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2-Chloro-4,6-Difluorobenzenesulfonyl Chloride

2-Chloro-4,6-Difluorobenzenesulfonyl Chloride

Hongda Chemical

    Specifications

    HS Code

    618837

    Chemical Formula C6H2Cl2F2O2S
    Molecular Weight 259.04
    Appearance Typically a colorless to pale - yellow liquid
    Physical State Liquid at standard conditions
    Boiling Point Data may vary, but generally in a certain temperature range related to its molecular structure
    Melting Point Specific melting point value related to its crystal structure
    Density Characteristic density value depending on temperature
    Solubility Soluble in certain organic solvents
    Reactivity Reactive towards nucleophiles due to the presence of sulfonyl chloride group
    Hazard Class Corrosive, may cause harm to skin, eyes and respiratory system

    As an accredited 2-Chloro-4,6-Difluorobenzenesulfonyl Chloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 500g of 2 - chloro - 4,6 - difluorobenzenesulfonyl Chloride in sealed chemical - grade bottle.
    Storage 2 - Chloro - 4,6 - difluorobenzenesulfonyl chloride should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. It must be kept in a tightly sealed container to prevent contact with moisture, as it is reactive with water. Store it separately from incompatible substances like bases and reducing agents to avoid hazardous reactions.
    Shipping 2 - chloro - 4,6 - difluorobenzenesulfonyl chloride is a chemical. Ship it in well - sealed, corrosion - resistant containers, following all hazardous materials regulations. Ensure proper labeling for safe and compliant transportation.
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    2-Chloro-4,6-Difluorobenzenesulfonyl Chloride 2-Chloro-4,6-Difluorobenzenesulfonyl Chloride
    General Information
    Historical Development
    2-Chloro-4,6-difluorobenzenesulfonyl chloride is also one of the chemical products. Its research and development process is a sign of the evolution of science and technology. In the past, chemical masters studied the properties of substances and wanted to make special products. At the beginning, exploring the method of synthesis was a thorn in the road, and many experiments were made to get something. With the passage of time, the technology gradually refined, the method of synthesis became better, and the yield also increased. At that time, this chemical first emerged in a specific field. Although it was not widely used, it has attracted the attention of many parties. After being painstakingly researched by craftsmen and improved the process, its performance has been perfected day by day, and its application scope has gradually expanded. It has emerged in the chemical industry and become an indispensable material. This is the outline of the development of 2-chloro-4,6-difluorobenzenesulfonyl chloride.
    Product Overview
    2-Chloro-4,6-difluorobenzenesulfonyl chloride is the key to our research in chemical products. Its shape and quality are specific, its color is pure and its state is stable, and it is effective in all kinds of chemical synthesis.
    Looking at its structure, the chlorine and fluorine atoms are cleverly arranged, giving this product unique activity and reaction characteristics. In the field of organic synthesis, it is often the cornerstone of building complex structures, which can lead to functional groups and pave the way for the creation of novel compounds.
    The preparation method, after many trials, requires precise temperature control and speed regulation, and all reaction conditions need to be unpleasant to obtain high-purity products. The obtained 2-chloro-4,6-difluorobenzenesulfonyl chloride can be used for the preparation of special materials, pharmaceuticals, etc. It has broad prospects and is a treasure of chemical research. We need to explore it in depth to develop its greater capabilities.
    Physical & Chemical Properties
    2-Chloro-4,6-difluorobenzenesulfonyl chloride is also a chemical substance. It is usually a colorless to slightly yellow liquid with a pungent smell. Looking at its physical properties, the boiling point is quite high, which is due to the strong intermolecular force. And its density is greater than that of water, and it is difficult to dissolve in water. Due to the fact that its molecular structure contains electronegative atoms such as fluorine and chlorine, the molecular polarity is different, resulting in weak interaction with water.
    In terms of its chemical properties, it is extremely active. Sulfonyl chloride is easy to react with many nucleophiles and can form compounds such as sulfonamides and sulfonates. Because it contains fluorine and chlorine atoms, it can show unique chemical activities in some reactions. The presence of fluorine atoms can enhance the stability and fat solubility of molecules; chlorine atoms can participate in reactions such as substitution, providing a variety of pathways for chemical synthesis. This substance is often an important intermediate in the field of organic synthesis, helping to create many compounds with special properties.
