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2-Chloro-4-(Trifluoromethoxy)Bromobenzene

2-Chloro-4-(Trifluoromethoxy)Bromobenzene

Hongda Chemical

    Specifications

    HS Code

    681409

    Chemical Formula C7H3BrClF3O
    Molecular Weight 289.45
    Appearance Liquid (usually)
    Boiling Point Around 190 - 200 °C
    Density Around 1.7 - 1.8 g/cm³
    Solubility In Water Low, practically insoluble
    Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, toluene
    Vapor Pressure Low at room temperature
    Flash Point Relatively high, potentially around 80 - 90 °C

    As an accredited 2-Chloro-4-(Trifluoromethoxy)Bromobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 100g of 2 - chloro - 4 - (trifluoromethoxy)bromobenzene in sealed, labeled container.
    Storage 2 - Chloro - 4 - (trifluoromethoxy)bromobenzene should be stored in a cool, dry, well - ventilated area away from heat sources and open flames. Keep it in a tightly sealed container to prevent leakage. As it is a chemical, store it separately from incompatible substances like oxidizing agents, reducing agents, and bases to avoid potential reactions.
    Shipping 2 - chloro - 4 - (trifluoromethoxy)bromobenzene is shipped in well - sealed, corrosion - resistant containers. Special care is taken to comply with hazardous chemical shipping regulations, ensuring safe transport to the destination.
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    2-Chloro-4-(Trifluoromethoxy)Bromobenzene 2-Chloro-4-(Trifluoromethoxy)Bromobenzene
    General Information
    Historical Development
    In the field of chemistry, the historical evolution of 2-chloro-4- (trifluoromethoxy) bromobenzene is quite profound. In the past, the road of chemical exploration was long, and many sages were committed to the study of compounds.
    At the beginning, the understanding of halogenated aromatics was still shallow, and only a little knowledge of their basic properties. As the years passed and the experimental technology improved, scholars began to focus on halogenated benzenes containing fluoroxy. For 2-chloro-4- (trifluoromethoxy) bromobenzene, predecessors have tried countless times, from the selection of raw materials to the exploration of reaction conditions, such as temperature, pressure, and catalyst preparation, all of them have been painstaking.
    After many setbacks and corrections, an effective way to prepare this compound was finally found. Its emergence in the field of organic synthesis has laid the foundation for many subsequent related studies, just like a shining star, illuminating the long journey of chemical exploration.
    Product Overview
    There is now a substance called 2-chloro-4- (trifluoromethoxy) bromobenzene. Its characteristics are unique and unique. This substance is synthesized by a delicate method and has undergone many trials before it can be formed.
    Looking at its structure, chlorine, bromine and trifluoromethoxy are in their respective positions and interact with each other, resulting in its unique properties. In the field of chemistry, it has a wide range of uses. Or it is a key raw material for organic synthesis, which can lead to various reactions and produce various products; or it can be used as the cornerstone of active ingredients in the development of medicine, for health and well-being.
    The production of this substance also requires careful selection of raw materials and strict control of conditions. Temperature, pressure, and reaction time are all key. It is difficult to get a good product with a little error. However, after unremitting research, a good method has been obtained and can be stabilized for all parties' needs. This 2-chloro-4- (trifluoromethoxy) bromobenzene is a treasure in the field of chemistry, with broad prospects and more innovations can be expected.
    Physical & Chemical Properties
    In 2024, in the field of chemical industry, 2-chloro-4- (trifluoromethoxy) bromobenzene, this compound, the physical and chemical properties are particularly important. Looking at its physical properties, at room temperature, it is mostly colorless to light yellow liquid, just like the clear oil recorded in ancient books, which is prone to change when exposed to light or heat. Its boiling point is about a specific range, as if it is keeping an inherent track. At this point, liquid and gas are transformed, just like ancient water turning into steam, following the laws of nature. The density is slightly heavier than that of water, and it is placed in water, such as a stone sinking abyss.
    When it comes to chemical properties, the groups of chlorine, bromine and trifluoromethoxy in their molecular structures, such as various princes, have their own characteristics. When encountering a nucleophilic reagent, it is as if it is attacked by an enemy, and it is easy to cause nucleophilic substitution, and chlorine or bromine atoms can be replaced. It can also combine with other organic molecules in a specific catalytic environment to form a new structure, just like the ancient marriage family, generate new branches, and contribute to organic synthesis. In chemical research, it is a key quality.
