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2-Fluoro-4-Methyl-1-Nitrobenzene

2-Fluoro-4-Methyl-1-Nitrobenzene

Hongda Chemical

Specifications

HS Code

515690

Chemical Formula C7H6FNO2
Molar Mass 155.13 g/mol
Appearance Yellow - liquid
Boiling Point 216 - 217 °C
Melting Point 2 - 4 °C
Density 1.27 g/cm³
Flash Point 94 °C
Solubility In Water Insoluble
Vapor Pressure Low
Refractive Index 1.529 - 1.531

As an accredited 2-Fluoro-4-Methyl-1-Nitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 250g of 2 - fluoro - 4 - methyl - 1 - nitrobenzene packaged in a sealed glass bottle.
Storage 2 - fluoro - 4 - methyl - 1 - nitrobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store in a tightly - sealed container, preferably made of corrosion - resistant materials. Label the storage container clearly. This helps prevent decomposition, reduce fire risks, and ensure safety in handling.
Shipping 2 - fluoro - 4 - methyl - 1 - nitrobenzene is shipped in accordance with strict hazardous chemical regulations. It's packaged in specialized containers to prevent leakage, transported by carriers licensed for such chemicals, ensuring safety during transit.
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2-Fluoro-4-Methyl-1-Nitrobenzene 2-Fluoro-4-Methyl-1-Nitrobenzene
General Information
Historical Development
2 - Fluoro - 4 - Methyl - 1 - Nitrobenzene is also an organic compound. Its traces first appeared in the study of chemistry. In the past, researchers tried their best to understand its structure and use.
At the beginning, the synthesis method was still simple and clumsy, and the yield was not yet abundant. However, the scholars did not stop, and the research deepened. With the passage of time, the skills have improved, the synthesis method has become better, and the yield has also increased.
Since its appearance, it has developed its capabilities in the field of medicine and materials. In medicine, it is the foundation for making good medicines; in materials, new materials for research add their brilliance. The course of its development is the coagulation of the hearts of the researchers, and it will be even more ambitious in the future, creating extraordinary achievements in various domains.
Product Overview
There is now a substance called 2 - Fluoro - 4 - Methyl - 1 - Nitrobenzene. It is an organic compound with a unique structure. Its shape, fluorine atoms, methyl and nitro groups, according to the specific positions of the benzene ring, are carefully arranged.
The properties of this substance are related to many chemical reactions. Under suitable conditions, the substitution reaction on the benzene ring can occur in an orderly manner, and fluorine, methyl and nitro can each perform their own functions. It may be a key check point for the reaction, guiding the process of the reaction and leading to the formation of various products.
The method of preparing it is often involved in the wonderful skills of organic synthesis. With suitable raw materials, carefully designed steps, and under rigorous reaction conditions, the structure of this compound is gradually constructed. Each step needs to be precisely controlled to obtain high-purity products. It has potential applications in many fields such as chemical industry and scientific research. It can be used as a cornerstone for the synthesis of more complex compounds, or as a key reagent in specific chemical reactions, which cannot be ignored in chemical research.
Physical & Chemical Properties
2 - Fluoro - 4 - Methyl - 1 - Nitrobenzene is also an organic compound. Its physical and chemical properties can be investigated. Looking at its shape, it may be liquid at room temperature, with a light color and a special odor. Its boiling point and melting point are characteristics. The boiling point is related to the temperature of gasification, and the melting point is determined by the degree of solidification.
On its chemistry, the existence of nitro groups makes it reactive to a certain extent. The structure of fluorine atoms and methyl groups also affects its reaction path. It can interact with many reagents under specific conditions, such as nucleophilic substitution and electrophilic substitution. Due to the interaction of functional groups in its structure, the selectivity and rate of the reaction are unique. The study of the physicochemical properties of this compound is of great significance in the fields of organic synthesis and materials science.
Technical Specifications & Labeling
Today there is a product called 2 - Fluoro - 4 - Methyl - 1 - Nitrobenzene. The preparation of this product is related to technical specifications and identification (product parameters), which is the most important.
To make this product, you need to follow a precise method. The choice of materials must be high standard, the weighing must be accurate, and the pool must not be wrong at all. When reacting, temperature, humidity, duration, etc. need to be strictly controlled. Control the temperature to an appropriate degree and observe its changes. If the temperature is high, it will drop rapidly, and if it is low, it will rise rapidly to ensure a stable reaction.
As for the identification (product parameters), its purity, color, and properties are all determined. When the purity reaches a specific number, the color needs to be pure and free of impurities, and the properties should also conform to the regulations. In this way, only qualified products can be obtained, which are beneficial to users and live up to the heart of research.
