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2-Chloro-4-Fluorobenzenethiol

2-Chloro-4-Fluorobenzenethiol

Hongda Chemical

Specifications

HS Code

412957

Chemical Formula C6H4ClFS
Molecular Weight 162.61
Appearance Typically a liquid with a characteristic odor
Boiling Point Approximately 198 - 200 °C
Density Data may vary, around 1.3 - 1.4 g/cm³
Solubility In Water Low solubility in water, as it is an organic compound
Solubility In Organic Solvents Soluble in common organic solvents like ethanol, ether, and dichloromethane
Flash Point Caution: Flammable, flash point data may be around 70 - 80 °C
Pka For the thiol group, pKa is likely in the range of 9 - 11, indicating relative acidity of the thiol

As an accredited 2-Chloro-4-Fluorobenzenethiol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 2 - chloro - 4 - fluorobenzenethiol in 500g bottles, well - sealed for chemical storage.
Storage 2 - Chloro - 4 - fluorobenzenethiol should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. It should be kept in a tightly - sealed container, preferably made of corrosion - resistant materials due to its potentially reactive nature. Store it separately from oxidizing agents, strong acids, and bases to prevent hazardous reactions.
Shipping 2 - Chloro - 4 - fluorobenzenethiol is shipped in tightly sealed, corrosion - resistant containers. These are packed in sturdy outer packaging to prevent damage during transit. Special care is taken due to its chemical nature to ensure compliance with safety regulations.
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2-Chloro-4-Fluorobenzenethiol 2-Chloro-4-Fluorobenzenethiol
General Information
Historical Development
2-Chloro-4-fluorothiophenol is also a chemical substance. Its origin is from the past, and it is difficult to study the physical properties of the family and explore the chemical transformation of the chemical substance. At the beginning, the knowledge of this compound is still unknown, and it has occasionally been observed in the laboratory.
It is difficult to explore the properties and methods of 2-chloro-4-fluorothiophenol. From the crude method, it is exquisite. I know a thing or two about it, to the point where I know the reverse.
Today, 2-chloro-4-fluorothiophenol has its uses in chemical, chemical, and other fields. Looking back at its history, it can be transformed into a new family, which is new and new. With the wonder of human creation, this compound has become famous. To this day, it is essential to replace it.
Product Overview
Description of 2-chloro-4-fluorothiophenol
Fu2-chloro-4-fluorothiophenol is a key material in organic synthesis. It has a unique chemical conformation, with chlorine and fluorine atoms attached to the benzene ring, and thiol groups are also connected to it.
Looking at its physical properties, at room temperature, it is often a colorless to slightly yellow liquid with a special mercaptan odor. Its physical constants such as boiling point and melting point are unique due to the interaction of atoms in the molecule, which is an important consideration in chemical operations.
In terms of its chemical properties, thiol groups are highly active and easily participate in many chemical reactions. It can be substituted with electrophilic reagents, and can also participate in condensation and other reactions under specific conditions. It is often a key intermediate in the preparation of fine chemicals such as medicines and pesticides, helping to synthesize a variety of complex organic molecules.
However, this substance also needs to be properly disposed of. Due to its special smell and some chemical properties, it should follow strict procedures when storing and using it to ensure safety and efficiency.
Physical & Chemical Properties
2-Chloro-4-fluoro-thiophenol has unique physical and chemical properties. Its shape or liquid, the concept of clear and transparent, has a specific taste. The number of boiling points, about in a specific range, varies depending on the air pressure. The melting point is also fixed, and its state changes at this temperature.
Its solubility is more soluble in organic solvents, such as water, slightly soluble or insoluble. Due to the molecular structure, chlorine and fluorine atoms interact with benzene rings and thiol groups, causing them to be different from different solvents.
Chemical activity, due to thiol groups, can react with many reagents. If it encounters with oxidants, thiol groups are volatile and become derivatives of high-valent sulfur. The chlorine and fluorine atoms also change the electron cloud distribution of benzene ring, which affects the difficulty of electrophilic and nucleophilic reactions.
Technical Specifications & Labeling
Today there is a product called 2 - Chloro - 4 - Fluorobenzenethiol. The process specifications and identification (commodity parameters) of this substance are the focus of our research.
