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2-Fluoro-4-Nitrobenzeneacetic Acid

2-Fluoro-4-Nitrobenzeneacetic Acid

Hongda Chemical

Specifications

HS Code

686190

Chemical Formula C8H6FNO4
Molar Mass 199.136 g/mol
Appearance Solid (usually white or off - white)
Melting Point Typically in a certain temperature range (exact value may vary depending on purity)
Solubility In Water Low solubility, being an organic acid with fluorine and nitro groups
Solubility In Organic Solvents Soluble in common organic solvents like ethanol, dichloromethane
Pka Value Indicative of its acidity, specific value related to the acidic - carboxyl group
Stability Stable under normal conditions but may react with strong bases, reducing agents

As an accredited 2-Fluoro-4-Nitrobenzeneacetic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 250g of 2 - fluoro - 4 - nitrobenzeneacetic Acid packaged in a sealed chemical - grade bottle.
Storage 2 - fluoro - 4 - nitrobenzeneacetic acid should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. Keep it in a tightly closed container to prevent moisture absorption and contact with air. Store it separately from oxidizing agents and incompatible substances to avoid potential chemical reactions. This storage method helps maintain its stability and safety.
Shipping 2 - fluoro - 4 - nitrobenzeneacetic acid should be shipped in sealed, corrosion - resistant containers. It must be labeled as a chemical with proper handling instructions, transported under controlled conditions to prevent spills and exposure, following all safety regulations.
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2-Fluoro-4-Nitrobenzeneacetic Acid 2-Fluoro-4-Nitrobenzeneacetic Acid
General Information
Historical Development
The industry of chemical industry has evolved from generation to generation, and the research of substances is changing with each passing day. 2 - Fluoro - 4 - Nitrobenzeneacetic Acid, its origin can also be investigated.
In the past, various sages worked hard in the field of organic synthesis. At first, I only knew a little about the properties of fluorine-containing and nitro compounds. After years of research, I found a way to introduce fluorine and nitro into phenylacetic acid. Early attempts were many mistakes, the yield was quite low, and there were many impurities.
However, the ancestors were determined and failed repeatedly. At some point, the technique was slightly advanced, and this compound could be obtained more steadily. With the passage of time, the instrument is refined, the theory is complete, the synthesis method is more and more exquisite, the yield is gradually increasing, and the quality is also excellent. So 2-Fluoro-4-Nitrobenzeneacetic Acid has developed its capabilities in the fields of medicine and materials, becoming a brilliant pearl in the history of chemical industry and the basis for future research and use.
Product Overview
2-Fluoro-4-nitrophenylacetic acid, an organic compound. Its color is pure, often in the shape of a crystal, like a fine jade, smooth and shiny.
This substance has specific properties and often shows an active state in chemical reactions. Its molecular structure is exquisite, and the position of fluorine and nitro groups gives it a unique chemical activity. The introduction of fluorine atoms increases its stability and reaction selectivity; the existence of nitro groups makes it have a different tendency in many reaction pathways.
In the process of synthesis, it can be obtained by various methods. Often based on phenylacetic acid, fluorine and nitro are introduced in sequence through halogenation and nitrification. The key to the process is to control the temperature, time and amount of reagents in the reaction, and to maintain the yield and purity.
2-fluoro-4-nitrophenylacetic acid has potential uses in medicine, materials and other fields. In medicine, it may be a key intermediate for creating new agents; in materials, it can be used as a raw material for optimizing performance and a material for assisting in the development of new functions. In fact, it is also an important compound in the field of chemistry.
Physical & Chemical Properties
2 - Fluoro - 4 - Nitrobenzeneacetic Acid is a chemical substance. Its properties are both physical and chemical. Physical, its color, often light, if crystalline, hard and brittle. It feels hard and brittle. Its melting is fixed, it melts, and it melts into a liquid. This is also a sign of physical transformation.
It has chemical properties, because it contains fluorine, nitro and other groups, the activity is special. The activity of fluorine atoms makes it easy to combine with others in a specific reaction. Nitro also affects its chemical properties. When encountering the original, it can generate the original reaction, and it is easy to react. Moreover, this acid is acidic and can cause neutralization and reaction, forming a phase. All this is essential for the physicalization of 2-Fluoro-4-Nitrobenzeneacetic Acid.
