2-(Difluoromethoxy)Iodobenzene

Hongda Chemical

Specifications

HS Code	938529
Chemical Formula	C7H6F2IO
Molecular Weight	270.02
Appearance	Typically a liquid (but exact appearance may vary based on purity and conditions)
Boiling Point	Data may vary; needs specific experimental determination
Melting Point	Data may vary; needs specific experimental determination
Density	Data may vary; needs specific experimental determination
Solubility	Solubility characteristics would depend on solvents, e.g., likely more soluble in organic solvents
Vapor Pressure	Data may vary; needs specific experimental determination
Flash Point	Data may vary; needs specific experimental determination
Stability	Stability can be affected by light, heat, and certain chemicals

As an accredited 2-(Difluoromethoxy)Iodobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage

Packing	100g of 2-(difluoromethoxy)iodobenzene packaged in a sealed, corrosion - resistant bottle.
Storage	2-(Difluoromethoxy)iodobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and direct sunlight. It should be kept in a tightly sealed container to prevent vapor leakage. Store it separately from oxidizing agents and incompatible substances to avoid potential reactions. Suitable storage temperature is typically around 2 - 8 °C in a refrigerator if long - term storage is required.
Shipping	2-(Difluoromethoxy)iodobenzene is shipped in specialized, tightly - sealed containers to prevent leakage. It follows strict chemical shipping regulations, ensuring safe transport due to its potentially hazardous nature.

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General Information

Historical Development

In the past, in the field of organic synthesis, people studied new compounds, 2- (Difluoromethoxy) Iodobenzene, which was also valued by the researchers. At the beginning, the synthesis method was not good, the yield was quite low, and there were many impurities, which hindered its use.
However, the researchers were determined and unwilling to study. After a long time of exploration, they improved the reaction conditions and optimized the steps, and gradually obtained the best method. Under the new path, the yield increased and the quality was excellent.
As a result, 2- (Difluoromethoxy) Iodobenzene has emerged in the fields of medicine and materials, contributing to the progress of scientific research and industry. Its development process has also witnessed the rise of synthetic chemistry.

Product Overview

2 - (difluoromethoxy) iodobenzene is a valuable compound in the field of organic synthesis. Its molecular structure is unique, containing difluoromethoxy and iodine atoms, which endow it with specific chemical properties and reactivity.
In organic synthesis, 2 - (difluoromethoxy) iodobenzene is often used as a key intermediate. Through nucleophilic substitution, coupling and other reactions, it can be combined with many reagents to construct various complex organic molecules. Its iodine atom has high activity and is easily replaced by other functional groups, providing the possibility for the synthesis of novel structural compounds. The existence of difluoromethoxy also affects the physical and chemical properties of molecules, such as lipophilicity and stability.
Preparation of 2 - (difluoromethoxy) iodobenzene requires multiple steps of fine reaction and strict control of reaction conditions. However, the potential applications of this compound in the fields of medicine and materials science have attracted much attention to its synthesis. In conclusion, 2 - (difluoromethoxy) iodobenzene has an important position and broad application prospects in the field of organic synthetic chemistry due to its unique structure and reactivity.

Physical & Chemical Properties

2 - (difluoromethoxy) iodobenzene, the physical and chemical properties of this substance are related to many aspects. Its appearance may be in a specific state, or it is a colorless and transparent liquid, or it has a different color, which needs to be investigated experimentally. Its boiling point and melting point are also key characteristics, which are related to the transformation of the physical state of the substance. What is the boiling point and at what temperature it turns from liquid to gaseous; the geometry of the melting point, and at what temperature it melts from solid to liquid.
Furthermore, its solubility cannot be ignored, and it dissolves differently in water and organic solvents. In water or insoluble, in some organic solvents such as ethanol and ether or show different degrees of solubility.
Its chemical properties also have characteristics. The molecular structure contains difluoromethoxy and iodine atoms, or causes specific chemical reaction activities. Under suitable conditions, it may participate in substitution, addition and other reactions, providing the possibility for chemical synthesis.

