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2-Chloro-3-Fluorobromobenzene

2-Chloro-3-Fluorobromobenzene

Hongda Chemical

Specifications

HS Code

471688

Chemical Formula C6H3BrClF
Molecular Weight 225.44
Appearance Liquid (predicted)
Boiling Point Approximately 195 - 205 °C (estimated)
Density Approximately 1.8 - 1.9 g/cm³ (estimated)
Vapor Pressure Low (due to relatively high molecular weight and polarity)
Water Solubility Low (organic halide, non - polar nature)
Flash Point Approximately 75 - 85 °C (estimated)
Odor Typical of halogenated aromatic compounds, pungent

As an accredited 2-Chloro-3-Fluorobromobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 500g of 2 - chloro - 3 - fluorobromobenzene packaged in a sealed, chemical - resistant bottle.
Storage 2 - chloro - 3 - fluorobromobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and ignition points due to its potential flammability. It should be kept in a tightly sealed container to prevent leakage and exposure to air or moisture, which could lead to chemical reactions. Store it separately from oxidizing agents and incompatible substances to avoid dangerous reactions.
Shipping 2 - chloro - 3 - fluorobromobenzene is shipped in sealed, corrosion - resistant containers. It must comply with hazardous chemical shipping regulations, ensuring proper labeling, secure packaging to prevent leakage during transit.
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2-Chloro-3-Fluorobromobenzene 2-Chloro-3-Fluorobromobenzene
General Information
Historical Development
2-Chloro-3-fluorobromobenzene is also an organic compound. Its origin can be traced back to the past. At the beginning, the field of chemistry began to explore halogenated aromatics. At that time, scholars studied various halogenation reactions in order to create new compounds.
In the process of synthesis, chemists worked hard. First, the selection of the halogenated site of the benzene ring took a lot of thought. After repeated tests, it was found that under specific catalysts and reaction conditions, chlorine, fluorine and bromine atoms can be introduced at specific positions in the benzene ring.
With the passage of time, the synthesis technology has become more and more exquisite. The reaction yield has gradually increased, and the purity of the product has also been improved. From crude early attempts to fine regulation, the synthesis process of this compound has undergone metamorphosis. Chemists have made unremitting efforts to make the preparation of 2-chloro-3-fluorobromobenzene more mature, paving the way for subsequent applications in many fields.
Product Overview
2-Chloro-3-fluorobromobenzene is also an organic compound. Its shape may be a colorless liquid with a special odor. The structure of this substance, on the benzene ring, chlorine atoms, fluorine atoms and bromine atoms are arranged in an orderly manner.
The method of preparation often starts with benzene, and through halogenation reactions, chlorine, fluorine and bromine atoms are introduced into the benzene ring. The reaction conditions, temperature, pressure and catalyst need to be carefully adjusted to obtain the product of this specific structure.
Its activity is active, and it is widely used in the field of organic synthesis. It can be used as an intermediate to make medicines, pesticides and special materials. When encountering nucleophiles, the halogen atoms on the benzene ring are easily replaced, generating a variety of new compounds, which are of great value in chemical research and industrial manufacturing.
Physical & Chemical Properties
2-Chloro-3-fluorobromobenzene is an organic compound. It has unique physical and chemical properties. Looking at its physical properties, under room temperature, or in a liquid state, the color is clear and transparent, and it has a special odor. Its boiling point and melting point depend on the characteristics of the molecular structure. Intermolecular forces cause its boiling point to be different from common hydrocarbons.
On chemical properties, the presence of halogen atoms makes the compound active. Chlorine, fluorine and bromine atoms can be used as check points for nucleophilic substitution in chemical reactions. The electron cloud distribution of aromatic rings varies due to the electronegativity of halogen atoms, which affects the activity and check point selectivity of electrophilic substitution reactions. It can react with many nucleophiles to generate new organic compounds. It has a wide range of uses in the field of organic synthesis and is also an important intermediate for the synthesis of complex organic molecules.
Technical Specifications & Labeling
Nowadays, there is a chemical substance called 2-Chloro-3-Fluorobromobenzene, and the technical specifications and identification (commodity parameters) of its preparation are the key. When preparing, follow a precise process. The selection of raw materials must meet the standards of high purity to ensure the quality of the product. The reaction conditions, such as temperature, pressure, and catalyst dosage, all need to be carefully controlled. If the temperature is too high or too low, the reaction can be biased, affecting the yield and purity of the product.
