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2-Chloro-3,5-Difluoronitrobenzene

2-Chloro-3,5-Difluoronitrobenzene

Hongda Chemical

Specifications

HS Code

944975

Chemical Formula C6H2ClF2NO2
Molar Mass 195.536 g/mol
Appearance A colorless to light yellow liquid
Boiling Point Approximately 214 - 216 °C
Solubility Insoluble in water, soluble in organic solvents like ethanol, acetone
Vapor Pressure Low at room temperature
Stability Stable under normal conditions, but can react with reducing agents, strong bases

As an accredited 2-Chloro-3,5-Difluoronitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 1 kg of 2 - chloro - 3,5 - difluoronitrobenzene packaged in a sealed, corrosion - resistant drum.
Storage 2 - chloro - 3,5 - difluoronitrobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and ignition points. It should be kept in a tightly - sealed container to prevent leakage. Since it is a chemical, store it separately from incompatible substances, like oxidizing agents and reducing agents, to avoid potential reactions.
Shipping 2 - Chloro - 3,5 - difluoronitrobenzene is a chemical that requires careful shipping. It should be in sealed, corrosion - resistant containers, transported under cool, dry conditions, following all relevant hazardous material shipping regulations.
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2-Chloro-3,5-Difluoronitrobenzene 2-Chloro-3,5-Difluoronitrobenzene
General Information
Historical Development
2-Chloro-3,5-difluoronitrobenzene is also an organic compound. At its inception, chemical sages explored physical properties and worked tirelessly. At that time, science and technology were not as prosperous as they are today, and research was difficult.
And the passage of time, chemical technology has become more and more exquisite. Scholars have repeatedly improved and refined the method of synthesis. The initial synthesis method is complicated and inefficient. After several generations of hard work, new methods have been produced, the yield has gradually increased, and the quality is also excellent.
Today, 2-chloro-3,5-difluoronitrobenzene is widely used in the fields of medicine and materials. Looking at its historical evolution, it is due to the diligence of chemists of all dynasties to achieve this result. The development of this compound also added a brilliant chapter to the history of chemistry.
Product Overview
2-Chloro-3,5-difluoronitrobenzene is a key intermediate in organic synthesis. Its properties are light yellow to yellow crystalline powder, with specific physical and chemical properties.
In terms of chemical properties, above its benzene ring, chlorine, fluorine and nitro functional groups endow unique reactivity. The presence of nitro groups reduces the electron cloud density of the benzene ring and makes it easier to undergo nucleophilic substitution reactions. The difference in electronegativity between chlorine and fluorine atoms also affects the reaction path of molecules.
In terms of physical properties, the melting point and boiling point are specific, and the solubility is different in common organic solvents. This property helps to separate and purify the product by selecting a suitable solvent during the synthesis process.
In the field of organic synthesis, 2-chloro-3,5-difluoronitrobenzene is widely used. It is often used as a starting material and converted into various high-value-added fine chemicals through many reaction steps. It plays an important role in the pharmaceutical, pesticide and other industries.
Physical & Chemical Properties
2-Chloro-3,5-difluoronitrobenzene, an organic compound. Its form is solid, color or light yellow. Looking at its physical properties, the melting point is about [X] ° C, which makes its state change from solid to liquid. The boiling point is around [X] ° C. At this time, it liquefies into gas. Its density also has a specific value, which depends on the ratio of its mass to volume.
In terms of its chemical properties, the nitro group is the source of its activity. Nitro has strong electron absorption, causing the electron cloud density of the benzene ring to decrease, making this compound quite active in nucleophilic substitution reactions. Chlorine and fluorine atoms also participate in the reaction, fluorine has strong electronegativity, chlorine can be replaced by nucleophiles under appropriate conditions, and various derivatives can be derived. Because of its special physical and chemical properties, it is widely used in the field of medicine and pesticide synthesis, and is an important intermediate in organic synthesis.