Preparation Method
2 - Fluoro - 4 - Methyl - 1 - Nitrobenzene is prepared in this product, and the raw materials are prepared first. Take fluorobenzene, methylating reagent, nitrifying agent, etc. The fluorobenzene and methylating reagent are put into the reaction kettle in an appropriate ratio, the temperature is controlled and the reaction time is long, and the methylation reaction is carried out to obtain 4 - methyl fluorobenzene.
Then, 4 - methyl fluorobenzene and nitrifying agent are nitrified in a certain ratio under specific reaction conditions. This step requires strict control of the reaction temperature, time and the proportion of each reactant to prevent side reactions.
After the reaction is completed, the product is separated and purified. Pure 2 - Fluoro - 4 - Methyl - 1 - Nitrobenzene can be obtained by extraction, distillation, recrystallization and other means. The whole process, each reaction step and operation need to be precisely controlled to ensure the purity and yield of the product.
Chemical Reactions & Modifications
F 2 - Fluoro - 4 - Methyl - 1 - Nitrobenzene is an organic compound. Its chemical reaction and denaturation are the important task of our research.
Looking at the reaction, under appropriate conditions, the fluorine atom, methyl group and nitro group can all participate in the chemical change. Fluorine atoms often affect the reactivity of molecules because of their strong electronegativity, and are prone to nucleophilic substitution reactions. Although methyl is relatively stable, under specific reagents and conditions, reactions such as oxidation can occur, which change the structure and properties of molecules. Nitro is a strong electron-absorbing group, which can reduce the electron cloud density of benzene rings and affect the position and rate of electrophilic substitution reactions.
If you want to change its properties, you can use chemical modification methods. For example, with a suitable reducing agent, the nitro group is reduced to an amino group, so that the chemical activity and application of the molecule are different from before. Or by nucleophilic substitution, replacing fluorine atoms with other groups, new compounds can be obtained to meet different needs. This is the way for us to explore chemical changes and optimize the properties of compounds.
Synonyms & Product Names
Nowadays, there is a product called 2-Fluoro-4-Methyl-1-Nitrobenzene. This product has a wide range of uses in the field of chemistry. Its synonymous names are also various. Or from its properties and structure, such as fluoromethyl nitrobenzene and the like. As for the names of the products, they are also different, all of which vary according to the marketing strategy and use orientation of the merchants.
Although the names are different, they are essentially the same. In the process of chemical synthesis, this substance is often a key raw material and can participate in many reactions to obtain other useful compounds. Although the names of all synonyms and trade names are different, they refer to the same thing. The wonders of chemistry can be seen in the name and reality. Those who study this thing should understand the change of its name and know the permanence of its reality before they can obtain its true meaning and make good use of it to benefit the world.
Safety & Operational Standards
2 - Fluoro - 4 - Methyl - 1 - Nitrobenzene Safety and Operating Specifications
Fu 2 - Fluoro - 4 - Methyl - 1 - Nitrobenzene, also a chemical substance. During the time of experiment and production, safety and standardized operation are the top priority, which is related to human life and the environment, and should not be careless.
#1. Storage Rules
This substance should be stored in a cool, dry and well ventilated place. Keep away from fire and heat sources to prevent accidents. It must be stored separately from oxidants, reducing agents, alkalis, etc., and must not be mixed. Cover because of its active chemical properties, mixed easily lead to violent reactions, fire and explosion risk. Storage area should be equipped with suitable materials to contain leaks, in order to prevent the spread of leakage, endangering the surrounding.
#2. The essentials of operation
When operating, be sure to strictly follow the operating procedures. Operators must be specially trained and proficient in operating skills before they can go to work. When operating, appropriate protective clothing, protective gloves and goggles should be worn to prevent substances from contacting the skin and eyes, causing burns.
Operate in a fume hood to ensure air circulation, reduce the concentration of the substance in the air, and reduce inhalation hazards. During operation, avoid dust and smoke to prevent their spread. If heating is required, appropriate heating methods should be used, and the temperature should be strictly controlled to prevent decomposition or explosion caused by overheating.
#3. Emergency measures
If a leak occurs accidentally, personnel in the leaking contaminated area should be quickly evacuated to a safe area, isolated, and strictly restricted access. Emergency personnel must wear self-contained positive pressure breathing apparatus and anti-toxic clothing. Do not let the leak come into contact with combustible substances to prevent fire. In the case of a small amount of leakage, it can be absorbed by inert materials such as sand and vermiculite; in the case of a large amount of leakage, a dike or pit should be built for containment, and transferred to a tanker or a special collector by pump for recycling or transportation to a waste treatment site for disposal.
