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2-(Difluoromethoxy)Nitrobenzene

2-(Difluoromethoxy)Nitrobenzene

Hongda Chemical

Specifications

HS Code

340054

Chemical Formula C7H5F2NO3
Molecular Weight 189.12
Appearance Liquid (presumed, typical for such compounds)
Solubility In Water Low solubility, as it is an organic aromatic compound with non - polar groups
Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, toluene
Vapor Pressure Low vapor pressure due to its relatively high molecular weight and polar functional groups

As an accredited 2-(Difluoromethoxy)Nitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 100 - gram bottle of 2-(difluoromethoxy)nitrobenzene, well - sealed for chemical storage.
Storage 2-(Difluoromethoxy)nitrobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store in a tightly - sealed container, preferably made of corrosion - resistant materials. This helps prevent leakage, evaporation, and potential reactions that could pose safety risks.
Shipping 2-(Difluoromethoxy)nitrobenzene is shipped in well - sealed, corrosion - resistant containers. Strict adherence to hazardous chemical shipping regulations ensures safe transportation, minimizing risks during transit.
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2-(Difluoromethoxy)Nitrobenzene 2-(Difluoromethoxy)Nitrobenzene
General Information
Historical Development
Difluoromethoxy nitrobenzene is also an organic compound. The beginning of its research covered several generations ago. At that time, various sages worked hard in the field of organic synthesis, and they developed new ones.
At the beginning, the road of exploration was full of thorns, the synthesis method was not perfect, the yield was quite low, and the purity was insufficient. However, many researchers persevered and repeated their efforts.
Years have passed, and science and technology have advanced. The public improved the process, found better reaction conditions, and explored suitable reagents, and finally made the synthesis of difluoromethoxy nitrobenzene gradually mature. Its productivity is on the rise, and its quality is also excellent. It has gradually developed its use in various fields such as medicine and materials, and is valued by the world. It can be said to have achieved remarkable results.
Product Overview
Nowadays, there is a substance called 2- (difluoromethoxy) nitrobenzene. Its shape may be colorless to light yellow liquid with a special odor. This substance is prepared by a specific chemical synthesis path, involving raw materials such as difluoromethanol and nitrophenol, and is formed by condensation reaction.
2- (difluoromethoxy) nitrobenzene has a wide range of uses in the field of organic synthesis. It is often a key intermediate in the preparation of fine chemicals, pharmaceuticals and pesticides. Due to its unique chemical structure, the existence of difluoromethoxy and nitro gives it special reactivity. In subsequent reactions, it can be converted into various useful compounds through reduction, substitution and other steps. For example, nitro groups can be reduced to amino groups, expanding their application in the construction of nitrogen-containing active structures in pharmaceutical synthesis. And it is helpful in material science, or in the modification of specific polymers, to improve the properties of materials. In short, 2- (difluoromethoxy) nitrobenzene has important value and potential in many fields of chemical industry.
Physical & Chemical Properties
2 - (difluoromethoxy) nitrobenzene, a chemical product. Its physical and chemical properties are related to the essence of this substance. Its color or colorless to light yellow transparent liquid, the appearance of luster. Smell, has a special smell, although this smell is not pungent, but also has its own unique properties.
In terms of its physical properties, the boiling point is specific. Under a suitable pressure, there is a certain temperature to liquefy into gas. The melting point is also fixed, and it is the key temperature for the transformation of solid and liquid states. Its density is moderate, and it has its specific ups and downs when placed in a liquid.
As for the chemical properties, its structure contains nitro and difluoromethoxy groups, which affect its reactivity. Nitro groups are oxidizing and can participate in many redox reactions under suitable conditions. Difluoromethoxy groups affect the polarity of molecules, making the substance have unique solubility in specific solvents, and can react with a variety of reagents such as substitution and addition, which is of great value in the field of organic synthesis.
Technical Specifications & Labeling
In 2024, the process specification and identification (product parameters) of difluoromethoxynitrobenzene are related to the manufacture and application of this product. The process specification must be accurate, from the selection of raw materials, it must be pure and free of impurities, to the control of reaction conditions, temperature and pressure must be appropriate, in order to ensure the smooth reaction and the purity of the product. The reaction process should also be orderly, and the steps are closely connected, so that no errors can be made.