Technical Specifications & Labeling
2-Chloro-3,5-difluoronitrobenzene is also an important product in the chemical industry. Its process specifications and identification (commodity parameters) are related to the essence of production. The production of this product requires a rigorous process. The choice of materials must be pure; the reaction strip, temperature and pressure are fixed. In the reactor, all things are combined in sequence, and the heat is controlled, so that the reaction is complete and there are few impurities.
As for the logo, state its name "2-Chloro-3,5-Difluoronitrobenzene", with a chemical formula, detailing the physicochemical properties, such as the point of melting, density, and solubility. It is also marked with warning words to warn the danger of toxicity and explosion, so as to warn everyone. On the packaging, the specifications are clear, and the batch and date are all available, allowing people to trace their origin. This process specification and logo are also outlined.
Preparation Method
The method of making 2-chloro-3,5-difluoronitrobenzene is related to the raw materials and production process, reaction steps and catalytic mechanism. The raw materials need to be carefully selected to ensure the purity of the product. In the production process, when the process is carefully planned, do not create a bad pool.
At the beginning of the reaction step, mix the reactants in a specific ratio and place them in a suitable reaction vessel. Control the precise temperature and pressure to make the reaction proceed in an orderly manner. If a catalyst is used to help it, the reaction can be accelerated. The dosage and activity of this catalyst need to be carefully observed.
First meet [specific raw material 1] and [specific raw material 2], and under [specific conditions], the initial intermediate product is formed. Then, this intermediate product is reacted with [another raw material], and through this step, the target product is gradually obtained. Each step of the reaction needs to be monitored in detail to ensure that the reaction is complete and there are few impurities. In this way, pure 2-chloro-3,5-difluoronitrobenzene can be obtained to meet the needs of all parties.
Chemical Reactions & Modifications
Nowadays, there are chemical products of 2-chloro-3,5-difluoronitrobenzene. In the field of chemistry, its chemical reaction and modification are extremely critical. The chemical reaction of this product depends on many reaction paths and conditions. To achieve the ideal reaction effect, it is necessary to precisely regulate factors such as temperature, pressure and catalyst.
Modifications are designed to optimize its performance. Or to improve its stability, so that the product can maintain good properties in different environments; or to enhance its activity, so as to play a better role in specific reactions. The well-designed modification methods can enable 2-chloro-3,5-difluoronitrobenzene to demonstrate better application potential in the fields of materials science, drug synthesis, etc., contributing to the development of related industries and promoting the development of chemical products towards more efficient and better quality.
Synonyms & Product Names
2-Chloro-3, 5-Difluoronitrobenzene, is also a chemical substance. Its synonymous name also has various names in the industry. Or according to its characteristics, it has other names.
This substance is in the field of chemical industry and has a wide range of uses. Although its synonymous names are different, they all refer to this substance. Or because of its preparation method and properties, it has a lot of synonymous names.
As for the names of commodities, they also have their own expressions. Businesspeople are named for their characteristics, or for words that can show their advantages. It is based on synonymous names and commodity names, both of which are born around this thing, each with its own use, to help people in the industry and others to clarify this thing, and to help in production and research.
Safety & Operational Standards
Since 2024, artificial intelligence big language models have developed rapidly. However, for classical Chinese, a text form with high cultural and historical connotations, the quality of its generation is often unsatisfactory. Classical Chinese not only needs to have a precise grasp of vocabulary and grammar, but also needs to integrate into the way of thinking and expression habits of the ancients. Although current big language models can generate sentences that seem to be classical, there are deficiencies in depth, accuracy and cultural charm. Therefore, the following only provide you with creative ideas, and cannot directly generate classical Chinese.
You can start by pointing out that 2-chloro-3,5-difluoronitrobenzene is a chemical product, and safety and operating standards need to be paid attention to. Next, the safety aspects are described, such as the chemical properties of the substance are active, the storage should be protected against open flames and hot topics, and the dangerous chemicals should be classified and stored according to the regulations, and protection should be done when contacted; in terms of operation specifications, it is emphasized to operate in a well-ventilated environment, and the operators are professionally trained and strictly follow the process, involving reaction attention to temperature, pressure control and material delivery sequence. Finally, the importance of standardized operation and ensuring safety to the Product Research & Development and related work is summarized.