In terms of labeling, the basic characteristics of the substance should be detailed, such as molecular formula, molecular weight, physical and chemical properties, etc. The product parameters should also be clear, including purity indicators, impurity limits, etc. In this way, it can be properly used in industrial production, scientific research applications, etc., to ensure safety and achieve high efficiency.
Preparation Method
To prepare 2-chloro-3-fluorobromobenzene, prepare raw materials. Beginning with benzene, by bromination, bromine and iron filings are used as agents to respond to it at temperature to obtain bromobenzene.
Substitute with chlorine and fluorine. Take bromobenzene, and chlorine in the environment of light or catalysis, so that the chlorine is substituted in the ortho or para-position to obtain bromobenzene containing chlorine. After that, fluoride is substituted, and a suitable fluorine substitution agent is used at a specific temperature and pressure to put fluorine into the benzene ring, and chlorine is substituted to obtain 2-chloro-3-fluorobromobenzene.
The key to its preparation is to control the temperature of the reaction, the time and the amount of agent, so that each step should be smooth and less impurities will be generated. And each step should be completed, and the method of purification, such as distillation, extraction, recrystallization, etc. must be used to remove impurities and purify the product to meet the quality requirements.
Chemical Reactions & Modifications
Modern chemistry is refined, and organic research is particularly prosperous. 2-Chloro-3-fluorobromobenzene has attracted much attention in organic synthesis. Its chemical reaction is related to the chemical industry and can be the basis for the preparation of other compounds.
However, its initial reaction may not be effective and there are many by-products. The ancient method was obtained by the method of halogenation. Although it is available, the conditions are strict and the yield is not high.
Today's scholars are thinking hard and changing, hoping to improve its properties. In the context of catalysis and reaction, we hope to obtain an efficient and pure method. With a new catalytic system, the reaction temperature is reduced, the speed is increased, and the by-product is also reduced. This change is in line with the purpose of chemical pursuit of precision and high efficiency, and it is expected to be more beneficial in the future. It will develop a new look in the field of organic synthesis and make the preparation and use of 2-chloro-3-fluorobromobenzene perfect.
Synonyms & Product Names
Today there is a thing called 2 - Chloro - 3 - Fluorobromobenzene. Although its name is different from the common saying, everyone in the industry knows what it is. There are many aliases for this thing, and the names are also different due to different industries, regions, and uses.
Or those who are named for their chemical structure characteristics, take their similarity and give them names, just like their halogenated benzene characteristics, and have similar names. There are also commercial needs, in order to recognize its characteristics and uses, another commercial name. Although the names are different, they actually refer to the same thing.
We study this thing and know that there are reasons behind all the names. Although the title is complicated, it is fundamental and does not depart from its sect. I hope that colleagues in the industry will know what each name refers to when communicating, so as to avoid confusion and promote the progress of this object research together.
Safety & Operational Standards
2-Chloro-3-fluorobromobenzene is an important chemical compound in chemical research. There are many strict regulations to be followed in terms of experimental operation and safety assurance.
First of all, the operating environment must be well ventilated. Because of its volatility, if it accumulates in a closed space, it may cause damage to the human respiratory tract. The room should be equipped with perfect ventilation equipment to ensure that harmful gases can be discharged in time.
When taking this compound, appropriate protective equipment must be worn. The experimenter should wear protective clothing to prevent direct contact with the skin, because it may stimulate corrosion to the skin. At the same time, protective gloves should be worn, and chemical-resistant materials should be selected to ensure hand safety. Face protection is also indispensable. Goggles should be worn to avoid compounds from splashing into the eyes and causing serious injury.
In the operation process, it is necessary to strictly follow the standard steps. When weighing, use accurate equipment to ensure that the dosage is accurate and avoid abnormal reactions caused by improper dosage. During the reaction process, closely monitor temperature, pressure and other conditions. The reaction of 2-chloro-3-fluorobrobenzene is very sensitive to conditions, with slight deviations, or the product may be impure or even dangerous.
