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2-Fluoro-4-Methylnitrobenzene

2-Fluoro-4-Methylnitrobenzene

Hongda Chemical

Specifications

HS Code

584922

Chemical Formula C7H6FNO2
Molar Mass 155.126 g/mol
Appearance Colorless to light yellow liquid
Boiling Point 206 - 208 °C
Melting Point 14 - 16 °C
Density 1.284 g/cm³
Solubility In Water Insoluble
Solubility In Organic Solvents Soluble in many organic solvents like ethanol, ether
Flash Point 86 °C
Vapor Pressure Low vapor pressure at room temperature
Stability Stable under normal conditions but can react with strong oxidizing agents

As an accredited 2-Fluoro-4-Methylnitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 250g of 2 - fluoro - 4 - methylnitrobenzene packaged in a sealed, chemical - resistant bottle.
Storage 2 - fluoro - 4 - methylnitrobenzene should be stored in a cool, well - ventilated area, away from heat and ignition sources. Keep it in a tightly sealed container to prevent leakage. Store it separately from oxidizing agents, reducing agents, and bases, as it may react with them. Use appropriate storage cabinets or areas designated for hazardous chemicals.
Shipping 2 - fluoro - 4 - methylnitrobenzene is a chemical. Ship it in tightly - sealed, corrosion - resistant containers. Follow regulations for hazardous chemicals, ensuring proper labeling and transport by carriers licensed for such substances.
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2-Fluoro-4-Methylnitrobenzene 2-Fluoro-4-Methylnitrobenzene
General Information
Historical Development
2 - Fluoro - 4 - Methylnitrobenzene is an organic compound. Its development process, although there is no such precise synthesis method in ancient times, chemical exploration continues to evolve. In the past, chemists studied organic synthesis and gradually understood various reaction mechanisms. In modern times, organic chemistry flourished, and synthesis technology became increasingly exquisite.
In order to obtain 2 - Fluoro - 4 - Methylnitrobenzene, chemists studied fluorination, nitrification and other reactions. At first, the reaction conditions were harsh and the yield was not high. After repeated experiments, the reaction reagents and conditions were improved, and the process was optimized. Today, the synthesis method is mature and can be prepared stably. This compound has emerged in the fields of medicine, materials, etc. With the advance of science and technology, its development will be even more brilliant, and its applications will also expand.
Product Overview
Today there is a thing called 2 - Fluoro - 4 - Methylnitrobenzene. Its shape is either pure crystal or liquid, pure and stable.
The preparation of this substance requires a delicate method to control various conditions, such as temperature, pressure and the ratio of various agents. The choice of its raw materials is also related to success or failure, and it must be pure and free of impurities.
In terms of its use, in the field of medicine, it is a special agent that can cure various diseases; in the field of agriculture, it can create effective medicines and protect the abundance of crops. And in the research and development of materials, it also has extraordinary skills to help the rise of new materials.
Looking at it, this 2 - Fluoro - 4 - Methylnitrobenzene, although it is a small matter, should not be underestimated in all industries, it is a treasure of scientific research and industry.
Physical & Chemical Properties
2 - Fluoro - 4 - Methylnitrobenzene is also an organic compound. Its physical and chemical properties are worth studying. Looking at its shape, at room temperature, it is either a colorless liquid or a crystalline state, with a special odor. Its boiling point and melting point are fixed, the boiling point is related to the temperature of gasification, and the melting point shows the degree of solidification.
In terms of its solubility, it is soluble and miscible in organic solvents such as ethanol and ether. This is due to intermolecular forces, which interact with solvents to cause them to blend. Its density is also a characteristic, which may be similar or different from water, and is related to the density of the substance.
Chemically, its fluorine-containing, methyl-containing, and nitro-containing groups are all active. Nitro groups change the electron cloud density of the benzene ring, making it easy to generate electrophilic substitution reactions; the presence of fluorine atoms affects the activity and selectivity of the reaction; methyl groups contribute to the spatial structure and electronic effects of molecules. All kinds of properties make 2-Fluoro-4-Methylnitrobenzene widely used in the field of organic synthesis.
Technical Specifications & Labeling
Now the production of 2 - Fluoro - 4 - Methylnitrobenzene is related to technical specifications and identification (commodity parameters), which is a matter of great importance. Its technical specifications, from the selection of raw materials, must be pure and free of impurities, the proportion is accurate, to the control of the reaction, the temperature and duration are fixed, and there can be no slight difference. The reaction device also needs to be clean and intact to ensure a smooth reaction.
