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What are the main uses of 2-chloro (trifluoromethyl) benzene?
2-% cyanogen (triethylmethyl) naphthalene is widely used. In the field of medicine, it can be used as a raw material for the synthesis of specific drugs. The unique structure of this substance can give it special pharmacological activity when building drug molecules. For example, it can help develop new drugs for specific diseases, such as some stubborn inflammation or difficult diseases, which is expected to bring good news to patients.
In materials science, it also plays an important role. It can participate in the creation of high-performance materials. If it is copolymerized with other compounds, it can prepare new polymer materials with excellent physical properties, or enhance the toughness and heat resistance of materials, or endow them with special optical and electrical properties. It has potential applications in high-end fields such as aerospace and electronic equipment.
In chemical production, it is an important intermediate. Through a series of chemical reactions, a variety of high-value-added chemical products can be derived. By precisely controlling the reaction conditions, diverse transformations can be achieved, thereby enriching the types of chemical products, meeting the needs of different industries, and enhancing the economic efficiency and competitiveness of the chemical industry.
In terms of scientific research and exploration, it is an ideal model for studying the relationship between molecular structure and properties. Scientists can deeply explore basic scientific issues such as the interaction mechanism between molecules and the distribution change of electron clouds through chemical modification and modification, providing important experimental basis and data support for the improvement and expansion of organic chemistry theory.
What are the physical properties of 2-chloro (trifluoromethyl) benzene?
2-% (triethylmethyl) silicon, its physical properties are very special. This material is usually a liquid color, and the ground is clear. Under normal conditions, its external appearance resembles clear water, and its fluidity is very good.
It is difficult to melt. Due to the characteristics of molecular force, the molten phase is low, usually at a low temperature, so that this material is easy to be liquid at a slightly higher temperature than its melting temperature. As for the boiling temperature, it is not very high. Under certain conditions, it can be melted at a low temperature.
In terms of density, the density of 2-% (triethylmethyl) silicon is very small. If the water is co-located with it, it can float on the water surface, and the limit is clear.
Solubility is also one of its important physical properties. This substance is soluble in water, and it is not easy to dissolve due to the matching force of its molecules. However, in many soluble substances, such as ether, toluene, etc., it has good solubility and can be miscible to form a homogeneous solution.
In addition, the solubility of 2-% (triethyl) silicon is low. In the open environment, it can be quickly washed into the air. It has a certain smell and is not pungent. However, it also has its own special interest, which can be used to identify this material. The density of its evaporation phase is higher than that of the air. If it is high, it is easy to gather at low temperatures. This is important for use and storage.
What are the chemical properties of 2-chloro (trifluoromethyl) benzene?
The chemical properties of 2-% cyanogen (triethylmethyl) naphthalene can be investigated. In this compound, the cyanyl group has high reactivity. The carbon-nitrogen triple bond in the cyanyl group is rich in electrons, which makes the group easy to react with electrophilic reagents. In case of halogenated hydrocarbons, the carbon atoms of the cyanyl group can attack the α-carbon of halogenated hydrocarbons, and a nucleophilic substitution reaction occurs, thereby increasing the carbon chain. This is an important means of increasing carbon in organic synthesis.
Furthermore, the naphthalene ring has a fused ring aromatic hydrocarbon structure and has a certain aromaticity. The electron cloud distribution on the naphthalene ring has its own characteristics, and the electron cloud density at the α-position is relatively high, so the electrophilic substitution reaction often occurs at When this substance encounters electrophilic reagents, such as halogenating agents, nitrifying agents, etc., the electrophilic reagents are prone to attack the alpha-position of the naphthalene ring and generate corresponding substitution products.
And triethyl methyl is attached to the naphthalene ring, which also affects the electron cloud distribution of the naphthalene ring. Triethyl methyl is an electron supply group, which can increase the electron cloud density of the naphthalene ring and enhance the electrophilic substitution reaction activity of the naphthalene ring. At the same time, the steric hindrance effect of triethyl methyl cannot be underestimated. During the reaction, the steric hindrance may affect the proximity of the reagent to the reaction check point, especially in the reaction involving larger volumes of reagents, or change the reaction selectivity, and tend to react where Overall, 2-% cyanotriethyl naphthalene exhibits unique chemical properties due to the cyano group activity, the aromaticity of naphthalene ring, and the electronic and spatial effects of triethyl methyl, which hold many potential reaction paths and applications in the field of organic synthetic chemistry.