The process specifications are determined from the method of synthesis, the combination of various raw materials, the temperature, pressure and time of the reaction. All elements must be controlled in a precise way to obtain good products.
For the identification (commodity parameters), the color and taste of this product need to be clear; its purity geometry, a number of impurities, are also key. Furthermore, the physical and chemical properties, such as the point of melting and boiling, and the ability to dissolve, should be clearly marked so that users can know their properties and make good use of them. In this way, it can be used in various applications to fully demonstrate the power of this thing.
Preparation Method
To prepare 2-chloro-4-fluorothiophenol, the method is as follows: Prepare raw materials, use 4-fluoro-2-nitrochlorobenzene as the starting material, and use sodium hydrosulfide as the sulfur source. In the first step, place 4-fluoro-2-nitrochlorobenzene and sodium hydrosulfide in an appropriate proportion in a reactor, control the temperature at about 60 to 80 degrees Celsius, and stir the reaction number. This is the step of nucleophilic substitution. Nitro is replaced by thiohydrogen to obtain 4-fluoro-2-chlorothiophenol sodium. Second, the product is treated with dilute acid, the pH is adjusted to acidic, and the 4-fluoro-2-chlorothiophenol sodium is converted into 2-chloro-4-fluorothiophenol. After extraction, distillation and other purification methods, the pure product can be obtained. The process requires temperature control, time control and material ratio to ensure complete reaction and improve yield.
Chemical Reactions & Modifications
Recently, the chemical and anti-chemical modification of 2-chloro-4-fluorothiophenol has been studied, and some results have been obtained. The properties of this compound are not special, and its reverse circuit has a research value.
In the normal reaction, 2-chloro-4-fluorothiophenol often follows the established principle, and the chlorine atom or fluorine atom can be arranged under specific conditions. However, we have used a new method to improve the anti-chemical medium and the uniformity of the catalyst, resulting in different chemical distributions.
Such modification makes 2-chloro-4-fluorothiophenol exhibit different chemical activities. This will not only deepen our understanding of its chemical properties, but also explore the synthesis of its derivatives. In the future, we will delve deeper into it, hoping to make it more useful in the fields of materials science or physical research.
Synonyms & Product Names
2-Chloro-4-fluoro-thiophenol is also a chemical substance. Its synonymous name and the name of the commodity are related to the identification and circulation of this substance. In the field of chemistry, there are many things, and the common image is also. 2-chloro-4-fluoro-thiophenol, or another name, to meet different scenarios and uses. The name of this compound is based on the rules of chemical naming, but in the city, either for convenience or to highlight its characteristics, it can be named as a different commodity.
The name of the synonym can help scholars and researchers communicate their meanings and avoid confusion. The name of the commodity is related to the promotion and identification of the market. Although the two expressions are different, they refer to this 2-chloro-4-fluorothiophenol. On the experimental stage, under the name of synonyms, this substance can be approved; on the road of commerce, under the name of commodities, it can be purchased explicitly. The two complement each other and are of great significance to the research of chemistry and the development of industry.
Safety & Operational Standards
2-Chloro-4-fluorothiophenol is a special chemical product. During its experiment and production process, safety and operating standards are of paramount importance, and it should not be slack.
In terms of safety, this substance has certain potential hazards. Its odor may irritate the respiratory tract, so when operating, it must be in a well-ventilated place, and effective ventilation equipment should be prepared to keep the air fresh and circulating to avoid the accumulation of harmful gases. If it comes into contact with the skin, it should be rinsed with a lot of water immediately, and then according to the specific situation, or seek medical treatment, it must not be taken lightly. If it splashes into the eyes, it is even more necessary to rinse with a lot of flowing water immediately. The rinsing time should be long, and then seek professional medical assistance quickly.
As far as the operating specifications are concerned, when taking the substance, precise measuring tools should be used to ensure that the dosage is accurate and correct, so as to achieve the expected effect of experiment or production. All kinds of instruments used must be carefully checked in advance to ensure that there is no damage, no blockage, and clean to prevent impurities from mixing and affecting the properties of the substance and the experimental results. During the operation, strictly follow the established procedures, and do not change the steps or adjust the parameters without authorization. After the experiment is completed, properly dispose of the remaining substances, and must not be discarded at will to prevent pollution to the environment. Relevant appliances also need to be cleaned, sorted and returned in time for next use.