    Technical Specifications & Labeling
    Nowadays, there are chemical products 2-chloro-4- (trifluoromethoxy) bromobenzene, and its technical specifications and identification (commodity parameters) are the key. The preparation of this product requires specific methods, the selection of raw materials must be precise, the proportion is accurate, and the reaction conditions must also be strictly controlled. Parameters such as temperature, pressure, and reaction time are all related to the quality and quantity of the product.
    In terms of labeling, its chemical composition, characteristics, hazard warnings, and safe use methods should be clearly marked. From the technical specification theory, all steps have standards to follow, and there must be no slack. In this way, the quality of 2-chloro-4- (trifluoromethoxy) bromobenzene can be ensured, and it can play its due role in industrial production and scientific research applications, and also ensure the safety of users and the harmlessness of the environment.
    Preparation Method
    The method of preparing 2-chloro-4-trifluoromethoxy bromobenzene is related to the raw materials and production process, reaction steps and catalytic mechanism. First, an appropriate amount of halogenated aromatics is taken as the base material, and the reagent containing trifluoromethoxy is placed in a special reactor. The temperature in the kettle is adjusted to a suitable range, about hundreds of tens of degrees Celsius, and the pressure is controlled at several atmospheres at the same time. Metal salts are used as catalysts to promote the reaction. After several hours, the raw materials gradually undergo chemical transformation and molecular remodeling. After the reaction is completed, the product is purified by distillation and extraction. During distillation, the temperature is precisely controlled, and the product is separated from impurities according to the difference in boiling points of different substances. In extraction, the suitable organic solvent is selected, the product is dissolved in it, and then separated and dried to obtain pure 2-chloro-4- (trifluoromethoxy) bromobenzene. In this process, the ideal yield and purity can be obtained by precise ratio of raw materials, stable control of reaction conditions, and proper catalysis.
    Chemical Reactions & Modifications
    F 2-chloro-4 - (trifluoromethoxy) bromobenzene is also an organic compound. In the field of chemistry, its reaction and modification are crucial.
    To make this substance, a specific halogenation reaction and etherification reaction are often used. When halogenating, choose an appropriate halogenating agent and precisely control its conditions, so that the halogen atom is just at the designated position of the benzene ring to achieve the desired structure. In the step of etherification, it is also necessary to be careful to choose an appropriate etherification reagent and catalyst, so that the trifluoromethoxy group can be successfully integrated.
    In the natural reaction, challenges are often encountered. If the reaction selectivity is difficult to control, side reactions are clustered, resulting in poor product purity. In order to improve its properties, efforts can be made to adjust the temperature, pressure, catalyst dosage, etc. according to the reaction conditions. Or specific substituents can be introduced to adjust the electron cloud density of the molecule and improve its reactivity and selectivity. After so much research, high purity and high performance 2-chloro-4 - (trifluoromethoxy) bromobenzene products can be obtained to meet the needs of chemical, pharmaceutical and other fields.
    Synonyms & Product Names
    Today there is a thing called 2-chloro-4- (trifluoromethoxy) bromobenzene. Although its name is complex, it is very important in our chemical research. There are also many aliases for this thing, each with its own origin. Or because of its nature, or because of its use, it is called differently.
    Looking at its name, "2-chloro-4- (trifluoromethoxy) bromobenzene", according to the chemical nomenclature, the position of its atoms and groups is precisely marked. And its trade name also varies with the needs of the market and the way it is used. The so-called methyl fluorobromochlorobenzene is given the name of its key atom, which is simple and clear; there are also those who call trifluoromethoxybromochlorobenzene, highlighting its unique group structure.
    Such foreign objects with the same name and the same name are not uncommon in the field of chemistry. They are all for easy research and use. When we study this thing, we must understand its names, so that we can travel freely in the road of experiments, explore its secrets, and make the best use of it, adding to the progress of chemistry.
    Safety & Operational Standards
    2-Chloro-4- (trifluoromethoxy) bromobenzene, this chemical substance is related to safe production and operation practices, and is extremely important and needs to be treated with caution.
    During production and preparation, all raw materials and reagents must be pure and free of impurities, and accurate measurement is required. The reaction device also needs to be strictly checked to ensure that the air is well sealed and there is no risk of leakage. When operating, follow the established procedures to control the reaction temperature, pressure and time without any slack. The reaction process needs to be closely monitored, and if there is any abnormality, it should be disposed of immediately.
    For storage, it should be placed in a cool, dry and well-ventilated place, away from fire and heat sources. Be sure to store it separately from oxidants, acids, alkalis, etc., and do not mix it. The storage area should be equipped with suitable materials to contain leaks.
    During transportation, ensure that the container is stable and free from damage or leakage. Transportation vehicles should be equipped with the corresponding variety and quantity of fire equipment and leakage emergency treatment equipment. Driving routes should avoid densely populated areas and follow the designated route.