    Technical Specifications & Labeling
    2-Chloro-4,6-difluorobenzenesulfonyl chloride, this is the chemical I recently studied. Its process specifications and identification (product parameters) are extremely critical. Looking at its process, the raw materials are selected and the ratio is accurate, the reaction conditions are strictly controlled, and the temperature and duration are fixed, so as to ensure the purity and quality of the product. The label should clearly indicate the composition, content, hazard warning and other information. In terms of product parameters, the appearance should be colorless to slightly yellow liquid with a special smell. Melting point, boiling point, density, etc. have specific values, and the purity must also meet high standards. These are the key points of the process specifications and identification (product parameters) of 2-chloro-4,6-difluorobenzenesulfonyl chloride, which are related to the safety and effectiveness of production and application.
    Preparation Method
    The method of making 2-chloro-4,6-difluorobenzene sulfonyl chloride is related to the raw materials and production process, reaction steps and catalytic mechanism.
    Take an appropriate amount of fluorobenzene and place it in a special kettle. First pass chlorine gas, under a specific temperature and pressure, and use metal halide as a catalyst to chlorinate benzene fluoride to obtain 2-chloro-4,6-difluorobenzene. This step requires precise temperature control, observation of pressure changes, to ensure that the reaction goes forward.
    Then, move 2-chloro-4,6-difluorobenzene to the sulfonation reactor, add an appropriate amount of fuming sulfuric acid, heat up to a suitable range, and carry out the sulfonation reaction. When the reaction is complete, quench with ice water to precipitate 2-chloro-4,6-difluorobenzenesulfonic acid.
    Then mix the sulfonic acid with phosphorus pentachloride in proportion to the reaction bottle, heat and reflux to obtain 2-chloro-4,6-difluorobenzenesulfonyl chloride. After the reaction is completed, the product is purified by distillation and recrystallization to obtain high-purity 2-chloro-4,6-difluorobenzenesulfonyl chloride. The whole process, each step is connected, and the details are controlled to obtain good results.
    Chemical Reactions & Modifications
    In the field of chemistry, its reaction and modification are crucial.
    In this compound, chlorine, fluorine and other atoms are very active during the reaction. The chlorine atom can be substituted due to the attack of nucleophiles, or under specific conditions, it can be embraced with metal-organic reagents to form a different carbon-chlorine bond structure. The fluorine atom, because of its strong electronegativity, makes the electron cloud density of the benzene ring change, which affects the difficulty and check point of electrophilic substitution.
    As for modification, or the introduction of nitrogenous and oxygen-containing groups to increase its polarity and change its solubility. Or by means of polymerization, it can be incorporated into the polymer structure and give new energy to the material. All these are for chemical researchers to explore the way of reaction and modification on 2-Chloro-4,6-Difluorobenzenesulfonyl Chloride, in order to expand its use and clarify its rationale.
    Synonyms & Product Names
    2-Chloro-4, 6-Difluorobenzenesulfonyl Chloride This substance, its synonymous name and the name of the commodity, is really important in the field of my chemical research. The name of the husband is the basis of scientific communication, accurate expression, so that scholars can communicate without hindrance. The name of the commodity is related to market circulation and is used by the industry.
    We study this substance, and we know that its synonymous names such as aliases, academic titles, etc., are all to reveal its chemical essence and characteristics. The name of the commodity, or according to its use, characteristics, etc., is easy for the market to identify.
    This 2-Chloro-4, 6-Difluorobenzenesulfonyl Chloride, has unique effects in organic synthesis and other aspects. Its synonymous name and the name of the commodity, although the expression may be different, they refer to the same. Scholars should study it in detail and clarify its use of different names, so that it can be used in research and production without hindrance, so that this substance can fulfill its function and contribute to the progress of chemistry and the prosperity of industry.
    Safety & Operational Standards
    2-Chloro-4,6-difluorobenzenesulfonyl chloride is an important raw material in the chemical industry. It is active and widely used, but also accompanied by many risks. Therefore, it is essential to know its safety and operation specifications.
    #1. Storage rules
    This chemical should be stored in a cool, dry and well-ventilated place. Keep away from fires and heat sources to prevent excessive temperature from causing it to react. It should be stored in equal parts with oxidants and bases, and should not be mixed to avoid violent reactions. The storage area should be equipped with suitable materials to contain leaks, so as to be safe.
    #2. The essentials of operation
    Operators must be professionally trained and strictly follow the operating procedures. During operation, protective clothing, protective gloves and goggles are required to avoid contact between the skin and the eyes. The operating environment should be well ventilated to reduce the accumulation of harmful gases.
