2-Chloro-4-fluorophenylboronic acid has a wide range of uses. In the field of organic synthesis, it is often a key reagent.
In organic synthesis, it can participate in the Suzuki coupling reaction. This reaction is extremely important and can form carbon-carbon bonds. 2-chloro-4-fluorophenylboronic acid can react with halogenated aromatics or halogenated olefins under the action of suitable catalysts and bases by virtue of its own structural properties. With this, chemists can prepare a series of organic compounds with specific structures and functions, such as novel drug molecules, photoelectric materials, etc.
In the field of drug research and development, the construction of many drug molecules requires precise carbon-carbon bond formation steps. The reaction involving 2-chloro-4-fluorophenylboronic acid can provide an effective way to synthesize pharmaceutically active ingredients with complex structures. Due to the presence of chlorine and fluorine atoms in its structure, it can endow the obtained products with unique physicochemical properties and biological activities, which is conducive to the development of drugs with more curative effects and lower side effects.
In the field of materials science, this substance also has important applications. In the preparation of organic optoelectronic materials, specific structural units are introduced through the Suzuki coupling reaction, which can regulate the photoelectric properties of the materials. For example, organic semiconductor materials with specific emission wavelengths or carrier transport properties are synthesized for use in devices such as organic Light Emitting Diodes (OLEDs) and organic solar cells to improve their performance and efficiency.

2-Chloro-4-fluorophenylboronic acid, its physical properties are as follows:
This substance usually appears as a white to off-white solid, which is a common appearance characteristic of many organic boric acid compounds. Its melting point is in a specific range, about [specific melting point value] degrees Celsius. The melting point is of great significance for the identification and purification of this compound. By means of melting point determination, its purity can be judged. If impurities exist, the melting point tends to decrease and the melting range becomes wider.
2-chloro-4-fluorophenylboronic acid has limited solubility in water and belongs to slightly soluble substances in water. However, it can be better dissolved in some common organic solvents, such as dichloromethane, tetrahydrofuran, N, N-dimethylformamide, etc. This solubility characteristic is quite critical in organic synthesis operations. For example, during the reaction, the appropriate reaction solvent needs to be selected according to its solubility to ensure the smooth progress of the reaction; during the separation and purification of the product, the difference in solubility can also be used to achieve separation from impurities by means of extraction.
From the perspective of density, its density is about [specific density value] g/cm3. The physical property of density is very important when it comes to measuring the volume for reaction or processing a large amount of the substance. The density data can accurately convert the mass and volume to ensure the accuracy of the experiment or production process.
In addition, the substance has a certain stability, but during storage, care should be taken to avoid contact with strong oxidizing agents, strong bases and other substances, as they may chemically react with them and cause deterioration. Under normal temperature and pressure, it can remain relatively stable for a certain period of time, but extreme conditions such as high temperature and high humidity may affect its stability.

There are various ways to synthesize 2-chloro-4-fluorophenylboronic acid. Common ones are as follows.
One is to use 2-chloro-4-fluorobrobenzene as the starting material. First, 2-chloro-4-fluorobrobenzene and magnesium chips are mixed in an organic solvent such as anhydrous ether or tetrahydrofuran under nitrogen protection. In this process, magnesium atoms are inserted between carbon-bromine bonds to form Grignard reagents. Then, the Grignard reagent is slowly dropped into borate esters, such as trimethyl borate, and 2-chloro-4-fluorophenylboronic acid can be prepared by hydrolysis steps. This method requires careful operation, and the requirements for anhydrous and anaerobic conditions are quite high. The yield is acceptable, and the reaction process is clear. It is often used by many synthesizers.
The second is to react with organolithium reagents with 2-chloro-4-fluorobromobenzene. 2-chloro-4-fluorobromobenzene reacts with organolithium reagents such as n-butyl lithium at low temperatures, such as -78 ° C, in anhydrous tetrahydrofuran solvent to form lithiated intermediates. The intermediate is extremely active, and then reacts with borate esters. After hydrolysis, the target product 2-chloro-4-fluorophenylboronic acid can also be obtained. This route has strong reactivity and harsh conditions, and requires precise temperature control. However, it can effectively avoid some side reactions and is beneficial to the improvement of product purity.
Third, transition metal catalysis can be used. Using 2-chloro-4-fluorobromobenzene as the substrate, under the action of transition metal catalysts such as palladium and nickel, such as tetrakis (triphenylphosphine) palladium, reacts with diphenyl alcohol borate esters to generate corresponding borate intermediates. This intermediate is hydrolyzed under alkaline conditions and converted into 2-chloro-4-fluorophenylboronic acid. This method has relatively mild reaction conditions, good selectivity and is more friendly to the environment. In recent years, it has been widely used, providing a new way for the synthesis of this compound. However, the cost of the catalyst may be a consideration.

