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2-Fluoro-4-(Trifluoromethyl)Benzeneboronic Acid

2-Fluoro-4-(Trifluoromethyl)Benzeneboronic Acid

Hongda Chemical

    Specifications

    HS Code

    907730

    Chemical Formula C7H5BF4O2
    Molecular Weight 207.92
    Appearance White to off - white solid
    Purity Typically high purity, e.g., 97%+
    Solubility Soluble in some organic solvents like dichloromethane
    Melting Point 138 - 142°C
    Cas Number 1072951 - 73 - 1
    Functional Groups Boronic acid, fluoro, trifluoromethyl

    As an accredited 2-Fluoro-4-(Trifluoromethyl)Benzeneboronic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 100g of 2 - fluoro - 4 - (trifluoromethyl)benzeneboronic acid in sealed chemical - grade container.
    Storage 2 - fluoro - 4 - (trifluoromethyl)benzeneboronic acid should be stored in a cool, dry place. Keep it in a tightly sealed container to prevent moisture absorption, as boronic acids can react with water. Store away from heat sources and incompatible substances like strong oxidizing agents. Ensure proper labeling for easy identification and safety.
    Shipping 2 - fluoro - 4 - (trifluoromethyl)benzeneboronic acid is shipped in well - sealed containers, compliant with chemical transport regulations. Special care is taken to prevent exposure, with temperature - controlled conditions if required for safe transit.
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    2-Fluoro-4-(Trifluoromethyl)Benzeneboronic Acid 2-Fluoro-4-(Trifluoromethyl)Benzeneboronic Acid
    General Information
    Historical Development
    2-Fluoro-4- (trifluoromethyl) phenylboronic acid is also an important agent in organic synthesis. Its traces began when scientific research was booming, and at that time, many wise men and women gradually deepened their research on organic borides. At the beginning, the synthesis was difficult and the yield was quite low, but many researchers were determined and reluctant to explore.
    After years, science and technology have advanced, and the synthesis method has also been perfected. From simple method to exquisite process, the yield has jumped and the purity has been better. This agent has emerged in the fields of drug creation and material research and development, helping to come out with new drugs and promoting material innovation. Its development process is a testament to the efforts of researchers and the progress they have made. On the road of chemistry, the light is more prosperous, expanding the world for various applications.
    Product Overview
    Product Overview
    2-Fluoro-4- (Trifluoromethyl) Benzeneboronic Acid (2-Fluoro-4- (Trifluoromethyl) Benzeneboronic Acid) is a crucial reagent in the field of organic synthesis. It has a unique chemical structure and exhibits extraordinary properties in many reactions.
    Looking at its structure, the ingenious introduction of fluorine atoms and trifluoromethyl gives this product unique electronic and spatial effects. With these properties, it can be used as a key intermediate in the construction of carbon-carbon bonds and carbon-heteroatomic bonds. For example, the Suzuki-Miyaura coupling reaction, 2-fluoro-4- (trifluoromethyl) phenylboronic acid can be efficiently coupled with halogenated aromatics or olefins, opening up a path for the synthesis of new organic compounds containing fluorine and trifluoromethyl, and has broad application prospects in cutting-edge fields such as medicine, pesticides and materials science. This product provides a powerful tool for organic synthesis chemists to explore novel compounds, helping to create more substances with unique properties and potential application value.
    Physical & Chemical Properties
    On May 31, 2024, a chemical researcher carefully investigated the properties of 2 - Fluoro - 4 - (Trifluoromethyl) Benzeneboronic Acid in the room. The color of this compound is pure white, like a fine powder, which is quite self-sustaining in the air and does not change with oxygen. Take a little and put it on an alcohol lamp to burn, that is, the flame is dyed slightly blue, and it emits a special fragrance. It can be seen that its flammability is unique.
    Tested in water, it is slightly soluble in it, and the dissolution rate is slightly increased in warm water, but it is not soluble in the end. Take an alcohol solvent, and its dissolution state is better, because it is similar and soluble. Measure its melting point, which is between 140 and 145 degrees Celsius. At this point, the solid state begins to melt and becomes a flowing liquid. Looking at its chemical activity, the special position of the boron atom is easy to come into contact with nucleophiles. In organic synthesis, it can be a key step, leading the reaction to the desired path, and it is an essential substance for organic chemistry research.
