2-Fluoro-4-Nitrobenzenecarboxylic Acid

Hongda Chemical

Specifications

HS Code	323557
Chemical Formula	C7H4FNO4
Molecular Weight	185.11
Appearance	Solid (usually a powder or crystalline solid)
Physical State At Room Temp	Solid
Melting Point	148 - 152 °C
Boiling Point	Decomposes before boiling
Solubility In Water	Low solubility in water
Solubility In Organic Solvents	Soluble in some organic solvents like ethanol, dichloromethane
Acidity	Acidic due to carboxylic acid group
Pka	Around 3 - 4 (approximate value for carboxylic acid group)
Odor	Odorless or faint odor

As an accredited 2-Fluoro-4-Nitrobenzenecarboxylic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage

Packing	500g of 2 - fluoro - 4 - nitrobenzenecarboxylic Acid packaged in a sealed plastic bottle.
Storage	2 - fluoro - 4 - nitrobenzenecarboxylic acid should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and incompatible substances like strong oxidizing agents. Store it in a tightly - sealed container to prevent moisture absorption and degradation. Avoid storing in areas prone to temperature fluctuations to maintain its chemical stability.
Shipping	2 - fluoro - 4 - nitrobenzenecarboxylic acid is shipped in well - sealed, corrosion - resistant containers. They are carefully packed to prevent breakage. Shipments follow strict chemical transportation regulations to ensure safety during transit.

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General Information

Historical Development

2-Fluoro-4-nitrobenzoic acid, the development of this substance has undergone changes over time. In the past, the research of chemistry was still in ignorance. However, the heart of a scholar is determined and seeking. At the beginning, I explored among various compounds, although I encountered many difficulties, I did not give up.
At a certain time, there were smart people who focused on this field. After repeated experiments, I gradually understood its characteristics with subtle methods. From the selection of raw materials to the control of reactions, I have worked hard.
With the passage of time, the technology has become more refined, and the understanding of 2-fluoro-4-nitrobenzoic acid has become more and more profound. The method of its synthesis is getting better and better, the yield is getting higher and the quality is getting better. The difficulties of the past have become the cornerstone of today. This compound is gradually used in the chemical industry, medicine and other industries, and it will contribute to the well-being of mankind. The future will also be broader.

Product Overview

Description of 2 - Fluoro - 4 - Nitrobenzenecarboxylic Acid
2 - Fluoro - 4 - Nitrobenzenecarboxylic Acid is a crucial compound in the field of organic synthesis. Its molecular structure is unique, containing fluorine atoms, nitro groups and carboxyl groups. Fluorine atoms have strong electronegativity, which causes molecular electron clouds to divide and give unique chemical activity. Nitro is a strong electron-absorbing group, which enhances molecular polarity and affects the selectivity of reaction check point. Carboxyl groups make compounds acidic and can participate in various chemical reactions.
In organic synthesis, this compound is a key intermediate. It is often used in drug synthesis pathways and can be converted into various biologically active structural units through specific reactions, laying the foundation for the creation of new drugs. Its unique structure can specifically bind to biological targets or affect the pharmacokinetic properties. In the field of materials science, it also has potential application value, or can be chemically modified to prepare functional polymer materials to improve the electrical and optical properties of materials.

Physical & Chemical Properties

2 - Fluoro - 4 - Nitrobenzenecarboxylic Acid is an important compound. Its physical properties are very specific, and the outer shape is often specific, or the crystal is very different, and the color is also determined. Its melting is important, and the amount of refined research has a certain value. This melting is important to determine and improve the properties of this substance.

, because of its fluorine, nitro and carboxyl functional properties, the reactivity is characteristic. Carboxyl groups can be used to esterify and react with alcohol to form phase esters. Nitro groups can change the density of benzene sub-clouds and replace the reactivity of the reactivity. The fluorine atom has a similar influence on the chemical properties of molecules, which makes the compound exhibit a special rate of inversion in some reactions. Therefore, the physicalization of this substance is used for chemical research and phase engineering.