As for the identification (commodity parameters), when its properties, color and taste geometry, melting point and boiling point, the purity must be clearly marked. In this way, this product can be properly used in various uses. The two, technical specifications and identification (product parameters), complement each other, ensuring the quality of 2-Fluoro-4-Methylnitrobenzene, which must not be taken lightly.
Preparation Method
In order to prepare 2 - Fluoro - 4 - Methylnitrobenzene, the raw material is crucial to the production process, reaction steps and catalytic mechanism.
To make it, 4 - Methylnitrobenzene is taken as the initial raw material, and a specific fluorine-containing reagent, such as Selectfluor, is used as the fluorine source. The reaction steps are as follows: In a suitable reaction vessel, add an appropriate amount of organic solvent, such as acetonitrile, to create an inert atmosphere. First put 4 - Methylnitrobenzene in it, stir it to disperse evenly, then slowly add the fluorine source, and control the temperature within a specific range, such as 30 to 50 degrees Celsius. This temperature is conducive to the steady progress of the reaction and the prevention of side reactions.
In the catalytic mechanism, an appropriate amount of Lewis acid catalyst, such as ZnCl ², can be introduced. It can activate the fluorine source, greatly increase the activity of fluorine atoms, and is easier to replace with 4-Methylnitrobenzene. It precisely replaces the hydrogen atoms at a specific position in the benzene ring, so as to efficiently prepare 2-Fluoro-4-Methylnitrobenzene. In this way, according to this process, it may be the goal of this preparation.
Chemical Reactions & Modifications
The product of this chemical process is called 2-Fluoro-4-Methylnitrobenzene. In the process of chemical reaction and modification, there are many things that can be studied.
Looking at the reaction, the preparation of raw materials, the control of temperature, and the choice of catalyst are all important. If it is not properly matched, the yield will be low; the temperature will not be suitable, or it will cause epigenesis; the catalyst will not be good, and the reaction will be sluggish. Therefore, if you want to improve its production, you must consider all the reasons in detail and find its appropriate value.
As for modification, it is used to increase its properties and expand its use. Or it can form other groups, change its polarity and solubility to meet different needs. Or adjust its crystal state and particle size to change its physical properties.
The chemist should study the beauty of the reaction and apply the modification method skillfully, so that this product can be used to the best of its ability, and it can be used in both work and research.
Synonyms & Product Names
2 - Fluoro - 4 - Methylnitrobenzene is also a chemical product. It has the same trade name and can be investigated. This compound, in the chemical field, has specific properties and uses. It is the same, or because of the product used by the person, and there are many. As for the trade name, the merchant depends on its market strategy and product characteristics.
The names of chemical products are many, but due to the region and school, they are the same. 2 - Fluoro - 4 - Methylnitrobenzene The same name refers to the specific chemical compound, or its manufacturing characteristics, or its reverse properties. The trade name is designed for market circulation, so that it can be promoted, or promoted, or its use.
Therefore, it is beneficial to explore the same trade name of 2-Fluoro-4-Methylnitrobenzene for chemical research and commercial use. It can be clear that its name is developed in different contexts, helping researchers and users better grasp the characteristics and uses of this thing.
Safety & Operational Standards
2-Fluoro-4-methylnitrobenzene is also a chemical substance. If you want to use this substance, you must first understand its safety and operation conditions, so as to be safe.
All who study this substance, enter the room, must abide by the rules. The first priority is safety, so that the place where it is stored is good and free from poisoning. Those who use it also wear clothes for use, wearing gloves for eyes and protection, to prevent substances from being damaged and muscles and eyes.
The process of its use, the amount of the product must be refined. 2-Fluoro-4-methylnitrobenzene is strong, and it is difficult to mix with other substances. Slowly enter, and keep mixing to prevent reaction. If you add it, it is especially difficult to control the temperature, and it should not be high or low, causing the reaction to go out of control.
If you finish the work, you can't place it at will, and it should be handled according to specific laws. The utensils used also need to be cleaned and removed.
Furthermore, if you keep this thing, it is appropriate to store it in the place where things are dry, and the source of fire and explosion. And the flammable and explosive materials should be placed separately to prevent accidents.
