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2-(Chloromethyl)-1,3-Difluorobenzene

2-(Chloromethyl)-1,3-Difluorobenzene

Hongda Chemical

Specifications

HS Code

936139

Chemical Formula C7H5ClF2
Molar Mass 164.564 g/mol
Appearance Colorless to light yellow liquid
Boiling Point 165 - 167 °C
Melting Point N/A
Density 1.28 g/cm³
Solubility In Water Insoluble
Vapor Pressure N/A
Flash Point 60 °C
Refractive Index 1.485

As an accredited 2-(Chloromethyl)-1,3-Difluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 250 - gram bottle packaging for 2-(chloromethyl)-1,3 - difluorobenzene chemical.
Storage 2-(Chloromethyl)-1,3 -difluorobenzene should be stored in a cool, well - ventilated area, away from heat sources and ignition points. It should be kept in a tightly - sealed container to prevent vapor leakage. Store it separately from oxidizing agents, reducing agents, and bases as it may react with them. Ensure the storage area has appropriate spill - containment measures.
Shipping 2-(Chloromethyl)-1,3 -difluorobenzene is shipped in specialized, well - sealed containers. Transport follows strict chemical safety regulations to prevent leakage, with careful handling to ensure safe transit due to its chemical nature.
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2-(Chloromethyl)-1,3-Difluorobenzene 2-(Chloromethyl)-1,3-Difluorobenzene
General Information
Historical Development
Fu 2 - (chloromethyl) -1,3 -difluorobenzene, an organic compound. Its production began before the number of times. At that time, the art of chemistry was gradually emerging, and various sages were in the laboratory, studying the physical properties and exploring the wonders of chemical synthesis.
At the beginning, the preparation method was still simple and coarse, the yield was not abundant, and the purity was also lacking. However, people of all generations have been reluctant to study and improve the process. As a result, its yield has improved day by day, and its purity has gradually improved.
To see its development, it depends on the diligence of advanced chemists, or breakthroughs in theory, or innovations in practice. Today's 2 - (chloromethyl) -1,3 -difluorobenzene has been widely used in the fields of medicine and materials, contributing to the development of the world and making great contributions.
Product Overview
Product Overview of 2- (chloromethyl) -1,3-difluorobenzene
Fu2- (chloromethyl) -1,3-difluorobenzene is a crucial raw material in the field of organic synthesis. In its molecular structure, chloromethyl is cleverly connected to difluorophenyl, giving this compound unique chemical activity.
Looking at its physical properties, at room temperature, it is usually a colorless to slightly yellow transparent liquid with a special odor and certain volatility. In terms of solubility, it can be soluble in many organic solvents, such as ethanol, ether, etc., but it is difficult to dissolve in water.
In terms of its chemical properties, chloromethyl is active and easy to initiate nucleophilic substitution reactions. The fluorine atoms on the aromatic ring make the compound exhibit unique reactivity under specific conditions. With this characteristic, 2- (chloromethyl) -1,3-difluorobenzene is widely used in the synthesis of fine chemicals such as medicine and pesticides. In the field of medicine, or to provide key intermediates for the development of new drugs; in the field of pesticides, or to help create high-efficiency and low-toxicity pesticide products, it is of great significance for human health and agricultural development.
Physical & Chemical Properties
2 - (chloromethyl) -1,3 -difluorobenzene, an organic compound. Its state may be liquid at room temperature, volatile. Look at its color, or colorless and clear. Smell it, or have a specific gas.
On its physical and chemical properties, it is more soluble in organic solvents. Its boiling point and melting point are all characteristics. The boiling point is about a certain degree, and the melting point is also the same. It is based on this compound. And its chemical properties are active, it can react with various reagents, and it has a wide range of uses in the field of organic synthesis. Its fluorine-containing and chlorine-containing groups endow it with unique properties, or affect the direction and rate of the reaction, which is of great benefit to chemical researchers.