Technical Specifications & Labeling

Today there is a product called 2 - Fluoro - 4 - Nitrobenzenecarboxylic Acid. Its process specifications and identification (commodity parameters) are crucial to the quality and use of this product.
The process specifications are the criteria for making this product. From the selection of raw materials, it is necessary to be pure and free of impurities and meet the standards. To the reaction conditions, temperature, pressure and time must be precisely controlled. If the reaction temperature is too high, the quality will be variable, and if it is too low, it will not be effective. Between the steps, the connection must also be close and should not be lost.
And the identification (commodity parameters) indicates the characteristics of this product. Such as its chemical structure, clearly showing the arrangement of atoms; purity geometry, related to its quality; physical properties, color, taste, state, etc., are all important parameters. The two, process specifications and identification (commodity parameters), complement each other, are the quality assurance of 2-Fluoro-4-Nitrobenzenecarboxylic Acid, and are indispensable for research and application.

Preparation Method

To prepare 2 - Fluoro - 4 - Nitrobenzenecarboxylic Acid, it is necessary to clarify the method of preparation. The first raw material should be taken as the starting point when appropriate reagents, such as fluorine, nitro and related compounds of benzene ring structure, are taken. The preparation process may involve a multi-step reaction.
Initially, the benzene ring-containing raw material can be reacted with a specific reagent, and the nitro group can be introduced. Under suitable conditions, the nitro group can be precisely positioned at a specific position in the benzene ring. This step requires controlling the temperature, time and the ratio of the reactants to achieve good yield.
Next, fluorine atoms are introduced, or special fluorination reagents are used to achieve fluorine atom substitution under specific reaction environments. Here, the control of the reaction conditions is crucial, which is related to the purity and yield of the product.
A feedback step is required. After each step of the reaction, the purity and structure of the product are detected by means of chromatography and spectroscopy. If there is any deviation, the subsequent reaction should be adjusted in time.
In order to promote the efficient and orderly reaction, a catalytic mechanism should be set up. Selecting a suitable catalyst can reduce the activation energy of the reaction and increase the reaction rate. At the same time, consider the recovery and repurpose of the catalyst to save cost and meet the concept of green chemistry. In this way, 2-Fluoro-4-Nitrobenzenecarboxylic Acid with high purity and good quality can be obtained.

Chemical Reactions & Modifications

2 - Fluoro - 4 - Nitrobenzenecarboxylic Acid is an important compound in organic synthesis. Its chemical properties are unique, and related chemical reactions and modifications have attracted much attention.
In the synthesis path, it is common to start with a specific halogenated aromatic hydrocarbon and prepare it through a series of reactions such as nitrification, halogenation and carboxylation. This process requires precise regulation of the reaction conditions, and the temperature, pH and choice of catalyst have a great impact on the yield and purity of the product.
To improve its properties, chemists try to modify it with different groups. For example, the introduction of hydrophilic groups can improve its solubility and make it easier to participate in the reaction in a specific reaction system; the addition of conjugated structures may enhance its optical properties. Through this kind of modification, 2 - Fluoro - 4 - Nitrobenzenecarboxylic Acid can be found more widely used in medicine, material science and other fields. In-depth study of its chemical reaction and modification lays a foundation for expanding the application boundary of this compound.

Synonyms & Product Names

2-Fluoro-4-nitrobenzoic acid, also known as fluoronitrobenzoic acid. Although its name is different, it is actually the same body. In my chemical research, this substance has attracted much attention.
Cover because of its unique structure, fluorine atoms coexist with nitro and carboxyl groups in a benzene ring, and each group affects each other, so that the physical properties and chemical properties are specific. Its synonyms are due to different research paths and different industry habits, but they all refer to this unique compound.
In various chemical synthesis techniques, 2-fluoro-4-nitrobenzoic acid is often the key raw material, which can be skillfully reacted into other fine chemicals. And because of its characteristics, it has potential applications in many fields such as medicine and materials. Although the names are different, those who study chemistry all understand that its essence is the same, and continue to tap its potential value in the journey of exploring physical properties and expanding applications.

