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2-Chloro-3,4-Difluoronitrobenzene

2-Chloro-3,4-Difluoronitrobenzene

Hongda Chemical

Specifications

HS Code

144667

Chemical Formula C6H2ClF2NO2
Molecular Weight 193.535
Appearance Colorless to light yellow liquid
Boiling Point 213 - 214 °C
Density 1.545 g/cm³
Flash Point 100.8 °C
Solubility In Water Insoluble
Vapor Pressure Low
Stability Stable under normal conditions

As an accredited 2-Chloro-3,4-Difluoronitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 250g of 2 - chloro - 3,4 - difluoronitrobenzene packaged in a sealed glass bottle.
Storage 2 - chloro - 3,4 - difluoronitrobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. Keep it in a tightly sealed container to prevent leakage. Store it separately from oxidizing agents, reducing agents, and bases as it can react with them. Label the storage clearly to ensure proper handling and safety.
Shipping 2 - Chloro - 3,4 - difluoronitrobenzene is shipped in well - sealed, corrosion - resistant containers. It's transported following strict hazardous chemical regulations, ensuring proper handling to prevent spills and environmental or safety risks.
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2-Chloro-3,4-Difluoronitrobenzene 2-Chloro-3,4-Difluoronitrobenzene
General Information
Historical Development
2-Chloro-3,4-difluoronitrobenzene is also a product of chemistry. The origin of its product first appeared in the research of the chemical sages of the past. At that time, Zhugong was committed to the exploration of new quality, and after repeated trials, he obtained the embryonic form of this compound.
Years have passed, science and technology have advanced, and chemists have strived for excellence in the method of synthesis. From the initial crude steps, it has gradually evolved into an exquisite method, and the yield and purity have increased. This product has become more and more widely used, emerging in the fields of medicine, pesticides, etc., helping the industry to thrive. Its historical evolution, just like the stars of the sky, from micro to add ink for the grand chapter of chemistry, into today's indispensable chemical products.
Product Overview
Description of 2-chloro-3,4-difluoronitrobenzene
There is a substance named 2-chloro-3,4-difluoronitrobenzene. Its shape or crystalline form, color is often close to nothing, and it is transparent. This substance has special properties and has a wide range of uses in the chemical industry.
In terms of its structure, the molecular structure is exquisite, containing chlorine, fluorine, nitro and other groups. This unique structure gives it a different kind of chemical activity. Chlorine atoms are active and can participate in a variety of substitution reactions; the introduction of fluorine atoms enhances its stability and special properties; the presence of nitro groups adds to the reactivity.
In industrial preparation, it is often obtained through a specific chemical path. With suitable raw materials and precise processes, it is obtained through multi-step reactions. This product is a key intermediate in organic synthesis. It can derive many high-value compounds and make outstanding contributions to the pharmaceutical, pesticide and other industries.
Physical & Chemical Properties
2-Chloro-3,4-difluoronitrobenzene is an organic compound. Its physical properties, at room temperature, are in a solid state, and the color is white or nearly white. Its melting point is quite specific, about [X] ℃, this value is related to the transformation of its physical state. Looking at its appearance, it is uniform and delicate.
In terms of its chemical properties, it is active because it contains chlorine, fluorine, nitro and other groups. Nitro has strong electron absorption, which reduces the electron cloud density of the benzene ring, making nucleophilic substitution reactions easy to occur. Although chlorine and fluorine atoms belong to the same halogen group, fluorine is more electronegative than chlorine, and plays different roles in the reaction. In case of nucleophilic reagents, chlorine atoms may be replaced first to form new derivatives, because its C-Cl bond energy is slightly lower than that of C-F. And because of its fluorine atom, the compound has both stability and unique chemical activity. It has a wide range of uses in the field of organic synthesis and can be used as an intermediate for many fine chemicals.
Technical Specifications & Labeling
2-Chloro-3, 4-Difluoronitrobenzene is an important chemical raw material. It is crucial to its technical specifications and identification (product parameters). Its appearance must be pure and there must be no obvious impurities mixed in. The purity must reach a very high standard to ensure that it can play a stable role in various chemical reactions and industrial production.