Technical Specifications & Labeling
Today there is a product named 2 - (chloromethyl) -1,3 - difluorobenzene. Its production method depends on specific process specifications. First take all raw materials and mix them in precise proportions. In clean vessels, control the temperature and control, and operate with appropriate equipment. When reacting, observe its color change and smell its gas, so that the reaction is complete and there are few impurities.
After making, check its quality, there must be clear standards. Looking at its color, when it is pure and free of impurities; measuring its degree, the value must be compliance; checking its quality, impurities must not exceed the limit. In this way, only qualified products can be used for various purposes. Process specifications and identification (product parameters) are essential to ensuring the quality of this product.
Preparation Method
To prepare 2 - (chloromethyl) -1,3 - difluorobenzene, the method of preparation is related to the raw materials and production process, reaction steps and catalytic mechanism. The first step is to clarify the selection of raw materials, when fluorobenzene-containing benzene is used as the base, supplemented by reagents that can introduce chloromethyl. The production process should control the temperature, pressure and time of the reaction. In the reaction step, the fluorobenzene-containing benzene is mixed with a specific reagent in a certain order to initiate the reaction. In the catalytic mechanism, a suitable catalyst can be found to promote the reaction rate and increase the yield of the product. In this way, after fine regulation of each end, it is expected to obtain pure 2 - (chloromethyl) -1,3 - difluorobenzene, which is the foundation for subsequent use.
Chemical Reactions & Modifications
Nowadays, there is a chemical substance called 2- (Chloromethyl) -1,3-Difluorobenzene. In the field of chemistry, its reaction and modification are crucial. To clarify its properties, various reactions need to be investigated.
Look at the reaction, or there is a change of nucleophilic substitution, and the halogenated methyl can attract nucleophilic reagents and cause structural changes. Or under specific conditions, the position of the fluorine atom can also initiate a reaction and change its chemical properties.
As for modification, chemical means can be used to increase its stability or adjust its activity. If a specific group is introduced or its spatial structure is changed, it is expected to obtain a product with better performance. Exploring the mysteries of this is the need for chemical research, and it is hoped that it can be used in various fields of industry and scientific research to develop its extraordinary uses.
Synonyms & Product Names
"Mengxi Brush Talk" is the crystallization of the wisdom of the ancients. Today, with its literary style, it is written about the same noun and trade name of the product "2- (Chloromethyl) -1,3-Difluorobenzene".
The husband "2- (Chloromethyl) -1,3-Difluorobenzene" is a key thing in the field of my chemical research. There are also many similar nouns, which are all recognized by the academic community. As for the product name, it varies according to the positioning and needs of different merchants.
The same noun has different titles either due to the evolution of chemical naming rules or due to the differences in regional academic exchanges. Of course, they all refer to the same chemical substance. The name of the product, the merchant wants to show its characteristics and advantages, in order to attract the attention of the market, so each has ingenuity.
Our chemical researchers, when exploring the nature and use of this thing, also need to clarify the various nouns and trade names, in order to communicate and research, correct and smooth, in order to promote the progress of chemical research and benefit the prosperity of related industries.
Safety & Operational Standards
Regarding the safety and operation specifications of 2- (chloromethyl) -1,3-difluorobenzene
Fu 2- (chloromethyl) -1,3-difluorobenzene is a common substance in chemical research. During its experimental operation, safety is the top priority and must not be ignored.
This substance has certain chemical activity and is related to personal safety, so the experimenter should strictly abide by the operating regulations. First and foremost, the experimenter must wear complete protective equipment. Wear protective clothing to protect against direct contact with the body; wear protective gloves, and the material must be resistant to the erosion of this chemical to avoid skin contact, allergies or more serious injuries. Goggles are also indispensable to prevent them from splashing into the eyes and damaging the eyesight.
Furthermore, the operating environment must be well ventilated. Performing relevant operations in the fume hood can dissipate volatile gases in time to avoid their accumulation in the air and reduce the risk of poisoning. After use, the utensils should not be disposed of at will, and should be properly disposed of according to regulations. After use, the container needs to be specially cleaned to remove residual substances to prevent pollution of the environment.
