2-Chloro-4-Fluoro-1-Nitrobenzene

Hongda Chemical

Specifications

HS Code	872905
Chemical Formula	C6H3ClFNO2
Appearance	Yellow - to - orange liquid
Boiling Point	210 - 212 °C
Melting Point	14 - 16 °C
Density	1.487 g/cm³
Solubility	Insoluble in water, soluble in organic solvents like ethanol, ether
Flash Point	87.8 °C
Vapor Pressure	Low vapor pressure at room temperature
Refractive Index	1.553

As an accredited 2-Chloro-4-Fluoro-1-Nitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage

Packing	500g of 2 - chloro - 4 - fluoro - 1 - nitrobenzene in a sealed, corrosion - resistant container.
Storage	2 - Chloro - 4 - fluoro - 1 - nitrobenzene should be stored in a cool, dry, well - ventilated area away from heat and ignition sources. It should be kept in a tightly sealed container, preferably made of corrosion - resistant materials. Separate it from incompatible substances like oxidizing agents, reducing agents, and bases to prevent potential reactions. Store it at a controlled temperature to avoid decomposition.
Shipping	2 - chloro - 4 - fluoro - 1 - nitrobenzene is a hazardous chemical. It must be shipped in accordance with strict regulations. Use appropriate packaging, label clearly, and ensure compliance with transportation safety requirements for dangerous goods.

Free Quote

Competitive 2-Chloro-4-Fluoro-1-Nitrobenzene prices that fit your budget—flexible terms and customized quotes for every order.

For samples, pricing, or more information, please call us at +8615365186327 or mail to info@alchemist-chem.com.

We will respond to you as soon as possible.

Tel: +8615365186327

Email: info@alchemist-chem.com

General Information

Historical Development

2-Chloro-4-fluoro-1-nitrobenzene is also an organic compound. At the beginning, chemists studied the physical properties and studied the preparation method. At the beginning, the road to exploration was full of thorns, and it was not easy to obtain pure this product. However, scholars have been unremitting, and after years of study, the reaction mechanism has gradually been clarified and the synthesis path has been optimized.
Prepared in the past, the conditions are harsh, and the yield is meager. Chemists have repeatedly tried and improved the steps, and the ratio of catalysts and reactants has improved. Then the yield has gradually increased, and the quality is also excellent.
With the passage of time, this compound has become more and more widely used. In the field of medicine, it is a key raw material for the synthesis of special drugs; in materials science, it has also emerged to help the research and development of new materials. Its historical evolution is the crystallization of chemist wisdom and sweat, adding brilliance to the chemical field and paving the way for the development of related industries.

Product Overview

2-Chloro-4-fluoro-1-nitrobenzene is an organic compound. It is a colorless to pale yellow liquid with a special odor. The preparation of this compound often requires delicate chemical skills.
In the laboratory, this substance can be obtained through specific reaction paths, such as halogenation, nitrification, etc. The substitution position of the halogen atom and the nitro group is precisely controlled on the benzene ring, resulting in the unique structure of 2-chloro-4-fluoro-1-nitrobenzene.
This substance is widely used in the chemical industry. It is often a key intermediate in the synthesis of many fine chemicals and can participate in the creation of drugs, pesticides and materials. Due to its fluorine, chlorine, nitro and other functional groups, it is endowed with special chemical activity and can react with a variety of reagents to build more complex organic molecular structures. It plays an important role in the stage of modern chemical synthesis.

Physical & Chemical Properties

2-Chloro-4-fluoro-1-nitrobenzene is also an organic compound. It has unique physical and chemical properties. Looking at its physical properties, at room temperature, it is a colorless to light yellow liquid with a special odor. Its boiling point is quite high, about 200 degrees Celsius, which is caused by intermolecular forces. Its density is greater than that of water, so it sinks in water. Regarding its chemical properties, above the benzene ring, functional groups such as chlorine, fluorine, and nitro give it active chemical activity. Nitro has strong electron absorption, which reduces the electron cloud density of the benzene ring and makes it more prone to nucleophilic substitution reactions. Although chlorine and fluorine atoms have different electronic effects, they can participate in various chemical reactions under suitable conditions, either as substitutes or additions, and are widely used in the field of organic synthesis.

