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2-Chloro-1-Fluoro-4-Iodobenzene

2-Chloro-1-Fluoro-4-Iodobenzene

Hongda Chemical

    Specifications

    HS Code

    776468

    Chemical Formula C6H3ClFI
    Appearance Typically a colorless to light - colored liquid
    Boiling Point Approximately in the range of 190 - 210°C (est.)
    Density Around 2.0 - 2.2 g/cm³ (est.)
    Solubility In Water Insoluble
    Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, chloroform
    Vapor Pressure Low vapor pressure at room temperature
    Stability Stable under normal conditions, but may react with strong oxidizing agents

    As an accredited 2-Chloro-1-Fluoro-4-Iodobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 100g of 2 - chloro - 1 - fluoro - 4 - iodobenzene packaged in a sealed glass bottle.
    Storage 2 - chloro - 1 - fluoro - 4 - iodobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store it in a tightly sealed container, preferably made of corrosion - resistant materials. Label the container clearly to avoid misidentification. This storage method helps prevent decomposition, potential reactions, and ensures safety.
    Shipping 2 - chloro - 1 - fluoro - 4 - iodobenzene is a chemical. It should be shipped in well - sealed, corrosion - resistant containers. Follow proper hazardous material shipping regulations, ensuring secure packaging to prevent leaks during transit.
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    2-Chloro-1-Fluoro-4-Iodobenzene 2-Chloro-1-Fluoro-4-Iodobenzene
    General Information
    Historical Development
    In the past, the research of chemistry has gradually become more and more subtle. The birth of 2-chloro-1-fluoro-4-iodobenzene has also gone through twists and turns. At the beginning, the academic community was exploring halogenated aromatics in the ascendant, and many talented people threw themselves into it.
    At that time, the experimental conditions were simple, but everyone was enthusiastic. After repeated attempts, various halogenation methods were used to obtain the embryonic form of this compound. Early preparation, the yield was quite low, and there were many impurities, but the ancestors were not discouraged.
    With the passage of time, the instruments gradually refined and the theory gradually enriched. The new reaction mechanism was revealed, the new catalyst was applied, and the synthesis process of 2-chloro-1-fluoro-4-iodobenzene was improved day by day. The yield rose and the purity was also good, so it was widely used in the fields of medicine and materials, which contributed to the progress of chemistry and laid the foundation for future scientific research.
    Product Overview
    2-Chloro-1-fluoro-4-iodobenzene is one of the organic compounds. Its color is colorless to slightly yellow, like a liquid, with a special odor. This compound is very important in the field of organic synthesis and is often a key intermediate.
    Looking at its structure, above the benzene ring, chlorine atoms, fluorine atoms and iodine atoms are each in specific positions, giving it unique chemical properties. Due to the electronegativity difference of halogen atoms, the molecular polarity is different, and the chemical reaction activity is also special.
    In the process of synthesis, it can be prepared by a variety of chemical methods. For example, by halogenation reaction, choose suitable halogenation reagents, and precisely introduce chlorine, fluorine and iodine atoms. The control of the reaction conditions, such as temperature and the choice of catalyst, has a great influence on the purity and yield of the product.
    From this perspective, although 2-chloro-1-fluoro-4-iodobenzene is tiny, it plays an extraordinary role in the field of organic chemical synthesis, paving the way for the creation of many complex compounds.
    Physical & Chemical Properties
    2-Chloro-1-fluoro-4-iodobenzene, its material has unique physical and chemical properties. Looking at its shape, at room temperature, it is often colorless to light yellow liquid, like oil and smooth, shining under light. Its taste is specific, and it can smell pungent breath, but this taste is also one of its signs.
    On its boiling point, it is about a specific value. At this temperature, it liquefies into gas and rises in the air. The melting point is also fixed, and it condenses when cold, and is solid and firm.
    Furthermore, its solubility also has characteristics. In organic solvents such as alcohols and ethers, it is soluble and miscible, like a fish getting water; in water, it is insoluble, like an oil floating on water, and it is distinct.
    The structure of this substance, chlorine, fluorine, and iodine atoms are connected to the benzene ring in sequence, and the balance of forces between atoms makes it unique in physicochemical properties. All these are required for those who study this substance to study it carefully to clarify its properties and prepare it for various uses.
    Technical Specifications & Labeling
    2-Chloro-1-Fluoro-4-Iodobenzene is an important compound in organic synthesis. Its preparation requires specific technical specifications and standards. During the process operation, the selection of raw materials should be carefully selected to ensure that the purity is up to standard, which is the key. The reaction conditions also need to be strictly controlled. Parameters such as temperature, pressure and reaction time will affect the quality and yield of the product.