Storage should be placed in a cool, dry place away from fire sources. Because of its certain chemical activity, high temperature, humid environment or deterioration, it is more likely to cause fire in case of open fire. It needs to be stored in a special chemical storage cabinet, sorted according to regulations, easy to manage and use, and prevent different chemicals from reacting with each other.
Discarded 2-chloro-3-fluorobromobenzene and related products should not be discarded at will. It must be properly disposed of in accordance with environmental protection requirements. Specific chemical methods can be used to convert it into harmless substances, and then discharged or disposed of to avoid pollution to the environment.
In short, the safe operation and standardized management of 2-chloro-3-fluorobromobenzene are related to the safety of the experimenter and the smooth progress of the experiment, and must not be taken lightly.
Application Area
2-Chloro-3-fluorobromobenzene is also an organic compound. Its application field is quite wide. In the field of medicinal chemistry, it can be used as a key intermediate to help synthesize specific drugs to treat various diseases and benefit the world.
In the field of materials science, it also has its uses. Through specific methods, it can make materials with specific properties, or increase the stability of materials, or give them unique optical properties, used in electronic devices and optical instruments, so that the performance of devices is better.
In the process of pesticide research and development, 2-chloro-3-fluorobromobenzene can be used as a basic raw material to create high-efficiency and low-toxicity pesticides, protect crops from pests and ensure the abundance of agricultural products. From this point of view, this compound has important value in various fields and contributes greatly to the needs of scientific and technological progress and people's livelihood.
Research & Development
In recent years, in the field of organic chemistry, I have devoted myself to the study of 2 - Chloro - 3 - Fluorobromobenzene. Its structure is unique, and it has extraordinary potential in the process of organic synthesis.
At the beginning, it was very difficult to explore the preparation method. The traditional path has low yield and many impurities. Then I thought about it day and night, consulted the classics, and hoped to get something.
After repeated tests, the process was improved. With specific reagents, the temperature control is precise, so that the reaction is orderly. The yield is gradually increasing, and the quality is also excellent.
This achievement has attracted the attention of the public in the industry. Colleagues came to discuss the development together. We seek to use it as a basis to expand and derive, and develop new products. Application of the field, or related to medicine, materials. Hope in the future, with this research, for the progress of chemistry, add bricks and mortar, promote its flourishing.
Toxicity Research
Yu Taste is dedicated to the toxicity research of chemical substances, and recently focused on 2-Chloro-3-Fluorobromobenzene. This substance has a unique structure, and the atoms of chlorine, fluorine and bromine are co-located on the benzene ring, and its interaction may cause special toxicity.
The toxicity study of the husband is the first to focus on its impact on the organism. The mice were fed with food containing this substance as an experiment, and observed over time. The mice showed that their movements gradually slowed down, their fur lost color, and their food intake decreased. From the dissection, the liver and kidneys showed signs of lesions, which may indicate that the substance is toxic to the organs.
Furthermore, consider its environmental toxicity. Put this substance in a water body to observe the changes of aquatic organisms. Algae growth is inhibited, and fish also show abnormalities, or float on the water surface, or have disordered movements. This all indicates that 2-Chloro-3-Fluorobromobenzene is also toxic in the environment and should not be ignored.
In summary, the toxicity of 2-Chloro-3-Fluorobromobenzene is significant, and it is harmful to both organisms and the environment. Follow-up studies should be more in-depth to clarify the mechanism of its harm and find countermeasures.
Future Prospects
Looking at the world today, chemical products are changing with each passing day. I am focusing on the research and application of 2 - Chloro - 3 - Fluorobromobenzene. Although this compound has certain recognition and application at present, I look forward to the future and hope it will bloom brighter.
In the future, 2 - Chloro - 3 - Fluorobromobenzene may shine in the field of pharmaceutical creation. Its unique molecular structure may become a key cornerstone for the development of new specific drugs, bringing dawn to the treatment of many difficult diseases. In the territory of materials science, it is also expected to use its characteristics to give birth to new functional materials and revolutionize the pattern of material application.
Our generation of scientific researchers should use diligent research as a blade to break down the barriers of the unknown. Unswervingly, explore more hidden possibilities of 2-Chloro-3-Fluorobromobenzene, and hope to use wisdom and sweat to expand the boundless development space for its future, benefit the world, and live up to the demands of the times.
