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2-Chloro-6-Fluorobenzene-1-Carbonyl Chloride

2-Chloro-6-Fluorobenzene-1-Carbonyl Chloride

Hongda Chemical

    Specifications

    HS Code

    629649

    Chemical Formula C7H3Cl2FO
    Molecular Weight 193.00
    Appearance Colorless to light yellow liquid
    Boiling Point Around 214 - 216°C
    Density Data may vary, around 1.4 - 1.5 g/cm³
    Solubility Soluble in organic solvents like dichloromethane, toluene
    Flash Point Data may vary, potentially around 90 - 100°C
    Pungency Strongly pungent odor
    Reactivity Highly reactive towards nucleophiles

    As an accredited 2-Chloro-6-Fluorobenzene-1-Carbonyl Chloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 100 g of 2 - chloro - 6 - fluorobenzene - 1 - carbonyl chloride in a sealed glass bottle.
    Storage 2 - chloro - 6 - fluorobenzene - 1 - carbonyl chloride should be stored in a cool, dry, well - ventilated area, away from sources of heat, ignition, and moisture. Store it in a tightly sealed container, preferably made of corrosion - resistant materials. Keep it separate from incompatible substances like bases, alcohols, and water - reactive chemicals to prevent dangerous reactions.
    Shipping 2 - chloro - 6 - fluorobenzene - 1 - carbonyl chloride is a chemical. Shipping requires proper containment in corrosion - resistant containers. It must follow hazardous materials regulations, with appropriate labeling for safe transportation.
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    2-Chloro-6-Fluorobenzene-1-Carbonyl Chloride 2-Chloro-6-Fluorobenzene-1-Carbonyl Chloride
    General Information
    Historical Development
    2-Chloro-6-fluorobenzoyl chloride, the development of this substance is really meaningful. In the past, the field of organic synthesis has gradually explored it. At first, researchers struggled to find a way to synthesize it in complex reactions. After many attempts, with wisdom and perseverance, the key path of synthesis was obtained.
    At that time, although the technology was limited, the public was determined. In a simple laboratory, the reagents were carefully prepared to observe the subtle changes of the reaction. Starting from the basic raw materials, through many steps, the structure of this compound was gradually constructed. With the advancement of research, the synthesis efficiency gradually increased and the purity also improved. The birth of this substance has contributed to the development of organic chemistry, opened a new chapter, attracted more scholars to study, and paved the way for progress in the field of chemistry.
    Product Overview
    2-Chloro-6-fluorobenzoyl chloride is also an organic compound. It is a white to slightly yellow crystalline powder with a special odor. It is widely used in the field of chemical synthesis. This compound contains chlorine and fluorine atoms, and its structure is unique, resulting in its special properties. In many organic synthesis reactions, it is often used as a key intermediate. Due to the activity of chlorine and fluorine atoms, it can react with many reagents to derive a variety of compounds. It has made significant contributions in the field of medicine and pesticide synthesis. It can precisely prepare the required drug and pesticide ingredients through specific chemical reactions to improve product performance and effect. The synthesis method requires strict control of reaction conditions, such as temperature, pressure, catalyst, etc., to ensure yield and purity. However, this substance may be toxic and irritating, and it must be operated in accordance with strict safety procedures and properly protected to prevent harm to personal safety and the environment.
    Physical & Chemical Properties
    2-Chloro-6-fluorobenzoyl chloride is one of the organic compounds. Its physical properties are mostly liquid at room temperature, and its color is nearly colorless to yellowish, with a pungent smell. Looking at its chemical properties, the acid chloride group is quite active, and it is easy to react with alcohols, amines, etc., to derive esters, amides and other substances. This is because the chlorine atom in the acid chloride is affected by the carbonyl group, the electron cloud density is reduced, and it is easy to leave, resulting in a significant increase in its reactivity. 2-Chloro-6-fluorobenzoyl chloride is widely used in the field of organic synthesis and can be used as a key intermediate to create fine chemicals such as medicines and pesticides, which is of great significance to promote the development of related industries.
    Technical Specifications & Labeling
    Today there is a product called 2-chloro-6-fluorobenzoyl chloride. Its process specifications and identification (product parameters) are crucial. In terms of process specifications, the synthesis process needs to be carefully controlled. From the selection of raw materials, choose pure and high-quality products, and the ratio must be accurate. The reaction conditions also need to be strictly controlled, such as temperature, or should be maintained in a certain range. If it is too high, the product will easily decompose, and if it is too low, the reaction will be slow. The pressure also needs to be appropriate to promote the smooth progress of the reaction.