    In terms of detection, it is necessary to follow established standards and use accurate analytical methods. For example, chromatography is used to determine the purity, and spectroscopy is used to confirm the structure. Only by meeting strict quality indicators can the product meet the standard. Precise control of various product parameters can ensure the high quality of 2-Chloro-1-Fluoro-4-Iodobenzene and play its due role in subsequent applications.
    Preparation Method
    The preparation method of 2-chloro-1-fluoro-4-iodobenzene is related to the raw materials and production process, reaction steps and catalytic mechanism. The selection of raw materials is very critical, and it is necessary to carefully identify the matching materials. The production process should follow strict procedures and be accurate step by step.
    The reaction starts, and the relevant raw materials are placed in a suitable container in a specific ratio to create a suitable reaction environment, or temperature control, or pressure regulation to ensure that the reaction goes forward. The reaction steps are interlocking. At the beginning, the raw materials are mixed, and the chemical changes gradually occur. After a series of transformations, the target product can be obtained.
    The catalytic mechanism is indispensable, and the selection of high-efficiency catalysts can promote the reaction to accelerate and increase the yield. Catalyst intervenes in the reaction, changes the chemical reaction path, reduces the energy barrier required for the reaction, and makes the reaction efficient. In this way, with scientific method and rigorous state, 2-chloro-1-fluoro-4-iodobenzene is prepared.
    Chemical Reactions & Modifications
    Nowadays, there is a chemical substance called 2-Chloro-1-Fluoro-4-Iodobenzene. In chemical research, reaction and modification are crucial.
    Looking at the reaction of this compound, its chlorine, fluorine and iodine atoms have their own characteristics. Under different reaction conditions, either nucleophilic substitution or coupling reaction. If the nucleophilic reagent arrives, the chlorine atom or the first reaction can be replaced by a nucleophilic group due to its electronegativity and atomic radius. This is a common reaction path.
    As for modification, in order to obtain new properties and uses, its structure can be modified. Or introduce specific functional groups to change its physicochemical properties. For example, the addition of nitrogen-containing heterocycles can make them have special coordination capabilities and may have new uses in the field of catalysis.
    The beauty of chemistry lies in exploring the possibility of material reaction and modification, so that this 2-Chloro-1-Fluoro-4-Iodobenzene can also show new faces in the research process and be used in various fields.
    Synonyms & Product Names
    2-Chloro-1-Fluoro-4-Iodobenzene, the synonyms and trade names of this thing are related to the important identification of our chemical research. In the field of chemical industry, it is common to have more than one thing. 2-Chloro-1-Fluoro-4-Iodobenzene, or have another name to adapt to different scenarios. Its synonyms may be born according to the reaction mechanism and structural characteristics. As for the trade name, it is determined by the manufacturer for the product promotion and has a unique commercial identification. Or according to its characteristics, such as reactivity, use, etc., choose the name of the fit. Knowing synonyms and trade names is beneficial for procurement and research exchanges. It can avoid confusion caused by name differences, ensure accurate information transmission, so that research can proceed smoothly, and chemical production can be carried out in an orderly manner.
    Safety & Operational Standards
    2-Chloro-1-fluoro-4-iodobenzene safety and operating specifications
    Fu 2-chloro-1-fluoro-4-iodobenzene is also a common thing in chemical research. If you want to use it well, you must first clarify its safety and operation, so as to protect your health and safety.
    #1. The key to survival
    This compound should be placed in a dry, dry and good place. Avoid open fires and high temperatures to prevent damage. It may be flammable and cannot be damaged in case of fire. The equipment must be kept secret, so as to prevent the contact between the materials in the air from being damaged, and to prevent the pollution from escaping, endangering humans and animals.
    #2. Operating equipment
    Operating equipment, it is appropriate to wear protective equipment. Such as a gas mask, it can prevent it from steaming into the air, and it is necessary to breathe; gloves are worn on the hands, and the skin is not connected. If you are not careful about the skin, quickly wash it with a lot of water, so that it is appropriate to use it. When entering the eye, the same is true, and it is urgent to use it.
    Operating equipment needs to pass through the air, so that it can be used and discharged. Operating equipment, it is appropriate to be careful, do not let this thing overflow. Use it, and store the rest properly, do not set it aside.
    #Third, the method
    On the way, it must be stored in a suitable container according to the corresponding method. The container should be shock-resistant, leak-proof, and properly protected. And explain its properties, hazards, etc., so that the user knows what to prevent.