In this way, strict adherence to safety and operating standards can ensure the smooth development of 2-chloro-4-fluorothiophenol-related work, avoid accidents, and maintain personnel safety and environmental cleanliness.
Application Area
2-Chloro-4-Fluorobenzenethiol, organic compounds are also. Its application field is quite wide, in the field of medicinal chemistry, it can be a key intermediate for the creation of new drugs. It covers its unique chemical structure and can interact with specific targets in organisms to help drugs accurately play their effects.
In the field of materials science, it is also possible. Or it can participate in the synthesis of special materials, endowing materials with unique properties, such as improving their stability and enhancing their functionality.
In the field of organic synthetic chemistry, it is an important building block for the construction of complex organic molecules. With its active functional groups, through exquisite reaction design, a variety of organic compounds can be derived, expanding the boundaries of organic synthesis, and providing a solid chemical foundation for the development of related fields.
Research & Development
In recent years, I have studied 2 - Chloro - 4 - Fluorobenzenethiol in the field of chemical industry. Its properties are different, and it has a unique effect in various reactions. At the beginning, analyze its structure, explore the arrangement of atoms and the connection of bonds, and understand why it has this property.
Then, try different methods to control it. After many attempts, the method is quite good, the yield is increasing, and the purity is also expected. And in different environments, looking at its changes, we know that temperature, pressure, and the amount of agent have an impact.
And think about its use, in the genus of medicine and materials, or it can open up new avenues. Therefore, join experts to explore the possibility. Although I have achieved something today, the road ahead is still far away. I must hold the heart of research, and hope to use it widely in the future, add luster to the industry, and promote the progress of this field.
Toxicity Research
To study the toxicity of 2-chloro-4-fluorothiophenol. Detail its chemical and physical properties, and study it in various reactions and environments.
Observe its structure, chlorine and fluorine are connected to benzene ring and sulfhydryl group, and this structure may cause unique toxicity. In the experiment, it was measured with various biological models. Apply it to mice to observe their behavior and physiological changes. Observe their eating and activity, check their organs, and test biochemical indicators.
And explore its degradation in the environment, observe its decomposition products, and measure its impact on the surrounding ecology. After research, it was found that 2-chloro-4-fluorothiophenol has certain toxicity, which disturbs biological physiological functions and also has latent risks in the environment. Follow-up research should be deepened to clarify its toxicology and seek prevention and control strategies to protect the safety of life and the environment.
Future Prospects
I have tried to study chemical substances. Looking at this product 2 - Chloro - 4 - Fluorobenzenethiol now, I think about its future development, and I have some thoughts.
This material is unique and may be of great use in various fields of chemical industry. Looking at today's situation, science and technology are changing, and the demand for materials is gradually increasing. This product may be made into a new type of material. With its characteristics, the material has extraordinary capabilities, and it can be used in electronics and medicine.
And the chemical industry is focusing on environmental protection. If this product can be used well, it may be used in a green process to reduce pollution and harm, which is convenient for the times. In the future, it may be possible to borrow the progress of scientific research to expand its use and expand its field. Research and development, explore its new quality, make it shine in various industries, become a treasure of the future chemical industry, develop infinite possibilities, contribute to the progress of the world, and make a grand road that has not yet been developed.
Where to Buy 2-Chloro-4-Fluorobenzenethiol in China?
As a trusted 2-Chloro-4-Fluorobenzenethiol manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 2-Chloro-4-Fluorobenzenethiol supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 2-Chloro-4-Fluorobenzenethiol?
2-Chloro-4-fluorothiophenol has a wide range of uses. In the field of medicinal chemistry, it is an indispensable key intermediate for the synthesis of many specific drugs. The structure of gointhiophenol has a unique chemical activity, which can be combined with other functional groups through various chemical reactions, so that compounds with complex structures and specific pharmacological activities can be constructed. For example, when developing new antimicrobial drugs, 2-chloro-4-fluorothiophenol can introduce specific groups to enhance the penetration of the drug into the bacterial cell wall and improve the antibacterial efficacy.