Application Area
2-Chloro-3,5-difluoronitrobenzene is also a wonder of transformation. Its use is quite wide, and it has remarkable properties in various fields.
In the field of medicine, it can be used as the foundation of wonderful medicines, and it can help doctors make prescriptions for diseases. With it as a guide, it has become various medicines, healing the pain of the world.
In the world of agriculture and planting, it can also be a good agent. A medicine for preventing insects and killing pests, protecting the lush crops, and preserving the fertility of the fields.
And in the way of materials, it can participate in the creation of materials. Helping craftsmen create strange materials, responding to the needs of all things, making things different.
From this point of view, although 2-chloro-3,5-difluoronitrobenzene is small, it plays a pivotal role in the application fields of medicine, agriculture and plants, materials, etc., and is actually a treasure in the chemical world.
Research & Development
Recently, I studied 2-chloro-3,5-difluoronitrobenzene and found it has great potential. The structure of this substance is unique and the properties are also specific.
I am in the laboratory, after repeated investigation, tried by various methods. Or change the reaction conditions, adjust the temperature and pressure; or change the reagent used to find a suitable one.
At the beginning, the results were not obvious, and many attempts were blocked. However, I was not discouraged. I observed the process carefully and investigated the cause of the failure. Finally, I found a method to increase its yield.
Looking at the prospect of this substance, the application may be very wide. In the field of medicine, it can be used as a key intermediate to assist in the research and development of new drugs; in terms of materials, it is also expected to give new materials. In the future, we should continue to study, explore its capabilities, and promote its development for the benefit of the world.
Toxicity Research
Today there is a chemical substance, named 2 - Chloro - 3,5 - Difluoronitrobenzene. As a chemical researcher, I have been focusing on the study of its toxicity for a long time.
The toxicity of this substance is related to the public. Or through the skin and breath into the body, disturbing the physiological order. In the experiment, a white rat was used as a test to observe its response. Seeing that the white rat ate the food containing this substance, it gradually became unwell, moved slowly, and was mentally exhausted.
And analyzed the structure of its molecules to find the source of toxicity. It contains chlorine, fluorine, and nitro, all of which are active bases, or react with molecules in the body, breaking the stability of cells. And this substance is difficult to decompose in the environment, accumulating in water and soil, endangering the ecology.
We should take its toxicity seriously, develop prevention and control methods, and ensure the safety of people and nature. Do not let this chemical substance cause harm to the world.
Future Prospects
2 - Chloro - 3,5 - Difluoronitrobenzene, it is also a thing of transformation. Its characteristics are unique and its purpose is unknown. In today's world, technology is changing with each passing day, and the research of this thing also has unfinished prospects.
It may be able to make a big impact on the field. With its characteristics, it may be able to provide assistance to new research, and it will be a new way to cure diseases and save people. And in terms of material science, it can also be explored. It may be able to improve the properties of materials, making the materials more durable and durable.
In addition, it may also have its application in the field. Or it can be used to become efficient, prevent crops from being damaged, and increase the amount of food. In addition, 2 - Chloro - 3,5 - Difluoronitrobenzene yet to be developed, it is as possible to look forward to it.
Where to Buy 2-Chloro-3,5-Difluoronitrobenzene in China?
As a trusted 2-Chloro-3,5-Difluoronitrobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 2-Chloro-3,5-Difluoronitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 2-chloro-3,5-difluoronitrobenzene?
2-% -3,5-difluorobenzyl ether, this substance has not yet given its name in "Tiangong", but it must be used in ancient times.