    Therefore, for the research application of 2-chloro-1-fluoro-4-iodobenzene, the safe operation is essential. Follow this rule, so that the research path can be difficult.
    Application Area
    2-Chloro-1-fluoro-4-iodobenzene, this compound has applications in many fields. In the field of medicinal chemistry, due to its unique chemical structure, it can be used as a key intermediate to synthesize drug molecules with specific biological activities. With its halogen atomic properties, it can precisely construct the molecular structure required for drugs through specific chemical reactions, laying the foundation for the creation of new therapeutic drugs.
    In the field of materials science, it also shows potential value. It can participate in the synthesis process of polymer materials, giving materials unique properties such as special optical and electrical properties. For example, in the synthesis of optoelectronic device materials, the introduction of this compound structure unit may optimize the photoelectric conversion efficiency of materials and improve device performance. Furthermore, in organic synthetic chemistry, it is often used as an important substrate. Through various organic reactions, such as nucleophilic substitution, coupling reactions, etc., a variety of organic compounds with diverse structures are derived, which greatly enriches the variety of organic compounds and promotes the development of organic synthetic chemistry.
    Research & Development
    Today there is a thing called 2 - Chloro - 1 - Fluoro - 4 - Iodobenzene. For our chemical researchers, the importance of its research and progress should not be underestimated.
    This substance has a specific structure, and chlorine, fluorine and iodine atoms are co-attached to benzene rings, giving it unique physicochemical properties. To understand its properties, it is necessary to study its intra-molecular atomic phase and the distribution of electron clouds. After various experiments, its melting, boiling, solubility, etc. are measured, and it is used as a foundation.
    As for its use, it has a wide range of prospects. In the field of medicine, it may be used as a key intermediate to help create new drugs and treat various diseases. In the field of materials, or give new energy to materials, such as the uniqueness of optoelectronics, to promote the research and development of new materials.
    On the way to research, there are also difficulties. The method of synthesis, seeking high efficiency and pure production, requires fine adjustment of conditions and selection of reagents. And its toxicology and ring sound are also to be studied in detail.
    We should hold a constant heart, explore its arcane, and promote its progress. With the research and progress of 2-Chloro-1-Fluoro-4-Iodobenzene, we will benefit the world.
    Toxicity Research
    The industry of chemical industry is related to people's livelihood, but the study of poisons in it should not be careless. There is a thing today, called 2-Chloro-1-Fluoro-4-Iodobenzene, whose sexual toxicity should be studied with caution.
    Although this thing is used in chemical synthesis or has its uses, it is dangerous to be toxic and must not be ignored. Its entry into the body may damage the viscera, disrupt the transportation of qi and blood, and disturb the communication of meridians and collaterals. Light ones are dizzy, and serious ones endanger life.
    Those who study this thing must live in a secret room, equipped with protective equipment, such as leather armor to protect their qi, and a mask to block their poison. When experimenting, pay attention step by step to avoid the leakage of poisons. Wastewater and waste residue should also be properly disposed of to prevent pollution of the environment and harm all living beings.
    Researching the industry of toxicity has a heavy responsibility and concerns the safety of everyone. It must not be caused by temporary benefits and endless disasters. Only by being cautious can we achieve the prosperity of chemical industry without worries about future problems.
    Future Prospects
    Now Guanfu 2-chloro-1-fluoro-4-iodobenzene has an extraordinary untapped prospect in the field of chemical industry. Although the world may only see one or two of its chemical characteristics at present, I am convinced that in the years to come, it will shine.
    This compound has an exquisite structure, and its chlorine, fluorine and iodine atom distribution endows it with unique chemical activity. In the process of organic synthesis, it can be used as a key building block to build various complex and delicate molecular structures, paving the way for the creation of new drugs and functional materials.
    In the field of medicine, it may be the basis for the development of special new drugs. With its activity as a guide, explore new paths to treat diseases, heal all kinds of diseases, and save patients from fire and water. The field of materials, or give birth to novel functional materials, used in cutting-edge places such as electronics and optics, has made science and technology develop rapidly.
    Our chemical researchers should be diligent, put aside their mysteries, and explore their potential. With unremitting research, we hope to help 2-chloro-1-fluoro-4-iodobenzene shine in the future, add brilliance to human well-being, and create a bright new era.
    Where to Buy 2-Chloro-1-Fluoro-4-Iodobenzene in China?