It also plays an important role in the field of materials science. In the process of preparing high-performance organic semiconductor materials, 2-chloro-4-fluorothiophenol can participate in the polymerization reaction and endow the material with unique electrical and optical properties. Due to the presence of fluorine and chlorine atoms, the electron cloud distribution of the material can be adjusted, and the charge transfer efficiency can be improved. The resulting organic semiconductor materials exhibit excellent performance in device applications such as organic light emitting diodes (OLEDs) and organic field effect transistors (OFETs).
Furthermore, in the field of pesticide chemistry, this compound can be used as an important raw material for the synthesis of high-efficiency and low-toxicity pesticides. With its chemical structure characteristics, pesticides with high selectivity and strong lethality to specific pests can be designed and synthesized, while reducing the harm to the environment and non-target organisms, meeting the needs of today's green pesticide development.
In summary, 2-chloro-4-fluorothiophenol has important uses in many fields such as medicine, materials, pesticides, etc., and is of great significance to promote the development of related industries.
What are the physical properties of 2-Chloro-4-Fluorobenzenethiol?
2-Chloro-4-fluorothiophenol is one of the organic compounds. Its physical properties are unique, let me come one by one.
Looking at its properties, at room temperature, it is mostly in the form of a colorless to light yellow liquid, with a clear and translucent appearance, just like the warm and moist jade liquid, which may be slightly shiny under light. This substance has a special smell, which can be smelled. Its taste may be irritating, and it has a unique smell of sulfur compounds. It is like being in a small chemical world that emits a unique smell.
When it comes to the melting point, due to the influence of chlorine and fluorine atoms in the molecular structure, the intermolecular forces are different. Its melting point is low, about -10 ° C to -5 ° C, just like the thin ice that has not yet condensed in winter. With a slight change in temperature, it is easy to change its shape.
In terms of boiling point, depending on factors such as intermolecular forces and relative molecular mass, the boiling point hovers roughly between 190 ° C and 200 ° C. If it needs to reach a specific temperature, it can boil and tumble, turning into a gaseous state.
The density is about 1.35g/cm ³ - 1.45g/cm ³, which is slightly heavier than the density of water. It is like a stable utensil that will slowly sink when thrown into water.
Solubility is also an important physical property. This compound is insoluble in water, because water is a polar solvent, and 2-chloro-4-fluorothiophenol has relatively weak polarity. According to the principle of "similar miscibility", the two are difficult to fuse. However, among organic solvents such as ethanol, ether, acetone, etc., it has good solubility, as if it can blend with these organic solvents and form a uniform solution system together.
In addition, 2-chloro-4-fluorothiophenol has a certain volatility. In the air, its molecules may gradually dissipate, just like the light mist, slowly drifting away, but its volatility is slightly slower than that of some low-boiling volatile compounds.
What are the chemical properties of 2-Chloro-4-Fluorobenzenethiol?
2-Chloro-4-fluoro-thiophenol is an organic compound with unique and interesting chemical properties.
As far as its acidity is concerned, the sulfur-hydrogen bond (S-H) in thiophenol compounds is relatively easy to dissociate due to the large radius of sulfur atoms and the weak binding force on hydrogen atoms, so it presents a certain acidity, and its acidity is stronger than that of the corresponding alcohols. In this compound, due to the existence of chlorine and fluorine atoms, the electronic effect changes, or the acidity is affected. Chlorine and fluorine are highly electronegative atoms, which have an electron-absorbing induction effect, which can enhance the stability of thiophenol negative ions, and then improve the acidity.
Talking about nucleophilicity, the outer layer of sulfur atom has lone pair electrons, which is nucleophilic. Under suitable reaction conditions, it can be used as a nucleophilic reagent to participate in many nucleophilic substitution reactions. In the nucleophilic substitution of halogenated hydrocarbons, the sulfur atom of thiophenol can attack the carbon atom of halogenated hydrocarbons, and the halogen atom leaves to form a new carbon-sulfur bond. In this compound, although chlorine and fluorine atoms occupy the position of benzene ring, they have a complex impact on the nucleophilicity of sulfur atoms. The electron-absorbing effect may reduce the electron cloud density of sulfur atoms and slightly weaken the nucleophilicity. However, factors such as steric hindrance need to be considered.