There are also regulations for storage. It should be placed in a cool, dry and ventilated place, away from fire and heat sources. Because of its flammability, in case of open fire or hot topic, it may cause fire or even explosion. And it must be stored separately from oxidizing agents, alkalis, etc., to prevent mutual reaction and danger.
When taking the substance, the action should be precise and gentle. The measurement process should be operated precisely according to the needs of the experiment. Do not take more waste, nor take less and cause experimental deviation. When transferring, beware of its dripping. If it is accidentally spilled, it should be disposed of immediately according to the emergency treatment process. Cover with absorbent material first to avoid diffusion, then collect it carefully and dispose of it in the specified manner.
In short, in the research and use of 2- (chloromethyl) -1,3-difluorobenzene, safe and standardized operation is the key to ensuring the smooth experiment, personnel safety and environmental harmlessness. Never take chances, and you must treat it with a rigorous attitude.
Application Area
Modern chemistry has advanced, and the research of substances has become increasingly profound. Today there is 2- (Chloromethyl) -1,3-Difluorobenzene, which has a wide range of application fields. In the field of pharmaceutical synthesis, it can be a key intermediate, assisting in the research of special drugs to treat various diseases and relieve the pain of the world. In the field of material science, it can participate in the prefabrication of new materials to increase its characteristics, such as strong and light, tough and resistant. It is used in equipment and appliances, and its effectiveness is extraordinary. In the field of fine chemicals, it can be used as raw materials to make various fine products and improve the quality of daily use. This is what 2- (Chloromethyl) -1,3-Difluorobenzene does. It emits light and heat in many fields and benefits people. It is a treasure of chemical research and has endless application prospects.
Research & Development
In recent years, in the field of organic synthesis, 2- (Chloromethyl) -1,3-Difluorobenzene has gradually attracted the attention of our chemical researchers. Its unique structure, containing chloromethyl and difluorophenyl, has different properties, and has great potential for the creation of medicine and pesticides.
We have tried to study the synthesis method of this compound, and through many tests, we have explored the optimal path. The selection of raw materials and the control of reaction conditions all play a key role. Factors such as temperature, catalyst type and dosage need to be carefully adjusted to obtain excellent yield and purity.
And its reaction mechanism is also the focus of our research. By means of spectroscopy and theoretical calculations, the reaction process and activity check point are clarified. Looking forward to the future, this compound will continue to be developed and expanded, shining brightly in the industry, promoting progress in the field of chemistry and benefiting the world.
Toxicity Research
Today there is a thing called 2- (Chloromethyl) -1,3-Difluorobenzene. As a chemical researcher, I explore its toxicity.
The toxicity of this thing is related to living things. Or invade the human body and disrupt its physiology. In the experimental environment, test it with a white rat to observe its state after eating this substance. See the white rat gradually tired, the vitality is sharply reduced, or its organs are damaged.
Also observe its impact on the environment, enter the water and soil, or stain it. Living things in the water are also harmed by it. Algae growth is blocked, and fish are also sick.
The study of toxicity should not be ignored. Only by understanding its nature can we prevent its harm, protect nature and human safety, and ensure harmonious coexistence of all things.
Future Prospects
I have been engaged in the research of chemical products for a long time, and I often think about the future development. Today there is 2- (Chloromethyl) -1,3-Difluorobenzene, and its future is promising.
This chemical has potential applications in many fields. In material synthesis, it may serve as a key intermediate to help create new high-performance materials and contribute to industrial development. In the process of pharmaceutical research and development, its unique structure may provide an opportunity for the exploration of new drugs for human health and well-being.
Although current research is still limited, I firmly believe that with time and unremitting research, more potential will be discovered. In the future, 2- (Chloromethyl) -1,3-Difluorobenzene is expected to shine brightly, causing changes in many fields such as chemical engineering and medicine, achieving extraordinary achievements and bringing endless benefits to future generations.