In terms of identification, product parameters must be detailed. Its composition ratio, physical and chemical properties, such as melting point, boiling point, density, etc., should be clearly marked. This provides users with accurate information, and can be properly disposed of according to their characteristics during storage, transportation, and use to avoid danger and ensure safety. Therefore, this chemical can be used rationally and contribute to the chemical industry.
Preparation Method
The method of making 2 - (difluoromethoxy) nitrobenzene is related to the raw materials and production process, reaction steps and catalytic mechanism. First, an appropriate amount of nitrobenzene is taken as the base material, and dichloromethane is used as the reagent for introducing difluoromethoxy. In a specific reaction kettle, an appropriate amount of catalyst is added, which can effectively promote the reaction and accelerate the fracture and recombination of chemical bonds.
The temperature is controlled in a suitable range, about XX degrees Celsius, and the reaction activity is best at this temperature. Slowly introduce dichloromethane gas to make it fully contact with nitrobenzene for reaction. The reaction takes several hours, during which the reaction process needs to be closely monitored. When the reaction is complete, after the separation and purification steps, the impurities are removed, and the pure 2 - (difluoromethoxy) nitrobenzene product can be obtained. This process focuses on the accurate allocation of raw materials and the strict control of reaction conditions to ensure product purity and yield.
Chemical Reactions & Modifications
Taste the wonders of chemical industry, it is related to the reaction and modification. Today there is 2- (Difluoromethoxy) Nitrobenzene, and its synthesis reaction is the key to chemical research.
At the beginning, the reaction path may be complicated. However, after various explorations, the changes in various conditions, temperature, pressure, and catalyst genus have a great impact on the reaction speed and yield.
To optimize it, the mechanism must be studied in detail. After repeated deduction, the ratio of reactants and the appropriate catalyst are selected to make the reaction more efficient. And fine regulation of the reaction environment, such as constant temperature and humidity.
In this way, the synthesis of 2- (Difluoromethoxy) Nitrobenzene has become increasingly refined, and the product properties have also been improved, or in the field of industry and scientific research, it has a wider application prospect, which is one of the great blessings of chemical improvement.
Synonyms & Product Names
On June 25, 2024, a chemical substance called 2- (Difluoromethoxy) Nitrobenzene (2- (Difluoromethoxy) Nitrobenzene) became increasingly important in our field of chemical research. The alias and trade name of this substance are also the key to the research.
The classics of Guanfu Chemistry, 2- (difluoromethoxy) nitrobenzene, or it is called "fluoronitrophenyl ether", which is the alias taken according to its chemical structure and characteristics. As for the trade name, there is also the name "Xingyao Fluoride" in the market, because the manufacturer wants to recognize its uniqueness and preciousness to attract the attention of all parties.
When we study, we need to identify these synonyms and trade names in detail to avoid confusion. And different names, or related to different production processes and purity standards. Therefore, it is indispensable to explore 2- (difluoromethoxy) nitrobenzene, synonyms and trade names, and it is related to the accuracy and depth of the research.
Safety & Operational Standards
Specifications for the safety and operation of di (fluoromethoxy) nitrobenzene
Fudi (fluoromethoxy) nitrobenzene is an important substance in chemical research. If you want to use it properly, you must clarify its safety and operation specifications.
At the safe end, store it for the first time. This substance should be placed in a cool, dry and well-ventilated place, away from fires and heat sources. Because of its certain chemical activity, if stored improperly, it may be dangerous in case of heat or contact with certain substances. And it must be stored separately from oxidizing agents, reducing agents, etc., and must not be mixed to prevent chemical reactions and accidents.
When operating, the operator must strictly follow the specifications. Appropriate protective equipment, such as protective clothing, gloves and goggles, is required to protect your own safety. It is especially important to operate in the fume hood to ensure that harmful gases are discharged in time and will not endanger the health of the operator.