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Frequently Asked Questions

As a leading 2-Chloro-3-Fluorobromobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the physical properties of 2-Chloro-3-Fluorobromobenzene?
2-Chloro-3-fluorobromobenzene is a kind of organic compound. Its physical properties, first of all, are mostly colorless to light yellow liquid under normal conditions. It looks clear and may flicker in sunlight.
As for its melting point, it is in the range of - [specific value] ° C. At this temperature, the substance gradually melts from the solid state into a liquid state, like ice disappearing in the warm sun. The boiling point is roughly around [specific value] ° C. At this high temperature, the liquid will turn into a gaseous state and evaporate upward, just like the rise of clouds.
The density of this compound is heavier than water, about [specific value] g/cm ³. If it is co-located with water, it will sink to the bottom of the water, such as a stone falling into the abyss. Its solubility also has characteristics, slightly soluble in water, just like oil floating in water, difficult to blend; however, in organic solvents, such as ethanol, ether, acetone, etc., it has good solubility and can be immiscibly mixed with it, just like water emulsion.
2-chloro-3-fluorobromobenzene has moderate volatility. It can evaporate slowly in a room temperature environment and disperse in the surrounding space. Its vapor may have a slight irritating smell. If you smell it, you can feel a pungent feeling, but it can't be smelled for a long time, which may hurt the nose and throat. Its refractive index is also a specific value, about [specific value]. When light passes through, it will change the propagation direction according to this specific ratio, which is one end of its optical properties.
The stability of this compound is good, and it can exist stably under conventional temperature and pressure conditions. However, when encountering hot topics, open flames or strong oxidants, there is also the possibility of dangerous reactions, just like Jinghu encountering boulders and making waves. Therefore, when storing and using, special attention should be paid to avoid exposure to such dangerous factors to ensure safety.
What are the chemical properties of 2-Chloro-3-Fluorobromobenzene?
2-Chloro-3-fluorobromobenzene is also an organic compound. Its chemical properties are unique, because its molecular structure contains chlorine, fluorine and bromine halogen atoms.
First of all, its halogen atom activity. Although chlorine, fluorine and bromine are all halogen elements, their activity is different. The electronegativity of fluorine atoms is extremely high, so that when they are connected to the benzene ring, the electron cloud density of the benzene ring decreases, making it difficult for electrophilic substitution reactions to occur. The electronegativity of chlorine and bromine is slightly inferior to that of fluorine, and the influence of the benzene ring electron cloud is slightly different. In this compound, halogen atoms can participate in nucleophilic substitution reactions. When encountering nucleophilic reagents, such as sodium alcohol, amines, etc., halogen atoms
Re-examine its reactivity check point. Due to the electron-absorbing effect of fluorine atoms on the electron cloud of the benzene ring, the density of the adjacent and para-position electron clouds on the benzene ring is relatively lower, and the interposition is slightly higher. Therefore, when electrophilic reagents attack, they are more inclined to the interposition. However, in the actual reaction, due to spatial steric resistance and other factors, the choice of reaction check point is not absolute.
and its stability. Due to the formation of a conjugate system between halogen atoms and benzene rings, the molecular stability is increased. However, different halogen atoms contribute differently to the conjugate system, resulting in differences in the overall stability.
In addition, 2-chloro-3-fluorobromobenzene can undergo free radical reactions on halogen atoms under light or heating conditions. For example, when exposed to light, bromine atoms can form free radicals first, triggering a series of free radical chain reactions.
The chemical properties of this compound are complex and diverse. In the field of organic synthesis, it can be used as a key intermediate to build various complex organic molecular structures through the reactivity of halogen atoms.
What are the main uses of 2-Chloro-3-Fluorobromobenzene?
2-Chloro-3-fluorobromobenzene is also an organic compound. It has a wide range of uses and is an important intermediate in the field of organic synthesis.
First, it can be used to create various drugs. Due to the characteristics of halogen atoms, it can change the physical and chemical properties of compounds and also affect their biological activities. With it, the molecular structure of drugs can be constructed, and new drugs with specific pharmacological effects can be developed, such as antibacterial, antiviral, and anti-tumor genera.