Technical Specifications & Labeling
Today there is a product called 2 - Fluoro - 4 - Nitrobenzeneacetic Acid. The technical specifications and identification (commodity parameters) of this product are related to its quality and use, and cannot be ignored.
Where this acid is prepared, it should be made according to the technical regulations. From the choice of materials, it is necessary to be pure, and impurities should not enter, so as to ensure its quality. The combination is also necessary. The temperature and dosage must be accurate. High temperature will damage, low will not be complete, the dose is inappropriate, and it will also damage its properties.
The design of the logo is to show its nature. Remember its color and taste shape, colorless or yellowish, the taste is specific, and the shape is crystalline. Mark its molecular weight, melting point, boiling point and other parameters to prove its authenticity. Remember its danger, this acid is corrosive, the user should be careful, comprehensive protection, so as not to hurt the body. According to this technical specification and logo, good products can be made and used properly.
Preparation Method
To prepare 2 - Fluoro - 4 - Nitrobenzeneacetic Acid, the raw materials and production process, reaction steps and catalytic mechanism are very important.
The raw materials are selected, and the pure substances related to fluorine, nitro and phenylacetic acid are used as the basis. At the beginning of the production process, the fluorine-containing raw materials and phenylacetic acid derivatives are skillfully mixed, and they are put into a special reaction kettle in a specific ratio. At the beginning of the reaction step, the temperature needs to be precisely controlled to a specific interval, and a high-efficiency catalyst is added to promote the substitution reaction between the two, and the fluorine atoms are delicately embedded in the predetermined position of the benzene ring. This process requires close attention to the rate and progress of the reaction, and fine-tuning the temperature and pressure in real time.
In terms of catalytic mechanism, the selected catalyst can greatly reduce the activation energy of the reaction and accelerate the reaction process. After the reaction is complete, a series of separation and purification methods, such as distillation, recrystallization, etc., remove impurities to obtain pure 2-Fluoro-4-Nitrobenzeneacetic Acid, so as to obtain a good method for preparing this substance.
Chemical Reactions & Modifications
Nowadays, there is a chemical substance 2 - Fluoro - 4 - Nitrobenzeneacetic Acid, and our generation is a chemical researcher to explore its chemical reaction and modification.
In this compound, the structure of fluorine, nitro and phenylacetic acid interacts, which affects its reactivity. Fluorine atoms have strong electronegativity, which can cause the electron cloud density of benzene ring to change, so that the electron cloud density of the o-para-position decreases, and the activity of electrophilic substitution is inhibited. However, nucleophilic substitution reactions may occur more easily. Nitro is also a strong electron-absorbing group, which enhances this effect.
If you want to modify the property, you can borrow the nucleophilic substitution reaction and introduce suitable groups. For example, attacking the benzene ring with nucleophilic reagents, replacing fluorine atoms, or modifying the side chain of phenylacetic acid to modify its functional group can make the compound acquire new properties and develop new uses in drug synthesis, material chemistry and other fields. Such exploration may open up new avenues for the application of this compound in various fields and contribute to the development of chemistry.
Synonyms & Product Names
2 - Fluoro - 4 - Nitrobenzeneacetic Acid is also a chemical product. The same name, the business name, can be investigated. This compound, or fluoro-nitrophenylacetic acid. The same name is slightly different due to the method used by the seller and the environment used. Or according to its manufacture, call other names, but all refer to this thing. As for the business name, each merchant acknowledges the quality of its products, and there are also properties. However, the study of its origin, all of which are 2 - Fluoro - 4 - Nitrobenzeneacetic Acid. In chemical research, it is very beneficial to know the same name and business name, in order to explore its properties and use its materials. The enabler will not be affected by the name, but will use other things, so that he can focus on the nature of this thing and reverse it, so as to promote the process of transformation.
Safety & Operational Standards
On June 15, 2024, a distressing high-altitude parabolic incident occurred in the Shanghai area. In the afternoon of the same day, near a residential building in Pudong New Area, Zhao was unfortunately hit in the head by a glass ashtray that fell from the sky. Zhao immediately fell to the ground and fell unconscious, and the surrounding people quickly dialed 120 emergency numbers. Zhao was rushed to a nearby hospital, but due to his serious injuries, he died after ineffective rescue.
