2-Fluoro-4-methylphenylboronic acid is an important chemical reagent in the field of organic synthesis. It has a wide range of uses and is often used as a key intermediate in the field of medicinal chemistry. The construction of many drug molecules relies on its participation in reactions to help introduce specific structural fragments, which in turn give drugs the desired activity and properties.
In the field of materials science, it also plays an important role. For example, in the synthesis of organic optoelectronic materials, it can integrate macromolecular structures through specific reaction paths to optimize the photoelectric properties of materials, such as improving fluorescence efficiency and improving charge transport capabilities, providing assistance for the preparation of high-performance organic Light Emitting Diodes, solar cells and other materials.
In addition, in the development of new catalysts, 2-fluoro-4-methylphenylboronic acid can be used as a ligand or participate in the construction of the active center of the catalyst. With its unique electronic effect and spatial structure, the activity and selectivity of the catalyst can be modulated, making the catalytic reaction more efficient and targeted.
Because of its structure containing boron-oxygen bonds and fluorine, methyl and other groups, it can participate in a variety of classical organic reactions, such as the Suzuki coupling reaction, which is an important method for building carbon-carbon bonds. In such reactions, 2-fluoro-4-methylphenylboronic acid has made great contributions to the precise synthesis of complex organic molecules. In short, 2-fluoro-4-methylphenylboronic acid plays an indispensable role in many chemistry-related fields, promoting research progress and technological innovation in various fields.

2-Fluoro-4-methylphenylboronic acid, this substance is a commonly used reagent in organic synthesis. Its physical properties are quite important and are related to many practical applications.
When it comes to appearance, it is usually white to off-white solid powder, with fine texture and pure color. This feature is easy to observe and identify, and is easy to distinguish in experiments and production.
In terms of melting point, it is about a specific temperature range, generally between [X] ° C and [X] ° C. The stability of the melting point is of great significance for the determination of its purity. If the purity is high, the melting point interval is narrow and close to the theoretical value; if it contains impurities, the melting point may decrease, and the interval will also become wider.
In terms of solubility, it has a certain solubility in common organic solvents such as ethanol, ether, dichloromethane, etc. In ethanol, under a certain temperature and stirring conditions, it can dissolve to form a uniform solution. This property makes it convenient to mix with other reactants in organic synthesis reactions and promote the reaction.
Density is also an important physical property, about [X] g/cm ³. This value is of great significance in solution preparation, material balance, etc. It helps to accurately calculate the required amount of the reaction and ensure that the reaction proceeds as expected.
In addition, 2-fluoro-4-methylphenylboronic acid is relatively stable in air, but long-term exposure to humid environments may react with moisture and affect its performance. Therefore, it needs to be stored in a dry, cool place and sealed to maintain its physical stability and ensure the quality and effect during use.

The synthesis of 2-fluoro-4-methylphenylboronic acid can follow the following steps.
Start with 2-fluoro-4-methylbromobenzene as the starting material. In a dry reaction bottle, fill with nitrogen to create an inert atmosphere. Dissolve an appropriate amount of 2-fluoro-4-methylbromobenzene into an organic solvent such as anhydrous ether or tetrahydrofuran and cool to a low temperature, usually about -78 ° C. At this low temperature, n-butyllithium (n-BuLi) is slowly added dropwise, and the rate of dropwise addition should be carefully controlled to prevent overreaction. 2-Fluoro-4-methylphenyl lithium intermediate is formed by lithium-halogen exchange reaction between n-butyllithium and 2-fluoro-4-methylbromobenzene. This intermediate is extremely active and needs to be kept at low temperature and inert environment.
Subsequently, the reaction system is maintained at low temperature, and trimethyl borate is slowly added to it. Trimethyl borate reacts with 2-fluoro-4-methylphenyl lithium intermediate to form a borate precursor of the desired product. After adding, the reaction mixture is gradually warmed to room temperature and stirred for a period of time to ensure that the reaction is fully carried out.
After the reaction is completed, the reaction solution needs to be post-treated. First, the reaction is quenched with an appropriate amount of dilute hydrochloric acid or dilute sulfuric acid to decompose the unreacted borate and other by-products. At this time, the product 2-fluoro-4-methylphenylboronic acid exists in the reaction solution in the form of free acid. Then, an organic solvent such as ethyl acetate is extracted for multiple extractions to improve the yield of the product. The organic phases are combined and dried with a desiccant such as anhydrous sodium sulfate to remove the residual moisture in the organic phase.
Finally, the organic solvent is removed by vacuum distillation, and the crude product can be further purified by column chromatography. Using silica gel as the stationary phase, select a suitable eluent, such as petroleum ether and ethyl acetate mixed in a certain proportion, perform column chromatography separation, collect the eluent containing the target product, and steam off the solvent to obtain pure 2-fluoro-4-methylphenylboronic acid.
Another alternative method can be used to replace 2-fluoro-4-methylbromobenzene with 2-fluoro-4-methyliodobenzene. The reaction steps are similar to the above, and this compound can also be synthesized. However, the activity of iodobenzene is usually higher than that of bromobenzene, and the reaction conditions may be slightly milder, but the cost may increase. And in each step of the reaction, it is necessary to pay attention to the precise control of the reaction conditions, including temperature, reagent dosage, reaction time, etc., in order to obtain the ideal yield and purity.

For 2-fluoro-4-methylphenylboronic acid, many matters need to be paid attention to during storage and transportation.
This compound has certain chemical activity. When stored, the first environment is dry. The cover is very sensitive to moisture, and in case of water vapor, or reactions such as hydrolysis, it will damage its purity and quality. Therefore, it should be placed in a dry, cool and well-ventilated place, away from water sources and humid places.
Temperature is also critical. It should be stored in a low temperature environment, usually 2-8 ° C, which can slow down its possible chemical reactions and maintain its chemical stability. Do not place it in a high temperature environment to prevent it from decomposing or deteriorating.
During transportation, the packaging must be sturdy and sealed. Choose suitable packaging materials, such as those with good moisture and shock resistance, to resist bumps and collisions during transportation. And the packaging should clearly identify its chemical properties and precautions to warn the person transporting it.
In addition, 2-fluoro-4-methylphenylboronic acid may react with other substances, so it is necessary to avoid contact with oxidants, strong bases and other substances during storage and transportation to prevent dangerous chemical reactions.
In general, when storing and transporting 2-fluoro-4-methylphenylboronic acid, it is necessary to follow the storage and transportation specifications of chemical substances, pay attention to moisture prevention, temperature control, proper packaging and avoid improper contact, so as to ensure its safety and quality.

I look at your question, but I am inquiring about the market price of 2-fluoro-4-methylphenylboronic acid. However, the price of this chemical often changes for various reasons, and it is difficult to give an exact price directly.
First, the trend of supply and demand is the key end. If the demand for this product is strong and the supply is limited, the price will be high; conversely, if the supply is abundant and the demand is thin, the price will be lower.
Second, the quality level also affects the price. Those with high purity and high quality must be higher than the ordinary one.
Third, the amount purchased will also affect the price. If you buy in large quantities, merchants may give discounts, and the price will be relatively low; if you buy a small amount, the price may be slightly higher.
Fourth, regional differences also lead to price differences. Different places have different prices due to transportation costs and market environments.
Fifth, the manufacturer's brand is also related to the price. Produced by well-known large factories, or due to reputation and quality assurance, the price is slightly higher.
According to my investigation, if you want to know the approximate market price, you can consult chemical product suppliers, traders, or consult the quotation of chemical product trading platforms. In this way, more accurate price information can be obtained. However, the current price is only for temporary reference. The market situation changes, and the price can change at any time.