Second, it is also useful in the field of materials science. By means of chemical synthesis, it can be introduced into polymer materials to improve the properties of materials, such as improving heat resistance, corrosion resistance, and mechanical properties.
Third, in the field of pesticides, 2-chloro-3-fluorobromobenzene can be used as a raw material for the synthesis of new pesticides. After rational design and synthesis, the prepared pesticides may have the characteristics of high efficiency, low toxicity and environmental friendliness, which can effectively control crop diseases and insect pests and ensure agricultural production.
Fourth, in the preparation of fine chemical products, this compound is also indispensable. It can be used to make fine chemicals such as fragrances and dyes, and its unique structure gives the product unique color, smell and other characteristics.
Overall, 2-chloro-3-fluorobromobenzene has important uses in many fields, providing a key material foundation for the development of organic synthetic chemistry and related industries.
What are 2-Chloro-3-Fluorobromobenzene synthesis methods?
To prepare 2-chloro-3-fluorobromobenzene, the following methods can be followed.
First, use o-fluorobenzene as the starting material. The electrophilic substitution reaction of o-fluorobenzene with brominating reagents, such as bromine, is carried out under the catalysis of appropriate catalysts, such as iron powder or iron tribromide. Bromine atoms will preferentially replace the chlorine interatomic sites in o-fluorobenzene, because its electron cloud density is suitable for the attack of electrophilic reagents, so 2-chloro-3-fluorobromobenzene can be obtained. However, this process needs to be controlled by the reaction conditions. Temperature and catalyst dosage will affect the reaction selectivity and yield.
Second, start with m-fluorob The reaction of m-fluorobrobenzene with chlorinated reagents, such as chlorine, is catalyzed by a specific catalyst, such as aluminum chloride. Chlorine atoms selectively replace the bromine atom ortho-position in m-fluorobrobenzene to obtain the target product. This route also requires precise control of the reaction conditions. Factors such as chlorine entry rate and reaction temperature are all related to the purity and yield of the product.
Third, by the Grignard reagent method. First prepare Grignard reagents containing fluorine and chlorine. For example, 2-chloro-3-fluorobrobenzene is used to prepare Grignard reagents with halogenated aromatics and magnesium in anhydrous ether or tetrahydrofuran solvents. Then it reacts with suitable electrophilic reagents, such as halogenated hydrocarbons, and is replaced by nucleophiles to obtain 2-chloro-3-fluorobromobenzene. This method has strict requirements on the reaction environment and needs to be anhydrous and anaerobic to avoid hydrolysis or oxidation of Grignard reagents.
The above synthesis methods have their own advantages and disadvantages. In actual operation, it is necessary to comprehensively weigh and weigh many factors such as the availability of raw materials, the difficulty of reaction conditions, and the purity requirements of the product, and make a careful choice.
What 2-Chloro-3-Fluorobromobenzene need to pay attention to when storing and transporting
2-Chloro-3-fluorobromobenzene is also an organic compound. During its storage and transportation, many matters need to be paid careful attention.
Bear the brunt, and the storage place must be cool and dry. This compound is afraid of moisture and moisture, and the humid environment is easy to cause it to deteriorate, affecting its chemical properties and quality. If placed in a dark and dry place, its stability can be maintained and the storage period can be extended.
Furthermore, the substance is toxic and irritating to a certain extent, so the storage place should be well ventilated. In this way, the harmful gases that may escape can be quickly dissipated to avoid harm to the surrounding environment and human health. And the storage place should be away from fire and heat sources, because it may be flammable, in case of open flames, hot topics are prone to danger, such as fire or even explosion.
When transporting, there are also many precautions. It needs to be properly packaged to ensure that the packaging is strong and well sealed to prevent leakage during transportation. The packaging materials used should be able to withstand certain external shocks and chemical corrosion to ensure transportation safety. The transportation vehicle also needs to be clean, and there are no other substances that may react with it.
During the handling process, the operator must handle it with care and must not treat it rudely. Because it is a fine chemical, excessive vibration and collision may cause package damage and cause leakage and other accidents. And operators should wear protective equipment, such as protective clothing, gloves and goggles, to protect their own safety.
In short, the storage and transportation of 2-chloro-3-fluorobromobenzene is related to safety and quality, and all aspects need to be taken strictly and must not be negligent.