Technical Specifications & Labeling

2-Chloro-4-fluoro-1-nitrobenzene is also an organic compound. The technical specifications and identification (product parameters) of its preparation are the key.
The method of preparation should follow strict procedures. The choice of raw materials must be pure and the proportion is accurate. The temperature, time and pressure of the reaction need to be carefully observed. If prepared by a certain method, the sequence of chlorination, fluorination and nitrification, the reaction conditions of each step are quite different. During chlorination, the temperature needs to be controlled in a certain range, and a specific catalyst is selected to ensure the smooth reaction and the purity of the product.
In terms of identification, its physical properties, color, taste and state need to be detailed. The identification of chemical properties, stability, reactivity and other parameters cannot be missed. Product parameters such as purity must meet high standards, and impurity content must be strictly controlled. This is the key to the technical specifications and labeling of 2-chloro-4-fluoro-1-nitrobenzene, which is related to its quality and application.

Preparation Method

To prepare 2-chloro-4-fluoro-1-nitrobenzene, the method is as follows: Prepare the raw materials, check their properties, and understand the reasons. Take the appropriate raw materials and synthesize them according to the exquisite process. First mix the raw materials in a certain way, control the temperature and pressure, and observe the reaction process. Or through multi-step reactions, in turn.
The initial raw materials are selected as pure to ensure the purity of the product. The reaction process is about success or failure, and it should be carefully studied. At each step of the reaction, you need to pay attention to the time and temperature to make the reaction moderate. After the reaction is completed, the impurities are removed by separation and purification to obtain pure 2-chloro-4-fluoro-1-nitrobenzene.
This compound is prepared by setting up a recycling mechanism, which can save raw materials and reduce costs. And in the reaction, pay attention to safety and avoid dangerous images, so that this compound can be prepared smoothly.

Chemical Reactions & Modifications

2-Chloro-4-fluoro-1-nitrobenzene is also a chemical compound. Its chemical and reverse modification is the most important thing.
Its reverse modification can be obtained by the method of phenyl, chlorine, fluorine, and nitrification. Chlorine substitution is the most important part, so that the chlorine atom is attached to the specific position of benzene, which involves the degree of reaction and catalysis. The same is true of fluorine substitution. The environment is the same, so that the fluorine can be accurately placed. Nitrification, control the weakness of acid and the negative effect, and replace it with the ideal.
To modify, or other groups can be introduced, which affects its physical and chemical properties. If you add a group or an amino group, you can increase its water content or change its anti-chemical activity. This is all based on refined research and anti-chemical principles, and good use of the method to achieve beneficial transformation. All this is the way of research, so as to improve the wonders of this compound and make it useful.

Synonyms & Product Names

2-Chloro-4-fluoro-1-nitrobenzene is also a chemical product. Although its name is the same, the same word and the name of the merchant are also complicated.
In the past, Fang's family first obtained this product, but it has no name. Because it contains chlorine, fluorine, and nitro groups in the benzene ring, it is called "chlorofluoronitrobenzene" in form, which is a simple and comprehensive word.
And in the market and trade, all merchants use their names. Because of its nature, it is called "stabilized chlorofluoronitrate", indicating its chemical stability. It is also used to call "dyeing aid 2-chloro-4-fluoro-1-nitrobenzene", because it is often used in the dyeing industry, as an auxiliary agent.
The difference between the same word and the commercial name is due to the special use and observation. However, in its origin, it all refers to this 2-chloro-4-fluoro-1-nitrobenzene product. In the research and business of chemistry, it is clear that the same word and the change of the commercial name can be used well and smoothly.

Safety & Operational Standards

2-Chloro-4-fluoro-1-nitrobenzene is also used in chemical products. Due to its safe operation, you must not be careless.
The manufacturing process, the general ratio of raw materials, and the quality of the product. In this case, the resistance, strength, etc., all need to be controlled by the grid. If the degree is high, it may cause reaction, and there is a risk of explosion; if the strength is lost, it will also affect the quality of the product, and even be dangerous.
The operation is difficult, and it is necessary to pass. 2-chloro-4-fluoro-1-nitrobenzene has certain toxicity and irritation. If the pass is not good, it will be harmful to the operator. And the workers need to use anti-rubber clothing, wear anti-rubber gloves, masks, etc., to prevent the skin from connecting and inhaling its steam.
If it is stored, it should be placed in a well-ventilated place. Fire source, Source, avoid direct light. Oxidation,
Therefore, the safe operation of 2-chloro-4-fluoro-1-nitrobenzene is not easy to operate, and it is interlocked. If there is a slight fear, it will be difficult to produce. Those who work hard must abide by the rules in order to maintain safety and environmental safety.

