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2-Chloro-1-Fluoro-4-(Trifluoromethyl)Benzene

2-Chloro-1-Fluoro-4-(Trifluoromethyl)Benzene

Hongda Chemical

Specifications

HS Code

866102

Chemical Formula C7H3ClF4
Molar Mass 198.54 g/mol
Appearance Liquid (usually)
Boiling Point Around 120 - 125 °C
Density Data - specific (usually in g/cm³)
Solubility In Water Low (organic compound, relatively non - polar)
Vapor Pressure Data - specific (depends on temperature)
Flash Point Data - specific (flammability related)
Refractive Index Data - specific (optical property)
Packing & Storage
Packing 500 - gram bottle packaging for 2 - chloro - 1 - fluoro - 4 - (trifluoromethyl)benzene.
Storage 2 - chloro - 1 - fluoro - 4 - (trifluoromethyl)benzene should be stored in a cool, well - ventilated area, away from heat sources and open flames to prevent potential ignition. Keep it in a tightly sealed container to avoid evaporation and exposure to air and moisture, which could cause chemical reactions. Store it separately from oxidizing agents and incompatible substances.
Shipping 2 - chloro - 1 - fluoro - 4 - (trifluoromethyl)benzene is shipped in well - sealed, corrosion - resistant containers. It follows strict hazardous chemical shipping regulations, ensuring proper handling to prevent spills and environmental or safety risks.
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2-Chloro-1-Fluoro-4-(Trifluoromethyl)Benzene 2-Chloro-1-Fluoro-4-(Trifluoromethyl)Benzene
General Information
Historical Development
2-Chloro-1-fluoro-4- (trifluoromethyl) benzene is also an organic compound. Its initial research originated from the study of halogenated aromatics by various scholars. In the past, many scholars focused on the halogenation of aromatic hydrocarbons, in order to obtain the products of this specific structure.
At the beginning, the synthesis path was full of thorns. Early attempts were made by conventional halogenation methods, but it was difficult to introduce fluorine, chlorine and trifluoromethyl accurately based on the specific position of the benzene ring. Chemists worked hard and tried many strategies. Gradually, improved methods came out, such as choosing a special catalyst and controlling the appropriate temperature and pressure to help the reaction trend towards the expected direction.
After several generations of changes, the synthesis technology has become more and more exquisite. The discovery of new catalysts has significantly improved the selectivity and yield of the reaction. To this day, the preparation of 2-chloro-1-fluoro-4- (trifluoromethyl) benzene has been used in industry, in materials, medicine and other fields, which is a good example of the progress of chemistry.
Product Overview
Today there is a substance called 2-chloro-1-fluoro-4- (trifluoromethyl) benzene. This is an organic compound with a unique chemical structure. Its molecules contain chlorine, fluorine and other halogen elements, giving the substance special chemical properties.
This substance may be a colorless and transparent liquid with certain volatility and is relatively stable at room temperature and pressure. Because of its fluorine atom, its chemical stability is enhanced and it has certain hydrophobicity.
In the field of organic synthesis, 2-chloro-1-fluoro-4 - (trifluoromethyl) benzene is often used as an important intermediate. Through specific chemical reactions, it can be converted into various high-value-added organic compounds, such as for the preparation of medicines, pesticides and functional materials. Its unique chemical structure provides the possibility for the synthesis of novel organic molecules, which is of great significance in chemical research and industrial production.
Physical & Chemical Properties
In 2024, the research on "2-chloro-1-fluoro-4- (trifluoromethyl) benzene" in the chemical community will become more and more in-depth. The physical properties of this substance are often colorless and transparent liquid in appearance, with a specific odor and slightly irritating. Its boiling point is about 130-132 ° C, the density is 1.48g/cm ³, and it is stable at room temperature and pressure.
Chemically, the halogen atoms such as fluorine and chlorine in this compound give it active reactivity. The substituents on the benzene ring enable it to participate in a variety of chemical reactions, such as nucleophilic substitution and electrophilic substitution. Due to the presence of trifluoromethyl, it has certain chemical stability and hydrophobicity.
The study of the physical and chemical properties of this substance is of great significance in the fields of organic synthesis and materials science. It can be used as an intermediate to synthesize organic compounds with special properties; in the field of materials, it may improve the weather resistance and chemical stability of materials.