The police immediately launched an investigation after receiving the police. Through on-site investigation, monitoring, and visiting surrounding residents, Qian, who lived on the 15th floor of the residential building, was quickly identified as a major suspect. After Qian arrived at the case, he confessed to the crime of throwing the ashtray out of the window because of an argument with his family.
Throwing objects from high altitude not only poses a serious threat to the safety of others, but also violates the bottom line of the law. According to Article 291 bis of the Criminal Law of the People's Republic of China, if the circumstances are serious, anyone who throws objects from a building or other high altitude shall be sentenced to fixed-term imprisonment of not more than one year, criminal detention or public surveillance, and or a fine. Qian's behavior has constituted the crime of throwing objects from high altitude, and what awaits him will be the severe punishment of the law.
This tragedy reminds us that throwing objects from high altitude is no small matter. Everyone should enhance their legal awareness and safety awareness, put an end to such behavior, and jointly protect the "safety above their heads".
Application Area
2-Fluoro-4-nitrophenylacetic acid has a wide range of application fields. In the process of pharmaceutical research and development, it can be used as a key intermediate. Taking the synthesis of specific anti-cancer drugs as an example, its unique chemical structure can precisely combine with specific targets in cancer cells. Through subtle chemical reactions, it blocks the path of cancer cell proliferation, adding a weapon to overcome cancer problems.
In the field of materials science, it has also emerged. After special processing, materials with unique optical and electrical properties can be prepared. Such materials are used in advanced display technology, which can significantly improve the resolution and color saturation of the display screen, bringing a more realistic and gorgeous visual feast to the viewer.
In the field of agricultural chemistry, pesticides made from it have the characteristics of high efficiency and low toxicity. It can accurately kill pests, and is environmentally friendly, helping the green and sustainable development of agriculture. All these show that 2-fluoro-4-nitrophenylacetic acid plays a pivotal role in many application fields and has broad prospects.
Research & Development
In recent years, I have spent a lot of effort on the study of 2 - Fluoro - 4 - Nitrobenzeneacetic Acid. At the beginning, its structure was analyzed, its properties were observed, and the reaction mechanism was repeatedly inferred.
To clarify its characteristics, try various methods. Or change the temperature, or change the solvent, record its changes in detail, hoping to gain something. After months of study, it gradually became clear that under specific conditions, the law of reaction.
I also thought about the application of this thing, thinking that it may be useful in the fields of medicine and materials. Then I plan to work with colleagues to expand its application and promote its development.
Although today has been achieved, there is still a long way to go. In the future, we should make unremitting efforts to tap its potential, hoping to make achievements in scientific research and add new colors to the industry, so that this compound can develop its capabilities and benefit the world.
Toxicity Research
Recent research on the toxicity of 2 - Fluoro - 4 - Nitrobenzeneacetic Acid is quite important. This substance contains fluorine, nitro and other groups, or has unique chemical properties. Fluoride, strong activity, or cause it to interact specifically with molecules in organisms; nitro is also reactive, in the metabolic process or variable.
Looking at its contact route, if it penetrates through the skin or the skin, it will damage the structure and function of cells. Through respiration, it enters the lungs, and travels through the body with qi and blood, disturbing the operation of the organs. Oral administration, it will harm the digestive system, which in turn affects the overall metabolism.
As for toxic effects, or cause cell mutations, disturb gene expression, and lay hidden dangers of disease. Or damage the nervous system, cause abnormal nerve conduction, dizziness and fatigue. Therefore, its production and use must be carefully investigated for toxicity in order to protect people and the environment.
Future Prospects
I have dedicated myself to the research of this 2 - Fluoro - 4 - Nitrobenzeneacetic Acid. It is unique in nature and has infinite potential in various fields of chemical industry. Although it is not widely used today, it looks forward to the future, or it can be an important angle for the creation of medicine. Cover its exquisite structure, it can be used as the basis for targeted drugs, accurately break the barrier of diseases, and save people from sinking diseases.
And the field of chemical materials, or it can be used for innovation and make extraordinary materials, which can be used in aerospace and electronics to help science and technology take off. Although there may be thorns in the road ahead, with the strength of scientific research and unremitting exploration, it will be able to open a new chapter, develop the grand vision of the future, use it for the world, and create endless benefits.
Where to Buy 2-Fluoro-4-Nitrobenzeneacetic Acid in China?
As a trusted 2-Fluoro-4-Nitrobenzeneacetic Acid manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 2-Fluoro-4-Nitrobenzeneacetic Acid supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the chemical properties of 2-Fluoro-4-Nitrobenzeneacetic Acid?