What are the preparation methods of 2-chloro (trifluoromethyl) benzene?
To prepare 2-chloro (triethylmethyl) benzene, the following ancient methods can be used.
First, benzene is used as the starting point, and the halogenated hydrocarbon is first reacted with the help of a catalyst. The halogenated hydrocarbon is selected from triethylmethyl halide, and the catalyst is commonly used anhydrous aluminum trichloride. This reaction is a Fu-gram alkylation reaction. The process is as follows: Under the action of the catalyst, the halogenated hydrocarbon generates a carbocation ion. This carbocation ion is electrophilic and will attack the electron cloud of the benzene ring, causing the hydrogen on the benzene ring to be replaced, resulting in 2-chloro (triethylmethyl) benzene. However, this reaction should be noted. Because the alkyl group has an electron-pushing effect, it will make the product benz In order to control side reactions, excessive benzene can be made, halogenated hydrocarbons can be fully reacted, and polyalkylation products can be reduced.
Second, benzene can be acylated first. The acylation product is obtained by reacting triethylmethylhalide with benzene under the catalysis of anhydrous aluminum trichloride. This reaction can effectively avoid multi-substitution side reactions. Because the acyl group is an electron-withdrawing group, it will reduce the electron cloud density of the benzene ring, so that the product is no longer easy to react with electrophilic reagents. Then the acylation product is reduced, and the zinc amalgam and concentrated hydrochloric acid are used as reducing agents. After the Clemson reduction reaction, the carbonyl group is reduced to methylene, and then 2-chloro (triethylmethyl) benzene is obtained
Third, the Grignard reagent method can also be used. First, the Grignard reagent is prepared from halogenated benzene, such as the Grignard reagent is obtained by reacting 2-chlorobromobenzene with magnesium in anhydrous ether. Then the Grignard reagent is reacted with triethylmethyl halide to obtain the target product 2-chloro (triethylmethyl) benzene. This process needs to be carried out in an anhydrous and anaerobic environment. Because the Grignard reagent is extremely active, it will react quickly in contact with water or oxygen and fail.
All the above production methods have advantages and disadvantages. In actual operation, it is necessary to comprehensively consider many factors such as the availability of raw materials, the difficulty of reaction conditions, and the purity requirements of the product. Choose the appropriate one and use it.
What are the precautions for using 2-chloro (trifluoromethyl) benzene?
2-% (triethylmethyl) silicon is a rare thing. When it is used, it is necessary to pay attention to all kinds of things in order to ensure its effectiveness and safety.
First, this silicon is easy to be oxidized. In case of sulfuric acid and nitric acid, it will immediately cause a strong reaction, or the danger of explosion. Therefore, when it is used, it must be oxidized. It must be placed in a dry and well-connected place, and it should be protected by inertness.
Second, 2-% (triethylmethyl) silicon is sensitive to moisture. If the temperature in the air is slightly higher, it is easy to evaporate and cause the reaction of hydrolysis, causing it to break down and reduce its performance. To use it, it needs to be operated in a dry environment, or in a glove box, and the equipment involved is fully dry, and no water vapor can be retained.
Third, because it has a certain resistance, and steaming or micro-toxicity. The use of the product must be guaranteed to be good, in order to prevent steaming and accumulation, harm to the body. If the product can be used, it is advisable to use a row operation, and the operator should also wear appropriate anti-staining equipment, such as gas masks, anti-staining gloves, etc., for their own safety.
Fourth, 2-% (triethylmethyl) silicon part gold or its compounds can also react. Such as gold, gold, or accelerate its decomposition. In the case of anti-phase equipment used in reverse containers, it is necessary to avoid using this gold material, and inert materials such as glass and polytetrafluoroethylene can be used to avoid accidents.
For the use of 2-% (triethylmethyl) silicon, it is necessary to follow the above procedures carefully before it can be used.