Therefore, the research of 2-fluoro-4-methylnitrobenzene is very important for safe operation. Those who do this must not slack a little, so as to ensure the safety of people.
Application Area
Today there is a thing called 2 - Fluoro - 4 - Methylnitrobenzene, which is widely used and worthy of study. This substance has its properties in various fields.
In the field of medicine, it can be used as a key intermediate to help physicians make special drugs to treat various diseases and relieve the suffering of the common people. In the field of material manufacturing, it can be the basis for the synthesis of novel materials, endowing materials with specific properties, or very tough, or with special optical and electrical capabilities. It is used in exquisite equipment and advanced electronic devices to increase its efficiency and develop its use. In the way of chemical synthesis, it is also an important role, introducing reactions, generating various products, and enriching chemical categories to meet the needs of the world. Its application in the field, such as the stars, shining brightly, for our generation of scientific researchers to study and explore, for the benefit of the world.
Research & Development
In recent years, in the field of organic synthesis, 2 - Fluoro - 4 - Methylnitrobenzene has gradually attracted the attention of researchers. My research aims to clarify its properties and improve its methods.
At the beginning, explore its physicochemical properties and understand its reaction rules. After many experiments, test the effects of different temperatures, pressures and agents. In the method of catalysis, try new agents and seek efficient ways.
Study its preparation, improve the old method, and seek green and simple ways. And think about its application in the fields of medicine and materials, and hope to expand its use.
Although there are many obstacles in the way of research, our generation is determined to solve the problem and promote the research and progress of 2-Fluoro-4-Methylnitrobenzene, which will contribute to the interest of science.
Toxicity Research
The toxicity of 2 - Fluoro - 4 - Methylnitrobenzene is being studied. This compound has been widely used in various fields of chemical industry, but its toxicity is unknown, so the research is very important.
After various experiments, animals were taken as samples and fed with food containing this compound. After a few days, the appearance showed that the vitality of the test animals gradually declined and the amount of food they ate decreased. And the functions of internal organs, such as liver and kidney, were different. The biochemical indicators were abnormal, which showed that 2 - Fluoro - 4 - Methylnitrobenzene had certain toxicity.
In addition to cell experiments, this compound was added to cultured cells to observe its effects on cell growth and proliferation. The results showed that it could inhibit cell growth and even cause apoptosis. It can be seen that 2-Fluoro-4-Methylnitrobenzene has the ability to damage biological cells. In summary, the toxicity of 2-Fluoro-4-Methylnitrobenzene cannot be ignored, and subsequent applications should be used with caution to prevent it from harming organisms and the environment.
Future Prospects
Wuguan 2 - Fluoro - 4 - Methylnitrobenzene This product has unique properties and a wide range of uses. In the field of chemical industry, it can be used as a raw material to make many fine products. Today's technology, although progress has been made, there is still room for improvement.
Looking to the future, with new technology, I believe that I will be able to find better synthesis methods to improve yield, reduce energy consumption and reduce pollution. At that time, this product may have greater potential in the pharmaceutical and material industries. The research and development of new materials may rely on its characteristics to achieve breakthroughs; the creation of medicine may also be leveraged to obtain new effective recipes.
Although the road ahead may be difficult, but the heart of scientific research is strong and unremitting exploration, the future will be able to fully develop the potential of 2-Fluoro-4-Methylnitrobenzene, and contribute to the progress of the world.
Where to Buy 2-Fluoro-4-Methylnitrobenzene in China?
As a trusted 2-Fluoro-4-Methylnitrobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 2-Fluoro-4-Methylnitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 2-fluoro-4-methylnitrobenzene?
2-% Jing-4-methylquinolinone. Although there is no accurate record of this substance in the era mentioned in Tiangong Kaiwu, it has been applied in ancient times based on modern chemical knowledge, or exists in many fields.
In the way of pharmacy, ancient doctors often searched for various kinds of herbs and stones to treat diseases. 2-% Jing-4-methylquinolinone, which contains nitrogen heterocyclic structure, may have potential medicinal activity. Although there is no modern method of precise extraction and synthesis in ancient times, some natural products may contain similar structural components. After repeated attempts, doctors have found that it has the ability to relieve specific diseases, such as clearing heat and relieving pain. The Compendium of Materia Medica contains many examples of drug exploration, and the same is true.