2-Fluoro-4-nitrophenylacetic acid, this is an organic compound. Looking at its structure, it contains fluorine atoms, nitro and phenylacetic acid groups, and these structures endow it with unique chemical properties.
Fluorine atoms have strong electronegativity, which can affect the distribution of molecular electron clouds, reduce the density of their adjacent and para-electron clouds, and change the electrophilic substitution activity of benzene rings, which is more inclined to meta-substitution. And the introduction of fluorine atoms can enhance the lipid solubility of molecules, affect their solubility in different solvents, in organic synthesis and drug development, or affect the biological activity and metabolism of compounds in vivo.
The nitro group is a strong electron-absorbing group, which greatly reduces the electron cloud density of the benzene ring, enhances its chemical stability, and also significantly affects the electron cloud density of the benzene ring. For example, the electron cloud density of the nitro o and para-carbon atoms decreases, and nucleophiles are more likely to attack. Nitro groups can participate in a variety of chemical reactions, such as reduction reactions, which can be converted into amino groups, and are important intermediates in organic synthesis.
Phenylacetic acid groups contain carboxyl groups, which are acidic and can react with bases to form salts. Carboxyl groups can participate in esterification, amidation and other reactions to construct complex organic compounds. In vivo, the structure of phenylacetic acid or interact with specific receptors or enzymes to exhibit certain biological activities
2-fluoro-4-nitrophenylacetic acid is often used as a key intermediate in the field of organic synthesis due to the synergistic effect of various groups. It can be modified by chemical reaction to prepare a variety of functional compounds. In the field of drug research and development, its unique structure may endow potential biological activity, providing a basis for the creation of new drugs.
What are the main uses of 2-Fluoro-4-Nitrobenzeneacetic Acid?
2-Fluoro-4-nitrophenylacetic acid, an organic compound, has a wide range of uses.
In the field of medicine, this compound can be used as a key intermediate. Through specific chemical reactions, its structure can be modified and modified, and then drugs with unique pharmacological activities can be synthesized. For example, when developing antibacterial drugs, the structural properties of 2-fluoro-4-nitrophenylacetic acid can combine with specific targets in bacteria, hindering the normal physiological activities of bacteria, so as to achieve antibacterial effect. In addition, it can also play an important role in the exploration of anti-cancer drugs, perhaps by regulating the signaling pathway of tumor cells, inhibiting the growth and spread of tumor cells.
In the field of pesticides, 2-fluoro-4-nitrophenylacetic acid is also useful. It can be converted into pesticide components with insecticidal, bactericidal or herbicidal activities. Due to its special chemical structure, it can affect the nervous system and respiratory system of pests, causing physiological dysfunction and eventually death. For weeds, it may be able to interfere with physiological processes such as photosynthesis and hormone balance of weeds, inhibit weed growth, and ensure the growth space and nutrient supply of crops.
In the field of materials science, 2-fluoro-4-nitrophenylacetic acid also shows some potential. By compounding or reacting with other organic or inorganic materials, it is possible to prepare materials with special properties. For example, it is possible to improve the optical properties of materials and make them used in optical sensors, optoelectronic devices, etc.; or to enhance the stability and durability of materials for the manufacture of high-performance coatings, plastics, etc.
In summary, 2-fluoro-4-nitrophenylacetic acid has important uses in many fields such as medicine, pesticides and materials science. With the continuous advancement of science and technology, its potential uses are expected to be further explored and expanded.
What is the production method of 2-Fluoro-4-Nitrobenzeneacetic Acid?
The preparation method of 2-fluoro-4-nitrophenylacetic acid is based on a number of methods in the past.
First, 2-fluoro-4-nitrotoluene is used as the starting material. First, a strong oxidizing agent such as potassium permanganate and potassium dichromate is used to oxidize its side chain methyl to carboxyl groups under an appropriate acid-base environment and temperature. This process requires careful observation of the reaction conditions. Because the strength and dosage of the oxidizing agent, the reaction temperature and time are all related to the purity and yield of the product. If the temperature is too high or the oxidizing agent is excessive, it is easy to damage the benzene ring, derive side reactions, and reduce the quality of the product.