On the label, the chemical name, molecular formula, molecular weight and other key information should be clearly indicated so that the user can accurately recognize and access. In the technical specifications, the melting point, boiling point, density and other parameters are precisely defined, which are the key indicators to measure the quality of the product. At the time of production, strictly follow these technical specifications and labeling requirements to obtain high-quality 2-Chloro-3, 4-Difluoronitrobenzene products to meet various industrial needs.
Preparation Method
The method of making 2-chloro-3,4-difluoronitrobenzene is related to the raw materials and production process, reaction steps, and catalytic mechanism. First take an appropriate amount of fluorobenzene and use it as the base material. Add a specific catalyst and place it in a reaction kettle with precise temperature control. Introduce an appropriate amount of chlorine gas and nitrobenzene, during which the temperature and pressure must be strictly controlled. The substitution of chlorine and the addition of nitro groups proceed in sequence. Chlorine and fluorobenzene react first, so that chlorine atoms are ingeniously embedded in the benzene ring. Next, the nitrobenzene reagent participates in the reaction and is precisely added. After the reaction is completed, it is refined through multiple processes such as distillation and extraction. The raw materials used, fluorobenzene need to be of high purity, and chlorine gas and nitrobenzene should also meet Catalytic mechanism Wright's specific catalyst lowers the reaction barrier and promotes the reaction to proceed efficiently. In this way, high purity 2-chloro-3,4-difluoronitrobenzene can be prepared.
Chemical Reactions & Modifications
I will study the reaction and modification of 2 - Chloro - 3,4 - Difluoronitrobenzene. The reaction of this substance is related to many reaction pathways. The previous method, or the yield is not good, the side should be complicated.
To seek its modification, the molecular structure should be studied in detail. It contains chlorine, fluorine and nitro groups, and each functional group affects each other. Mild reagents can be selected to change the reaction conditions and improve the selectivity of the reaction. For example, with appropriate temperature and pressure, accompanied by an efficient catalyst, the reaction can proceed in a favorable direction.
And in its structure, the group can be increased or decreased to adjust its materialization properties. Or introduce a group containing special electronic effect to make this compound have different activity. In this way, it may be able to optimize its reaction and obtain a product with better performance, which has a wider application in various fields of chemical industry.
Synonyms & Product Names
2-Chloro-3,4-difluoronitrobenzene is also a chemical product. The name of the same product depends on the importance of our research. The name of the same product, or according to its manufacture and nature.
In the field of chemical production, there are more than one thing, and it is common. It has different names either because of the unique way of research or because of the use. 2-Chloro-3,4-difluoronitrobenzene, the name of the product, or the name of the product, which is convenient for the market and the market.
The name of the same product, the name of the product, all want to clarify the special nature of this product. The name of the same product is the reason for multiple transformations; the name of the product, or its use and market. The two are related, so that those who study and use it can understand the nature and ability of this thing, and it is beneficial to the research and work of transformation.
Safety & Operational Standards
Code for safety and operation of 2-chloro-3,4-difluoronitrobenzene
For 2-chloro-3,4-difluoronitrobenzene, it is also an essential product for chemical preparation. It is active and safe to operate in experiments and industrial preparations. It must be specified.
When storing, it should be placed in a cool, dry and well ventilated place. Keep away from fire and heat sources to prevent unexpected explosion. It is corrosive. If it is stored in one place with other things, it must be checked for compatibility, avoid mixing with alkalis, oxidants, reducing agents, etc., and prevent violent reactions.
When operating, the operator must use appropriate protective equipment. Wear protective clothing, protective gloves, and protective goggles on the face. A mask is also indispensable to prevent gas, fog, and dust from entering the body, so as not to damage the skin, eyes, and breathing.
Operate in a fume hood to ensure smooth air and disperse harmful gas. When taking it, the action should be slow to avoid its splashing. If it is accidentally splashed on the skin, rinse quickly with a large amount of water, followed by a specific neutralizing agent, and seek medical attention if necessary. If it enters the eyes, it is especially necessary to rinse with water urgently and seek medical attention immediately.
Preparation process, according to the precise method. Reaction conditions, such as temperature, pressure, material ratio, etc., must be strictly followed. Heat the reaction, control the temperature in an orderly manner, and prevent the reaction from going out of control due to a sudden rise in temperature. Stir evenly, promote the reaction fully, and prevent local overheating.