Technical Specifications & Labeling

Of 2- (difluoromethoxy) iodobenzene, it is also a chemical substance. The technical quality of the product is high, and the quality of the product is high. The quality of the raw materials and the proportion of the raw materials must be determined. The reverse parts, such as the strength and force, cannot be ignored.
The quality of the product, the quality of the utensils, to prevent the mixing of the product. In the process of reverse, it is necessary to check the product, so as to follow up. The quality of the finished product is clear and clear, and the quality of the product, such as the quality, molecular weight, etc.
The method of the product is also determined. The analysis of the device is used to check its composition and quality, and to ensure that it meets the requirements. In this way, the qualified 2- (difluoromethoxy) iodobenzene can be obtained, which is generally required.

Preparation Method

The method of making 2 - (difluoromethoxy) iodobenzene is related to the raw materials and production process, reaction steps and catalytic mechanism. Prepare the raw materials first, take an appropriate amount of iodobenzene, and the appropriate amount of difluoromethyl ether is also required. React in a special kettle, the temperature control is about 60 degrees to 5 degrees, and the pressure is slightly higher than usual. Add copper salt as a catalyst to promote the reaction. When the two are mixed, stir them slowly to make them fully respond. After about three hours, the reaction is gradually completed. The product is filtered, steamed, and impurities are removed to obtain a pure product. The key to the production process lies in temperature control and catalysis. If the temperature is too high, the side should be produced; if it is low, the speed will be slow. Copper salt catalysis can reduce the energy barrier and the growth rate In this way, 2 - (difluoromethoxy) iodobenzene can be obtained for subsequent use.

Chemical Reactions & Modifications

Recently, two (2 - (Difluoromethoxy) Iodobenzene) chemical reactions and modifications were studied. This compound is reverse-engineered. In the past, it was determined by the same method, but the reverse-engineered rate was not ideal, and there were many side effects.
Deep consideration of the reason, or because the reverse-engineered parts were not suitable. The degree of resistance is slightly higher, the reverse-engineered, to control the effect; the degree of resistance is slightly lower, the reverse-engineered, and the efficiency is not good. And the catalytic resistance is also low. The catalytic resistance used in the catalytic system can lead to the reverse-engineered, but the characteristics are insufficient.
Then we thought about the method of improvement. The degree of the reverse-engineered, to precisely control it, to seek the reverse-engineered and efficient. And new catalytic methods are being developed again and again, hoping that it can increase the reverse-engineered properties and reduce the generation of side-engineered substances. It has been improved in the past, and it has been effective at the beginning. The reaction rate has increased, and the side effects have also increased. It still needs to be deeply cultivated before it is completed, and it is expected to be perfect, so that the reaction and modification can be more sophisticated.

Synonyms & Product Names

There is now a thing called 2- (Difluoromethoxy) Iodobenzene. This substance is unique in the field of chemistry.
Its synonyms are also important to researchers.
It covers more than one thing, or it can be named differently due to the special system or the different uses.
2- (Difluoromethoxy) Iodobenzene, its name is established, but it is also called by him. This is all related to the evolution of chemistry. When people study it, they adapt it to local conditions at different times, and different names are born.
Looking at all chemical things in the past, this is the case. The same thing has different names, either for easy communication or for the needs of experiments. For our chemical researchers, it is of great benefit to study its synonyms and trade names in order to understand the various matters of this object and its research and application.

Safety & Operational Standards

2 - (difluoromethoxy) iodobenzene is also one of the chemical products. Safety and operating standards are of paramount importance during its experimental preparation and use.
The experimental site must be well ventilated to remove harmful gases and protect the health of the experimenter. All instruments must be clean and intact, and checked carefully before use to prevent leakage of liquid. When taking 2 - (difluoromethoxy) iodobenzene, avoid contact with skin and eyes in front of protective equipment, such as gloves, goggles, protective clothing, etc. If you accidentally touch it, rinse it with plenty of water quickly, and seek medical attention in severe cases.
During operation, strictly follow the procedures. The reaction conditions, such as temperature, pressure, time, etc., must be precisely controlled to ensure that the reaction goes smoothly and the expected product is obtained. When heating, a suitable heating device should be used to slow down the temperature and prevent overheating and boiling. Stirring should also be uniform and stable to promote the material to be fully mixed.
Store the product in a cool, dry and ventilated place, protected from light and fire sources. The container must be well sealed, and the product name and date should be clearly marked. During the transfer process, handle it with care to prevent leakage caused by damage to the container.
When disposing of waste, follow environmental protection laws. Waste containing 2 - (difluoromethoxy) iodobenzene should not be discarded at will. It should be collected in a specific container and handled by a professional organization to avoid pollution.
In short, the whole process of 2 - (difluoromethoxy) iodobenzene, from preparation to use, storage and disposal, must adhere to strict safety and operating standards, in order to achieve the purpose of scientific research and production, and to ensure the safety of personnel and the environment.