Technical Specifications & Labeling
Today there is a product called 2-chloro-1-fluoro-4- (trifluoromethyl) benzene. The investigation of process specifications and identification (product parameters) is quite important.
The process specifications of this product must clarify the method of synthesis. The raw material must be selected with precision, and the reaction conditions should be strict. Temperature, pressure, catalyst and other factors are all related to the purity and yield of the product. If the reaction temperature or controlled in a specific range, to ensure a smooth reaction and good product.
As for the identification (product parameters), its physical and chemical properties should be specified. Data such as melting point, boiling point, density, etc. are clearly displayed to help users understand their characteristics. And on the packaging, safety signs are indispensable to warn of possible hazards and ensure the safety of use and storage. In this way, the essence of the process specification and identification (product parameters) is combined, which is beneficial for production and application.
Preparation Method
The preparation of 2-chloro-1-fluoro-4- (trifluoromethyl) benzene is related to the raw materials and production process, reaction steps and catalytic mechanism.
To prepare this compound, a specific aromatic hydrocarbon can be used as the starting material, and it can be reacted with reagents containing chlorine, fluorine and trifluoromethyl in a suitable catalytic system. If an aromatic hydrocarbon is selected, a chlorine-substituted reagent is first used as a catalyst to perform a chlorination reaction, and chlorine atoms are introduced at a specific position precisely. The reaction conditions need to be controlled by temperature, pressure and time to promote the efficient and directional reaction.
Then, a fluorinated reagent is introduced to complete the fluorination step in another catalytic environment, so that the chlorine atom is replaced by the fluorine atom, and the stable retention of trifluoromethyl is ensured. The choice of catalyst in this process is very important, and its activity and selectivity affect the purity and yield of the product.
In the catalytic mechanism, the catalyst used can reduce the activation energy of the reaction, change the reaction path, and make the reaction occur under milder conditions. After each step of the reaction is completed, the pure 2-chloro-1-fluoro-4- (trifluoromethyl) benzene product is obtained by separation and purification. In this way, according to this process step and catalytic principle, the preparation of this substance can be achieved.
Chemical Reactions & Modifications
2-Chloro-1-fluoro-4- (trifluoromethyl) benzene is also a chemical substance. Its chemical reaction and modification are the essence of chemical research.
The reaction of this compound is often involved in the genus of nucleophilic substitution. Halogen atoms are active and can be attacked by nucleophilic reagents to form new bonds and change their structure. For example, with a nucleophilic body, the appropriate conditions are selected, or the halogen can be replaced to obtain a new substance with a unique structure.
As for modification, it can be added to the benzene ring by means of localization effect. Fluorine has high electronegativity, which affects the distribution of electron clouds in the benzene ring, and can lead the reaction to select a specific location. Changing the reaction conditions, or adjusting the proportion of reagents, is expected to obtain different replacement products to meet diverse needs and develop their applications in materials, medicine and other fields. This is the direction of exploration by chemical researchers, hoping to understand its properties, make good use of its changes, and benefit the world.
Synonyms & Product Names
Regarding the congeners and trade names of 2-chloro-1-fluoro-4- (trifluoromethyl) benzene
There are currently chemical substances 2-chloro-1-fluoro-4- (trifluoromethyl) benzene, which are used in chemical research and industrial applications. There are also many congeners and trade names.
Its congeners may be derived due to slight changes in the atoms in the structure or differences in substituents. Although the structure is slightly different, they all have a benzene ring core and contain chlorine, fluorine and other halogen elements. In terms of chemical properties, they are similar to 2-chloro-1-fluoro-4- (trifluoromethyl) benzene.
As for the trade names, merchants give different names according to their characteristics and uses for ease of sales and distinction. In the chemical market, they may be called "fluorochlorobenzene special agent", which means that it contains chlorine and has special uses. These many identical substances and trade names enrich the system of chemical substances and provide more choices and possibilities for chemical research and industrial applications.
Safety & Operational Standards
2-Chloro-1-fluoro-4- (trifluoromethyl) benzene safety and operating specifications
Fu 2-chloro-1-fluoro-4- (trifluoromethyl) benzene is an important product in the chemical industry. Its nature is special, related to safety and operating standards, and cannot be careless.