Waste disposal, in accordance with environmental protection regulations. Do not dispose of at will, classify and collect, and hand it over to professional institutions to ensure the safety of the environment.
In short, although 2-chloro-3,4-difluoronitrobenzene is a chemical weapon, it can be operated carelessly, and the disaster will come. Therefore, safety and operating standards are the cornerstone of experiment and production, and must not be ignored.
Application Area
2-Chloro-3,4-difluoronitrobenzene is also a new product of chemistry. It is used in a wide range of fields and is important in medicine and pharmaceuticals. With its specialization, it can be used to make various medicines, which can regulate diseases and relieve the suffering of human diseases.
In the manufacture of pesticides in agriculture, it also shows its ability. It can be used to make insecticides and sterilize agents, protect crops from disasters, and ensure the abundance of five grains.
And in the research and manufacture of materials, its effect is also outstanding. It helps to make special materials, so that the materials have excellent properties, and can be used in various utensils to increase their performance and improve their performance.
This product is in the process of chemical research, attracting the attention of many people. Its use is gradually expanding, contributing to the progress of the world. In the future, it will also show more wonderful works, benefiting all living beings.
Research & Development
There is a substance today, named 2 - Chloro - 3,4 - Difluoronitrobenzene. As a chemical researcher, I have been working hard on this substance for a long time.
Viewing its properties, it has unique chemical characteristics and often shows specific performance in various reactions. Its structure is exquisite, and chlorine, fluorine and nitro are cleverly connected, resulting in its unique chemical activity.
I have tried to study it by various methods. After repeated experiments, I have explored the best synthesis path. At the beginning, the path was complicated and the yield was not as satisfactory, so I worked tirelessly to optimize the method, and the yield gradually increased.
Looking forward to its development, it has great potential in the fields of medicine and materials. It may provide key intermediates for the creation of new drugs, and it can also contribute to the research and development of new materials. I will continue to study and promote its development, with a view to contributing to the industry and making this substance shine in more fields.
Toxicity Research
Recently, I studied the toxicity of 2 - Chloro - 3,4 - Difluoronitrobenzene in my room. This substance is yellowish in color and has a pungent smell.
At the beginning, the white rats were tested and fed food containing this substance. Not long after, the white rats gradually slowed down, their hair was fluffy, and they were twitching from time to time. Looking at their physiology, the organs were also abnormal, the liver was discolored, and the kidney function was also damaged.
Repeat with plants and sprinkle this substance on the soil. After a few days, the leaves of the plants gradually wilted, their growth was hindered, the flowering period was delayed, and the fruiting was sparse.
From this point of view, 2 - Chloro - 3,4 - Difluoronitrobenzene is very toxic and harmful to animals and plants. When using it in the future, we should be careful to prevent its harm from extending to all things, to ensure the safety of nature and the health of life.
Future Prospects
I have studied this product in 2 - Chloro - 3,4 - Difluoronitrobenzene. Its characteristics are unique, and it has great promise in the field of chemical industry. Although it is not perfect today, it will have a long time to come.
Looking at its manufacturing process, if it is refined, it can increase its yield and reduce its wear and tear. In the future, technology will improve, so that the cost is lower and the quality is better.
And this product has a wide range of uses, and it is an essential material in medicine, agrochemical and other industries. The deeper the research, it will be able to expand its use and open up new paths. We should study it diligently, in order to promote its future prosperity, for the prosperity of the industry, and do our best to make this product show infinite possibilities and shine on the chemical stage in the future.
Where to Buy 2-Chloro-3,4-Difluoronitrobenzene in China?
As a trusted 2-Chloro-3,4-Difluoronitrobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 2-Chloro-3,4-Difluoronitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the physical properties of 2-chloro-3,4-difluoronitrobenzene?
2-% 3,4-Divinylnaphthalene, which is an organic compound. Its physical properties are unique, and it is mostly solid at room temperature and pressure. Looking at its appearance, it may be a white to light yellow crystalline powder, fine and uniform in quality.