Where to Buy 2-(Chloromethyl)-1,3-Difluorobenzene in China?
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Frequently Asked Questions

As a leading 2-(Chloromethyl)-1,3-Difluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What is the main use of 2- (Chloromethyl) -1,3-Difluorobenzene?
2-%28Chloromethyl%29-1%2C3-Difluorobenzene is 2- (chloromethyl) -1,3-difluorobenzene, which has a wide range of uses.
In the field of medicinal chemistry, it is an important intermediate in organic synthesis. It can participate in the construction of complex drug molecular structures and introduce specific functional groups through a series of reactions to help develop new drugs. Taking the synthesis of some antibacterial and antiviral drugs as an example, 2- (chloromethyl) -1,3-difluorobenzene can be used as a starting material to react with other reagents to gradually build a biologically active drug skeleton, making great contributions to human health.
In the field of materials science, it also plays a key role. It can be used to synthesize special performance polymer materials. Because it contains chloromethyl and difluorophenyl groups, these functional groups endow materials with unique physical and chemical properties. For example, synthesized polymer materials may have good thermal stability, chemical stability and electrical properties, and have potential applications in high-end fields such as electronic devices and aerospace. For example, the manufacture of high-performance circuit board insulation materials, or special plastics for aerospace parts, 2- (chloromethyl) -1,3-difluorobenzene may play an important role in promoting the continuous development of materials science.
What are the physical properties of 2- (Chloromethyl) -1,3-Difluorobenzene?
2-%28Chloromethyl%29-1%2C3-Difluorobenzene, the Chinese name 2- (chloromethyl) -1,3-difluorobenzene, is an organic compound. Its physical properties have many characteristics.
Looking at its properties, under normal temperature and pressure, it is mostly colorless to light yellow liquid, clear and transparent, without visible impurities. This substance is relatively stable in air, but it needs to avoid direct light and hot topic environment to prevent chemical changes.
When it comes to melting point and boiling point, the melting point is about -50 ° C to -40 ° C, and the boiling point is roughly in the range of 180 ° C to 190 ° C. Such melting boiling point characteristics make it possible to achieve phase transition under specific temperature conditions. When heated to near the boiling point, it will convert from liquid to gaseous; when cooled to near the melting point, it will condense from liquid to solid.
Its density is heavier than that of water, about 1.3g/cm ³. When mixed with water, it will sink to the bottom of the water, forming obvious stratification. And slightly soluble in water, but it can be well miscible with many organic solvents, such as ethanol, ether, acetone, etc. This solubility facilitates its use as a reactant or solvent in organic synthesis reactions.
In addition, 2- (chloromethyl) -1,3-difluorobenzene has a certain volatility and can smell a special smell in the air. However, its volatility is not extremely strong, and under conventional storage conditions, the volatilization rate is relatively slow. However, in a poorly ventilated environment, its volatile gases may accumulate, causing the concentration in the air to rise. Attention should be paid to the operation, which should be carried out in a fume hood to ensure safety.
Is 2- (Chloromethyl) -1,3-Difluorobenzene Chemically Stable?
2-%28Chloromethyl%29-1%2C3-Difluorobenzene is 2- (chloromethyl) -1,3-difluorobenzene. The stability of the chemical properties of this substance is the key to chemical research and practice.
Looking at its structure, there are chloromethyl and difluorine atoms connected to the benzene ring. In chloromethyl, the carbon-chlorine bond polarity is quite strong, and the chlorine atom has electron absorption, resulting in a decrease in the electron cloud density of this part. This characteristic makes the carbon-chlorine bond vulnerable to nucleophilic reagent attack and nucleophilic substitution reaction occurs, so the stability is affected.
Furthermore, fluorine atoms are extremely electronegative. After connecting with the benzene ring, the electron cloud distribution of the benzene ring is changed by induction effect and conjugation effect. Although the stability of the benzene ring is enhanced to a certain extent, it also has a significant impact on the density of ortho and para-electron clouds, resulting in different chemical activities.
