2-Chloro-4-fluoro-1-iodobenzene is one of the organic compounds, which is widely used in the field of organic synthesis.
First, it can be used as a pharmaceutical intermediate. In the process of drug development, many molecules with specific biological activities need to be constructed as starting materials. By means of organic synthesis, functional group transformation and modification can be used to prepare drugs with different pharmacological effects. For example, in the synthesis of some antibacterial and antiviral drugs, 2-chloro-4-fluoro-1-iodobenzene can be used as a key structural unit to introduce other active groups through a series of reactions, thereby optimizing the efficacy and selectivity of the drug.
Second, it also has applications in materials science. In the preparation of new optoelectronic materials, this compound can participate in the molecular design of materials due to its unique electronic structure and chemical properties. By compounding or copolymerizing with other organic or inorganic materials, the electrical and optical properties of the materials can be regulated, such as functional materials used in the preparation of organic Light Emitting Diodes (OLEDs), organic solar cells and other devices, to improve their luminous efficiency, charge transport performance, etc.
Third, as a building block for organic synthesis. Due to the existence of different halogen atoms on the benzene ring, various nucleophilic substitution, metal catalytic coupling and other reactions can be used to construct more complex organic molecular structures. Such as Suzuki coupling reaction, Stille coupling reaction, etc., can make 2-chloro-4-fluoro-1-iodobenzene react with other boron and tin-containing reagents to form carbon-carbon bonds, expand the skeleton of molecules, and provide an effective way for the synthesis of natural products and organic functional molecules with specific structures and functions.

2-Chloro-4-fluoro-1-iodobenzene, an organohalogenated aromatic hydrocarbon, has unique physical properties. It is mostly liquid at room temperature. Due to the increase in molecular polarity caused by halogen atoms in the molecule, its boiling point is higher than that of non-polar compounds with similar molecular masses. However, the specific boiling point varies depending on impurities and measurement conditions, and is about 150-200 ° C.
The density of this substance is greater than that of water, and it will sink to the bottom when mixed with water. In terms of solubility, because it is an aromatic hydrocarbon derivative, it has a certain hydrophobicity and has little solubility in water, but it is soluble in common organic solvents, such as ether, dichloromethane, chloroform, etc. This property is convenient for its separation and purification as a reactant or intermediate in organic synthesis.
2-chloro-4-fluoro-1-iodobenzene has low vapor pressure and relatively weak volatility. This property should be noted when storing and using. Although it is not volatile, if it is in a high temperature or poor ventilation environment, there may still be vapor accumulation, which brings latent risk.
In addition, the presence of chlorine, fluorine and iodine atoms in the molecule endows the compound with special chemical activity and affects its physical properties. Different halogen atoms have different electronegativity, which makes the molecular electron cloud unevenly distributed, enhances the intermolecular force, and further affects its physical properties such as boiling point, melting point and solubility.

There are methods for making 2-chloro-4-fluoro-1-iodobenzene, which have several advantages, as detailed below.
One is based on halogenation. You can first take benzene derivatives containing suitable substituents, and use chlorinated reagents, such as thionyl chloride or phosphorus oxychloride, under appropriate conditions to conduct chlorination reactions to introduce chlorine atoms. Then, with fluorinated reagents, such as potassium fluoride, etc., with the help of a phase transfer catalyst, the fluorine atom is replaced. Finally, iodine atoms are introduced by a combination of iodizing reagents, such as iodine elements and suitable reducing agents. The steps in this process are clear, but the reaction conditions of each step need to be carefully regulated to ensure the purity and yield of the product.
Second, through the Grignard reagent method. First, a halogenated benzene reagent containing chlorine or fluorine is prepared, and it is reacted with iodine-containing compounds, such as iodoalkanes or iodoaromatics, under suitable solvents and reaction conditions. In this process, the preparation of Grignard reagents requires an anhydrous and oxygen-free environment, which requires high operation requirements. However, if properly controlled, the structure of the target molecule can be effectively constructed.
Third, cross-coupling reaction is also a good strategy. Chlorine and fluorine-containing phenylboronic acid or borate esters are selected to cross-couple with iodoaromatic hydrocarbons under the catalysis of transition metal catalysts such as palladium catalysts. Such reaction conditions are relatively mild and the selectivity is good, but the catalyst cost is high, and the reaction post-treatment may be more complicated.
The method of preparing 2-chloro-4-fluoro-1-iodobenzene has its own advantages and disadvantages. Although the halogenation reaction steps are complex, the raw materials are common; the Grignard reagent method is harsh on conditions, but it can accurately construct the structure; the cross-coupling reaction conditions are mild, and only the cost and post-treatment need to be considered. If you want to prepare it, you should choose the best method according to the actual situation.

2-Chloro-4-fluoro-1-iodobenzene is an organic compound. When storing and transporting, many matters need careful attention.
Bear the brunt. When storing, you must find a cool, dry and well-ventilated place. This compound is quite sensitive to heat and humidity, and high temperature or humidity can easily cause it to decompose or deteriorate. If placed in a humid place, the moisture may react with the compound, which will damage its purity and quality. Therefore, where it is stored, the humidity should be controlled at a low level, and the temperature should not be too high to ensure the stability of its chemical properties.
In addition, because of its certain toxicity and irritation, it must be stored away from fire, heat and oxidizing agents. This compound is exposed to open flames or hot topics, or there is a risk of combustion and explosion; contact with oxidizing agents may also trigger violent chemical reactions, endangering safety. Therefore, it should be stored separately from such dangerous substances, and the storage area must be equipped with fire extinguishing and emergency response equipment.
As for transportation, it should not be taken lightly. It is necessary to ensure that the packaging is tight and well sealed to prevent leakage. During transportation, avoid collisions and vibrations to avoid package damage. If transported by vehicle, the appropriate temperature and humidity should be maintained in the compartment, and it should be avoided from mixing with other substances that may react.
In addition, personnel engaged in storage and transportation must be professionally trained and familiar with the characteristics, hazards and emergency treatment methods of the compound. In the event of an unexpected situation such as leakage, it should be able to quickly and properly dispose of it according to the established plan to prevent the harm from expanding. In short, the storage and transportation of 2-chloro-4-fluoro-1-iodobenzene requires careful treatment of all aspects to ensure the safety of personnel and the environment is not polluted.

Looking at this question, I am inquiring about the market price of 2-chloro-4-fluoro-1-iodobenzene. However, the price of the market is constantly changing, and it is affected by various factors, making it difficult to directly determine.
The price of the cover is related to the trend of supply and demand. If there are many applicants for this product, but there are few suppliers, the price will increase; conversely, if you ask for less and more, the price will fall. And the cost of production is also a major factor. The price of raw materials, the difficulty of preparation, and the amount of energy consumption can all affect the cost, which in turn affects the selling price.
Furthermore, the price varies from region to region. In different places, due to the difference in logistics fees and taxes, the price is also different. In places where commerce is prosperous and logistics is convenient, the price may be relatively easy; in remote places, due to difficult transportation, the price may be slightly higher.
There is a situation of market competition again. If there are many competitors in the same industry, each competing for market share, or lowering its price to attract customers; if there is a unique company without a semicolon, the right to set the price depends on its hand, and the price may be higher.
If you want to know the exact price, you should consult merchants specializing in chemical raw materials, platforms for trading chemical products, or refer to recent market transaction records to obtain its accurate value. It is absolutely impossible to speculate out of thin air, and it is necessary to rely on actual evidence to understand the price of its market change.