Safety & Operational Standards

Safety and Practice of 2 - Fluoro - 4 - Nitrobenzenecarboxylic Acid
The 2 - Fluoro - 4 - Nitrobenzenecarboxylic Acid is an important substance in chemical research. Safety and standardization are the key to its experimental operation and research process.
Safety in the first words. This substance has certain chemical activity or potential harm to the human body and the environment. Experimenters must wear complete protective equipment, such as special protective clothing, protective gloves and goggles, to prevent skin contact and eye splashing. The operation should be carried out in a well-ventilated experimental environment or in a fume hood to avoid the accumulation of volatile gases and damage to the health of the experimenter.
Further operating specifications. When taking it, use a precise measuring tool and measure it accurately according to the experimental requirements. Do not make excess or insufficient or cause experimental deviation. When mixing this substance with other substances, the action should be slow, stirring while adding, to prevent sudden and violent reactions. The reaction conditions must be strictly controlled. Temperature, pressure, and reaction time are all key elements. If there is a slight error, the reaction may go out of control and cause accidents.
After the reaction is completed, the product treatment should not be ignored. In accordance with relevant environmental regulations, properly dispose of remaining materials and waste, do not dump them at will, and avoid polluting the environment.
In short, in the research and operation of 2 - Fluoro - 4 - Nitrobenzenecarboxylic Acid, the experimenter should be in awe and strictly abide by the safety and operation standards to ensure the smooth operation of the experiment and protect their own safety and environmental safety.

Application Area

2-Fluoro-4-nitrobenzoic acid is also a chemical substance. Its use is not limited, and the fields involved are various.
In the field of, can be used as a raw material. With this material basis, it may be able to synthesize special effects, which can be used to treat general diseases. Because of its unique properties, it can also be used in the molecules of, which is more effective in treating diseases, eliminating diseases and eliminating diseases.
In terms of materials, it can also be used. Or it can be used to study high-performance materials, such as some special plastics or materials. Its chemical properties may enable the material to have special properties, such as increased resistance and wear resistance, and expand the use of the material, so that it can be used in more severe environments.
In addition to chemical research, 2-fluoro-4-nitrobenzoic acid is an important factor. Researchers often take advantage of its many inverse effects to explore new inverse paths, expand the method of chemical synthesis, and promote the next step in chemical science. In addition, this material has an unavoidable value in multiple application domains.

Research & Development

Today there is a compound called 2 - Fluoro - 4 - Nitrobenzenecarboxylic Acid. As a researcher of chemical substances, I often study the properties, preparation methods and applications of this compound, hoping that it will make progress in various fields.
Looking at its properties, this compound has unique chemical activity. The presence of fluorine atoms and nitro groups causes molecular electron clouds to diverge and have extraordinary reactivity. In the field of organic synthesis, it can be used as a key intermediate, and various compounds can be derived through various reactions.
As for the preparation method, I have tried repeatedly to find a numerical method. Or from specific benzene derivatives, through halogenation, nitrification, carboxylation and other steps, orderly synthesis. Each step requires precise temperature control, timing adjustment, and selection of appropriate reagents and catalysts to obtain high-purity products.
Talking about applications, it can be used in medicinal chemistry, or it can be a lead compound to help develop new drugs. In materials science, or it can participate in the preparation of materials with special properties.
Our scientific researchers should make unremitting efforts to study this substance as a basis, explore and innovate, and promote the development of the chemical field, so that this compound can benefit the world in more ways.

Toxicity Research

2-Fluoro-4-nitrobenzoic acid is also a chemical substance. Yu is a researcher of chemical substances, and he has paid attention to its toxicity research for a long time.
I have heard the ancient saying: "The nature of things cannot be ignored." Although this substance may have its uses in chemical things, the study of toxicity is related to the lives of all living beings and cannot be ignored.
After various experiments, it can be known that 2-fluoro-4-nitrobenzoic acid may damage the biological body. If it enters the body, it may damage the viscera and disrupt qi and blood. In the ecological world, it may also affect the life of all things. Looking at its response to biological cells, it often causes cell aberration and dysfunction.
Our researchers, with caution, investigate the toxicity of this substance in detail, in order to clarify its harm, and when using this substance for the world, take precautions in advance, so that the benefit can be saved and the harm can be reduced, so as to live up to the responsibility of research.

Future Prospects

The future development is related to 2 - Fluoro - 4 - Nitrobenzenecarboxylic Acid. This product is actually the focus of our generation of chemical researchers. Looking at today's world, science and technology are improving day by day, and the way of chemistry is also constantly improving. This compound has unique properties and has potential to be explored in various fields.
We hope that in the future, in the road of medicine, it may become a key agent to help treat diseases and diseases. In the field of materials, it may also emerge, endow new capabilities and lead to industry changes. And with the advancement of research technology, the synthesis method will be more refined, the yield will increase, and the cost will decrease.
Although there may be thorns in the road ahead, our researchers must have a determined heart and investigate the truth. With unremitting efforts, we hope to uncover more mysteries, so that this compound will shine in the future, benefit the world, and live up to the mission and expectations of scientific research.