Under common conditions, without the interference of specific reagents or external factors, 2- (chloromethyl) -1,3-difluorobenzene can remain relatively stable. However, when encountering nucleophilic reagents, such as hydroxide ions, amines, etc., the carbon-chlorine bond is easily broken, and nucleophilic substitution occurs to form corresponding alcohol and amine derivatives. In case of high temperature, light or free radical initiators, chloromethyl may also initiate free radical reactions, which affect the stability.
Also consider its environment. If it is an acidic or alkaline medium, it will also change its electron cloud distribution and reactivity due to protonation or deprotonation, which will affect the stability.
In summary, the stability of 2- (chloromethyl) -1,3-difluorobenzene is not absolute, and it is affected by the interaction of functional groups in the structure, external reagents and environmental factors. It needs to be properly disposed of according to its characteristics during practical application and storage to ensure safe and effective use.
What are the synthesis methods of 2- (Chloromethyl) -1,3-Difluorobenzene?
To prepare 2 - (chloromethyl) -1,3 -difluorobenzene, there are two common methods. The first is the halogenated benzyl method, which starts with 1,3 -difluorobenzene and reacts with formaldehyde and hydrogen chloride under the catalysis of Lewis acid such as anhydrous aluminum chloride. In this reaction, the benzene ring of 1,3 -difluorobenzene is electrophilically substituted, and the chloromethyl positive ion generated by the interaction of formaldehyde and hydrogen chloride attacks the benzene ring to obtain the target product. When reacting, pay attention to the ratio of reaction temperature and raw materials. If the temperature is too high, side reactions will easily occur, and improper ratio will affect the yield.
The second is the halogenated hydrocarbon substitution method. First, 1,3-difluorobenzene is obtained by bromomethylation of 2- (bromomethyl) -1,3-difluorobenzene. The commonly used reagent is N-bromosuccinimide (NBS) and an initiator such as benzoyl peroxide. React under light or heating conditions. Then, by the method of halogen ion exchange, 2- (bromomethyl) -1,3-difluorobenzene is reacted with chlorinated salts such as sodium chloride in a suitable solvent such as acetone, and the bromine ion is replaced by chloride ion to obtain 2- (chloromethyl) -1,3-difluorobenzene. In this way, the bromomethylation step should control the reaction conditions to prevent the formation of polybrominates; the halogen ion exchange step needs to choose a suitable solvent and reaction time to promote the complete reaction.
2- (Chloromethyl) -1,3-Difluorobenzene What to pay attention to when storing and transporting
2-%28Chloromethyl%29-1%2C3-Difluorobenzene is 2- (chloromethyl) -1,3-difluorobenzene. When storing and transporting this substance, many matters need to be carefully paid attention to.
It has certain chemical activity. When storing, the first environment is selected. It should be placed in a cool, dry and well-ventilated place, away from fire and heat sources. Because it is more sensitive to heat, high temperature is easy to cause chemical reactions, or there is a risk of decomposition and polymerization, which threatens storage safety. For example, some chemicals have caused violent reactions due to improper storage temperature, causing the storage container to break.
Furthermore, it should be stored separately from oxidants, strong bases, etc., and must not be mixed. This is because 2- (chloromethyl) -1,3-difluorobenzene comes into contact with oxidants or undergoes an oxidation reaction. When the reaction is severe, it can cause combustion or even explosion; when it encounters strong alkali, uncontrollable chemical reactions may also occur.
The packaging must be tight to ensure sealing. To prevent it from volatilizing and escaping, polluting the environment, and to avoid its contact with air and moisture. Because it is left in the air for a long time, or interacts with oxygen and moisture, it changes the chemical properties. During transportation, choose qualified transportation tools to ensure that the container is stable and there are no bumps and collisions on the way to prevent package damage and leakage. Transportation personnel also need professional training and are familiar with emergency response measures. If there is a leak during transportation, it can respond quickly and effectively to reduce harm. In this way, the safe storage and transportation of 2- (chloromethyl) -1,3-difluorobenzene can be guaranteed.