    When it comes to the identification (product parameters), the purity must reach a specific standard, and the impurity content must not exceed the limit. The appearance should have a specific color and shape, which is the key to distinguish the advantages and disadvantages. Only by strictly adhering to process specifications and accurate identification (product parameters) can we ensure the high quality of this product and play its due role in the chemical industry.
    Preparation Method
    The method of preparing 2-chloro-6-fluorobenzoyl chloride is related to the raw materials and production process, reaction steps and catalytic mechanism.
    To make this product, the raw materials need to be selected first. Based on specific halogenated aromatics and acylating reagents, the ratio of the two is delicately mixed to lay the foundation for the reaction. The first step of the reaction is that halogenated aromatics and acylating reagents are fused in a specific solvent, heated to a suitable temperature, so that the molecules are active and interact. This process requires precise temperature control. If it is too high temperature, the reaction will be excessive and the product will be difficult to control; if it is too low temperature, the reaction will be slow and take a long time.
    As for the catalytic mechanism, a high-efficiency catalyst needs to be introduced. It can reduce the activation energy of the reaction and make the reaction more likely to occur. The amount of catalyst also needs to be considered. If it is too small, the catalytic effect will be poor, and if it is too much, it will increase the cost and lead to side reactions.
    After this raw material screening, delicate steps and reasonable catalysis, 2-chloro-6-fluorobenzoyl chloride can be obtained, but each step needs to be carefully controlled to ensure the quality and quantity of the product.
    Chemical Reactions & Modifications
    Nowadays there is a chemical thing called 2 - Chloro - 6 - Fluorobenzene - 1 - Carbonyl Chloride. In the way of chemical research, reaction and modification are the key.
    To observe the reaction, when observing its conditions, rate and product. This compound, when encountering a certain reagent, under a specific temperature and pressure, may change from substitution and addition. In the way of modification, groups can be added or the structure can be adjusted to change its properties. If you want to increase its stability, you can modify the surrounding atoms; if you want to change its activity, or change its functional group position.
    Our chemists study this mystery, hoping to control its reaction and modification, so that this compound can be used in the fields of medicine and materials to the best of its ability, for the well-being of the world, and for the science of chemistry.
    Synonyms & Product Names
    2-Chloro-6-fluorobenzoyl chloride is a new substance in the chemical industry. It has many different names, which is a common situation in the chemical industry. It covers more than one thing, both in ancient times and today. In the field of chemical industry, every new substance is produced, and its name depends on its nature or structure.
    Guanfu 2-chloro-6-fluorobenzoyl chloride, its name is determined by its chemical structure. However, in the market and industry, it is also called by him. This is all due to the different customs and habits of people in different places. The ancient things, one place has the name of one place, and one industry has one industry.
    This substance has a wide range of uses and is an important raw material in the process of chemical synthesis. Although its synonyms are various, they all refer to the same thing. Those of us who are in this industry should be familiar with its various names to avoid confusion, so that we can use it smoothly and without delay when researching and using it, so that this chemical treasure can perform its functions and benefit the world.
    Safety & Operational Standards
    On June 13, 2024, the safe production and operation specifications of the chemical substance 2-chloro-6-fluorobenzoyl chloride are related to the important affairs of our chemical researchers. This article is specially written for explanation.
    2-chloro-6-fluorobenzoyl chloride is highly corrosive and irritating, and is related to personal safety and environmental impact. The operation must be rigorous.
    In terms of storage, it should be placed in a cool, dry and well-ventilated place, away from fire and heat sources. This substance should be stored separately from oxidants, alkalis, alcohols, etc., and should not be mixed. The storage area should be equipped with suitable materials to contain leaks.
    During the operation, the operator must undergo special training and strictly abide by the operating procedures. It is recommended that the operator wear a self-priming filter gas mask (full mask), wear a rubber acid and alkali-resistant clothing, and wear rubber acid and alkali-resistant gloves. Avoid generating smoke or dust, and prevent steam from leaking into the air of the workplace. Avoid contact with oxidants, alkalis, and alcohols. When handling, pack and unload lightly to prevent damage to packaging and containers. Equip with the corresponding variety and quantity of fire-fighting equipment and leakage emergency treatment equipment. Empty containers may have harmful substances left, and they must be properly disposed of.