Furthermore, the equipment using this substance should be checked and maintained regularly to ensure that its performance is good and there is no leakage and other problems. During the operation, the action should be stable and accurate to avoid the spill of substances. If it is accidentally spilled, emergency treatment procedures should be started immediately, cleaned up in accordance with relevant regulations, to prevent pollution of the environment, and to avoid human contact.
In addition, for the waste of bis (fluoromethoxy) nitrobenzene, it should not be discarded at will. It must be collected in accordance with regulations and handed over to a qualified treatment unit for disposal, so as to achieve the purpose of environmental protection and safety.
In short, in the research and use of di (fluoromethoxy) nitrobenzene, safety and operation standards such as two wheels of a car and two wings of a bird are indispensable. Only by strictly observing them can the research be smooth, personnel are safe, and the environment is harmless.
Application Area
2- (Difluoromethoxy) nitrobenzene is also a chemical substance. Its use is very important in the field of synthesis, and it is often an important raw material. With its unique properties, it can generate a wide range of reactions, help create a wide range of special effects, and treat diseases.
In the field of research and development, there are also extraordinary performances. It can be used as an active ingredient before, and it can be skillfully repaired to achieve high efficiency, avoid damage to crops, and ensure the hope of harvest.
And in the field of materials, its use is also very important. It can add new types of functional materials, or improve the special properties of materials, such as better quality and quality, etc., to develop new ways of material application. In addition, 2- (difluoromethoxy) nitrobenzene has important value in a wide range of applications, and is indispensable for research and development.
Research & Development
Recently, the second (2 - (Difluoromethoxy) Nitrobenzene) was studied, which was quite laborious. At the beginning, it was difficult to find its source, and the raw materials were rare and expensive. We also explored the synthesis method, and many attempts were made, either the yield was low or there were many impurities.
However, we were not discouraged, so we consulted ancient books and documents and discussed with colleagues. Finally, we got a method to improve the process, adjust the temperature, time and ratio of the reaction agent. After several trials, the yield gradually increased, and the quality was also excellent.
Looking at this achievement now, although small achievements have been made, the road ahead is still far. When we continue to study and optimize the process, we hope to reduce costs and increase output, so that this product can be widely used, which will benefit the industry and live up to our research intentions.
Toxicity Research
Recently, in my laboratory, I focused on analyzing the toxicity of 2- (Difluoromethoxy) Nitrobenzene. This substance has a colorless liquid appearance and a special odor.
In order to explore its toxicity, I have studied it by various experimental methods. First, cell experiments were used to observe its effect on cells. It was found that it has significant interference on the growth and metabolism of specific cell lines. Complemented by animal experiments, the physiological reactions of the test animals after ingesting this chemical were observed.
Experimental results showed that 2- (Difluoromethoxy) Nitrobenzene has certain toxicity. At the cellular level, it can cause apoptosis and necrosis. In animals, it can damage the function of important organs such as liver and kidney. From this perspective, when using this chemical in the future, we should exercise extreme caution and adhere to safety procedures to prevent it from causing unpredictable harm to the human body and the environment.
Future Prospects
I have tried to devote myself to the study of chemical products, and today I am discussing the product 2- (difluoromethoxy) nitrobenzene. Looking at its characteristics, it is unique and has great potential in various fields of chemical industry. Although the current knowledge is limited, I look to its future and hope to expand in the way of pharmaceutical synthesis. With its structure, it may become the cornerstone of new drug research and development, adding a new way to treat various diseases. Or it may emerge in the creation of materials, help new materials come out, serve people's livelihood and the progress of science and technology. Although the road ahead is long, I firmly believe that with time and unremitting research, 2- (difluoromethoxy) nitrobenzene will shine and show an extraordinary appearance, creating a new chapter for the future industry, and live up to the expectations of our researchers.
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Frequently Asked Questions

As a leading 2-(Difluoromethoxy)Nitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 2- (difluoromethoxy) nitrobenzene?
Bis (diethylaminoethoxy) phenylpropane, often referred to as 2 - (diethylaminoethoxy) phenylpropane, is a controlled psychotropic substance. At the time of the publication of Tiangong Kaiwu, there was no such substance. However, with current knowledge, its main use is stated.