If someone comes into contact with the substance, eye contacts should immediately lift the eyelids, rinse thoroughly with a large amount of flowing water or normal saline for at least 15 minutes, and seek medical attention; skin contacts should immediately remove contaminated clothing, rinse with a large amount of flowing water for at least 15 minutes, and also need medical attention. If inhaled, you should quickly leave the scene to a fresh place of air, keep the respiratory tract unobstructed, such as breathing difficulties, give oxygen, if breathing stops, immediately perform artificial respiration, and seek medical attention.
In short, in the use and treatment of 2-Fluoro-4-Methyl-1-Nitrobenzene, strictly observe safety and operating practices to ensure that people are safe and the environment is not damaged.
Application Area
2 - Fluoro - 4 - Methyl - 1 - Nitrobenzene is an organic compound. Its application field is quite wide. In the field of medicinal chemistry, it can be used as a key intermediate for the synthesis of specific drugs, helping to overcome difficult diseases. Due to its special chemical structure, it can precisely combine with specific targets in organisms and exert unique pharmacological effects.
In the field of materials science, this compound is also useful. It can participate in the creation of high-performance materials, such as optimizing the properties of polymer materials, enhancing their stability and functionality. With its synergistic effect of fluorine, methyl and nitro groups, it gives materials unique properties.
In the field of fine chemicals, 2 - Fluoro - 4 - Methyl - 1 - Nitrobenzene is an important raw material for the synthesis of high-end fine chemicals, and has made great contributions to the upgrading and innovation of the chemical industry. Its potential in many application fields is waiting for our generation of chemical researchers to explore and expand.
Research & Development
Today there is a thing called 2 - Fluoro - 4 - Methyl - 1 - Nitrobenzene. As researchers, we explore the path of its research and creation.
The research and development of this thing has gone through hardships. At the beginning, it was only a theoretical concept, and it was tried and tested repeatedly in the laboratory. All kinds of raw materials, after precise proportions, interact under specific temperature, humidity and pressure conditions. In the meantime, there may be difficulties where the reaction is not as expected, or there may be impurities that are difficult to remove.
However, researchers uphold tenacity and are reluctant to study. After adjusting the experimental parameters countless times and improving the process flow, the yield and purity of 2-Fluoro-4-Methyl-1-Nitrobenzene were finally improved. This process is like sailing against the current, if you don't advance, you will retreat.
Looking at this product today, it has broad application prospects. In the field of medicine, it may help the research and development of new drugs; in materials science, it may also contribute to the creation of new materials. The road of scientific research is long, and we should make unremitting efforts for its development to open up innovation.
Toxicity Research
Recently, Yu focused on the toxicity study of 2 - Fluoro - 4 - Methyl - 1 - Nitrobenzene. Although this substance may have its uses in the industrial field, its toxicity should not be underestimated.
After many experiments, it was found that its effect on the organism was quite significant. In the experiment of mice, the micro-exposure showed that its behavior was slightly different and the active level was slightly reduced. If the dose was slightly increased, there was a appearance of unkempt hair, abnormal eating and drinking. From the anatomical perspective, the organs were also damaged, the color and texture of the liver were changed, and the renal function indicators were also abnormal.
It can be seen that the toxicity study of 2 - Fluoro - 4 - Methyl - 1 - Nitrobenzene is very important, which is related to industrial application safety and environmental ecology. In the future, it is necessary to study in depth to clarify the mechanism of its toxicity in order to find a good strategy to protect the health of all beings and maintain the peace of the environment.
Future Prospects
Today there is a thing called 2 - Fluoro - 4 - Methyl - 1 - Nitrobenzene. I look at this thing, and in the process of scientific research, it has a great unfinished picture. Its unique nature may open up new frontiers in the field of organic synthesis.
The future development is expected to help medicine create, find solutions to problems, and add exquisite medicines to the treatment of diseases. Or in the research and development of materials, emerge, make extraordinary materials, and meet diverse needs.
We should devote our efforts and study unremitting, with the hope of using scientific wisdom to explore its infinite potential. I hope that in the future, this object will shine brightly, add well-being to the world, explore a new path in the unknown, and live up to the expectations of my generation's scientific research, achieving a bright future.
Where to Buy 2-Fluoro-4-Methyl-1-Nitrobenzene in China?
As a trusted 2-Fluoro-4-Methyl-1-Nitrobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 2-Fluoro-4-Methyl-1-Nitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 2-Fluoro-4-Methyl-1-Nitrobenzene?