    If a leak occurs accidentally, the personnel in the leakage contaminated area should be quickly evacuated to the safe area, and quarantined, and access should be strictly restricted. It is recommended that emergency personnel wear self-contained positive pressure breathing apparatus and anti-acid and alkali work clothes. Do not let leaks come into contact with combustible substances (such as wood, paper, oil, etc.). Cut off the source of leakage as much as possible. Prevent flowing into restricted spaces such as sewers and drainage ditches. In the case of small leaks, mix with sand, dry lime or soda ash. It can also be rinsed with a large amount of water, diluted with washing water and placed into the wastewater system. In the case of large leaks, build a dike or dig a pit for containment. Transfer to a tanker or a special collector by pump, recycle or transport to a waste treatment site for disposal.
    Safe production and standardized operation are the constant principles of our chemical researchers. When dealing with chemicals such as 2-chloro-6-fluorobenzoyl chloride, more caution should be taken to ensure their own safety and environmental integrity, and to promote the steady progress of chemical research.
    Application Area
    2-Chloro-6-fluorobenzoyl chloride has a wide range of application fields. In the field of medicinal chemistry, it can be used as a key intermediate to help synthesize a variety of specific drugs, such as targeted therapeutic agents for specific diseases. With its unique chemical structure, it can accurately act on the lesion and improve the curative effect. In the field of materials science, it also has important value. After specific reactions, it can participate in the synthesis of high-performance functional materials, such as materials with special optical and electrical properties, which can be used in optoelectronic equipment and other fields. In the field of fine chemicals, it is also indispensable. It can be used to prepare high-end coatings, fragrances and other fine chemicals, giving products unique quality and performance. All these highlight the important position and broad prospects of 2-chloro-6-fluorobenzoyl chloride in many application fields.
    Research & Development
    In recent years, I have been focusing on the research of 2 - Chloro - 6 - Fluorobenzene - 1 - Carbonyl Chloride. It is unique in nature and has great potential in various fields of chemical industry.
    At the beginning, I analyzed its structure and explored its physicochemical properties, but encountered many difficulties. However, I did not dare to slack off, studying day and night. After months of work, I have made a little progress.
    In order to find a good way to prepare, I tried various paths. Or change the conditions of the reaction, or change the reagents used, repeatedly consider and carefully debug. During the period of failure, the more frustrated and the braver.
    From today's perspective, although there is a slight improvement in the rate and purity of synthesis, there is still a long way to go before it can be widely used. I should make unremitting efforts to make greater breakthroughs, so that it can shine in industrial production, scientific research and other ends, and contribute to the development of our country's chemical industry.
    Toxicity Research
    Wenfu 2-chloro-6-fluorobenzoyl chloride, our chemists, often study the toxicity. The study of toxicity is related to the safety of living beings and cannot be ignored.
    View 2-chloro-6-fluorobenzoyl chloride is sexually active, and it often changes when it encounters other things. After various experiments, it can be seen that it is irritating to the skin and eyes. If you touch it carelessly, the skin will be red, swollen and painful, and the eyes will feel tingling and unclear.
    And if the gas of this thing is inhaled by the mouth and nose, it enters the lungs, or causes cough, chest tightness, and damages the respiratory system. Therefore, when studying this thing, protective equipment must be used, and the experimental environment should be passed to avoid its harm, so as to protect my own safety and protect the experimental week. The study of toxicity is the weight of chemical research and cannot be ignored.
    Future Prospects
    Fu2-chloro-6-fluorobenzoyl chloride is an important raw material for organic synthesis. Looking at its current situation, although it has been used in various fields, there is still a broad space for its future development.
    In the process of pharmaceutical research and development, this compound may provide a key intermediate for the creation of new drugs. With the current medical needs for overcoming difficult diseases, it may help to synthesize specific drugs and cure diseases.
    In the field of materials science, it is also expected to emerge. With the advance of science and technology, the demand for special performance materials is becoming more and more popular. The ingenious transformation of 2-chloro-6-fluorobenzoyl chloride may lay the foundation for the development of high-performance and multi-functional new materials.
    And with the prosperity of the concept of green chemistry, optimizing its preparation process to make its production more environmentally friendly and efficient will be the key to future development. With time, rational development and utilization, this compound will surely shine in many aspects and meet the diverse needs of future social development.
    Where to Buy 2-Chloro-6-Fluorobenzene-1-Carbonyl Chloride in China?
    As a trusted 2-Chloro-6-Fluorobenzene-1-Carbonyl Chloride manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 2-Chloro-6-Fluorobenzene-1-Carbonyl Chloride supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 2-Chloro-6-Fluorobenzene-1-Carbonyl Chloride?
    2-Chloro-6-fluorobenzoyl chloride is a crucial chemical raw material in the field of organic synthesis. It has a wide range of uses and plays a key role in many fields.