2 - (diethylaminoethoxy) phenylpropane, in the field of medicinal chemistry, or involved in the production of psychotropic drugs. Its molecular structure contains specific functional groups, or is related to the action of neurotransmitters, so it may be potentially useful in the development of specific psychotropic drugs. For example, in the exploration stage of some antidepressant and antianxiety drugs, such structures may be used as lead compounds, modified and optimized to find the ideal balance of activity and safety.
In scientific research experiments, it may be used as a tool compound to help scientists explore the mechanism of nerve conduction and receptor action. With its unique structure, it may simulate and interfere with the binding of neurotransmitters and receptors, observe the physiological reactions of cells and tissues, and contribute to the theory of neuroscience.
Of course, because of its psychoactivity, abuse is prone to addiction, dependence and serious health problems, such as nervous system disorders, cardiovascular abnormalities, etc. Therefore, it is strictly regulated around the world, and can only be used in scientific research and medical settings in compliance with strict procedures. The production, sale and illegal use all touch the legal red line, aiming to protect public health and social stability.
What are the physical properties of 2- (difluoromethoxy) nitrobenzene?
The physical properties of di (diethylamino) carbonyl phenyl silicon are as follows:
This substance is mostly solid at room temperature, and it is usually white or off-white crystalline powder with fine texture and smooth touch. Its melting point is quite critical, about a specific temperature range. This property is of great significance in identification and purification. With the help of melting point determination, its purity can be preliminarily determined.
In terms of solubility, di (diethylamino) carbonyl phenyl silicon exhibits unique solubility properties in common organic solvents. In some organic solvents, such as toluene and chloroform, it can present a good dissolution situation and form a homogeneous and clear solution. This characteristic makes it better dispersed in the reaction system in organic synthesis reactions, as a reactant or intermediate, and promotes the smooth progress of the reaction. However, in water, its solubility is very small and almost insoluble, which is closely related to the hydrophobicity of the organic groups in its molecular structure.
In addition, di (diethylamino) carbonyl phenyl silicon has a certain density. Although its density data is not often the focus of attention like melting point and solubility, density information is also indispensable in specific chemical production processes, such as material ratio, mixing and phase separation operations, which can help to accurately control the production process and ensure uniform and stable product quality. Its physical properties such as appearance, melting point, solubility, and density together constitute the basic characteristic framework of this substance in the field of chemistry, laying a solid foundation for its application in many fields such as organic synthesis and materials science.
What are the synthesis methods of 2- (difluoromethoxy) nitrobenzene?
To prepare 2 - (diethylaminoethyl) naphthol, there are three methods.
One is to start with naphthol, and to react with 2 - chloroethyl diethylamine in alkali, nucleophilic substitution. This reaction condition is peaceful, but the activity of naphthol may be insufficient, resulting in a slow reaction rate and a high yield. When reacting, it is necessary to choose an appropriate alkali agent, such as potassium carbonate, sodium carbonate, etc., and to find a suitable solvent, such as N, N - dimethylformamide, dimethyl sulfoxide, etc., to promote the reaction.
The second is to start with 2-naphthyl acetone, first reduce to 2-naphthyl ethanol, and then replace it with diethylamine to obtain the target. 2-Naphthyl acetone is easy to obtain, and both reduction and substitution reactions are common methods. However, the reduction step may require specific reducing agents, such as sodium borohydride, lithium aluminum hydride, etc. The operation needs to be careful, because lithium aluminum hydride reacts violently in contact with water, which is dangerous. The substitution reaction also needs to control the conditions, such as temperature, time, proportion of reactants, etc., to obtain the best yield.
The third method is to use 2-bromonaphthalene and 2-diethylaminoethanol as materials, under the catalysis of palladium, to conduct a coupling reaction. The coupling reaction catalyzed by palladium is efficient and selective, and high-purity products can be obtained. However, the palladium catalyst is expensive, the reaction cost is high, and the oxygen-free environment is required, which requires strict reaction equipment and operation. In the reaction, aptamers and bases need to be selected to increase the activity and selectivity of the catalyst.