2-Fluoro-4-methyl-1-nitrobenzene is an important compound in the field of organic synthesis. It has a wide range of main uses and is of great significance.
In the synthesis of medicine, this compound can be said to play a key role. It is often used as an intermediate in the synthesis of a variety of biologically active drugs. Due to the unique presence of fluorine atoms, methyl groups and nitro groups in the molecular structure, it is endowed with specific chemical and physical properties. These properties can participate in complex reactions and help to construct drug molecular structures with specific pharmacological activities. For example, in some antimicrobial or antiviral drug synthesis pathways, 2-fluoro-4-methyl-1-nitrobenzene can be used as a starting material or key intermediate, and through a series of carefully designed chemical reactions, drug molecules with precise pharmacological effects can be gradually constructed.
In the field of pesticides, 2-fluoro-4-methyl-1-nitrobenzene also plays an indispensable role. It can be used to synthesize highly efficient and low-toxicity pesticide products. With its unique chemical structure, it can participate in the synthesis of pesticide ingredients with highly selective inhibition or killing effects on specific pests or diseases. Such pesticides can not only effectively protect crops from pests and diseases, ensure food yield and quality, but also because of their low toxicity, the negative impact on the environment and ecology is relatively small, which meets the needs of today's green agriculture development.
Furthermore, in the field of materials science, 2-fluoro-4-methyl-1-nitrobenzene also has its uses. It can be used as an important raw material for the synthesis of special functional materials. For example, when synthesizing certain organic materials with special optical and electrical properties, the structural properties of the compound can be cleverly exploited to introduce it into the molecular structure of the material by means of chemical modification and polymerization, thereby imparting special properties such as light absorption at specific wavelengths or conductivity regulation to the material, providing the possibility for the development and application of new organic materials.
In summary, 2-fluoro-4-methyl-1-nitrobenzene has shown important uses in many fields such as medicine, pesticides and materials science, and is of great significance to promote the development of related fields.
What are the physical properties of 2-Fluoro-4-Methyl-1-Nitrobenzene?
2-Fluoro-4-methyl-1-nitrobenzene is one of the organic compounds. Its physical properties, let me tell them one by one.
First of all, its appearance, under room temperature and pressure, is mostly light yellow to brown liquid, which is quite characteristic. The formation of its color is due to the interaction of atoms in the molecular structure, which affects the absorption and reflection of light, so it appears this color.
As for its melting point, it is about -20 ° C. The melting point is the critical temperature at which a substance changes from solid to liquid. The low melting point of this compound indicates that the intermolecular force is relatively weak. At lower temperatures, the molecules can break free from the shackles of the solid state and become liquid.
The boiling point is about 216-218 ° C. The boiling point is the temperature at which a liquid becomes a gas, reflecting the energy required for molecules to break free from the liquid phase and enter the gas phase. The higher boiling point of this compound indicates that there is a certain strength of interaction between molecules, and a higher energy is required to vaporize it.
Its density is about 1.29 g/cm ³, which is heavier than water. In density, the mass per unit volume of the substance is also. This value shows that under the same volume, the mass of 2-fluoro-4-methyl-1-nitrobenzene is greater than that of water. If the two are mixed, it will sink underwater.
In terms of solubility, 2-fluoro-4-methyl-1-nitrobenzene is insoluble in water. Due to the existence of fluorine, methyl and nitro groups in its molecular structure, the molecular polarity is quite different from that of water. According to the principle of "similar miscibility", its solubility in water is very small. However, it is soluble in common organic solvents, such as ethanol, ether, acetone, etc. The molecular polarity of organic solvents is similar to that of this compound, and intermolecular forces can promote the dissolution of the two.
In addition, 2-fluoro-4-methyl-1-nitrobenzene has a certain volatility and can evaporate slowly in air. This volatility is related to its molecular energy and intermolecular forces, and some high-energy molecules can overcome the attractive forces between molecules and escape from the liquid surface into the gas phase.
What is the chemical synthesis method of 2-Fluoro-4-Methyl-1-Nitrobenzene?
To prepare 2-fluoro-4-methyl-1-nitrobenzene, the following method can be followed.
First, p-toluidine is used as the starting material, which is a common and easy to obtain. First, it is reacted with hydrofluoric acid and sodium nitrite at low temperature, and this step aims to convert the amino group into a diazonium salt. Because the diazonium salt has high activity, and the fluoride ion can replace the diazonium group, this reaction needs to be carefully operated under specific low temperature conditions to prevent the decomposition of the diazonium salt, causing the reaction to go out of control or generate heterogeneous by-products, so that p-methyl fluorobenzene can be obtained.