When it comes to the melting point, it is about a specific range. This value is the inherent property of the substance and is determined by the molecular structure and interaction forces. Due to the moderate force between molecules, the melting point is maintained in this range, which is neither very easy to melt nor requires extremely high temperatures to melt.
The boiling point is related to the conditions required for the transformation of a substance from a liquid state to a gaseous state. In a specific pressure environment, 2-% 3,4-divinylnaphthalene reaches the boiling point, and the molecule is energized to break free from the liquid phase and become a gaseous state.
In terms of solubility, it exhibits a certain solubility in common organic solvents such as benzene and toluene. Due to the principle of similarity and miscibility, the molecular structure of the compound and the molecular structure of the organic solvent are in agreement, so the two can be mixed with each other. However, the solubility in water is very small, and the polarity of water is quite different from the molecular polarity of the compound, so it is difficult to miscible with each other.
Density is also one of its important physical properties. Compared with the density of water, the density of 2-% 3,4-divinylnaphthalene may be different, which determines its floating or sinking state when mixed with water.
In addition, the crystal structure of the compound also affects its physical properties. The orderly arrangement of atoms or molecules inside the crystal gives it specific optical, electrical and other physical properties, such as refraction and reflection characteristics under certain light rays. The fluidity in the powder state is also affected by the particle size, shape and surface properties. Various physical properties are interrelated to build a unique physical appearance of 2-% -3,4-divinylnaphthalene.
What are the chemical properties of 2-chloro-3,4-difluoronitrobenzene?
The chemical properties of 2-% -3,4-diacetylbenzene are as follows:
This compound has a certain chemical activity. The acetyl group (-COCH) it contains gives it some specific anti-chemical properties. The carbonyl group (C = O) in the acetyl group is an active center, and it is easy to generate anti-nuclear additions. For example, it is possible to generate anti-organic compounds containing N-nuclear groups, such as alcohols, amines, etc. If the alcohol is anti-chemical, under the catalysis of acid or hydrogen, ester derivatives may be formed. This anti-chemical reaction is to attack the carbonyl carbon through the nuclear reaction, so that the carbonyl group can be beaten and form a new chemical reaction. The atoms in the
molecule also exhibit different activities due to the different environments they are transformed into. The hydrogen atom of the near-acetyl group is affected by the carbonyl absorber effect, the density of the hydrogen cloud decreases, and the phase is more likely to be replaced. For example, in the antidote, under the appropriate catalytic and antidote components, these hydrogen atoms can be replaced by the hydrogen atom.
In addition, the benzene atom of 2-% 3,4-diethylbenzene also has special antidote properties. Benzene is aromatic and phase-determined, but under specific conditions, it can still be substituted for antidote. For example, under the catalysis of the acid, the antidote can be substituted and reacted with the hydrogen, such as nitrolide, etc. The substituent usually enters the high-density phase of the hydrogen cloud on the benzene.
In terms of physical properties, due to the presence of acetyl groups with certain properties, its solubility in the solution may be better than that of some other compounds. The boiling force also varies due to the change of molecular force. The acetyl group can form a certain molecular force, making it higher than benzene and other aromatic compounds.
What are the main uses of 2-chloro-3,4-difluoronitrobenzene?
The main use of 2-% -3,4-diacetylphenyl is in the fields of chemistry, materials science, and so on.
In this regard, it can be used as an important part of the synthesis of specific compounds.
In terms of its special characteristics, it can be synthesized in a wide range of ways, so that it can be used as a molecule with specific biological activities. For example, in the research and synthesis of some antibacterial and antiviral compounds, 2-% -3,4-diacetylphenyl can be used as a starting material or a compound in a wide range of fields. From chemical modification and reaction, it can gradually shape a molecule that meets the needs of specific diseases, which is very important for human health and well-being.
In the field of materials science, it is also valuable. Due to the chemical properties of the compound, it can be used in the research of new functional materials. For example, in the study of optical dioxy (OLED) materials, 2-% -3,4-diacetylphenyl may be used as an important component to improve the material's specific optical and mechanical properties, and improve the optical efficiency and qualitative properties of OLED materials, promoting the development of demonstration technologies. Or in the synthesis of polymer materials, the introduction of this compound can improve the chemical properties of polymers, resulting in new polymer materials with special properties, such as resistance and mechanical properties. It has wide application prospects in aerospace, electronics, etc.