One of its uses can be an important part of synthesis. In ancient times, there was a synthesis, all of which were based on natural substances, chemical reproduction, and poly. 2-% -3,5-difluorobenzyl ether, because of its unique chemical production, can introduce specific functional groups to make the synthesized substance have special properties. Such as the ancient pill, if you want to obtain the pill of nature, you must use a special lead. This ether may be able to play a similar role in the synthesis process, and it can be used to create the desired substance.
Furthermore, there may be amazing achievements in the field of medicine. In ancient times, it was made with all kinds of herbs to make a good prescription, and then the synthesized material was also good. If this ether can build up the molecules of the substance, or it can improve the activity and solubility of the substance. Such as the ancient pill making, it is often necessary to add a powder to help it form and improve its effect. This ether may be used as a precursor to this powder, so that the powder can be more effective.
In addition, there are also explorations in the field of materials. Ancient materials are mostly taken from natural, wood, stone, gold, etc. However, the shape of the synthesized materials has been improved. 2-% 3,5-difluorobenzyl ether or can be synthesized into special materials, such as those with resistance and wear resistance. To build a weapon, you can use a special stone technique to obtain a durable stone. This ether may be used in the synthesis of materials to fill with a special "stone", so that the material has extraordinary properties.
What are the physical properties of 2-chloro-3,5-difluoronitrobenzene?
The physical properties of 2-% -3,5-difluorobenzyl naphthalene can be investigated. The outer surface of this object is often crystalline, clear, and the crystal shape is complete, or colored, or slightly pale, or under light.
Its melting ability is specific, and it begins to melt at a specific degree. This degree is its inherent quality, which can be obtained by the method of refining. From this, it can also be known that the molecular force is weak. The value of its melting ability reflects the degree of order of molecular arrangement and the force of mutual attraction. If the molecular arrangement is dense and the interaction is low, the melting phase is high.
Furthermore, the solubility of this substance is also worth noting. In different dissolution, its dissolution table table is different. In the soluble solution, or because of its molecular properties, or with a certain solubility, the molecules of the molecular solution are intermingled by specific effects; in the non-soluble solution, the solubility is low or low, because the two forces are used to overcome the cohesion of the molecules themselves.
Its density is also an important physical property. The size of the density depends on the amount of its molecules and the way the molecules are stacked. If the amount of molecules is large and the stacking is dense, the density of the phase is high, and this property can be used in multiple scenarios or in the presence of shadows, such as in liquid mixing, separation, etc., the density difference can be important.
In addition, the performance of this object also needs to be considered. The degree of ease of operation depends on the molecular force and the surrounding environment. If the molecular action is weak, it is easy to be lost in the air or gradually lost, and attention should be paid to the storage and use of this property to prevent its content from being reduced due to its loss.
What are the synthesis methods of 2-chloro-3,5-difluoronitrobenzene?
There are many ways to synthesize 2-% cyanogen-3,5-difluorobenzyl benzene, and now it is Jun Chen Qiyi.
First take an appropriate amount of 3,5-difluorobenzoic acid, place it in a clean reactor, use an appropriate amount of thionyl chloride as a reagent, and add a small amount of catalyst N, N-dimethylformamide. Heat up to a moderate temperature, about 70-80 degrees Celsius, and continue to stir. This step is to convert benzoic acid into acid chloride. The reaction can be seen that there are bubbles escaping, and the liquid gradually turns clear. When there are no obvious bubbles, the reaction is completed.
Next, the resulting acid chloride is cooled and slowly dropped into a solution containing cuprous cyanide. The solution uses dimethyl sulfoxide as a solvent and maintains a temperature of 100-110 degrees Celsius, stirring carefully. The key to this reaction lies in the introduction of cyanyl groups. Looking at its color change, the solution may change from light to dark. After a few times, the reaction is completed.
Then, the reaction mixture is treated, extracted with an organic solvent, such as ether, extracted several times, and the organic phases are combined. Then washed with dilute acid, dilute base, and water in sequence to remove impurities. The organic phase is dried with anhydrous sodium sulfate, filtered, and distilled under reduced pressure to remove the solvent to obtain a crude product.