2-Chloro-4-fluorophenylboronic acid is a commonly used reagent in organic synthesis. During storage and transportation, many matters must not be ignored.
When storing, the first environment. It should be placed in a cool, dry and well-ventilated place. This is because it is quite sensitive to humidity and temperature. If the environment is humid, it is easy to cause hydrolysis, and high temperature may cause changes in its chemical properties, causing it to deteriorate and lose its original reactivity. Therefore, the temperature should be controlled in a specific range, usually 2-8 ° C, which can be achieved by refrigeration.
Furthermore, be sure to pack tightly. Use a sealed container to prevent excessive contact with air. Moisture and oxygen in the air may react with this substance. If oxygen or oxidize it, the moisture will cause hydrolysis, which will damage its quality. The packaging materials used also need to be considered, glass containers or plastic containers can be used, but it is necessary to ensure that it has no chemical reaction with 2-chloro-4-fluorophenylboronic acid.
When transporting, caution is also required. This substance may belong to the category of hazardous chemicals and needs to be properly transported in accordance with relevant regulations and standards. The means of transportation must be clean, dry and free of other substances that may react with it. Violent vibrations and collisions should be avoided on the way to prevent package damage and leakage.
If a leak occurs, emergency response cannot be delayed. It is necessary to quickly evacuate the surrounding personnel and isolate the leakage area. Disposal personnel should wear appropriate protective equipment to prevent contact poisoning. A small amount of leakage can be absorbed by dry sand, vermiculite and other inert materials; a large amount of leakage needs to be dammed and contained before proper disposal.
In short, 2-chloro-4-fluorophenylboronic acid is the key to storage and transportation, temperature and humidity control, strict packaging, transportation regulations and emergency preparedness, and caution is required to ensure its quality and safety.

The market price range of 2-chloro-4-fluorophenylboronic acid is difficult to sum up. Its price often changes due to various factors.
First, the supply and demand trend has a great impact. If the market demand for 2-chloro-4-fluorophenylboronic acid is strong and the supply is limited, the price will increase; conversely, if the supply exceeds the demand, the price will decrease.
Second, the cost of raw materials is also the key. If the price of raw materials required for the preparation of this compound rises, the production cost of 2-chloro-4-fluorophenylboronic acid will also increase, and the price will increase; if the price of raw materials falls, the opposite will happen.
Third, the quality of the production process is related. Sophisticated craftsmanship can reduce costs and increase output, which is conducive to price stability or reduction; if the process is complex and the cost is high, the price is also difficult to reduce.
Fourth, the market competition situation affects the price. There are many manufacturers producing this product in the market, and the competition is fierce. In order to compete for a share, the price may be reduced; there are few manufacturers, and the competition is slow, and the price may remain high.
There are regional differences. Different regions have different prices due to different transportation costs and market environments. Generally speaking, the price per gram may range from tens to hundreds of yuan, but this is only a rough estimate. The actual price must be determined according to the current market conditions.