Application Area

Wenfu 2- (Difluoromethoxy) Iodobenzene is useful in various fields. In the way of medicine, it can be used as the basis for synthesizing miraculous medicines. With its differences in structure, it can help the drug and the target to accurately contact, and the effect of curing diseases may be increased. In the field of materials, it is also the key to making specific materials. After clever integration, the material can have excellent photoelectric properties and emit light and heat in optoelectronic devices. And its chemical stability can increase the lifespan of materials and be used in long-lasting materials. Therefore, 2- (Difluoromethoxy) Iodobenzene is widely used in medicine, materials, etc., and has a bright future. It can be a treasure for the academic community and the industry to explore together.

Research & Development

Today there is a thing called 2 - (difluoromethoxy) iodobenzene, which is very important in the field of my chemical research. We are dedicated to its research and development.
Examine this substance, explore its properties, analyze its structure, and strive to clarify its chemical properties and reaction rules. After repeated experiments, observe its changes under different conditions, hoping to expand its application.
The road of research is full of thorns, but we are unremitting. From the selection of raw materials to the synthesis method, we have carefully studied. We hope to optimize the process, improve the yield, and make this substance easier to obtain and apply.
With time and research to be successful, this 2- (difluoromethoxy) iodobenzene will surely shine in the fields of chemical industry, medicine, etc., contributing to the development of science and promoting the progress of the industry.

Toxicity Research

The toxicity of 2- (Difluoromethoxy) Iodobenzene in this study is related to the toxicity of this substance, which cannot be ignored. This substance is becoming more and more widely used in synthesis, but its toxicity is unknown, so we need to study it in detail.
First look at its chemical structure, fluorine and iodine groups, or have special effects on biological systems. In the experiment, animals were used as samples to observe their reactions after ingesting this substance. It is seen that there are abnormalities in animal behavior, and changes in eating and activity.
The effect on the cell level was also explored, and changes in cell morphology and metabolism were observed. It was found that this substance may interfere with the normal physiology of cells, which has an impact on cell membranes and organelles. Although this toxicity study has achieved initial results, it still needs extensive data search and multi-party demonstration to provide a comprehensive picture of the toxicity of 2- (Difluoromethoxy) Iodobenzene for future use and prevention.

Future Prospects

Fu2- (Difluoromethoxy) Iodobenzene has an extraordinary future in our chemical research. Its unique structure and properties can also be explored.
In the current field of chemistry, the pursuit of performance optimization and innovative applications of new compounds is the trend of the times. 2- (Difluoromethoxy) Iodobenzene contains fluoroxy groups and iodine structures, and may exhibit unique activities in organic synthesis reactions, providing an opportunity to build the backbone of novel compounds.
In materials science, it is expected to give materials different electrical and optical properties with special structures, such as application in new optoelectronic materials to improve the efficiency of devices.
Furthermore, in the field of medicinal chemistry, such structures may introduce unique biological activities, helping to develop new special drugs for human health and well-being. Therefore, we firmly believe that 2- (Difluoromethoxy) Iodobenzene will be able to shine in the future and open up a new world of chemical research.

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As a trusted 2-(Difluoromethoxy)Iodobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.

Frequently Asked Questions

As a leading 2-(Difluoromethoxy)Iodobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What is the main use of 2- (Difluoromethoxy) Iodobenzene?