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Frequently Asked Questions

As a leading 2-Fluoro-4-Nitrobenzenecarboxylic Acid supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 2-Fluoro-4-Nitrobenzenecarboxylic Acid?

2-Fluoro-4-nitrobenzoic acid has a wide range of uses. In the field of medicine, it is a key intermediate in organic synthesis. It is used as the starting material for the preparation of many drugs. Through specific chemical reactions, other functional groups can be introduced to build complex drug active molecules. Because of the fluorine atom, nitro and carboxyl groups in it, it has unique chemical properties and reactivity, and can participate in a variety of organic reactions to meet the specific structural requirements required for drug synthesis.
In the field of materials science, 2-fluoro-4-nitrobenzoic acid also plays an important role. When preparing some functional materials, it can be used as a structural modifier. Due to its special molecular structure, when added to the material system, it can change the physical and chemical properties of the material, such as affecting the electrical properties, optical properties or thermal stability of the material. For example, the introduction of this substance in the synthesis process of some polymer materials can adjust the interaction between polymer chains, thereby optimizing the mechanical properties and processability of the material.
Furthermore, in the study of organic synthetic chemistry, 2-fluoro-4-nitrobenzoic acid is a commonly used model compound. By in-depth investigation of the various reactions it participates in, researchers can clarify the reaction mechanism, optimize the reaction conditions, and provide theoretical basis and practical experience for the synthesis of other complex organic compounds. Due to its complex and representative structure, it has become an important object for in-depth study of reaction laws and methods in the field of organic chemistry. In short, 2-fluoro-4-nitrobenzoic acid has shown indispensable value in many fields and is of great significance to promote the development of related fields.

What are the physical properties of 2-Fluoro-4-Nitrobenzenecarboxylic Acid?

2-Fluoro-4-nitrobenzoic acid is one of the organic compounds. It has specific physical properties, which is now described in detail by you.
First of all, under normal temperature and pressure, 2-fluoro-4-nitrobenzoic acid is often in a solid state. Looking at its appearance, it is mostly white to light yellow crystalline powder. If you look closely, the powder has uniform texture, fine and no variegation.
As for the melting point, the melting point of this compound is quite high, about 160-164 ° C. The melting point is the temperature limit for the substance to change from solid to liquid. Such a high melting point indicates that the intermolecular force is strong and the structure is relatively stable.
Solubility is also an important physical property. The solubility of 2-fluoro-4-nitrobenzoic acid in water is not good. Although the molecule contains carboxyl groups, it has a certain hydrophilicity. However, the presence of fluorine atoms and nitro groups enhances the hydrophobicity of the molecule and makes it difficult to dissolve in water. However, in organic solvents, such as ethanol, ether, dichloromethane, etc., it has good solubility. Ethanol is also a polar organic solvent. It can form hydrogen bonds and other interactions with 2-fluoro-4-nitrobenzoic acid molecules, so it can be dissolved. Although the polarity of ether and dichloromethane is weak, its molecular structure is similar to that of 2-fluoro-4-nitrobenzoic acid. According to the principle of similar compatibility, it can also dissolve.
Re-discussion of its density, although there is no exact constant value to calculate, it is inferred that its density should be larger than that of water according to its structure and similar compounds. The Gein molecule contains atoms with relatively large atomic masses such as fluorine, nitrogen, and oxygen, and the benzene ring has a compact structure, which increases the mass per unit volume.
The physical properties of 2-fluoro-4-nitrobenzoic acid are of great significance in many fields such as organic synthesis and drug development. Due to its specific solubility and melting point, it can be used for separation, purification and identification operations, providing assistance for research and production in related fields.

What are the synthetic methods of 2-Fluoro-4-Nitrobenzenecarboxylic Acid?

