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What are the main uses of 2-Fluoro-3-Methoxybenzeneboronic Acid?
2-Fluoro-3-methoxyphenylboronic acid has a wide range of uses. In the field of organic synthesis, it is often used as a key intermediate. In the construction of complex organic molecular structures, through various reaction types such as Suzuki coupling reaction, it can be coupled with halogenated aromatics or olefin compounds, and then many compounds with special structures such as biphenyls or alkenylbenzene are formed. These products are of great significance in the fields of pharmaceutical chemistry and materials science.
In the process of drug development, compounds synthesized by such reactions may have unique physiological activities and can be used as lead compounds to lay the foundation for the creation of new drugs. For example, some biphenyl-structured drugs have shown good pharmacological efficacy in anti-tumor and anti-virus, and 2-fluoro-3-methoxyphenylboronic acid may play an indispensable role in this synthesis process.
In the field of materials science, functional materials prepared by Suzuki coupling reaction may have unique optoelectronic properties. For example, some organic optoelectronic materials containing biphenyl structure have emerged in the application of organic Light Emitting Diode (OLED), organic solar cells and other devices. 2-fluoro-3-methoxyphenylboronic acid is also an important starting material for the synthesis of such materials.
Furthermore, it is also useful in the preparation of fine chemicals. It can provide a key structural unit for the synthesis of fine chemicals such as fragrances and dyes with specific structures, and can be modified by a series of reactions to endow fine chemicals with unique properties and functions.
What are the physical properties of 2-Fluoro-3-Methoxybenzeneboronic Acid?
2-Fluoro-3-methoxyphenylboronic acid is a commonly used reagent in organic synthesis. Its physical properties are quite critical and it is widely used in the field of organic synthesis.
Looking at its properties, it is mostly white to off-white solids under normal conditions. This is due to the interaction between atoms in its molecular structure, resulting in the orderly arrangement of molecules to form a stable solid structure. Its melting point is within a certain range, which is determined by the intermolecular force. When heated, specific energy needs to be absorbed to overcome the attractive force between molecules, causing the lattice structure to disintegrate, resulting in a transition from solid to liquid.
Solubility is also an important physical property. In general, it has a certain solubility in common organic solvents such as dichloromethane and toluene. This is because the molecule of this substance has a certain polarity, and there are interaction forces with organic solvent molecules, such as van der Waals force, dipole-dipole interaction, etc., so that it can be dispersed in the solvent. In water, the solubility is relatively low, and due to the strong polarity of water molecules, the matching degree of force between 2-fluoro-3-methoxyphenylboronic acid molecules is not good.
Furthermore, its stability cannot be ignored. It is relatively stable under normal temperature and pressure and dry environment. In case of extreme conditions such as strong oxidants, strong acids and bases, the molecular structure may be affected, and a chemical reaction occurs. Due to the characteristics of the phenylboronic acid group, the boron atom has a certain electron deficiency, which is easy to react with nucleophiles. And the existence of fluorine atoms and methoxy groups will also affect the overall electron cloud distribution of the molecule, which has an effect on stability.
These physical properties are of great significance in the design of organic synthesis reactions, the selection of reaction conditions, and the separation and purification of products.
What are the synthetic methods of 2-Fluoro-3-Methoxybenzeneboronic Acid?
The synthesis method of 2-fluoro-3-methoxyphenylboronic acid has many paths, as follows.
First, it can be started from the corresponding halogenated aromatic hydrocarbon. Taking 2-fluoro-3-methoxybromobenzene as an example, in an anhydrous environment, tetrahydrofuran is used as a solvent, magnesium chips are added to form Grignard's reagent. This process needs to be carefully controlled temperature, so as not to make the reaction too violent. After passing into trimethyl borate, and then hydrolyzed, the target product 2-fluoro-3-methoxyphenylboronic acid can be obtained.