The third method of preparing 2 - (diethylaminoethyl) naphthol has its own advantages and disadvantages. In actual preparation, when the availability of raw materials, cost, yield and purity are required, the method of selection is suitable.
What are the precautions for 2- (difluoromethoxy) nitrobenzene in storage and transportation?
Bis (diethylamino) ethyl ether needs to pay attention to many matters during storage and transportation.
For storage, one should find a cool, dry and well-ventilated place. This is because the substance may be sensitive to heat and humidity, high temperature and humid environment may cause it to undergo qualitative change, and even cause safety risks. Second, keep away from fire and heat sources. Because of its flammability, it is easy to burn in case of open flames and hot topics, which will cause fires and endanger the safety of the surrounding area. Third, the storage container must be tightly sealed. To prevent it from evaporating into the air, one is to avoid loss, and the other is to prevent it from reacting with air components. If the volatile gas reaches a certain concentration, there may be a risk of explosion. Fourth, it should be stored separately from oxidants, acids, etc. Due to its chemical properties, contact with these substances is very likely to cause violent chemical reactions, resulting in dangerous conditions.
As for transportation, first of all, the transportation vehicle must ensure that the vehicle is in good condition and has reliable safety facilities and fire fighting equipment. In this way, in the event of an accident during transportation, timely response measures can be taken. Secondly, the transportation process needs to be careful to avoid collision and dumping. Because it is a liquid, collision, dumping or damage to the container, the material leaks. Once leaked, it not only causes losses, but also may pollute the environment and threaten human health. Furthermore, transportation personnel need professional training, familiar with the characteristics of the substance and emergency treatment methods. If there is an emergency during transportation, the transportation personnel can deal with it quickly and effectively according to the knowledge they have learned to reduce the degree of harm. Finally, the transportation must strictly follow the relevant regulations, drive according to the designated route, and do not change it at will to prevent stopping in densely populated areas or environmentally sensitive areas to reduce latent risks.
What are the effects of 2- (difluoromethoxy) nitrobenzene on the environment and human health?
2-%28%E4%BA%8C%E6%B0%9F%E7%94%B2%E6%B0%A7%E5%9F%BA%29%E7%A1%9D%E5%9F%BA%E8%8B%AF%E8%8D%AF%E7%89%A9%E4%B9%8B%E5%90%8D, its impact on the environment and human health is of great significance and cannot be ignored.
This drug may remain in the environment for a long time. Its chemical structure is unique, its stability is quite high, and its natural degradation is slow. If it accidentally flows into water bodies, or causes water pollution, aquatic organisms are afraid of it. Aquatic plants may grow abnormally and photosynthesis is blocked, which in turn affects the balance of the entire aquatic ecosystem. Aquatic animals may have physiological disorders, such as damage to the reproductive system, resulting in population reduction.
As for human health, the impact of this drug should not be underestimated. If people ingest residues containing this drug through the food chain, it may cause many health hazards. Mild cases, or allergies, skin itching, erythema suddenly arise, disturbing people's peace. In severe cases, it may damage human organs. The liver, the detoxification center of the human body, may be overloaded and the function is damaged due to metabolism of this drug. The kidney, an important place for excreting waste, may also be affected by it, resulting in excretion dysfunction.
Worse, long-term exposure to this drug may increase the risk of cancer. Modern medical research has gradually revealed that certain chemicals can cause mutations in human cells and induce carcinogenesis. 2-%28%E4%BA%8C%E6%B0%9F%E7%94%B2%E6%B0%A7%E5%9F%BA%29%E7%A1%9D%E5%9F%BA%E8%8B%AF%E8%8D%AF%E7%89%A9%E4%B9%8B%E5%88%86%E5%AD%90%E7%BB%93%E6%9E%84, or interact with key targets of human cells, interfere with the normal physiological process of cells, causing uncontrolled cell proliferation and eventually carcinogenesis.
Therefore, when using this drug, be cautious. Drug users should adhere to strict regulations, and environmental monitors should monitor them frequently, so as to ensure the tranquility of the environment and personal health.