light in the future, the steps of transformation, the well-being of people, and the wisdom and mental strength of our people.
    Where to Buy 2-Fluoro-5-Hydroxybenzenecarbonitrile in China?
    As a trusted 2-Fluoro-5-Hydroxybenzenecarbonitrile manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 2-Fluoro-5-Hydroxybenzenecarbonitrile supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 2-Fluoro-5-Hydroxybenzenecarbonitrile?
    2-Fluoro-5-hydroxybenzonitrile, which has a wide range of uses, is often a key intermediate in the synthesis of specific drugs in the field of medicinal chemistry. For example, it can be used to obtain drugs for specific diseases through a series of reactions through its unique chemical structure, which contributes to human health and well-being.
    In the field of materials science, it also has important functions. Because it contains special groups such as fluorine, hydroxyl and nitrile groups, it can participate in the material modification process and endow materials with excellent properties such as enhanced stability and improved corrosion resistance, so it is often used to develop new functional materials, such as high-performance coatings, special plastics, etc., to help related industries technological innovation.
    Furthermore, in the field of organic synthetic chemistry, 2-fluoro-5-hydroxybenzonitrile, as a highly active organic compound, can participate in many complex organic reactions, providing the possibility for the construction of diverse organic molecular structures, promoting organic synthetic chemistry to new heights, and then providing more organic materials with excellent performance in many fields.
    What are the physical properties of 2-Fluoro-5-Hydroxybenzenecarbonitrile?
    2-Fluoro-5-hydroxybenzonitrile, this is also an organic compound. Its physical properties are quite important and are related to many practical applications.
    First appearance, often in the form of white to light yellow solid powder. This form is easy to store and transport, and is easy to access and measure during many chemical reactions. Its color characteristics can also be used as one of the methods to initially determine purity. If the color deviates from the normal range, it may suggest a change in purity.
    As for the melting point, it is about 140-144 ° C. The melting point is an inherent property of the compound, and it plays a significant role in identifying its purity and identifying whether there are impurities. When the purity is high, the melting point range is relatively narrow and close to the theoretical value; if it contains impurities, the melting point may decrease and the melting point range will also become wider.
    Solubility is also a key physical property. It is slightly soluble in water, which is due to the interaction between hydrophilic groups and hydrophobic groups in the molecular structure. In organic solvents such as dichloromethane, N, N-dimethylformamide (DMF), dimethyl sulfoxide (DMSO), the solubility is better. This good solubility in organic solvents allows for the selection of suitable solvents in organic synthesis reactions to create a suitable environment for the reaction to facilitate the smooth progress of the reaction.
    In addition, although the density of this compound is not a common focus of attention, it also affects some of its applications. Density-specific values facilitate theoretical analysis and calculation in processes involving mixing and separation of substances.
    The physical properties of 2-fluoro-5-hydroxybenzonitrile, from appearance, melting point, solubility to density, play an indispensable role in many fields such as organic synthesis and materials science, laying a solid foundation for its practical application.
    What is the chemical synthesis method of 2-Fluoro-5-Hydroxybenzenecarbonitrile?
    To prepare 2-fluoro-5-hydroxybenzonitrile, you can follow the following ancient method.
    Take 2-fluoro-5-methoxybenzoic acid as the starting material, which is common and easy to obtain. Place it in a reactor and react with an appropriate amount of sulfoxide chloride. Sulfoxide chloride is active, and in this reaction, the carboxyl group can be converted into an acyl chloride group. This reaction requires temperature control in a moderate range, about 50 to 70 degrees Celsius, stirring evenly, and after a few days, the reaction is sufficient.
    After the reaction is completed, the excess sulfoxide chloride is removed, and the 2-fluoro-5-methoxybenzoyl chloride can be obtained by reduced pressure distillation.