    First, in the field of pharmaceutical synthesis, this compound is a key intermediate. Through specific chemical reactions, it can be skillfully converted into unique drug molecules. In the preparation of many antibacterial and anti-inflammatory drugs, 2-chloro-6-fluorobenzoyl chloride acts as an indispensable starting material. Its unique chemical structure can endow drugs with specific biological activities and pharmacological properties, helping drugs to better exert therapeutic effects.
    Second, in the field of pesticide creation, 2-chloro-6-fluorobenzoyl chloride is also very useful. After a series of reactions, a variety of highly efficient pesticide products can be synthesized. Such pesticides have excellent killing effects on pests, while having a relatively small impact on the environment. For example, the synthesis of some new pesticides relies on the introduction of specific functional groups of 2-chloro-6-fluorobenzoyl chloride to enhance the insecticidal activity and selectivity of pesticides.
    Furthermore, in the field of materials science, this compound also has outstanding performance. It can be used as a raw material for the synthesis of special polymer materials. Through a carefully designed polymerization reaction, 2-chloro-6-fluorobenzoyl chloride is integrated into the main chain or side chain of the polymer, giving the material unique physical and chemical properties, such as excellent heat resistance, corrosion resistance, etc., to meet the special needs of different engineering materials.
    In addition, in the synthesis of fine chemical products, 2-chloro-6-fluorobenzoyl chloride is also often used. For example, it is used in the synthesis of some high-end coatings, dyes and fragrances. The products involved in the synthesis have outstanding advantages in color, stability and aroma durability.
    In conclusion, 2-chloro-6-fluorobenzoyl chloride, with its unique chemical properties, plays a pivotal role in many fields such as medicine, pesticides, materials science, and fine chemicals, providing a key material basis for the development of various fields.
    What are the physical properties of 2-Chloro-6-Fluorobenzene-1-Carbonyl Chloride?
    2-Chloro-6-fluorobenzoyl chloride is an important compound in organic chemistry. Its physical properties are crucial and of great significance in chemical synthesis and other fields.
    Let's talk about the appearance first. At room temperature, 2-chloro-6-fluorobenzoyl chloride is often a colorless to light yellow liquid, with a uniform texture and a clear and transparent appearance. This appearance characteristic is easy to identify. In practice, if you see a liquid with such a property at a glance, you need to consider whether it is this substance.
    Besides the smell, it emits a pungent and corrosive smell. This smell is very unique and uncomfortable to smell. Because of its corrosive odor, it is necessary to take good protection when using and storing to prevent the odor from causing damage to the human body.
    Boiling point is also one of its important physical properties. The boiling point of 2-chloro-6-fluorobenzoyl chloride is within a certain range, specifically around [X] ° C. The characteristics of the boiling point determine its physical state change under conditions such as heating. When heated to the boiling point, it will change from liquid to gaseous state, which is crucial in separation and purification operations such as distillation.
    In terms of melting point, it also has a specific value, which is about [X] ° C. The meaning of the melting point is that when the temperature drops below the melting point, it will solidify from a liquid state to a solid state. Knowing the melting point, during storage and transportation, it can be prevented from solidifying due to low temperature and affecting subsequent use according to temperature conditions.
    In terms of density, the density of 2-chloro-6-fluorobenzoyl chloride is greater than that of water, about [X] g/cm ³. This means that if it is mixed with water, it will sink to the bottom of the water. This property can be used in some experiments or industrial production processes involving liquid-liquid separation to achieve preliminary separation from other substances through density differences.
    In terms of solubility, it is difficult to dissolve in water, but soluble in organic solvents such as ether and dichloromethane. This solubility characteristic is widely used in organic synthesis reactions. Many organic reactions are carried out in an organic solvent environment, and it can participate in various chemical reactions by virtue of its solubility in organic solvents, so as to achieve the synthesis of the target product.
    In addition, 2-chloro-6-fluorobenzoyl chloride is chemically active because its structure contains chlorine atoms, fluorine atoms and acyl chloride groups. Acyl chloride groups are prone to hydrolysis, alcoholysis, aminolysis and other reactions, and are often used as important reaction intermediates in organic synthesis to construct more complex organic compound structures.
    In conclusion, the physical properties of 2-chloro-6-fluorobenzoyl chloride, from appearance, odor, to melting point, density, solubility, etc., all play a decisive role in its application in chemical and organic synthesis fields. Only by in-depth understanding can we make better use of it.
    What are the synthesis methods of 2-Chloro-6-Fluorobenzene-1-Carbonyl Chloride?
    The synthesis of 2-chloro-6-fluorobenzoyl chloride has always been studied by chemists. There are many methods, and now there are one or two.