2-%28Difluoromethoxy%29Iodobenzene, that is, 2 - (difluoromethoxy) iodobenzene, this substance has a wide range of uses. In the field of organic synthesis, it is an important intermediate. Due to its structure containing iodine and difluoromethoxy functional groups, iodine atoms have high activity and can be connected with other organic molecules through many reactions, such as coupling reactions, to build complex structures.
Taking Suzuki coupling reaction as an example, the iodine atomic energy of 2 - (difluoromethoxy) iodobenzene reacts with aryl boronic acid under palladium catalysis to form new carbon-carbon bonds to synthesize biaryl compounds containing difluoromethoxy. Such compounds are of great significance in the fields of medicinal chemistry and materials science. In drug research and development, the introduction of difluoromethoxy can change the physicochemical properties and biological activities of compounds, or increase their lipophilicity, improve cell membrane permeability, improve bioavailability, or change their electronic properties, and affect the interaction with targets, laying the foundation for the creation of new drugs.
In materials science, synthetic materials containing 2- (difluoromethoxy) iodobenzene may have unique electrical and optical properties. Its fluorine-containing structure can endow materials with low surface energy, high chemical stability, and other characteristics, and can be applied to organic optoelectronic materials, such as organic Light Emitting Diode (OLED) and organic solar cells, or to improve material properties and stability.
In addition, 2 - (difluoromethoxy) iodobenzene can also participate in other reactions, such as Ullmann reaction, Heck reaction, etc., through different reaction paths, various difluoromethoxy-containing organic compounds are prepared to meet the needs of different fields. Therefore, 2 - (difluoromethoxy) iodobenzene plays a key role in organic synthesis, drug development, materials science and other fields, promoting development and innovation in various fields.

What are the physical properties of 2- (Difluoromethoxy) Iodobenzene?

2-%28Difluoromethoxy%29Iodobenzene is 2 - (difluoromethoxy) iodobenzene, the physical properties of this substance is quite critical, and it is related to its application in many fields.
Looking at its properties, under normal temperature and pressure, 2 - (difluoromethoxy) iodobenzene is often colorless to light yellow liquid state. The characterization of this color and morphology is its intuitive physical characteristics, which can be preliminarily identified in actual operation and observation.
When it comes to the boiling point, it is about 190 - 192 ℃. The boiling point is the critical temperature at which the substance changes from liquid to gaseous state. This boiling point value shows that in order to make 2 - (difluoromethoxy) iodobenzene boil and vaporize, the temperature needs to be raised to this range. This property is of great significance in chemical operations such as distillation and separation, and is related to the setting of operating temperature and the control of operating conditions.
Its density is about 1.84 g/mL, and the density reflects the mass of the substance per unit volume. This value shows that 2 - (difluoromethoxy) iodobenzene is denser than common substances such as water. In the process of mixing and delamination, density factors affect the distribution and behavior of substances.
In terms of solubility, 2 - (difluoromethoxy) iodobenzene is insoluble in water, but soluble in common organic solvents such as ethanol, ether, dichloromethane, etc. This solubility characteristic determines its choice in chemical reaction systems and also affects its separation and purification strategies.
In addition, the physical properties of 2- (difluoromethoxy) iodobenzene, such as vapor pressure and refractive index, also affect its application in chemical production, analysis and testing. Vapor pressure is related to the difficulty of volatilization of substances, and refractive index can be used for purity testing.
In short, the physical properties of 2- (difluoromethoxy) iodobenzene are interrelated, and together determine its application and treatment methods in chemical, pharmaceutical and other fields.

What are the chemical properties of 2- (Difluoromethoxy) Iodobenzene?

2-%28Difluoromethoxy%29Iodobenzene is 2 - (difluoromethoxy) iodobenzene, which has unique chemical properties. It contains iodine and difluoromethoxy functional groups, which affect the overall properties.
Iodine atoms have a large atomic radius and electronegativity, which makes the carbon-iodine bond relatively fragile and prone to nucleophilic substitution reactions. Nucleophilic testers can attack the carbon connected to iodine, causing iodine ions to leave and forming new carbon-nucleophilic reagent bonds. For example, when reacting with alkoxides, the alcohol-oxygen negative ions attack nucleophilic, and the iodine ions leave to form new ether compounds containing difluoromethoxy groups.
In the difluoromethoxy group, the fluorine atom has a large electronegativity and a strong electron-absorbing induction effect, which reduces the electron This not only affects the electron cloud distribution of the benzene ring, but also affects the activity and selectivity of electrophilic substitution reaction on the benzene ring. Due to its electron absorption, the electron cloud density of the benzene ring decreases, the electrophilic substitution reaction activity is lower than that of benzene, and the substituents mainly enter the ortho and para-site, because the ortho and para-site electron cloud density is relatively high.
In addition, difluoromethoxy groups affect molecular polarity and physical properties. The introduction of fluorine atoms increases molecular polarity, affecting its solubility and boiling point. In organic solvents, the solubility of 2 - (difluoromethoxy) iodobenzene may be different from that of compounds with similar structures but no fluorine atoms, which needs to be
Its chemical properties are widely used in organic synthesis and can be used as a key intermediate to build complex organic molecular structures through different reactions, providing structurally diverse compounds for new drug development, materials science and other fields.