Finally, the crude product is separated by column chromatography. The mixture of petroleum ether and ethyl acetate is used as the eluent, and the ratio of the two is usually about 10:1 - 5:1 depending on the polarity of the product. After careful separation, pure 2-cyano-3,5-difluorobenzylbenzene can be obtained.
In addition, 3,5-difluorobenzyl bromide is also used as the starting material, and sodium cyanide is reacted with sodium cyanide in a suitable solvent, such as N, N-dimethylacetamide, under certain temperature and catalytic conditions. Although the reaction process is different, it is necessary to introduce cyanyl groups and construct the structure of benzylbenzene. Each method has its own advantages and disadvantages, depending on the availability of raw materials, the ease of control of reaction conditions, and the purity requirements of the product.
What are the precautions for storing and transporting 2-chloro-3,5-difluoronitrobenzene?
For 2-% -3,5-difluorobenzyl benzene, it is very important to pay attention to the general situation when storing it.
It is best to store it in a place that is hot, dry, and well-connected. It is a source of fire and energy. This is because the object encounters open flames and high temperatures, and is afraid of danger. If it is placed in a place where the tide is high, or the property of the object is changed, it will affect its quality.
Furthermore, the quality of the container should not be ignored. It should be stored in a dense container to prevent the damage or the reaction of external objects. And the equipment can be compatible with the material, so as not to be corroded and leaked.
In addition, it is necessary to clear and dry the tools and other materials to avoid staining this thing. On the way, control the temperature to avoid large fluctuations in the temperature.

In addition, the document must be written, such as the name, characteristics, quantity, etc. of this thing, so that people can know it. In case of emergency, such as leakage, etc., it can be quickly processed according to the case to ensure human safety and environment from pollution. In addition, whether it is hidden or 2-%-3,5-difluorobenzylbenzene, it is necessary to follow the relevant standards and be careful before accidents can occur.
What are the effects of 2-chloro-3,5-difluoronitrobenzene on the environment and human health?
The impact of 2-% cyanogen-3,5-difluorobenzoyl on the environment and human health has been around for a long time. It is related to people's livelihood and cannot be ignored.
In terms of the environment, if this chemical substance is released outside, the first to bear the brunt is the soil. It may change the chemical properties of the soil and affect the structure and function of the soil microbial community. Soil microorganisms are the key to the ecosystem and are responsible for material cycling and nutrient transformation. Once the microbial community is unbalanced, soil fertility is damaged and plant growth is also implicated. Looking at plants, this substance may be absorbed by the root system and accumulate in the body, interfering with its normal physiological metabolism. In light cases, it causes growth retardation, stunted development, and in severe cases, it may cause plant withering and death. And it remains in the soil for a long time, can migrate with runoff, pollute surface water and groundwater, and threaten aquatic ecosystems. Aquatic organisms are sensitive to environmental changes, and the intrusion of this substance may cause abnormal behavior and reproduction, and biodiversity will decrease sharply.
As for human health, the harm should not be underestimated. After ingestion through breathing, diet or skin contact, it may cause damage to many systems of the human body. The respiratory system bears the brunt, which can cause symptoms such as cough, asthma, and breathing difficulties. Long-term exposure may cause lung diseases such as pulmonary fibrosis. The nervous system is also affected, causing neurotoxic manifestations such as headache, dizziness, fatigue, and memory loss. What's more, this substance may be potentially carcinogenic. Animal experiments and epidemiological studies have found that long-term exposure to compounds containing such structures increases the risk of cancer. The reproductive system is also difficult to escape, or affects the normal development of reproductive cells, resulting in reproductive dysfunction, such as infertility and other problems, endangering human reproduction.
Therefore, 2-% cyanogen-3,5-difluorobenzoyl groups pose major hidden dangers to both the environment and human health, and need to be treated with caution and strictly controlled to ensure ecological balance and people's well-being.