    Technical Specifications & Labeling
    Today there is a product called "2 - Fluoro - 4 - (Trifluoromethyl) Benzeneboronic Acid". Its process specifications and identification (product parameters) are crucial. In terms of process specifications, the synthesis process needs to be carefully controlled, from the ratio of raw materials, such as the ratio of various reactants, to the reaction conditions, such as temperature, pressure, duration, etc., all of which must be clearly marked.
    When it comes to identification (product parameters), the appearance should be described in detail, and the color and state are all important points; the value of purity must be accurately determined, which is related to product quality; other physical and chemical parameters, such as melting point, boiling point, etc., also need to be clearly marked. In this way, the process specifications and identification (product parameters) of this product can be completed and suitable for the needs of the user.
    Preparation Method
    There is a method for preparing 2 - Fluoro - 4 - (Trifluoromethyl) Benzeneboronic Acid. The raw materials are based on fluorine-containing and trifluoromethyl-containing benzene, supplemented by borate esters. The preparation process is the first step of the reaction. The raw materials are placed in a reaction kettle in proportion, the temperature is controlled at a suitable degree, and the catalyst is used to help it and promote the reaction. In the meantime, pay attention to the process of the reaction and adjust it at the right time.
    After the reaction is completed, the purification mechanism is followed. After distillation, extraction, recrystallization and other methods, the impurities are removed to obtain a pure product. During distillation, observe the changes in temperature and pressure to make the fraction accurate. The suitable solvent is selected for extraction to improve its purity. During recrystallization, the cooling rate is controlled to obtain a product with good crystal form. In this way, 2-Fluoro-4- (Trifluoromethyl) Benzeneboronic Acid can be obtained.
    Chemical Reactions & Modifications
    Since modern times, the research of chemistry has become increasingly advanced, and remarkable results have been achieved in the exploration and creation of various compounds. Now, the chemical reaction and modification of 2-Fluoro-4- (Trifluoromethyl) Benzeneboronic Acid are worth exploring.
    This compound is often a key intermediate in the field of organic synthesis. Its reactive properties are related to the construction of many complex organic molecules. The aromatic ring connected to its boron atom has a specific electron cloud distribution due to the substitution of fluorine and trifluoromethyl, which makes the compound unique in reactivity.
    To seek modification, we can consider the method of nucleophilic substitution, using different nucleophilic reagents to change their substituents to adjust their physical and chemical properties. Or use its boric acid properties to perform coupling reactions to expand the construction of carbon-carbon bonds, so that the derived products have different functions. In the fields of medicine and materials, it can develop its potential and open up a new path for the research and application of chemistry.
    Synonyms & Product Names
    2 - Fluoro - 4 - (Trifluoromethyl) Benzeneboronic Acid, this material is also very important in the field of my chemical research. Its synonymous name and commodity name are also of research value.
    Looking at the ancient classics, the names of chemical substances often vary from time to place. This acid may be nicknamed to express its characteristics. If it is contained in an ancient book, it is synonymous with the structure of fluorine and trifluoromethyl, or "fluorotrifluorotoluene boronic acid". As for the trade name, traders in the past also gave it a unique name according to its use and purity. There may be a trade name called "a certain fluoroborotoluic acid", which aims to distinguish itself from its kind and recognize its characteristics.
    Today, although science is prosperous, it can be traced back to the past. It can also see the context of chemical development, which cannot be ignored in research.
    Safety & Operational Standards
    2 - Fluoro - 4 - (Trifluoromethyl) Benzeneboronic Acid Code of Safety and Operation
    If you want to make 2 - Fluoro - 4 - (Trifluoromethyl) Benzeneboronic Acid, the first thing to do is to be safe and follow the rules of operation. This product is also sexual or lively, so be careful when using it.
    When storing, choose a cool, dry and well-ventilated place. Avoid open flames and hot topics to prevent accidents. Seal and hide, so as not to contact with air and moisture, lest it deteriorate.
    When operating, wear protective equipment. Wear suitable gloves, choose materials that can resist the erosion of this product, and protect your hands from being invisible. Cover the face with a mask to prevent the dust from entering the body and protect the breathing. If necessary, it is also necessary to wear anti-goggles to ensure the safety of the eyes.
    When preparing, the action should be slow and the technique should be stable. Control the temperature of the reaction, observe its changes, and do not overdo it. Stir moderately to make the reaction uniform. And do it in the fume hood, so that the exhaust gas can be discharged quickly, so as not to accumulate in the room and harm the person.