    When using, operators must undergo special training and strictly abide by the operating procedures. It is recommended that operators wear self-priming filter gas masks (full masks), tape gas suits, and rubber gloves. The operating environment should be well ventilated, away from fire and heat sources. Use explosion-proof ventilation systems and equipment. Prevent steam leakage into the workplace air. Avoid contact with oxidizing agents, acids, and alkalis.
    In the event of a leak, quickly evacuate personnel from the contaminated area of the leak to a safe area, quarantine, and strictly restrict access. Cut off the source of fire. It is recommended that emergency personnel wear self-contained positive pressure breathing apparatus and anti-virus clothing. Cut off the source of leakage as much as possible. Prevent it from flowing into restricted spaces such as sewers and drainage ditches. Small leaks: Absorb with sand, vermiculite or other inert materials. Large leaks: Construct embankments or dig pits for containment. Cover with foam to reduce vapor disasters. Transfer to a tanker or special collector with a pump, recycle or transport to a waste disposal site for disposal.
    These are the safety and operation specifications for 2-chloro-4- (trifluoromethoxy) bromobenzene, which are related to personnel safety and the environment and should not be ignored.
    Application Area
    2-Chloro-4- (trifluoromethoxy) bromobenzene is also an organic compound. Its application field is quite wide. In the field of pharmaceutical synthesis, it is often a key intermediary. Based on this compound, it can make many special drugs, treat various diseases, and save people from diseases. In the creation of pesticides, it also has extraordinary performance. It can derive high-efficiency and low-toxicity pesticides, protect crops from pests, and ensure a bumper harvest. And in the field of materials science, it also has its application. Or it can help develop new materials with specific properties, suitable for different scenarios. In short, 2 - chloro - 4 - (trifluoromethoxy) bromobenzene has important value in various application fields, which can contribute to the development of various industries and promote their prosperity.
    Research & Development
    In recent years, Yu dedicated himself to the research of 2-chloro-4- (trifluoromethoxy) bromobenzene. This compound has great potential in the field of organic synthesis.
    At the beginning, I explored the method of its synthesis, and went through various attempts. The traditional path has many obstacles, and the yield is not as satisfactory. So I thought about new ways, studied the literature, referred to ancient methods, and also learned from Westerners' wonderful skills.
    After repeated experiments, adjusted the reaction conditions, controlled temperature, adjusted speed, and selected a suitable catalyst. Finally, a method was obtained, which can increase its yield and the purity of the product is also good.
    On this basis, look forward to the future development. This compound may be used to create new types of pharmaceuticals to fight difficult diseases; it is also expected to be used in the preparation of exquisite materials to improve the properties of materials. I will continue to study and hope to expand its application, contribute to the academic and industrial circles, and promote its steady progress in research and development.
    Toxicity Research
    2-Chloro-4- (trifluoromethoxy) bromobenzene is also a chemical substance. As a chemical researcher, it is a priority to investigate its toxicity.
    Viewing this substance may have its uses in the field of chemical synthesis. However, the study of toxicity should not be ignored. At the beginning, try it with various experimental organisms. Observe its state after contact with this substance, observe its behavior and physiological changes.
    If the skin touches it, there may be signs of irritation, such as redness, swelling, and pain. If you inhale its breath, it may damage your breathing system, and the risk of coughing, wheezing, and even choking is not a lie. And after entering the body, it can damage the liver and kidney through the process of metabolism, or leave damage to the organs.
    Although this substance has its value in industry and scientific research, the toxicity must be studied in detail to understand the harm, so that it can be used effectively to avoid disasters and ensure the safety of people and the environment.
    Future Prospects
    I have studied 2 - Chloro - 4 - (Trifluoromethoxy) Bromobenzene. Looking at its properties, it has unique chemical properties and may have great potential in various fields.
    Looking to the future, one is in pharmaceutical research and development, or as a key intermediate, to help create new drugs and relieve the suffering of patients. Second, in materials science, it can produce new functional materials, suitable for high-tech. Third, in fine chemicals, it can optimize production processes and improve product quality.
    Although current research has made progress, the road ahead is still long. It is necessary for our generation of researchers to make unremitting exploration to understand its more potential, hope for human well-being, and expand a broad path, so that this material can bloom in the untapped opportunity and become a powerful pillar for future development.
    Where to Buy 2-Chloro-4-(Trifluoromethoxy)Bromobenzene in China?
    As a trusted 2-Chloro-4-(Trifluoromethoxy)Bromobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 2-Chloro-4-(Trifluoromethoxy)Bromobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What is the main use of 2-Chloro-4- (Trifluoromethoxy) Bromobenzene?