Application Area

2-Chloro-4-fluoro-1-nitrobenzene is also a new product of chemistry. It has a wide range of uses and has significant effects in various fields.
In the field of medicine, it is the key material for making effective and good medicines. Based on it, it can be developed to treat diseases and help heal the body of patients. The chemical industry is also indispensable. With its characteristics, it can form a variety of fine chemicals and expand the chemical category. Farming also helps. In order to make high-efficiency pesticide raw materials, it can protect crops from pests and diseases and ensure a bumper harvest.
In the field of material science, it is also useful. Or can assist in the research of new materials, with specific properties, applied to high-tech, unlimited prospects. From this point of view, the wide application of 2-chloro-4-fluoro-1-nitrobenzene, the deep impact, is actually the best in chemical products, in all fields of progress, all add help, for the industry's attention, the future road will be more bright.

Research & Development

In recent years, I have been in the field of chemistry, focusing on the research of 2 - Chloro - 4 - Fluoro - 1 - Nitrobenzene. Its unique nature, in the process of organic synthesis, has extraordinary potential.
At the beginning, analyze its structure, explore the wonder of its bonding, and understand the root of its chemical activity. Then, study the method of synthesis and try various paths. Or adjust the change of temperature and pressure, or change the choice of reagents and solvents, after repeated attempts, we can get an efficient method.
And looking at its application, in the creation of medicine, it can be a key intermediate and a new agent; in the research and development of materials, it also adds unique properties and develops broad prospects.
Although I have gained something today, I know that the road ahead is still far away. In the future, Ji Neng will explore its characteristics, expand the boundaries of application, and make it shine in various fields, contributing to the progress of chemistry and the prosperity of society.

Toxicity Research

2-Chloro-4-Fluoro-1-Nitrobenzene is an organic compound, and it is crucial to study its toxicity.
This substance has certain toxicity. In experimental exploration, if animals are used as samples, many physiological abnormalities may be seen after ingestion. It may damage the liver, kidneys and other key organs of animals, causing functional disorders. And it also affects the nervous system, causing changes in animal behavior and reactions.
From the perspective of chemical properties, the presence of chlorine, fluorine and nitro in its structure may be the source of toxicity. These groups are highly active and easily react with molecules in organisms, interfering with normal physiological and biochemical processes.
Furthermore, in the environment, if this compound spreads, it is also harmful to the ecology. Or enriched through the food chain, threatening many organisms. Therefore, the toxicity study of 2-Chloro-4-Fluoro-1-Nitrobenzene can provide a solid scientific basis for its safe use, environmental monitoring and protection measures to reduce its potential threat to organisms and the environment.

Future Prospects

Wuguanfu 2 - Chloro - 4 - Fluoro - 1 - Nitrobenzene is a treasure for future chemical research. Its unique structure and properties are strange. Although it is currently known, its future development cannot be limited.
In the field of organic synthesis, it may pave the way for the creation of new materials. With its special substituents, it can trigger unique chemical reactions and provide a new strategy for the synthesis of complex compounds with special functions.
Furthermore, it may become a key building block in the process of drug development. With its unique chemical properties, it is expected to build innovative drugs with excellent curative effect and low side effects, adding new wings to human health and well-being.
Although there may be difficulties and obstacles ahead, we chemical researchers should have a firm heart and unremitting exploration. Convinced that in the future, 2 - Chloro - 4 - Fluoro - 1 - Nitrobenzene will surely shine, develop its endless potential, and bring innovation to the world.

Where to Buy 2-Chloro-4-Fluoro-1-Nitrobenzene in China?

As a trusted 2-Chloro-4-Fluoro-1-Nitrobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.

Frequently Asked Questions

As a leading 2-Chloro-4-Fluoro-1-Nitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 2-Chloro-4-Fluoro-1-Nitrobenzene?