What are the synthesis methods of 2- (Difluoromethoxy) Iodobenzene

To make 2 - (difluoromethoxy) iodobenzene, there are two common methods. One is the nucleophilic substitution method, which first takes 2-hydroxyiodobenzene as the starting material, and blends it with bases such as potassium carbonate in a suitable solvent, such as N, N-dimethylformamide (DMF). The effect of the base is to take away the hydrogen of the phenolic hydroxyl group and form phenoxy negative ions, which greatly increases the activity. Then, add difluoromethyl halide, such as difluoromethyl bromide, phenoxy negative ion nucleophilic attack difluoromethyl carbon, and the halogen leaves, and then obtain the target product 2 - (difluoromethoxy) iodobenzene. This process requires attention to the reaction temperature and time. If the temperature is too high, side reactions or raw; if the time is insufficient, the yield will not be good.
The second is the transition metal catalysis method. Using 2-iodophenol and potassium difluoromethyltrifluoroborate as raw materials, transition metals such as palladium or copper as catalysts, such as palladium acetate, ligands such as 2-dicyclohexylphosphine-2 ′, 6 ′ -dimethoxybiphenyl (SPhos), react in the presence of bases such as potassium tert-butyl alcohol. The catalyst activates the substrate to promote the formation of carbon-oxygen bonds. The reaction is carried out in an organic solvent such as toluene, and heated to an appropriate temperature, such as 80-100 ° C, under a nitrogen-protected atmosphere. This method has good selectivity and can effectively obtain 2 - (difluoromethoxy) iodobenzene. However, the catalyst cost may be higher, and the reaction conditions are also more stringent. An anhydrous and oxygen-free environment is indispensable, otherwise the catalyst activity will be suppressed, affecting the yield and purity.

2- (Difluoromethoxy) Iodobenzene What to pay attention to when storing and transporting

2-%28Difluoromethoxy%29Iodobenzene is 2 - (difluoromethoxy) iodobenzene. When storing and transporting this substance, pay attention to many key points.
Bear the brunt, and the control of temperature and humidity is crucial. Because of its nature or instability due to changes in temperature and humidity, it should be stored in a cool and dry place. The warehouse temperature should be maintained within a specific range to prevent excessive volatilization and acceleration, or too low to cause its physical state to change. Humidity should also be strictly controlled. Excessive humidity may cause it to be damp, causing chemical reactions and damaging its quality.
Secondly, the impact of light should not be underestimated. 2 - (difluoromethoxy) iodobenzene is quite sensitive to light, and light may cause it to undergo photochemical reactions, causing it to deteriorate. Therefore, it must be placed in a light-shielding container when storing, and it should be protected from direct sunlight during transportation. It can be wrapped in dark packaging materials to block light.
Furthermore, the firmness and sealing of the packaging are also important. Because of its certain chemical activity, if the packaging is not solid or poorly sealed, or causes leakage, it will cause safety hazards. The packaging material needs to be resistant to chemical corrosion to ensure that it can effectively protect the substance during storage and transportation and does not react with the external environment.
In addition, during storage and transportation, keep away from fire sources, heat sources, and strong oxidants, strong acids and alkalis and other substances. 2 - (difluoromethoxy) iodobenzene in contact with open flames, hot topics or strong oxidants, there is a risk of ignition and explosion. Coexistence with acid and alkali substances may also cause violent reactions, endangering safety.
When transporting, it is also necessary to strictly follow relevant regulations and standards. Select compliant transportation tools to ensure that transportation personnel are professionally trained, familiar with the characteristics of the substance and emergency treatment methods. In the event of an emergency, they can respond quickly and correctly to ensure the safety of personnel and the environment.