    2-Chloro-4- (trifluoromethoxy) bromobenzene is a crucial compound in the field of organic synthesis. Its main uses cover the following ends.
    In the synthesis of medicine, this compound is often a key intermediate. Due to the unique electronic effect and spatial structure of trifluoromethoxy and halogen atoms, the molecule is endowed with special physicochemical properties and biological activities. Using this as a starting material, compounds with complex structures and specific pharmacological activities can be constructed through many chemical reactions, such as nucleophilic substitution, coupling reactions, etc. For example, it may be used to create new antimicrobial drugs. By combining its special structure with key targets in bacteria, it inhibits the growth and reproduction of bacteria and contributes greatly to human health and well-being.
    In the field of pesticides, there are also significant uses. Due to its unique chemical structure, high-efficiency, low-toxicity and environmentally friendly pesticides can be derived. Such pesticides can precisely act on specific physiological processes of pests, such as interfering with the transmission of the pest's nervous system, or inhibiting the activity of key enzymes in its body, thus achieving good insecticidal effect. At the same time, it has little impact on the environment and non-target organisms, which is in line with the current needs of green agriculture development.
    In the field of materials science, 2-chloro-4- (trifluoromethoxy) bromobenzene has also emerged. It can be used as a raw material for the synthesis of special functional polymer materials. After polymerization, its structural units are introduced into the polymer chain, giving the material such as excellent chemical resistance, thermal stability or optical properties. For example, packaging materials used in high-end electronic devices can rely on their good performance to ensure the stable operation of electronic devices in complex environments.
    In summary, the unique structure and properties of 2-chloro-4 - (trifluoromethoxy) bromophenyl have non-negligible uses in many fields such as medicine, pesticides and materials science. It is an important cornerstone of organic synthetic chemistry and promotes the continuous development of related fields.
    What are the physical properties of 2-Chloro-4- (Trifluoromethoxy) Bromobenzene?
    2-Chloro-4- (trifluoromethoxy) bromobenzene is one of the organic compounds. Its physical properties are quite characteristic, let me tell you in detail.
    Looking at its appearance, under room temperature and pressure, it is mostly colorless to light yellow liquid, clear and translucent, like a clear spring, but its chemical properties should not be underestimated. The smell of this substance has a special aroma, but it should be smelled with caution, because it may have a certain impact on the human body.
    When it comes to the melting point, the melting point is very low, and it is difficult to form a solid state at common ambient temperatures. The boiling point is relatively moderate, and the specific value varies depending on the conditions of accurate determination. This property makes it easy to volatilize and flow within a certain temperature range, just like smart water, which can move freely in the container.
    In terms of solubility, 2-chloro-4 - (trifluoromethoxy) bromobenzene exhibits good solubility in organic solvents. Common organic solvents such as ethanol, ether, and dichloromethane can be fused with it, just like water emulsion blends to form a uniform system. However, in water, its solubility is minimal, just like the mutual exclusion of oil and water, and it is difficult to dissolve.
    Density is also one of its important physical properties. Compared to water, its density is slightly higher, so if it is placed in the same container as water, it can be seen that it sinks to the bottom of the water, like a stone falling into a deep pool, which is clearly recognizable.
    In addition, the stability of this compound is acceptable, and there is also potential danger in the event of hot topics, open flames or strong oxidants. Like a calm lake, although it is calm, it can also set off violent waves if it is thrown into boulders.
    The above is the main physical property of 2-chloro-4- (trifluoromethoxy) bromobenzene, which has important uses in many fields such as organic synthesis. However, when using it, be careful and follow relevant procedures to ensure safety.
    What are the synthesis methods of 2-Chloro-4- (Trifluoromethoxy) Bromobenzene?
    There are several methods for synthesizing 2-chloro-4- (trifluoromethoxy) bromobenzene.
    First, halogenated aromatics are used as starting materials. You can first take suitable halogenated benzene, such as p-chlorobromobenzene, and make it react with trifluoromethoxylation reagents. This reaction needs to be carried out under suitable reaction conditions, such as selecting a suitable base and solvent. The base can be potassium carbonate, sodium carbonate, etc., and the solvent can be N, N-dimethylformamide (DMF), dimethyl sulfoxide (DMSO) and the like. Under the condition of heating, the trifluoromethoxy negative ion in the trifluoromethoxylation reagent attacks the specific position of the halogenated benzene and replaces the corresponding halogen atom, thereby generating the target product 2-chloro-4- (trifluoromethoxy) bromobenzene. The key to this method is to precisely control the reaction conditions to ensure the selectivity and yield of the reaction.