2-Chloro-4-fluoro-1-nitrobenzene is a crucial raw material in organic synthesis and is widely used in many fields.
First, in the field of medicinal chemistry, it is often a key intermediate in the synthesis of many specific drugs. Through a series of chemical reactions, it can be structurally modified and modified to construct molecular structures with specific pharmacological activities. For example, in the synthesis of some antimicrobial drugs and anti-tumor drugs, 2-chloro-4-fluoro-1-nitrobenzene can be used as a starting material. After halogenation, nitro reduction, amination and other steps, it can be combined with other active groups to prepare drugs with definite curative effect.
Second, in the field of pesticide chemistry, it also plays an important role. It can be used to synthesize highly efficient, low-toxic and environmentally friendly pesticides. Based on it, pesticides, fungicides and other pesticides that target specific pests or diseases can be created through chemical synthesis. With their unique molecular structure, such pesticides have high selectivity and biological activity for target organisms, which helps to improve crop yield and quality and ensure the safety of agricultural production.
Furthermore, in the field of materials science, 2-chloro-4-fluoro-1-nitrobenzene can be used as an important monomer in the synthesis of functional materials. Polymer materials with special properties can be prepared by polymerization or reaction with other compounds, such as materials with good thermal stability, optical properties or electrical properties, which show potential application value in electronic devices, optical instruments, etc.
In summary, 2-chloro-4-fluoro-1-nitrobenzene plays an indispensable role in the fields of medicine, pesticides and materials science due to its unique chemical structure, and promotes the development and progress of related industries.

What are the physical properties of 2-Chloro-4-Fluoro-1-Nitrobenzene?

2-Chloro-4-fluoro-1-nitrobenzene is one of the organic compounds. It has specific physical properties, as follows:
Looking at its properties, under normal temperature and pressure, 2-chloro-4-fluoro-1-nitrobenzene is a light yellow to brown liquid, which can help to distinguish. And because of the characteristics of its molecular structure, it has a certain volatility and can be slightly emitted in the air.
When it comes to the melting point, it is between -10 ° C and -5 ° C. At this low temperature, the substance changes from a solid state to a liquid state. The determination of the melting point helps to analyze its purity and characteristics. The boiling point is in the range of 205 ° C to 210 ° C. At this temperature, the liquid boils into a gaseous state. The value of this boiling point is also an important physical property characterization.
The density of this compound is about 1.48g/cm ³, which is heavier than water. If mixed with water, it will sink to the bottom. And it is insoluble in water, which is due to the difference between molecular polarity and water molecular polarity. However, in organic solvents such as ethanol, ether, acetone, etc., it has good solubility and can be miscible with organic solvents. This property is crucial in the process of organic synthesis and separation.
In addition, the vapor pressure of 2-chloro-4-fluoro-1-nitrobenzene has corresponding values at a specific temperature. The vapor pressure reflects the equilibrium relationship between the gas phase and the liquid phase, and affects its diffusion and reaction rate in the environment. At the same time, its refractive index is also a specific constant, and the determination of refractive index can be used to identify the substance and analyze its purity.
From the above, it can be seen that the various physical properties of 2-chloro-4-fluoro-1-nitrobenzene are of great significance for its application in organic synthesis, chemical production, and analysis and testing.

Is 2-Chloro-4-Fluoro-1-Nitrobenzene chemically stable?

The stability of the chemical properties of 2-chloro-4-fluoro-1-nitrobenzene is related to many aspects. This compound contains chlorine, fluorine, nitro and other functional groups. The presence of chlorine and fluorine atoms, due to their high electronegativity, can affect the electron cloud density distribution of the benzene ring, causing the electron cloud density of the benzene ring to decrease, making it difficult for electrophilic substitution reactions to occur, which has an important impact on its chemical stability.
Nitro is also a strong electron-absorbing group, which works synergistically with chlorine and fluorine to further reduce the electron cloud density of the benzene ring. In chemical reactions, it can make the benzene ring more prone to attack by nucleophiles rather than electrophiles. However, in this compound, the strength of the chemical bonds between the atoms also affects its stability. Carbon-chlorine, carbon-fluorine, and carbon-nitro bonds all have certain strength. Under normal conditions, high energy is required to break these chemical bonds.
If it is in a mild environment and no specific reagents react with it, 2-chloro-4-fluoro-1-nitrobenzene may remain relatively stable. However, in high temperatures, strong acids and bases, or in the presence of strong oxidizing agents and reducing agents, its stability may be challenged. For example, in a strong alkali environment, chlorine atoms may undergo nucleophilic substitution reactions and be replaced by groups such as hydroxyl groups; in the case of strong reducing agents, nitro groups may be reduced to amino groups, etc.
In summary, the chemical stability of 2-chloro-4-fluoro-1-nitrobenzene is not absolute, but varies according to the specific environment and the chemical substances it comes into contact with. It is relatively stable under ordinary conditions, but its chemical properties may change significantly when specific chemical conditions change.