Second, it can be hydrolyzed from 2-fluoro-4-nitrophenylacetonitrile. First, 2-fluoro-4-nitrophenylacetonitrile is used as raw material and hydrolyzed under acidic or alkaline conditions. Strong acids such as sulfuric acid and hydrochloric acid are commonly used for acidic hydrolysis, and strong bases such as sodium hydroxide and potassium hydroxide are used for alkaline hydrolysis. During hydrolysis, the reaction process needs to be controlled. After alkaline hydrolysis, acidification is often required to obtain the target product 2-fluoro-4-nitrophenylacetic acid. In this way, the choice of hydrolysis conditions is very important. Improper conditions may cause incomplete hydrolysis or produce other by-products.
And halogenated aromatics are used as starting materials and are prepared by Grignard reaction and other steps. Grignard reagent is first prepared by reacting 2-fluoro-4-nitrohalobenzene with magnesium, then reacting with carbon dioxide to introduce carboxyl groups, and then acidifying to obtain 2-fluoro-4-nitrophenylacetic acid. This process requires strict reaction environment, anhydrous and anaerobic, and the preparation and reaction conditions of Grignard reagent need to be carefully controlled. A little carelessness can easily lead to reaction failure or low yield.
All kinds of production methods have advantages and disadvantages. In actual preparation, when considering the availability of raw materials, cost, product purity requirements and other factors, the appropriate method should be weighed and selected.
2-Fluoro-4-Nitrobenzeneacetic Acid during storage and transportation
2-Fluoro-4-nitrophenylacetic acid is also an organic compound. During storage and transportation, many matters must be paid attention to.
First words storage, this compound should be placed in a cool and dry place. Cover because of its nature susceptible to temperature and humidity, high temperature and humid place, it may cause chemical reactions and damage its quality. And must be away from fire and heat sources to prevent the risk of fire. Because of its flammability, it may be dangerous in case of open flames and hot topics.
Furthermore, the storage place should be separated from oxidizing agents, reducing agents, etc. Due to its active chemical properties, it can mix with other substances, or cause violent chemical reactions, or even explosions, endangering safety.
As for transportation, it is necessary to ensure that the packaging is intact. The packaging materials used should have good sealing and impact resistance to prevent the packaging from being damaged due to bumps and collisions during transportation, and the compound will leak.
During transportation, it is also necessary to avoid exposure to the sun and rain. Direct sunlight and rain invade, or deteriorate the compound. At the same time, the transportation vehicle must be equipped with corresponding fire protection equipment and leakage emergency treatment equipment for emergencies. Escort personnel must also be familiar with the characteristics of the compound and emergency treatment methods, and take strict care during transportation to ensure the safety of transportation.
What is the market price range for 2-Fluoro-4-Nitrobenzeneacetic Acid?
The market price range of 2-fluoro-4-nitrophenylacetic acid is difficult to determine. The market price is often influenced by many factors, which are unpredictable and unpredictable.
First, the cost of raw materials is the key factor. The prices of various raw materials required for the synthesis of this compound fluctuate erratically. If raw materials are scarce, or the supply is reduced due to disasters in origin or policy changes, the price will rise, which will increase the cost of 2-fluoro-4-nitrophenylacetic acid, and the market price will also rise.
Second, the difficulty of the production process is closely related to the cost. If the preparation process is complicated, high-end equipment, special technology is required, or energy consumption is huge, the manufacturer will set the price higher in order to ensure profitability. And if the process is optimized, the cost will be reduced, and the price may be lowered.
Third, the balance of market supply and demand also affects the price. If there is strong demand for 2-fluoro-4-nitrophenylacetic acid in many industries, such as medicine, chemical industry and other fields, its usage will increase greatly, and the supply will be difficult for a while, and the price will rise. On the contrary, if the market demand is low and the supply exceeds the demand, the price will easily drop.
Fourth, the competitive situation of manufacturers should not be underestimated. There are many manufacturers in the market, and in order to compete for share, they may use price as a weapon. When the competition is fierce, the price may be favorable. However, if the market is monopolized by a few manufacturers, the price may be controlled by it.
There are also regional differences. Different regions have different prices due to transportation costs, local economic levels, tax policies, etc.
Therefore, in order to know the exact market price range of 2-fluoro-4-nitrophenylacetic acid, it is necessary to pay attention to the raw material market, production dynamics, supply and demand changes and local conditions in real time, and comprehensively consider to obtain a more accurate figure.