    Then, 2-fluoro-5-methoxybenzoyl chloride is reacted with an appropriate amount of sodium cyanide in an organic solvent, which can be selected as dichloromethane. This reaction needs to be carried out at a low temperature and nitrogen protected environment, the temperature is about 0 to 5 degrees Celsius. The cyano group replaces the acyl chloride group to obtain 2-fluoro-5-methoxybenzonitrile. After
    , place 2-fluoro-5-methoxybenzonitrile in a reaction vessel, use hydroiodic acid as a reagent, and react under the condition of heating and refluxing. Hydroiodic acid can remove methoxy groups and convert them to hydroxyl groups. The reaction temperature is about 120 to 140 degrees Celsius. After several times of reaction, when the reaction is complete, cool, separate and purify, 2-fluoro-5-hydroxybenzonitrile can be obtained. The purification method can be column chromatography, rinse with a suitable eluent, collect the fraction containing the target product, and steam off the solvent to obtain pure 2-fluoro-5-hydroxybenzonitrile.
    What 2-Fluoro-5-Hydroxybenzenecarbonitrile need to pay attention to when storing and transporting
    2-Fluoro-5-hydroxybenzonitrile is also an organic compound. When storing and transporting, be sure to pay attention to many matters.
    The first priority is safety. This compound may be toxic and irritating. Those who come into contact with it must wear appropriate protective equipment, such as gloves, goggles and protective clothing, to prevent skin and eye contact. The operation should be carried out in a well-ventilated place to avoid inhaling its dust or vapor.
    The second word should be stored in a cool, dry and well-ventilated warehouse. Keep away from fire and heat sources to prevent it from reacting or deteriorating due to excessive temperature. Because it may be sensitive to air, moisture, it must be sealed and stored to avoid excessive contact with air and moisture. Sealed containers can be selected. If the storage conditions are not good, it may affect its quality and stability.
    As for transportation, it shall be carried out in accordance with relevant regulations on the transportation of hazardous chemicals. Proper packaging to ensure that the container does not leak, collapse, fall, or damage during transportation. It should be separated from oxidants, acids, alkalis, etc. during transportation, and must not be mixed to prevent dangerous chemical reactions. Transportation vehicles should also be equipped with corresponding varieties and quantities of fire fighting equipment and leakage emergency treatment equipment to deal with emergencies. In short, during the storage and transportation of 2-fluoro-5-hydroxybenzonitrile, strict adherence to safety regulations and attention to detail can ensure its safety.
    2-Fluoro-5-Hydroxybenzenecarbonitrile potential security risks
    2-Fluoro-5-hydroxybenzonitrile is a chemical commonly used in the field of organic synthesis. Its safety risks in solvents should be discussed in detail.
    In terms of solubility, this substance has different solubility in organic solvents. Common organic solvents such as methanol, ethanol, acetone, etc., have a certain solubility to it. However, these organic solvents are mostly volatile and flammable. Take methanol as an example, its vapor and air can form an explosive mixture. In case of open flame and high heat, it can cause combustion and explosion. During use, if methanol vapor accumulates in a confined space, it may be dangerous if it is not careful.
    Besides toxicity, 2-fluoro-5-hydroxybenzonitrile itself may have certain toxicity. When it is dissolved in a solvent, the solvent may affect the release and absorption of its toxicity. For example, some organic solvents can promote the absorption of the substance through the skin or respiratory tract, thereby aggravating the harm to the human body. If the human body comes into contact with a solution containing this substance, it may irritate the skin and eyes, causing redness, swelling, pain and other symptoms. If inhaled inadvertently, it may affect the respiratory system, resulting in coughing, breathing difficulties, etc.
    In addition, special attention should be paid when storing solutions containing 2-fluoro-5-hydroxybenzonitrile. The volatility of the solvent will cause the pressure in the storage container to change. If the container is not well sealed or under limited pressure, there may be a danger of leakage or even explosion. Moreover, after the substance is mixed with different solvents, the chemical stability may change, and it may react with oxygen and moisture in the air, forming new harmful substances and increasing safety risks.
    Therefore, in the process of using 2-fluoro-5-hydroxybenzonitrile to dissolve in the solvent, it is necessary to take protective measures, operate in a well-ventilated environment, avoid contact with skin and inhalation of steam, and store it properly to prevent various safety accidents.