What is the preparation method of 2-Chloro-4-Fluoro-1-Nitrobenzene?

The method of preparing 2-chloro-4-fluoro-1-nitrobenzene is often followed as follows.
First, 2-chloro-4-fluoroaniline is used as the starting material. The diazotization reaction is carried out at low temperature with sodium nitrite and dilute sulfuric acid. This process requires careful observation of the temperature, which is generally controlled between 0-5 ° C to prevent the growth of side reactions. After the diazotization is completed, the resulting diazo salt is mixed with sodium nitrite and fluoroboronic acid solution to obtain a diazoate precipitation of fluoroboronic acid. Thereafter, the precipitation is heated and decomposed to obtain 2-chloro-4-fluorobenzene. Finally, the nitration reaction of 2-chloro-4-fluorobenzene is carried out with mixed acid (concentrated sulfuric acid and concentrated nitric acid). Under appropriate temperature and reaction time, the target product 2-chloro-4-fluoro-1-nitrobenzene can be obtained. In this route, the control of the conditions of the diazotization reaction is the key. If the temperature is too high, the diazonium salt will easily decompose and the yield will be reduced.
Second, 4-fluoro-1-nitrobenzene is used as the raw material. React it with chlorine gas in the presence of an appropriate catalyst such as iron powder or ferric chloride. In this halogenation reaction process, the amount of catalyst and the reaction temperature have a great influence on the selectivity of the product. If the temperature is too low, the reaction rate is slow; if the temperature is too high, it is easy to produce polychlorinated by-products. After careful regulation of the reaction conditions, chlorine gradually replaces the hydrogen atom on the benzene ring, and 2-chloro-4-fluoro-1-nitrobenzene can be prepared.
Third, 2-chloro-1-nitrobenzene is used as the starting material. In a specific organic solvent, fluorination reagents such as potassium fluoride are added, and the fluorination reaction is carried out with the help of a phase transfer catalyst. The phase transfer catalyst can promote the smooth progress of the reaction at the two-phase interface and improve the reaction efficiency. In this reaction, the choice of solvent, the amount of fluorination reagent and the reaction time need to be carefully considered in order to obtain 2-chloro-4-fluoro-1-nitrobenzene in a high yield.

What are the precautions in storage and transportation of 2-Chloro-4-Fluoro-1-Nitrobenzene?

2-Chloro-4-fluoro-1-nitrobenzene is an important raw material commonly used in organic synthesis. When storing and transporting, special attention should be paid to the following things:
First, the choice of storage place. This substance should be stored in a cool and well-ventilated warehouse. Because it is easy to decompose when heated, it must be kept away from fire and heat sources. The temperature of the warehouse should be controlled within a suitable range to prevent danger caused by excessive temperature. And the relative humidity of the warehouse should not be too high, otherwise it may affect its quality.
Second, the packaging must be rigorous. This substance is toxic and corrosive to a certain extent. If the packaging is not tight, it may cause leakage, endangering the environment and personal safety. Commonly used packaging materials must be resistant to corrosion and have good sealing performance. Warning labels should be clearly marked on the outside of the package, such as toxic, harmful, corrosive, etc., so that relevant personnel can identify.
Third, attention should be paid to isolation when storing. 2-chloro-4-fluoro-1-nitrobenzene should not be mixed with oxidants, reducing agents, alkalis and other substances. Because of its contact with these substances, or violent chemical reactions, it can cause serious accidents such as fires and explosions.
Fourth, ensure safety during transportation. Transportation vehicles must have corresponding qualifications and protective equipment, and drivers and escorts must also undergo professional training. They are familiar with the dangerous characteristics of the substance and emergency treatment methods. During transportation, severe bumps and vibrations of vehicles should be avoided to prevent packaging damage.
Fifth, regular inspection. Whether during storage, before and after transportation, the packaging and storage conditions of 2-chloro-4-fluoro-1-nitrobenzene should be carefully inspected. If the packaging is found to be damaged, leaking signs, or the storage conditions do not meet the requirements, effective measures should be taken immediately.
Only when storing and transporting 2-chloro-4-fluoro-1-nitrobenzene, strictly following the above precautions can maximize the safety of personnel and the environment and avoid accidents.