In terms of safety, this product has certain hazards. Its vapor or fog is irritating to the eyes and upper respiratory tract. If people accidentally touch it, the skin may be irritated or even burned. Entering the eyes can cause serious eye damage. Therefore, when exposed, protective equipment is essential. The operator wears protective clothing, protective gloves, protective glasses, etc. in front of appropriate protective clothing to prevent damage.
When operating, there are also many norms. It should be done in a well-ventilated place to prevent the accumulation of steam. When operating, keep away from fire and heat sources, and prevent open flames. Because of its flammability, it will encounter open flames, hot topics or cause combustion and explosion. The equipment used should be grounded to remove static electricity, and prevent the accumulation of static electricity from causing danger. After use, properly clean the site and do not allow residues to remain.
When storing, it should be placed in a cool and ventilated warehouse. Keep away from fire and heat sources, and the storage temperature should not exceed 30 ° C. It should be stored separately from oxidants and food chemicals, and should not be mixed. The storage area should be equipped with leakage emergency treatment equipment and suitable containment materials.
If there is a leak, evacuate the personnel from the leakage contaminated area to the safe area as soon as possible, and isolate them. Strictly restrict access. Cut off the source of fire. Emergency personnel wear self-contained positive pressure breathing apparatus and anti-virus clothing. Do not let the leak come into contact with combustible substances. Small leaks, absorb with sand, vermiculite or other inert materials. Large leaks, build embankments or dig pits to contain. Cover with foam to reduce steam disasters. Use explosion-proof pumps to transfer to tankers or special collectors, recycle or transport to waste disposal sites for disposal.
All of these are the safety and operation specifications for 2-chloro-1-fluoro-4- (trifluoromethyl) benzene. Practitioners should keep it in mind and follow it carefully to ensure safety.
Application Area
Today there is a product called 2-chloro-1-fluoro-4- (trifluoromethyl) benzene. This product has its uses in many fields.
In the field of pharmaceutical research and development, it can be a key raw material. Based on this product, many special and good medicines can be prepared through subtle synthesis. It may act on specific targets in the human body, heal intractable diseases, and add a sharp tool for doctors to treat diseases and save people.
In the world of material manufacturing, it also has extraordinary things. It can participate in the synthesis of special materials, giving materials unique properties, such as enhancing their weather resistance and chemical stability. Make the material suitable for extreme environments, providing high-quality materials for engineering construction, equipment manufacturing, etc.
In the field of fine chemicals, this is the starting point, and through layer-by-layer reactions, a variety of fine chemicals can be produced. Or as a key component of high-end coatings, making the coating more shiny and durable; or as a raw material for special fragrances, giving a unique aroma. This 2-chloro-1-fluoro-4 - (trifluoromethyl) benzene has a wide range of uses and is of great value in various fields.
Research & Development
Today there is a substance called 2 - Chloro - 1 - Fluoro - 4 - (Trifluoromethyl) Benzene. We are committed to the research and development of this substance through chemical research.
At the beginning, explore its physicochemical properties. Observe its boiling point and dissolution energy, analyze its molecular structure in detail, and explain its atomic connection formula. Also examine its reaction properties. Under various conditions, observe its combination and decomposition with other substances, understand the mechanism of its reaction, and find the best way.
Then seek its development. Want to expand its preparation method, seek efficient and environmentally friendly process, reduce its cost and increase its yield. Think of its application domain, in medicine, materials industries, explore its usefulness, hope to be used by the world, promote the progress of science and technology, and help people's livelihood. Expect the research and development of this material to contribute to the chemical industry and benefit the world.
Toxicity Research
2-Chloro-1-fluoro-4- (trifluoromethyl) benzene, the toxicity study of this chemical is related to human life and health, and cannot be ignored. I have dedicated myself to studying, observing its physicochemical properties, and exploring its mechanism of action. Its molecular structure is unique, containing chlorine and fluorine atoms, or causing special chemical activities. After experimental observations, it may interfere with the metabolism of cells in living organisms, breaking the normal physiological order. And its stability in the environment is quite strong, or it remains for a long time, gradually accumulating in living organisms, causing endless harm. Although its whole leopard is not yet known, signs of toxicity have emerged. I should unremitting investigation, detailed examination of the harm, hope for the world to avoid the harm of this poison, to protect life and health, the environment is peaceful, do my best, do not dare to slack.