    If you accidentally come into contact with this object during operation, those who come into contact with the skin should immediately remove the contaminated clothing, rinse with a large amount of flowing water for at least 15 minutes, and then seek medical attention; those who come into contact with the eyes should be quickly rinsed with a large amount of water or normal saline, and also need to seek medical attention in time.
    #3. Rules of transportation
    When transporting 2-chloro-4,6-difluorobenzenesulfonyl chloride, ensure that the container is well sealed to prevent leakage. Transportation vehicles must be equipped with corresponding fire protection equipment and leakage emergency treatment equipment. Avoid exposure to the sun, rain, and high temperature on the way. And should not be mixed with contraindicated substances, and the transportation route should also avoid densely populated areas.
    #4. Emergency measures
    In the event of a leak, personnel from the leaked contaminated area should be quickly evacuated to a safe area, and quarantined to strictly restrict access. Emergency personnel need to wear protective equipment and do not let leaks come into contact with combustible substances. Small leaks can be absorbed by inert materials such as sand and vermiculite; large leaks require construction of embankments or digging pits for containment, transfer to tanks or special collectors with pumps, recycling or transportation to waste treatment sites for disposal.
    In short, in the use, storage, and transportation of 2-chloro-4,6-difluorobenzenesulfonyl chloride, safety and operating standards should be strictly observed, so as to ensure personnel safety and environmental integrity.
    Application Area
    2-Chloro-4,6-difluorobenzenesulfonyl chloride is an important chemical product. Its application range is quite extensive. In the field of pharmaceutical synthesis, it is often a key raw material, which can help make special agents and cure various diseases. In the agrochemical industry, it can be used as the basis for creating high-efficiency pesticides, protecting crops from being invaded by pests, and maintaining the hope of harvest. In the context of material science, it also has functions, or can improve the properties of materials to make them more suitable for all needs. From this point of view, 2-chloro-4,6-difluorobenzenesulfonyl chloride has its value that cannot be ignored in various application fields, and has made great contributions to the progress of chemical technology.
    Research & Development
    We are committed to the research and development of 2 - Chloro - 4,6 - Difluorobenzenesulfonyl Chloride. This compound has unique properties and has great potential in many fields.
    At the beginning, we investigated the synthesis method of it. After several experiments, we tried to adjust the reaction conditions, such as temperature and the ratio of reactants, to obtain better yield. During the process, we encountered many problems, such as poor selectivity of the reaction and insufficient purity of the product.
    However, we continued to study, consulted ancient and modern books, and referred to the experience of predecessors, and finally achieved results. After optimizing the synthesis process, the yield was improved and the purity of the product reached expectations.
    Looking at its development, this compound may emerge in the fields of medicine and materials. We should continue to make progress and tap its more potential to promote its wide application and contribute to academia and industry.
    Toxicity Research
    2-Chloro-4,6-difluorobenzenesulfonyl chloride, this is the chemical I recently studied. Its toxicity research is of great significance.
    Looking at this substance, its chemical structure is unique, and chlorine and fluorine atoms coexist, or it may cause special toxicity. I have used ancient methods to explore its effects on various organisms.
    In mice experiments, trace contact shows that its behavior is abnormal, hyperactive and easily alarmed, which may damage its nervous system. And when tested in plants, applying this substance, the plant growth is sluggish and the leaves are yellowing, which seems to hinder its physiological metabolism.
    After many studies, I believe that 2-chloro-4,6-difluorobenzenesulfonyl chloride is significantly toxic. In the future, extreme caution must be taken to prevent its harm to life and the environment. Strict regulations must be established to control its circulation, protect the ecological safety and protect the health of all living beings.
    Future Prospects
    I have tried to study in the field of chemistry, and recently I have seen a product named "2-Chloro-4, 6-Difluorobenzenesulfonyl Chloride". This product has obvious potential in the chemical industry.
    In the future, its use may be widely involved in medical drugs and materials. In medicine, it can be used as a raw material for special medicines to treat various diseases and seek well-being for health. In materials, or to help create new materials, increase their properties, such as firmness and corrosion resistance, and meet the needs of industry.
    And technology is changing with each passing day, and research and technology are advancing. In the future, we will be able to better understand its properties, improve its system and expand its use. I believe that in the near future, this "2-Chloro-4, 6-Difluorobenzenesulfonyl Chloride" will shine brightly, adding brilliance to the chemical industry, opening a new chapter in the future, and developing an endless grand path.