Furthermore, in the dye industry, ancient dyers pursued color quite highly. 2-% Jing-4-methylquinolinone or because of its special structure, can be treated to become a dye component, adding color to fabrics. Ancient dyers mostly took colors from natural plants and minerals. This substance may be used to explore new colors for it. For example, the discovery process of indigo and other dyes is to continuously try the color application of natural substances.
In addition, in the field of alchemy, ancient alchemists wanted to refine the elixir of immortality, often mixing various strange substances. If 2-% Jing-4-methylquinolinone exists in alchemy raw materials or participates in complex chemical reactions, although it may not be able to achieve the effect of longevity, it may cause some unexpected chemical phenomena and add to the accumulation of ancient chemical knowledge. As recorded in Ge Hong's "Baopuzi" about alchemy, there were many unexpected discoveries that promoted chemical cognition at that time.
What are the physical properties of 2-fluoro-4-methylnitrobenzene?
2-% Jiang-4-methylquinolinone is an organic compound, and its physical properties are quite critical, which is related to many application fields.
Looking at its morphology, under room temperature and pressure, 2-% Jiang-4-methylquinolinone is often in a solid state, mostly white or off-white crystalline powder. This morphology makes it relatively stable during storage and transportation, and it is not easy to change its properties significantly due to slight changes in the outside world.
When it comes to the melting point, it has been determined by many experiments that its melting point is within a specific range. This value provides an important reference for determining the purity of the compound and the timing of related chemical operations. The characteristics of the melting point also reflect the strength of intermolecular forces, which helps researchers to understand its microstructure.
In terms of solubility, 2-% Jiang-4-methylquinolinone behaves differently in different solvents. In organic solvents such as ethanol and acetone, it has a certain solubility, but it is relatively low in water. This solubility characteristic is of great significance in the separation, purification and preparation of compounds. According to the difference in its solubility in different solvents, a suitable solvent can be selected for effective separation and purification operations, which also helps to design suitable dosage forms and improve its bioavailability.
In addition, the physical properties such as density and boiling point of 2-% Jiang-4-methylquinolinone, although they are not often mentioned as above, are indispensable in specific industrial processes and theoretical studies. The density data is related to the relationship between its mass and volume, and is of guiding value in the ratio of materials and the design of reaction vessels; the boiling point provides theoretical support for the distillation and separation of compounds.
In short, the physical properties of 2-% Jiang-4-methylquinolinone, from appearance to melting point, solubility, etc., have laid the foundation for research and application in the fields of chemistry and medicine, helping researchers to better understand this compound, and then reasonably apply it in practical production and scientific research.
What are the chemical properties of 2-fluoro-4-methylnitrobenzene?
2-%E6%B0%9F-4-%E7%94%B2%E5%9F%BA%E7%A1%9D%E5%9F%BA%E8%8B%AF%E7%9A%84%E5%8C%96%E5%AD%A6%E6%80%A7%E8%B4%A8%E5%A6%82%E4%B8%8B%E6%89%80%E8%BF%B0:
This compound is a unique substance in the field of organic chemistry. Its structural properties give it specific chemical activity. 2-Hydroxy-4-methylpyrimidinylthiophene, containing thiophene ring and pyrimidine group, and has hydroxy and methyl substitutions at specific positions.
The presence of hydroxy-OH makes the compound hydrophilic. Hydroxyl groups can participate in the formation of hydrogen bonds, whether with similar molecules or with molecules with surrounding electronegative atoms. This hydrogen bond affects its physical properties, such as melting point, boiling point and solubility. At the same time, the hydroxyl group is also an active check point, which is easy to participate in various chemical reactions. For example, under appropriate conditions, esterification can occur, and the corresponding ester compounds can be formed by reacting with acids. The substitution of
4-methyl has an impact on the electron cloud distribution of the molecule. Methyl as the power supply group increases the electron cloud density of the thiophene ring and the pyrimidine group, thereby enhancing the nucleophilicity of the molecule. This property makes the compound more active in the electrophilic substitution reaction, and it is easy to react with electrophilic reagents. The substitution check point is mostly affected by the joint action of methyl and other groups. The conjugation system of the
pyrimidine group and the thiophene ring endows the molecule with special electron delocalization properties. This conjugated structure enhances the stability of the molecule and affects its optical properties, making it possible to absorb or emit light at specific wavelengths, which may have potential applications in the field of photochemistry. At the same time, the conjugated system also affects the reactivity of the molecule, making the molecule more prone to reactions involving electron transfer. The presence of the
thiophene ring brings aromatic-related chemical properties to the compound. The π electron cloud distribution of the thiophene ring enables it to undergo typical aromatic electrophilic substitution reactions, such as halogenation, nitrification, sulfonation, etc. The reaction check point is closely related to the localization effect of the substituent.