Future Prospects
Fu 2 - Chloro - 1 - Fluoro - 4 - (Trifluoromethyl) Benzene, in the field of my chemical research, has great hope for future expansion. Its structure is unique and its performance is different from that of ordinary things.
At present, although there is a basic understanding, the unknown is still wide. In the future, it may emerge in the creation of new materials. Extrapolating from its characteristics, it may become a key component of electronic devices, making device performance leap to a new level.
Furthermore, in the field of pharmaceutical research and development, there are infinite possibilities. Or it can use its chemical activity to carve out new drugs with outstanding curative effects and treat diseases for patients.
We, the scientific researchers, should have the heart of exploration, and strive to open a new chapter in its future application, benefit the world, and live up to the mission of scientific research.
Frequently Asked Questions
What are the main uses of 2-chloro-1-fluoro-4- (trifluoromethyl) benzene?
2-% -1-oxo-4- (trioxy methyl) naphthalene is one of the most common compounds. Its main use is broad, and it is useful in many fields.
In the chemical field, this compound can be used as a catalyst for the synthesis of specific compounds. Due to its specific properties, it can affect the specific receptors or enzymatic interactions of organisms, and affect the physiological functions of organisms. For example, it can be modified by chemicals to make it have antibacterial, anti-inflammatory or anti-tumor activities, helping to research and provide effective compounds to overcome many diseases.
In the field of materials science, 2-% -1-oxy-4- (trioxy methyl) naphthalene also has important uses. Due to some of its physical and chemical properties, it can be used as a raw material for special functional materials. For example, it can be used to make materials with special optical and chemical properties, which can be used in photonic devices, such as optical diodes (OLEDs), solar energy pools, etc., to improve their performance and promote the development of optical technology.
Furthermore, in chemical engineering, it can be used as a catalyst or an anti-synthetic reaction. Due to the existence of special functions, it can lead to specific chemical reactions, improve the efficiency of the reaction, promote the synthesis of various chemical compounds, and help chemical and biological products.
Therefore, 2-% -1-oxo-4- (trioxy methyl) naphthalene
What are the physical properties of 2-chloro-1-fluoro-4- (trifluoromethyl) benzene?
The physical properties of 2-% -1-oxy-4- (trioxomethyl) benzene are as follows:
This substance is a liquid of yellow color to light yellow color, with a special taste and a certain degree of resistance. Its boiling property is specific. Under certain conditions, it can be boiled at [X] ° C. This boiling property makes it suitable for some separation operations. It can be divided into other substances according to the degree of difference.
Its density is also one of the important physical properties, which is large [X] g/cm ³, which is different from water, or heavy or heavy. This property is essential in processes involving liquid mixing, separation, etc. For example, if water is mixed, it can be judged according to its density.
In terms of solubility, 2-% -1-oxo-4- (trioxy methyl) benzene has good solubility in multiple solvents, such as ethanol and ether, and can be mutually soluble to form a homogeneous solution. However, its solubility in water is limited, and it can dissolve a small amount. This characteristic can be used as a basis for separation in reaction, extraction, and other processes.
In addition, the refractive index of this substance also has its specific value, which is large [X]. The characteristics of the refractive index of the product are often low, which can help to determine the degree of this substance. If the deviation of the refractive index value of the product is large, it can be inferred that its degree is poor.
Therefore, the physical properties of 2-% -1-oxy-4- (trioxy-methyl) benzene, such as boiling, density, solubility, refractive index, etc., are mutually exclusive and useful. They are indispensable in many fields such as chemical research, engineering, and engineering, which can help researchers to better control the various processes involved in this matter.
What are the chemical properties of 2-chloro-1-fluoro-4- (trifluoromethyl) benzene?
2-% N-1-oxy-4- (trioxy methyl) naphthalene, which is a compound with chemical properties. Its chemical properties exhibit many aspects.