    One of them can be obtained by reacting 2-chloro-6-fluorobenzoic acid with chlorination reagents. Among the chlorination reagents, the common one is sulfinyl chloride ($SOCl_2 $). Place 2-chloro-6-fluorobenzoic acid in an appropriate reaction vessel, add an appropriate amount of sulfinyl chloride, and add a small catalyst, such as N, N-dimethylformamide (DMF). The reaction between the two is caused by heating. The thionyl chloride is substituted with the carboxyl group of benzoic acid to form 2-chloro-6-fluorobenzoyl chloride, and the sulfur dioxide and hydrogen chloride gas are escaped. The reaction is roughly as follows:
    2 dollars -chloro-6-fluorobenzoic acid + SOCl_2\ xrightarrow {catalyst, heated} 2-chloro-6-fluorobenzoyl chloride + SO_2 ↑ + HCl ↑ $
    Second, 2-chloro-6-fluorobenzoyl is used as the starting material. The methyl group is converted into a carboxyl group by oxidation reaction. The commonly used oxidants such as potassium permanganate ($KMnO_4 $) or potassium dichromate ($K_2Cr_2O_7 $) are oxidized under acidic conditions to obtain 2-chloro-6-fluorobenzoic acid. Then, according to the previous method, react with chlorination reagents to obtain the target product 2-chloro-6-fluorobenzoyl chloride.
    Or, using 2-chloro-6-fluorobenzaldehyde as a raw material, oxidize to obtain 2-chloro-6-fluorobenzoic acid first, and then chlorinate. The method of oxidizing benzaldehyde can use a mild oxidizing agent, such as manganese dioxide ($MnO_2 $), to react under specific conditions. The subsequent chlorination steps are similar to those described above.
    All methods have their own advantages and disadvantages, and they need to be selected according to the actual situation, such as the availability of raw materials, cost, difficulty of reaction conditions, etc., to achieve the best synthesis.
    What are the precautions for 2-Chloro-6-Fluorobenzene-1-Carbonyl Chloride in storage and transportation?
    2-Chloro-6-fluorobenzoyl chloride is a very special kind of chemical substances. When storing and transporting, many matters must be paid attention to.
    First word storage. This substance is very easy to react with water vapor in the air, so it must be stored in a dry place. The humidity of the surrounding environment must be strictly controlled to avoid the risk of water vapor intrusion. In addition, its nature is active and dangerous when heated. It should be stored in a cool place. The temperature should not be too high. It should be maintained in a specific low temperature range for security. And because of its corrosive nature, the storage container must be made of corrosion-resistant materials, such as specific glass materials or special plastics, and must be tightly sealed to prevent leakage.
    As for transportation, there are also many details. The transportation equipment must be specially treated to ensure that it is clean and dry, and there are no impurities left. The loading process must be handled with caution to prevent the container from being damaged by collision and leakage. During transportation, it is still necessary to pay close attention to the ambient temperature and humidity, and regulate it in a timely manner. If it is transported over a long distance, it is necessary to regularly check the integrity of the container. In addition, the transportation personnel must be professionally trained to be familiar with the characteristics of this substance and emergency treatment methods. In the event of an accident such as leakage, they can be disposed of quickly and properly to reduce the harm.
    In summary, 2-chloro-6-fluorobenzoyl chloride has strict requirements for the environment, containers and personnel during storage and transportation, and all links must not be neglected to ensure safety.
    What is the market price of 2-Chloro-6-Fluorobenzene-1-Carbonyl Chloride?
    Today, there is 2-chloro-6-fluorobenzoyl chloride, and its market is determined by the market.
    First, the raw materials are not available. 2-chloro-6-fluorobenzoyl chloride requires specific raw materials, and the location, harvest, and supply and demand of raw materials make it different. If the supply of raw materials is low, it must be low; the supply is low, or the demand is low.
    Second, the manufacturing method is cost-dependent. Different methods are easy to have, and the required cost, energy, and manpower are different.
    Third, the needs of the market are of paramount importance. If a certain field, the demand for this compound in the fields of chemical synthesis and material research increases greatly, and the supply is not in demand, and the demand must be increased; on the contrary, if the demand is low, the demand will also decline.
    Fourth, the difference in regions also has an impact. Different places have different costs, costs, and market costs. In places with high costs, it may be high or high; while in some places with low costs and low costs, it may be low.
    Therefore, in order to know the market value of 2-chloro-6-fluorobenzoyl chloride, it is necessary to observe the general factors such as raw material market, production cost, market supply and demand, and region, and often note the chemical industry market.