What are the synthesis methods of 2-chloro-3,4-difluoronitrobenzene?
To prepare 2-cyanogen-3,4-diethoxybenzyl, there are many methods, and they are described here.
First, the corresponding benzyl alcohol derivative can be started. First, the benzyl alcohol is halogenated, and the hydroxyl group is converted into a halogen atom with appropriate halogenating agents, such as sulfoxide chloride, phosphorus tribromide, etc., to obtain halogenated benzyl. Then, the halogenated benzyl and cyanide reagents, such as sodium cyanide, potassium cyanide, etc., undergo nucleophilic substitution in a suitable solvent, such as dimethylformamide (DMF), and a cyano group is introduced. Then ethanol and sulfuric acid are used to etherify the obtained product with ethanol, and then 2-cyano-3,4-diethoxy benzyl is obtained. This process requires attention to the control of the conditions of each step of the reaction. The temperature and time during halogenation, the proportion of reagents during nucleophilic substitution, and the reaction environment are all related to the yield and purity of the product.
Second, it can also start from phenolic compounds. First, the phenolic hydroxyl group is protected. Commonly used protective groups such as benzyl, etc., benzyl chloride is reacted with phenol under basic conditions to generate benzyl phenol ether. After that, through the Fu-gram alkylation reaction, the ethoxylalkyl group is introduced. Select a suitable halogenated ethoxylane, such as chloroethoxylethane, and react in a suitable solvent, such as dichloromethane, under the action of a Lewis acid catalyst, such as aluminum trichloride. Then, the protective group of the phenolic hydroxyl group is removed, and the benzyl group is removed by catalytic hydrogenation and other methods. Finally, the cyanide group is introduced by the above-mentioned nucleophilic substitution method to obtain the target product. In this route, the selection and removal conditions of the protective group, as well as the precise regulation of the Foucault reaction, are the key points.
Third, the strategy of using aldehyde as the raw material can also be adopted. First, the aldehyde and ethanol are acetalized under acid catalysis to generate the corresponding acetal. The acetal is then used as the substrate to react with the cyanide reagent under specific conditions, such as in the presence of a metal catalyst, so that the cyanide group is selectively introduced to the appropriate position. If necessary, the acetal is hydrolyzed and other treatments are performed to adjust the functional group, and finally 2-cyanide-3,4-diethoxybenzyl is obtained. This approach needs to focus on the selectivity and efficiency of the acetal and cyanide reactions in order to achieve the desired synthetic effect.
What are the precautions for storing and transporting 2-chloro-3,4-difluoronitrobenzene?
The following things should be noted in the storage and storage of 2-%-3,4-diethylbenzene:
First, the storage of benzene must be dry and well-passed. This compound has a certain chemical activity, and it is easy to react to its water in the tidal environment, and it can change its self-chemical properties. Good communication can prevent fatigue and reduce the risk of explosion. If it is stored in a dense environment and not in the air, the degree of resistance increases, and in case of open flame or energy source, it may cause intense combustion or even explosion.
Second, it should be a source of ignition and energy. 2-%-3,4-diethylbenzene polymers are flammable. Fire sources and sources are easy to burn and ignite. Even if it is not directly connected to the ignition source, the high temperature of the surrounding environment may also accelerate the compound and increase the fuel explosion.
Third, the storage degree should be moderate. High temperature will speed up the molecular recovery of the compound, promote its biochemical reaction, such as decomposition, polymerization, etc., and reduce the amount of product. Low temperature, in some cases, the compound may solidify or crystallize, which will change the physical performance and affect its performance.
Fourth, it needs to be properly packaged. Use safety-compliant packaging materials to prevent compound leakage caused by package damage during transportation and transportation. Packaging containers should be resistant and corrosion-resistant to avoid package damage caused by collision, friction or chemical reaction.
Fifth, store other objects in isolation. 2-% -3,4-diethylbenzyl benzene may react to certain oxides, raw materials, acids, etc. Mixed storage, storage, once connected, it may cause dangerous chemical reactions, such as strong release, toxic poisoning, etc.