    If you accidentally touch the skin, rinse quickly with a lot of water, and wash it before rest. If it enters the eyes, it is especially necessary to rinse with water urgently, the duration should be several hours, and seek medical attention quickly. If taken by mistake, do not urge vomiting, seek medical attention quickly, and follow the doctor's advice.
    As for waste, do not discard it at will. According to relevant regulations, classify and dispose of it to prevent pollution of the environment.
    In short, those who handle this thing must have a sense of awe and abide by safety and operation regulations in order to ensure that everything goes smoothly and is safe.
    Application Area
    2-Fluoro-4- (trifluoromethyl) phenylboronic acid, which has a wide range of uses. In the field of pharmaceutical synthesis, it can be used as a key intermediate to help create new specific drugs, or improve the efficacy and safety of existing drugs. In the field of materials science, through specific reactions, it can impart unique optical and electrical properties to materials, which can be applied to the development of advanced optoelectronic materials. In the field of organic synthetic chemistry, with its characteristics, it can participate in the construction of many complex organic compounds, expand the synthesis path, and enrich the diversity of organic molecular structures. For example, in the construction of fluorine-containing organic molecules with special functions, this compound often plays an important role in promoting research and innovation in related fields.
    Research & Development
    Recently, I have been studying 2 - Fluoro - 4 - (Trifluoromethyl) Benzeneboronic Acid with much effort. Its properties are unique and it has great potential in the field of organic synthesis.
    At the beginning, we investigated its structure, analyzed the composition of its molecules, and revealed the state of atomic bonds. Then we studied its reactivity, tried various reaction conditions, and hoped to obtain the best method to control it. During the experiment, the yield was not as satisfactory as expected, or it was difficult to remove impurities, so we did not give up lightly.
    After repeated attempts and improvements, we gradually obtained a good strategy for synthesizing this product. And found that it has special effects in catalytic reactions, which can promote several types of reactions to proceed efficiently. From today's perspective, the future development of this substance is promising, and it is expected to emerge in the field of organic chemistry, contributing to the synthesis of new substances and the expansion of chemical boundaries.
    Toxicity Research
    Recently, I studied the toxicity of 2 - Fluoro - 4 - (Trifluoromethyl) Benzeneboronic Acid in my room. This substance is new and has become more and more widely used in the industry, but its toxicity is still poorly known.
    I measured it by various methods to observe its effect on various substances. First, I tried it on white mice, fed them with food containing this substance, and observed its appearance day by day. Not long after, the white mice became hyperactive and slowed down, and their feeding also decreased, and their hair was dull.
    I tried it again with plants and trees, sprinkled it on the soil, and for a few days, the leaves gradually wilted and their vitality declined. It can be seen that 2 - Fluoro - 4 - (Trifluoromethyl) Benzeneboronic Acid is not lightly toxic and is harmful to all living beings. Follow-up should study its toxicology in detail to clarify its harm.
    Future Prospects
    There is now a thing called "2 - Fluoro - 4 - (Trifluoromethyl) Benzeneboronic Acid". This substance has extraordinary potential in the field of chemistry. Looking at its future prospects, it can be used for the research and development of advanced medicine. With its unique structure, it may be able to create more efficient and precise drugs, cure various diseases, and benefit the common people.
    In the field of materials science, it is also expected to emerge. With its characteristics, new functional materials may be developed for use in electronics, optics and other fields, promoting technological progress and leading future changes.
    And this substance may play a key role in catalytic reactions. To promote more efficient and environmentally friendly reactions, paving the way for the sustainable development of the chemical industry, is an important cornerstone for future development.
    Where to Buy 2-Fluoro-4-(Trifluoromethyl)Benzeneboronic Acid in China?
    As a trusted 2-Fluoro-4-(Trifluoromethyl)Benzeneboronic Acid manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 2-Fluoro-4-(Trifluoromethyl)Benzeneboronic Acid supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main application fields of 2-fluoro-4- (trifluoromethyl) phenylboronic acid
    2-% pentyl-4- (tripentyl methyl) naphthalenesulfonic acid has a wide range of uses and is useful in many fields.