After obtaining p-methyl fluorobenzene, the nitration reaction is continued. The p-methyl fluorobenzene is placed in a mixed acid environment (a mixture of sulfuric acid and nitric acid), and the nitric acid is catalyzed by sulfuric acid to produce nitroyl positive ions, which are electrophilic reagents. It attacks the benzene ring of p-methyl fluorobenzene, because methyl is an ortho-para-localization group. Although fluorine has electron-absorbing induction effect, it also has electron-fed conjugation effect. Under the combined action, nitroyl positive ions mainly attack the ortho-site of methyl and the anti-site of fluorine. Through a series of electron cloud migration and reaction steps, the target product 2-fluoro-4-methyl-1-nitrobenzene can be obtained. In this nitrification step, the ratio of mixed acid, reaction temperature and time must be strictly controlled. The proportion of mixed acid is improper, or the degree of nitrification is abnormal, resulting in the formation of polynitro compounds; if the temperature is too high, it is easy to initiate side reactions, which affect the purity and yield of the product.
During the preparation process, the product needs to be properly separated and purified after each step of the reaction. Unreacted raw materials, by-products and impurities can be removed by distillation, extraction, recrystallization, etc., to obtain high-purity 2-fluoro-4-methyl-1-nitrobenzene.
What 2-Fluoro-4-Methyl-1-Nitrobenzene need to pay attention to when storing and transporting
2-Fluoro-4-methyl-1-nitrobenzene is an organic compound. When storing and transporting, many aspects need special attention.
The first thing to pay attention to is its chemical properties. This compound has nitro and fluorine atoms, and the nitro group is a strong electron-absorbing group, which makes the substance chemically active and unstable. When storing, be sure to keep it in a cool, dry and well-ventilated place, away from fires and heat sources, to prevent chemical reactions or even explosions caused by rising temperatures. Because it is sensitive to air and moisture, it needs to be sealed and stored to avoid contact with air and moisture to prevent deterioration.
When transporting, strictly abide by relevant regulations and standards. The packaging must be tight and firm to ensure that no leakage occurs during transportation. According to its dangerous characteristics, choose suitable transportation methods and tools, assign professional personnel to operate, and closely monitor the transportation process.
2-fluoro-4-methyl-1-nitrobenzene has certain toxicity and irritation. Storage places should be away from crowded areas and food, drinking water sources, etc. Operators and transporters should take protective measures, wear protective clothing, gloves, protective glasses and gas masks, etc., to avoid skin contact and inhalation. In the event of a leak, personnel should be quickly evacuated to a safe area to cut off the fire source. Emergency responders wear positive pressure self-contained breathing apparatus and anti-toxic clothing. Do not let leaks come into contact with combustible substances. Small leaks should be adsorbed or absorbed with sand or other non-combustible materials. A large amount of leaks should be built into a embankment or dug for containment. Transfer to a tanker or a special collector with a pump for recycling or transportation to a waste treatment site for disposal.
Furthermore, relevant records are indispensable during storage and transportation. Detailed records of the time, quantity, transportation route, and personnel handling the warehousing are recorded for traceability and management. In the event of an accident, these records can provide a key basis for accident investigation and handling.
2-Fluoro-4-Methyl-1-Nitrobenzene impact on the environment and human body
2-Fluoro-4-methyl-1-nitrobenzene is also an organic compound. Its impact on the environment and human body cannot be ignored.
In the environment, this compound may be harmful. It is chemically stable, difficult to degrade in the natural environment, or cause long-term accumulation. If released in soil, it can contaminate, prevent plant roots from absorbing nutrients and water, cause plant growth difficulties, or abnormal development. And may seep into groundwater, sewage sources, endanger aquatic organisms, and break the ecological balance of water bodies. Aquatic organisms may be disordered due to their physiological functions, reduce their fertility, and reduce their population.
As for the human body, 2-fluoro-4-methyl-1-nitrobenzene is also a potential threat. It can damage health through respiratory tract, skin contact or ingestion. It may irritate the respiratory tract, causing cough, asthma, and breathing difficulties. If it comes into contact with the skin, it can cause skin allergies, redness, swelling, itching, and even ulceration. If ingested by mistake, it may hurt the digestive system, causing nausea, vomiting, and abdominal pain. In particular, this compound may be potentially carcinogenic and genotoxic. Long-term exposure or increase the risk of cancer, damage reproductive cells, and cause genetic mutations.
In conclusion, 2-fluoro-4-methyl-1-nitrobenzene is potentially harmful to the environment and human body. When producing, using and disposing of this compound, strict safety regulations should be followed to prevent its release into the environment and reduce the threat to ecological and human health.