In terms of redo Thiophenol is easily oxidized by mild oxidants such as oxygen in the air to form disulfides. During this process, the valence of sulfur atoms increases and an oxidation reaction occurs. And due to the electronic effect of chlorine and fluorine atoms on the benzene ring, the oxidation reaction activity may change. Under specific conditions, if a strong reducing agent is encountered, it may cause the halogen atoms on the benzene ring to undergo reactions such as reductive dehalogenation, etc. However, such reaction conditions are more severe, requiring specific reagents and environments.
And because it contains halogen atoms such as chlorine and fluorine, in some reactions, halogen atoms can participate in the reaction. For example, under metal catalysis, the coupling reaction of halogenated aromatics can occur, and more complex organic molecular structures can be constructed. Its chemical properties are rich and diverse, and it has potential application value in organic synthesis and other fields.
What are 2-Chloro-4-Fluorobenzenethiol synthesis methods?
The synthesis method of 2-chloro-4-fluorothiophenol, although the ancient book "Tiangong Kaiwu" does not contain the synthesis method of this specific compound, we can deduce it according to chemical principles and previous methods of synthesizing analogs.
First, 2-chloro-4-fluoroaniline is used as the starting material. First, it reacts with sodium nitrite and hydrochloric acid at low temperature to form a diazonium salt. This reaction requires fine temperature control, about 0-5 ° C, to prevent the decomposition of diazonium salts. The diazonium salt reacts with potassium thiocyanate to form 2-chloro-4-fluorobenzene thiocyanate. After acid or base catalyzed hydrolysis, 2-chloro-4-fluorophenylthiophenol can be obtained.
Second, 2-chloro-4-fluorobromobenzene is used as raw material. Under the protection of inert gas, it reacts with magnesium chips to prepare Grignard's reagent. Grignard's reagent reacts with carbon disulfide to generate 2-chloro-4-fluorophenyldithiocarboxylate. After acid treatment, it can be converted into the target product 2-chloro-4-fluorophenylthiophenol.
Third, 2-chloro-4-fluorobenzoic acid is used as the starting material. It is first converted into an acyl chloride, and then reacted with potassium thioacetate to form 2-chloro-4-fluorobenzene thioacetate. Finally, it is hydrolyzed and acidified under alkaline conditions to obtain 2-chloro-4-fluorothiophenol.
Synthesis requires precise control of various reaction conditions, such as temperature, reaction time, and reactant ratio. The equipment used also needs to be clean and dry to ensure smooth reaction and improve product purity and yield.
What are the precautions in storage and transportation of 2-Chloro-4-Fluorobenzenethiol?
2-Chloro-4-fluorothiophenol is an organic compound. When storing and transporting, many matters need to be paid attention to.
It is toxic and irritating to a certain extent, and is harmful to both the human body and the environment. When storing, it should be placed in a cool and well-ventilated place, away from fire, heat sources, and direct sunlight. It is easy to decompose due to heat, releasing toxic gases and causing safety accidents. The container must be sealed to prevent leakage.
2-chloro-4-fluorothiophenol is sensitive to air and moisture. In the air or in contact with water, or chemically react, the quality and stability will be reduced. Therefore, the storage place should be dry and can be protected by inert gas if necessary.
Because it is an organic sulfur compound, it has a special odor and is flammable. The storage area should be kept away from oxidants, acids, etc., to prevent violent reactions.
When transporting, choose appropriate packaging and transportation methods in accordance with relevant regulations. The packaging must be strong, sealed, and marked with clear warning signs to indicate its danger. During transportation, ensure that the container does not leak, collapse, fall, or damage, and prevent mixed transportation with other items.
Those who operate and come into contact with this substance need professional training and operate in strict accordance with the operating procedures. Wear appropriate protective equipment, such as gas masks, chemical safety glasses, acid and alkali gloves, etc., to avoid direct contact.
If a leak occurs during storage or transportation, personnel from the contaminated area of the leak should be quickly evacuated to the safe area, quarantined, and access should be strictly restricted. Emergency personnel wear self-contained positive pressure breathing apparatus and anti-virus clothing to cut off the source of the leak as much as possible. Small leaks, mixed with sand, dry lime or soda ash, collected in a dry, clean, covered container. Large leaks, build a dike or dig a pit to contain, covered with foam, reduce vapor disasters, and transfer to a tanker or special collector by pump, recycled or transported to a waste disposal site for disposal.