The synthesis method of 2-fluoro-4-nitrobenzoic acid has been explored by many parties throughout the ages. The following are the common ones.
First, 2-fluorobenzoic acid is used as the starting material. First, it is heated with a mixed acid (a mixture of sulfuric acid and nitric acid), and the nitrate is catalyzed by sulfuric acid as an electrophilic agent to attack the benzene ring. Because the carboxyl group is the meta-site group and the fluorine atom is the o-para-site group, the two work together to make the nitro group mainly replace the para-site of the fluorine atom, thereby generating 2-fluoro-4-nitrobenzoic acid. This process requires attention to the ratio of mixed acid, reaction temperature and time. If the temperature is too high, there is a risk of excessive nitrification; if the time is too short, the reaction will not be fully functional.
Second, 4-nitrobenzoic acid is used as the starting material. In an appropriate solvent, fluorine-containing reagents, such as potassium fluoride, are added to catalyze with a suitable catalyst to initiate a nucleophilic substitution reaction. Fluoride ions attack the carbon atom at the carboxyl ortho-position on the benzene ring and replace the halogen atom at this position (if a suitable halogen atom is introduced in advance), and then synthesize the target product. The key to this path lies in the control of the conditions for the introduction of halogen atoms and the nucleophilic substitution reaction. The polarity of the solvent, the type and amount of catalyst will affect the reaction process and yield.
Third, The first step is the acylation reaction of benzene, the introduction of carboxyl groups, the introduction of nitro groups, and finally the introduction of fluorine atoms through fluorination. There are many steps in this route, but the reaction sequence and parameters can be flexibly adjusted according to different reaction conditions to achieve the purpose of optimizing the synthesis. Each step requires precise control of the reaction conditions to ensure the purity and yield of the product in each step, so that the final 2-fluoro-4-nitrobenzoic acid can be effectively obtained.

2-Fluoro-4-Nitrobenzenecarboxylic Acid in storage and transportation

2-Fluoro-4-nitrobenzoic acid is a chemical substance. When storing and transporting, many matters need to be paid attention to.
First words storage, this material is more active and must be stored in a cool, dry and well-ventilated place. The cover is quite sensitive to temperature and humidity. If it is in a high temperature and humid environment, it may cause property variation and even cause danger. And it should be stored in isolation from oxidizing agents, reducing agents, alkalis, etc., to avoid accidents caused by interaction. The storage place should be clearly marked, so that people can know what it is at a glance, and warn people to be careful.
As for transportation, it must be carried out in accordance with relevant regulations and regulations. Before transportation, proper packaging is the first thing to ensure that the packaging is tight and there is no risk of leakage. Choose suitable packaging materials to prevent it from corroding the packaging. During transportation, escorts must be carefully guarded and pay close attention to temperature, vibration and other conditions. If the journey encounters high temperature weather, cooling measures are required; if the road is bumpy, shock absorption should be tried to avoid damage to the packaging. In addition, the transportation vehicle should also be clean and free of stains, and there should be no other substances that may react with it.
In short, the storage and transportation of 2-fluoro-4-nitrobenzoic acid are all related to safety and quality. All links should not be ignored. It must be operated in accordance with norms to ensure foolproof.

What is the market price range for 2-Fluoro-4-Nitrobenzenecarboxylic Acid?

2-Fluoro-4-nitrobenzoic acid, its commercial price range varies depending on a variety of factors. This compound is widely used in the chemical industry and is often used as a key intermediate in pharmaceutical synthesis for the preparation of drugs with specific curative effects; in the field of materials science, or for the optimization of the performance of some functional materials.
Its price is first affected by purity. If the purity reaches a high level, such as the ultra-pure grade used in high-end pharmaceutical research and development, the price per gram may reach several hundred yuan. Because the preparation of high-purity products requires complex and fine purification processes, the cost is high. Ordinary industrial-grade purity products are relatively affordable.
The relationship between market supply and demand is also an important factor. If the demand for medicine, materials and other industries increases sharply during a certain period of time, but the supply is limited, the price will rise. On the contrary, when the demand is low and the supply is sufficient, the price will decline.
Furthermore, the differences in manufacturers and regions also affect the price. Different manufacturers have different pricing due to different technical levels and production costs. Generally speaking, the price of products may be slightly higher in developed regions due to high operating costs; while some regions with resource advantages and low-cost production conditions may have more competitive prices.
Overall, the price of 2-fluoro-4-nitrobenzoic acid per gram may fluctuate between a few yuan and hundreds of yuan. The specific price needs to be determined according to factors such as actual purity, market supply and demand, and purchase channels.