    Second, start from phenolic compounds. First, the corresponding phenol is halogenated to obtain a halogenated phenol derivative. After that, the halogenated phenol derivative is reacted with the trifluoromethylation reagent. A trifluoromethylation reagent such as sodium trifluoromethanesulfonate can be used to convert phenolic hydroxyl to trifluoromethoxy under the action of copper salts or other catalysts, and then 2-chloro-4- (trifluoromethoxy) bromobenzene can be prepared. In this path, the selectivity of the halogenation step and the activity and selectivity of the catalyst have a great influence on the formation of the final product.
    Third, the cross-coupling reaction catalyzed by palladium. Select a suitable halogenated aromatic halide, such as 2-chloro-4-bromoiodobenzene, and react with trifluoromethoxy borate or other nucleophiles containing trifluoromethoxy groups in the presence of a palladium catalyst. Palladium catalysts such as tetra (triphenylphosphine) palladium, under the action of bases, catalyze the cross-coupling of halogenated aromatics with nucleophiles to form carbon-oxygen bonds to obtain 2-chloro-4- (trifluoromethoxy) bromobenzene. This method relies on the high-efficiency catalytic performance of palladium catalysts and the synergistic effect of each component in the reaction system to achieve the effective synthesis of the target product.
    Each synthesis method has its own advantages and disadvantages. The appropriate synthesis path should be comprehensively considered according to actual needs, such as the availability of raw materials, cost, and difficulty in controlling reaction conditions.
    What are the precautions for 2-Chloro-4- (Trifluoromethoxy) Bromobenzene during storage and transportation?
    2-Chloro-4- (trifluoromethoxy) bromobenzene is a chemical commonly used in organic synthesis. When storing and transporting, many important items must not be ignored.
    First of all, this substance needs to be stored in a cool, dry and well-ventilated place. The cover is prone to change when exposed to heat or moisture due to its chemical properties. Heat can cause its molecular activity to increase, triggering decomposition or other chemical reactions; humid environment may cause moisture to participate in the reaction and cause it to deteriorate. Therefore, the temperature of the warehouse should be controlled within a specific range, and the humidity should also be paid attention to. And because of its certain toxicity and irritation, the storage place must be kept away from fire and heat sources, and it must be stored in isolation from oxidants, acids, alkalis, etc., to prevent interaction and unexpected disasters.
    As for transportation, caution is also required. Transportation vehicles should ensure that they are in good condition and have corresponding anti-leakage, fire and explosion-proof facilities. This chemical must be properly packaged, and the packaging materials used should be able to resist vibration, collision and friction, so as not to leak. During transportation, escorts must strictly guard their posts and pay close attention to the status of the goods. Driving routes should avoid crowded places and important places to prevent leakage and endanger the public. If a leak occurs, emergency measures should be taken immediately, evacuate surrounding personnel, seal the scene, and properly dispose of it in accordance with relevant procedures.
    In conclusion, 2-chloro-4- (trifluoromethoxy) bromobenzene is related to safety and quality in all aspects of storage and transportation, and must not be neglected.
    What is the market price of 2-Chloro-4- (Trifluoromethoxy) Bromobenzene?
    Today, there is a question about the market price of 2-chloro-4- (trifluoromethoxy) bromobenzene. This compound is also an important raw material for organic synthesis, and is widely used in many fields such as medicine, pesticides, and materials science.
    It is not easy to know its market price. It often changes due to a variety of factors. The first to bear the brunt is the state of market supply and demand. If the market demand for it is strong and the supply is limited, the price will rise; on the contrary, if the supply exceeds the demand, the price will drop.
    Furthermore, the cost of production is also the key. The price of raw materials, the simplicity of the production process, and the amount of energy consumption will all affect its cost. If raw materials are scarce and expensive, or the production process is complicated, many steps and expensive equipment are required, or energy consumption is huge, the cost will rise and the price will also be higher.
    In addition, the number of manufacturers and the competitive situation also affect the price. There are many manufacturers, and the competition is fierce. In order to compete for market share, there may be price reductions; if there are few manufacturers, it is almost monopolistic, and the pricing power is in the hands of a few, and the price may remain high.
    In addition, the price varies depending on the region. In places with convenient transportation and mature markets, the price may be relatively stable and reasonable due to low logistics costs and smooth information flow; in remote places, the price may be higher due to inconvenient transportation and small market size.
    According to the current situation, the price of 2-chloro-4- (trifluoromethoxy) bromobenzene may fluctuate within a certain range due to the intertwining of the above factors. However, the exact price needs to be checked in detail on the chemical raw material trading platform and consulted with manufacturers and merchants.