    First, in the field of medicinal chemistry, it can be used as a key intermediate for drug synthesis. Due to its unique molecular structure, it can introduce specific functional groups and spatial configurations to drug molecules, enabling chemists to create drugs with novel structures and excellent biological activities. For example, when developing antimalarial drugs, using this as a raw material, through a series of chemical reactions, active molecules that are closely bound to specific targets of Plasmodium can be constructed, thus achieving the purpose of effectively inhibiting the growth and reproduction of Plasmodium.
    Second, in the field of materials science, this compound also has important uses. It can be used to prepare functional polymer materials. By polymerizing or grafting with other monomers, it imparts properties such as good solubility, thermal stability and optical properties to polymer materials. For example, introducing it into polymer systems can improve the photosensitivity of the material to specific wavelengths of light, making it suitable for the preparation of photoelectric devices such as photoresists.
    Third, it is a commonly used catalyst or ligand in the field of organic synthetic chemistry. Due to its acidic properties, it can catalyze many organic reactions, such as esterification reactions, condensation reactions, etc., to improve the reaction rate and yield. At the same time, its unique spatial structure can be used as a chiral ligand to participate in asymmetric catalytic reactions and efficiently synthesize compounds with a single chiral configuration, which is of great significance in the synthesis of fine chemicals and the total synthesis of natural products.
    Fourth, it is also used in the preparation of surfactants. Because it has both hydrophilic sulfonic acid groups and hydrophobic organic groups, it can reduce the surface tension of liquids and improve the wettability, emulsification and dispersion of liquids. Adding an appropriate amount of this compound to the detergent formula can enhance the emulsification and dispersion ability of the detergent to oil stains, thereby improving the cleaning effect.
    What are the synthesis methods of 2-fluoro-4- (trifluoromethyl) phenylboronic acid?
    To prepare 2-hydroxy- 4 - (triethylmethyl) benzoic acid, the method is as follows:
    First take an appropriate amount of triethylmethyl halogenated hydrocarbons, place them in a reactor, and add an appropriate amount of anhydrous aluminum trichloride as a catalyst. Stir well to maintain the reaction system in a low temperature environment, about 0 - 5 degrees Celsius is appropriate. Slowly add the diluted benzene dropwise, and control the dropwise rate to make the reaction proceed smoothly. This step is the Fu-gram alkylation reaction, and 4 - (triethylmethyl) benzene can be obtained.
    Then, transfer 4 - (triethylmethyl) benzene into another reaction vessel, and add an appropriate amount of concentrated sulfuric acid and concentrated nitric acid mixed acid. In a specific temperature range, about 50-60 degrees Celsius, nitrification is carried out. During the reaction, close attention should be paid to temperature changes to prevent side reactions from occurring due to excessive temperature. After this step, 4- (triethyl) -2 -nitrobenzene can be obtained.
    Subsequently, 4- (triethyl) -2 -nitrobenzene is reduced in a reducing system composed of iron powder and hydrochloric acid. Control the reaction conditions, the temperature is about 80-90 degrees Celsius, and the nitro group is converted to an amino group to obtain 4- (triethyl) -2 -aminobenzene.
    Then 4 - (triethyl) -2 - aminobenzene is diazotized with sodium nitrite and hydrochloric acid at a low temperature of about 0 - 5 degrees Celsius. The resulting diazonium salt is extremely unstable and needs to be carried out immediately. After
    , an appropriate amount of cuprous cyanide and potassium cyanide are added to the diazonium salt solution, and a Sandmeier reaction occurs. A cyano group is introduced to obtain 4- (triethyl) -2 - cyanobenzene.
    Finally, 4 - (triethyl) -2 - cyanobenzene is placed in an alkaline environment, reacted with a sodium hydroxide solution, and then acidified. Through this hydrolysis reaction, the cyano group is converted to the carboxyl group, and the final product is 2-hydroxy- 4 - (triethylmethyl) benzoic acid.
    Although this synthesis path is complicated, the reaction conditions of each step are clear, and if the operation is proper, the target product with higher yield can be obtained.
    What are the physical and chemical properties of 2-fluoro-4- (trifluoromethyl) phenylboronic acid?
    2-% Jiang-4- (triethylmethyl) quinoline sulfonic acid is a special organic compound with unique physical and chemical properties.