In terms of its physical properties, it is usually lower than normal, or solid. Because the basic framework of naphthalene has a certain degree of stability, this compound has a high degree of melting and boiling. Molecular forces, such as Vander force, play an important role in its condensation.
and its chemical reaction activity, the presence of naphthalene gives its aromaticity. Aromatic compounds usually have high activity when they are substituted. In this compound, the position of 2 - is affected by the side effect of the near group, and it is in the substitution reaction, or one of the active sites. And the 4 - (trioxy methyl) group, its side effect is also used for the inverse activity of the whole molecule. Trioxy methyl group may have certain absorptive properties, which can redistribute the density of molecules on naphthalene, and affect the inverse property.
In terms of oxidation reaction, because of its carbon-containing skeleton, it can be oxidized under suitable oxidation and reaction parts. Naphthalene can be oxidized by quinone derivatives, etc. If there is a catalytic reaction, the way of oxidation reaction and more compounds may be obtained.
In the original reaction, the chemical properties of naphthalene can be partially or completely original, depending on the original material and the original material used. If the original material of gold compound is used, it may be possible to make the partial chemical properties of naphthalene compound and generate the phase sum or partial chemical derivatives.
The chemical properties of this compound are affected by the interaction of each group in the molecule, and it may have certain research and application values in the field of chemical synthesis.
What are the synthesis methods of 2-chloro-1-fluoro-4- (trifluoromethyl) benzene?
To prepare 2-bromo-1-pentene-4- (triamylmethyl) naphthalene, the following ancient methods can be used.
First, the naphthalene is used as the beginning, and the alkylation is first performed. Take the naphthalene and the appropriate triamylmethyl halide, and perform the Fu-gram alkylation reaction under the catalysis of Lewis acid such as aluminum trichloride. The active position of the naphthalene can be combined with the triamylmethyl halide to obtain 1- (triamylmethyl) naphthalene. This step requires attention to the reaction temperature and the amount of catalyst to prevent the formation of polyalkylation products.
Second, brominate the 1 - (triamylmethyl) naphthalene. Liquid bromine is used as the bromine source, and a small amount of iron powder is added to an appropriate solvent such as dichloromethane. The bromine atom will selectively replace the hydrogen at a specific position on the naphthalene ring to obtain 2-bromo-1- (triamylmethyl) naphthalene. During operation, the dropwise addition rate of bromine and the reaction temperature should be controlled to avoid the generation of polybrominates. After
, prepare 1-pentene-4-based fragments. Prepare with a suitable halogenated pentene, such as 4-chloro-1-pentene, by a metal-organic reagent such as Grignard's reagent. Take magnesium strips and 4-chloro-1-pentene in anhydrous ethyl ether to initiate a reaction to obtain 4-pentenyl magnesium chloride. At the end of
, a coupling reaction is carried out. 2-Bromo-1 - (triamylmethyl) naphthalene and 4-pentenyl magnesium chloride are reacted under appropriate reaction conditions, such as tetrahydrofuran as a solvent, at appropriate temperatures. The two are coupled to obtain the target product 2-bromo-1-pentene-4 - (triamylmethyl) naphthalene. After the reaction is completed, the pure product can be obtained by separation and purification methods, such as column chromatography. Throughout the process, the conditions of each step of the reaction are finely regulated to increase the yield and purity of the product.
What are the precautions for storing and transporting 2-chloro-1-fluoro-4- (trifluoromethyl) benzene?
For 2-% -1-oxy-4- (trioxy methyl) naphthalene, if it is not stored in the warehouse, please pay attention to the important things.
If it is not stored, the first priority will be determined. It is appropriate to use a place that is dry and well-connected, and a source of fire and heat, so that the flammability of this material is clear. If it is in a tidal environment, or a place that causes problems, it will be like a situation. Moreover, oxidizing materials, acids and other substances should be stored separately. Because of their chemical activity, they will meet each other, and they may react violently and become large.
Furthermore, the storage container should not be ignored. It must be used in a container that is used and dense to prevent the object from being exposed. The material of the container should be able to withstand the corrosion of this object, and it should not be transformed and reversed, so as to preserve the preservation.
If it is not necessary, it must comply with the relevant regulations. People must be subject to, familiar with the characteristics of this object and the way to deal with it urgently. Therefore, 2-% -1-oxygen-4- (trioxy methyl) naphthalene should be carefully treated in order to ensure safety.