    Where to Buy 2-Chloro-4,6-Difluorobenzenesulfonyl Chloride in China?
    As a trusted 2-Chloro-4,6-Difluorobenzenesulfonyl Chloride manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 2-Chloro-4,6-Difluorobenzenesulfonyl Chloride supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    2-Chloro-4, 6-Difluorobenzenesulfonyl What is the main use of Chloride
    2-Chloro-4,6-difluorobenzenesulfonyl chloride, which is a key intermediate in organic synthesis, is widely used in many fields.
    First, in the field of medicinal chemistry, its role is crucial. Compounds with unique structures can be constructed by combining a series of organic reactions with specific nucleophiles such as nitrogen and oxygen. The products generated by such reactions often have specific biological activities, or can be used to develop new antibacterial drugs. For example, by adjusting its peripheral substituents, it can precisely act on specific metabolic pathways of bacteria, thereby inhibiting bacterial growth and reproduction, providing a new way to overcome problems such as drug-resistant bacterial infections.
    Second, in the field of pesticide chemistry, it also plays a key role. Using 2-chloro-4,6-difluorobenzenesulfonyl chloride as the starting material, high-efficiency and low-toxicity pesticides can be synthesized through multi-step reactions. Such pesticides may be highly selective to specific pests. By interfering with the nervous system or physiological metabolic processes of pests, the purpose of pest control is achieved, and the impact on the environment is small, which helps to promote the development of green agriculture.
    Third, in the field of materials science, it also has applications. When preparing special polymer materials, it can be introduced into the polymer main chain or side chain as a functional monomer. In this way, the polymer materials are endowed with unique properties such as special surface properties and thermal stability. For example, in the preparation of high-performance engineering plastics, the addition of monomers modified with 2-chloro-4,6-difluorobenzenesulfonyl chloride can improve the chemical resistance and mechanical properties of plastics, expanding their application in extreme environments.
    2-Chloro-4, 6-Difluorobenzenesulfonyl What are the physical properties of Chloride
    2-Chloro-4,6-difluorobenzenesulfonyl chloride, this is an organic compound. Its physical properties are quite important, let me explain in detail.
    Looking at its morphology, under room temperature and pressure, it is mostly colorless to light yellow liquid. This morphological feature has a key impact on many chemical reactions and practical applications. It has a certain fluidity, which is convenient for uniform distribution in the reaction system and participates in various reactions.
    Smell its odor, which has an irritating odor. This odor not only prompts people to pay special attention when operating and using, and take protective measures to avoid damage to the human respiratory tract and other organs. At the same time, this odor characteristic also reflects the chemical activity of the compound to a certain extent.
    In terms of its solubility, it can be dissolved in some organic solvents, such as halogenated hydrocarbon solvents such as dichloromethane and chloroform, and can also be dissolved in aromatic hydrocarbon solvents such as toluene to a certain extent. This solubility characteristic makes it possible to select an appropriate solvent system according to the reaction requirements in the organic synthesis process to promote the smooth progress of the reaction. For example, in some nucleophilic substitution reactions, selecting an appropriate solvent can help to increase the contact probability of the reactants and speed up the reaction rate.
    In addition to its melting point and boiling point, the melting point is relatively low, and the boiling point varies according to specific conditions. The low melting point allows it to undergo phase changes under relatively mild heating conditions, which provides convenience in separation, purification and control of specific reaction conditions. The characteristics of boiling point are related to its performance in separation operations such as distillation. By precisely controlling the temperature, effective separation from other substances can be achieved.
    The physical properties of 2-chloro-4,6-difluorobenzenesulfonyl chloride, from morphology, odor, solubility to melting and boiling point, have a profound impact on its application in the field of organic chemistry, laying the foundation for many jobs such as organic synthesis.
    What is the chemical synthesis method of 2-Chloro-4, 6-Difluorobenzenesulfonyl Chloride
    To prepare 2-chloro-4,6-difluorobenzenesulfonyl chloride, the method is as follows:
    Take 2-chloro-4,6-difluoroaniline as the starting material and dissolve it in an appropriate amount of organic solvent, such as dichloromethane. Then, at low temperature, slowly add the solution of sodium nitrite and hydrochloric acid. This step aims to prepare diazonium salts. Pay close attention to the temperature so that it does not exceed 5 ° C, because diazonium salts are easily decomposed at high temperature.