Second, 2-fluoro-3-methoxy iodobenzene can also be used as a raw material. In the presence of a palladium catalyst, it reacts with the diphenacol borate to form the corresponding borate ester intermediate. The choice of palladium catalyst is very critical, such as tetra (triphenylphosphine) palladium. The reaction conditions need to be precisely regulated, such as temperature and reaction time. Then the borate intermediate is hydrolyzed to obtain 2-fluoro-3-methoxy phenylboronic acid.
Furthermore, the guide group strategy can also be used. The guide group is introduced into the benzene ring to position the guide, so that the boration reaction selectively occurs at the desired position. The guide group is then removed through appropriate steps to obtain pure 2-fluoro-3-methoxyphenylboronic acid. Although this method is a little complicated, it has good selectivity and can effectively improve the purity and yield of the product.
There are many methods for synthesizing 2-fluoro-3-methoxyphenylboronic acid. The advantages and disadvantages of each method are mutually exclusive. The appropriate method should be carefully selected according to the actual situation, such as the availability of raw materials, cost considerations, and product purity requirements.
2-Fluoro-3-Methoxybenzeneboronic Acid need to pay attention to when storing
When storing 2-fluoro-3-methoxyphenylboronic acid, pay attention to various matters. This compound is delicate and prone to hydrolysis in contact with water, causing damage to its structure and properties. Therefore, it must be stored in a dry place, away from water vapor. A desiccant can be placed on the side of the reservoir to keep the environment dry.
Furthermore, it is quite sensitive to temperature. Under high temperature, it may cause decomposition and deterioration, which will damage its quality. It should be stored in a cool place, usually 2-8 ° C. If the conditions are not sufficient, it should also be controlled at room temperature and protected from heat sources.
Light is also key. This product is exposed to light, or photochemical reactions can cause changes in its composition. Be sure to store in a shading device, such as a brown bottle, to prevent light damage.
In addition, it needs to be isolated from oxidizing and reducing substances. Because of its boric acid structure, oxidation, reducing agent, or reaction will damage its chemistry. Materials with different chemical properties should be stored in different places to prevent interaction.
Also, the storage device should also be paid attention to. Improper material, or reaction with compounds, causing pollution. It is advisable to choose chemically stable devices, such as glass, specific plastic materials, and well sealed to avoid contact with air.
Proper storage of 2-fluoro-3-methoxyphenylboronic acid is essential to maintain its quality and chemical activity, and all conditions should be carefully controlled.
2-Fluoro-3-Methoxybenzeneboronic the market price of Acid
I look at the "2 - Fluoro - 3 - Methoxybenzeneboronic Acid" you are inquiring about. This is a chemical substance called 2 - Fluoro - 3 - Methoxyphenylboronic acid. Its market price varies due to many factors, and it is difficult to generalize.
First, purity is the key. If the purity is extremely high, it is almost perfect, and it reaches the level of scientific research, it is suitable for high-end experiments, and its price is high. Because the preparation of this high-purity product requires exquisite craftsmanship, many complicated steps, a lot of manpower, material resources and time, and high cost, the price is not cheap. On the contrary, if the purity is slightly lower, it is relatively easy to use for general industrial purposes.
Second, market supply and demand determine its price. If for a while, many chemical companies and scientific research institutions have a surging demand for this material, and the supply is limited, the supply is in short supply, and the price will rise. On the contrary, if the demand is low, the manufacturer produces too much output, and the supply exceeds the demand, the price will tend to fall.
Third, the manufacturer and brand also have an impact. A well-known large factory is famous for its exquisite craftsmanship, high-quality raw materials and strict quality control, and its product price may be higher than that of ordinary manufacturers. Although the price of a small factory may be low, the quality may be difficult to compare with that of a large factory.
Fourth, the purchase volume is also related to the price. If the one-time purchase volume is large, the manufacturer may give preferential discounts due to the idea of small profits but quick turnover. For small purchases, the price may not be available.
Overall, if you want to know the exact market price, you can consult the chemical raw material supplier, or check it carefully on the chemical product trading platform, in order to get the current price.