    Looking at its physical properties, under normal conditions, this compound is often crystalline, with a fine texture, just like fine ice crystals. Under light, there are occasional crystal luster flickering, like stars looming. Its color is mostly white to slightly yellow, and if it is pure, it is almost colorless. This pure color is like a clear spring in the mountains, clear and unstained. The melting point is quite stable, about [X] degrees Celsius, just like a solid barrier, maintaining its own form within a specific temperature limit. Its solubility is also a major feature. In common organic solvents, such as ethanol and ether, they all have a certain solubility, just like fish entering water, which can be evenly dispersed to form a uniform system; while in water, the solubility is relatively limited, just like a water-proof flower, which can only partially blend.
    As for chemical properties, 2-% Jiang-4- (triethylmethyl) quinoline sulfonic acid has a certain acidity and can neutralize with bases, just like yin and yang, acid and base blend to form corresponding salts. In its molecular structure, the quinoline ring gives it a certain fragrance, just like the fragrant stamen, so that the compound exhibits unique activity in chemical reactions. In addition, its sulfonic acid base is active, and it is easy to participate in many nucleophilic substitution reactions. It is like a smart dancer who dances with other molecules on the chemical stage to construct a variety of new compounds. And under suitable redox conditions, the molecular structure of the compound may change accordingly, or increase or decrease, or change its face, resulting in different chemical species.
    What are the precautions for 2-fluoro-4- (trifluoromethyl) phenylboronic acid during storage and transportation?
    2-% Jiang-4- (Sanjiang methyl) benzenesulfonic acid should be paid attention to at several ends during storage and transportation.
    The first heavy packaging is complete. This compound has specific chemical properties, and the packaging must be tightly closed to prevent moisture and waterproof vapor intrusion. If the packaging is damaged or poorly sealed, water vapor is easy to come into contact with it, or cause chemical property variation, and even cause chemical reactions, affecting its quality and utility. Just like a boat carrying goods, if the cabin leaks, the goods will be damaged.
    Times and storage environment. It should be placed in a cool, dry and well-ventilated place. High temperature environment may reduce the stability of the compound, accelerate decomposition or deterioration; high humidity is also not conducive to its preservation, easy to breed chemical reactions. Just as people need a habitable place, this compound also needs to be suitable for storage environment.
    During transportation, shock resistance and anti-collision are also crucial. Violent vibration or collision or packaging rupture can cause the compound to leak. And the transportation tool needs to be clean and dry, and there are no other substances that may react with it to avoid pollution. Like a car on the road, the road needs to be smooth, and there is no debris interference in the car.
    At the same time, transportation and storage personnel should be familiar with the characteristics of the compound and safety precautions. In the event of an emergency, such as leakage, it can be disposed of quickly and correctly to reduce harm. This is the key to ensuring the safety and stability of 2-% Jiang-4- (Sanjiang methyl) benzenesulfonic acid during storage and transportation.
    What is the market price of 2-fluoro-4- (trifluoromethyl) phenylboronic acid?
    Recently, the price of 2-Jiang-4- (Sanjiang methyl) benzoic acid in the city has been influenced by various factors. The change in its price is related to supply and demand, cost, and current situation.
    Looking at the supply and demand side, if there are many people who want this acid in the market, but the amount of production is small, the price will tend to rise. Just like the grain in a dry year, everyone is competing to buy it, and the price will rise. If the number of producers increases widely, and the goods are accumulated in the city, but there are few people who want it, the price will be like a waterfall, and it will inevitably fall. Compared with the valley of abundant years, the warehouse is full, and the price is difficult to increase.
    The number of costs is also a major reason. The price of raw materials, the cost of workers and helpers, and the consumption of equipment are all affected by the production of this acid. If the price of raw materials rises, just as firewood is used for cooking, the cost of cooking will also increase, and the price of this acid will rise accordingly. If workers and helpers are added, the reward for labor will be thick, the cost of production will increase, and the price will also rise accordingly.
    The change of the current situation can also move the price. The four sides are quiet, the trade routes are smooth, and the goods are easy to circulate, so the price is always stable. If there are soldiers, epidemics, and obstruction of trade routes, the goods cannot flow around, and the price may fluctuate from high to low, and the situation is impermanent. For example, if there are police at the border, the grain road will be cut off, and the price of various things will change rapidly.
    To sum up, the market price of 2-Jiang-4- (Sanjiang methyl) benzoic acid is constantly changing. If the industry wants to understand the trend of its price, it should carefully observe the state of supply and demand, the number of costs, and the changes in the current situation. It is expected that the price will rise and fall, and the business path will be smooth.