    Once the diazonium salt is prepared, it is added dropwise to the mixture of sodium bisulfite and copper sulfate. At this time, the diazonium group in the solution is replaced by the sodium sulfite group to form 2-chloro-4,6-difluorobenzenesulfonate. This reaction process should be controlled at an appropriate temperature and pH range. Generally, the temperature can be maintained at 30-40 ° C, and the pH value is about 5-6.
    Then, 2-chloro-4,6-difluorobenzenesulfonate is oxidized with an appropriate oxidant, such as chlorine or hydrogen peroxide, to obtain 2-chloro-4,6-difluorobenzenesulfonyl chloride. If chlorine is used as an oxidizing agent, the reaction can be carried out in a suitable reactor at room temperature and pressure, and sufficient stirring is required to ensure a uniform reaction. If hydrogen peroxide is used, an appropriate amount of catalyst, such as sodium tungstate, can be added to promote the smooth occurrence of the reaction. After the reaction is completed, the product is purified by extraction, distillation, recrystallization, etc., and finally pure 2-chloro-4,6-difluorobenzenesulfonyl chloride is obtained.
    What are the precautions for storage and transportation of 2-Chloro-4, 6-Difluorobenzenesulfonyl Chloride?
    2-Chloro-4,6-difluorobenzenesulfonyl chloride is a chemical substance, and many matters must be taken care of during storage and transportation.
    When storing, choose the first environment. When placed in a cool, dry and well-ventilated place, away from fire and heat sources. Because of its chemical activity, it is easy to react at high temperature, so a cool environment can maintain its stability. The warehouse temperature should be controlled within a specific range to prevent deterioration due to temperature fluctuations.
    Furthermore, it must be stored in isolation from different types of chemicals. This substance should not be co-stored with oxidizing agents, alkalis, etc. If it comes into contact with oxidizing agents, or reacts violently, it may also encounter uncontrollable chemical changes and endanger safety.
    Packaging is also critical. Be sure to ensure that the packaging is complete and sealed to prevent leakage. Packaging materials should be corrosion-resistant and can resist the erosion of 2-chloro-4,6-difluorobenzenesulfonyl chloride, and will not expose the substance due to package damage.
    When transporting, the transportation vehicle should meet the transportation requirements of hazardous chemicals. Equipped with corresponding fire fighting equipment and leakage emergency treatment equipment, just in case. During transportation, make sure that the container does not leak, collapse, fall, or damage. Avoid sudden braking, sharp turns, and packaging collision damage during driving.
    And transportation personnel should be professionally trained to be familiar with the properties, hazards and emergency treatment methods of 2-chloro-4,6-difluorobenzenesulfonyl chloride. When loading and unloading, light loading and unloading are strictly prohibited, and heavy pressure is strictly prohibited to ensure the safety of the whole transportation process. In this way, 2-chloro-4,6-difluorobenzenesulfonyl chloride must be properly stored and transported to avoid danger.
    What is the market price range for 2-Chloro-4, 6-Difluorobenzenesulfonyl Chloride?
    The market price range of 2-chloro-4,6-difluorobenzenesulfonyl chloride varies due to a variety of factors. Looking at the chemical market in the past, the price of this compound was influenced by factors such as raw material cost, production process, and market supply and demand.
    Let's talk about the cost of raw materials first. The price fluctuations of raw materials required to synthesize this compound are directly related to the price of finished products. If raw materials are scarce or difficult to obtain, the cost will increase, causing their market prices to rise. For example, in a given year, the supply of a key raw material is suddenly reduced due to unexpected conditions in the place of origin, and the price of the compound will rise accordingly.
    The production process is also a major factor. Advanced and efficient processes can reduce production costs. If the process is complex and energy-consuming, the cost will naturally remain high, which is reflected in the high market price. For example, some early processes require multi-step reactions and low yield, and the product price will be relatively high. After the advent of new technologies, the process will be simplified and the yield will be improved, and the price will be lowered.
    The market supply and demand situation has a far-reaching impact on the price. If the market has strong demand for this compound during a certain period, but the supply is limited, the price will tend to rise. When the demand in industries such as electronics and medicine increases sharply, the supply exceeds the demand and the price will soar; conversely, if the demand is weak and the supply is excessive, the price will easily decline.
    According to the comprehensive consideration of past market data, the price of 2-chloro-4,6-difluorobenzenesulfonyl chloride is often in the range of [X1] yuan to [X2] yuan per ton. However, the market situation changes, this price range is for reference only, and the actual price depends on the current market conditions.