In summary, the chemical properties of 2-hydroxy- 4-methylpyrimidinylthiophene are rich and diverse, and it may have broad application prospects in many fields such as organic synthesis and medicinal chemistry due to its unique molecular structure.
What are the synthesis methods of 2-fluoro-4-methylnitrobenzene?
To prepare 2-hydroxy-4-methylpyridyl benzyl ether, there are various methods.
First, it can be obtained by the reaction of 2-hydroxy-4-methylpyridine and benzyl halogen under the action of alkali. Among them, benzyl halides such as benzyl chloride and benzyl bromide can be selected. The base can be selected from potassium carbonate, sodium carbonate, etc. During the reaction, 2-hydroxy-4-methylpyridine and base are first dissolved in a suitable solvent, such as N, N-dimethylformamide (DMF), acetone, etc., and then benzyl halogen is slowly added. The reaction temperature and time are controlled, usually in the temperature range from room temperature to heated reflux, and the reaction time is even tens of hours. After post-treatment, such as extraction, washing, drying, column chromatography or recrystallization, pure 2-hydroxy- 4-methylpyridyl benzyl ether can be obtained.
Second, 2-chloro-4-methylpyridyl and benzyl alcohol are used as raw materials to react in the presence of bases and catalysts. Bases can be sodium hydroxide, potassium hydroxide, etc. Catalysts such as potassium iodide and crown ether can promote the reaction. First, 2-chloro-4-methylpyridine, benzyl alcohol, base and catalyst are co-placed in the reaction vessel, alcohol solvent or dioxane, etc., heated and stirred to make the reaction sufficient. After the reaction is completed, the target product can also be obtained by conventional separation and purification methods.
Third, the metal salt of 2-hydroxy-4-methylpyridine is reacted with benzyl halogen. First, 2-hydroxy-4-methylpyridine is made into metal salts, such as sodium salts and potassium salts, which can be obtained by interacting with metal sodium, potassium or their hydrides. The metal salt is then reacted with benzyl halogen in a suitable solvent, such as tetrahydrofuran, and purified through careful separation to obtain 2-hydroxy- 4-methylpyridyl benzyl ether. All methods have advantages and disadvantages, and the actual preparation needs to be comprehensively considered according to the availability of raw materials, cost, difficulty of reaction conditions and other factors, and the optimal method is selected.
What are the precautions for storing and transporting 2-fluoro-4-methylnitrobenzene?
For 2-% Jiang-4-methylpentyl ether, there are several ends that should be added during storage and transportation.
The first thing to focus on is its chemical properties. This substance has a specific chemical structure and properties, and is quite sensitive to environmental factors such as temperature, humidity, and light. If the temperature is too high, it may cause chemical reactions, and even cause decomposition, polymerization, etc., which will damage its quality. Therefore, when storing, choose a cool, dry and well-ventilated place, avoid direct sunlight, and maintain a suitable temperature range to prevent qualitative changes.
During transportation, also pay attention to vibration and collision. This substance may be damaged by strong vibration and then leak. The packaging must be sturdy and reliable, and the contents should be properly fixed to reduce its shaking during transportation. And the means of transportation should run smoothly and avoid bad road conditions to prevent accidents.
Furthermore, safety is extremely critical. 2-% Jiang-4-methylpentyl ether may have certain toxicity, flammability or irritation. Storage place, when away from fire sources, heat sources and oxidants, etc., prepare corresponding fire and emergency facilities. When transporting, it must be operated in strict accordance with relevant safety regulations. Transport personnel should be familiar with its characteristics and emergency response methods. In case of leakage, they can respond quickly and properly to ensure the safety of personnel and the environment.
In addition, label identification should not be ignored. No matter whether it is stored or transported, the name, ingredients, hazard characteristics, emergency treatment methods and other information should be clearly marked on the container. This is convenient for personnel to identify. In an emergency, correct measures can be taken according to the label to avoid serious consequences due to improper handling. In summary, the storage and transportation of 2-% Jiang-4-methylpentyl ether must take into account various factors and operate strictly to ensure its safety and quality.