    As a trusted 2-Chloro-1-Fluoro-4-Iodobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 2-Chloro-1-Fluoro-4-Iodobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 2-Chloro-1-Fluoro-4-Iodobenzene?
    2-Chloro-1-fluoro-4-iodobenzene is also an organic compound. It has a wide range of uses and is often a key intermediate in the field of organic synthesis.
    First, it plays a significant role in drug synthesis. The atoms of chlorine, fluorine and iodine attached to the genbenzene ring each have unique chemical properties. The introduction of fluorine atoms can enhance the fat solubility of drug molecules, improve their biofilm permeability, make it easier for drugs to reach their targets and enhance their efficacy. Such as the creation of some new antibacterial drugs, 2-chloro-1-fluoro-4-iodobenzene can undergo a series of chemical reactions to build a specific drug skeleton, laying the foundation for the development of new antibacterial drugs with high efficiency and low toxicity.
    Second, in the field of materials science, it also has important uses. Due to the presence of halogen atoms in its structure, it can participate in many polymerization reactions. For example, in the preparation of high-performance polymer materials, this is used as a raw material, and the polymerization reaction can endow the materials with special electrical and optical properties. The resulting polymers may have good electrical conductivity and can be used as conductive materials for electronic devices; or have unique fluorescent properties, showing application potential in optical display materials.
    Third, in the synthesis of pesticides, it is also indispensable. Through rational design of reactions, it is converted into pesticide active ingredients containing specific functional groups. Due to its structural characteristics, the prepared pesticides may have high selectivity and high-efficiency killing ability for specific pests, and have little impact on the environment, which is in line with the current trend of green pesticide development. For example, for some crop pests, pesticides synthesized from 2-chloro-1-fluoro-4-iodobenzene can precisely act on the physiological system of pests, inhibit their growth and reproduction, and reduce the harm to beneficial organisms and the environment.
    What are the physical properties of 2-Chloro-1-Fluoro-4-Iodobenzene?
    2-Chloro-1-fluoro-4-iodobenzene is one of the organic compounds. Its physical properties are worth studying in detail.
    Under normal temperature and pressure, it often appears as a colorless to light yellow liquid. When it is pure, it has a clear appearance and specific flow characteristics. The melting point of this substance is between -20 ° C and -10 ° C, and the boiling point is in the range of 180 ° C to 190 ° C. The characteristics of melting point and boiling point are key factors in chemical separation and purification processes.
    Its density is also an important physical property. It is about 2.0-2.2 g/cm ³, which is heavier than water, so if placed in water, it will sink to the bottom of the water. The determination of density is crucial in chemical metrology, material ratio, etc.
    As for solubility, this compound has good solubility in common organic solvents such as ethanol, ether, dichloromethane, etc. However, its solubility in water is very small. This property has a great impact on the selection of solvents and product separation in organic synthesis.
    The vapor pressure of 2-chloro-1-fluoro-4-iodobenzene is lower at room temperature, which means that its volatility is not very strong. However, under higher temperature or reduced pressure, the degree of volatilization will increase. The properties of vapor pressure are indispensable for the setting of storage and transportation conditions.
    In addition, its refractive index is also a specific value, about 1.60 - 1.65. The refractive index can be used to identify the purity of substances and is also an important indicator for chemical analysis and testing.
    These physical properties are of key significance in many fields such as chemical production, organic synthesis, material preparation, etc., and are an important basis for scientific research and industrial practice.
    What are 2-Chloro-1-Fluoro-4-Iodobenzene synthesis methods?
    There are several common methods for making 2-chloro-1-fluoro-4-iodobenzene.
    First, it can be started from a suitable benzene derivative. If p-fluorochlorobenzene is used as a raw material, iodine atoms are introduced through halogenation reaction. First, put p-fluorochlorobenzene in an appropriate reaction vessel, add an appropriate amount of iodine source, such as iodine elemental substance, and add a catalyst, such as copper salt catalyst, such as cuprous iodide. Under suitable temperature and reaction conditions, this catalyst can prompt iodine atoms to replace hydrogen atoms at specific positions on the benzene ring. After careful reaction regulation and separation and purification operations, the target product 2-chloro-1-fluoro-4-iodobenzene can be obtained. This process requires attention to the precise control of the reaction temperature. If the temperature is too high, side reactions will breed, and if it is too low, the reaction rate will be slow, which will affect the yield.
    Second, iodine-containing benzene derivatives can also be used as starting materials for halogen exchange reactions. Select benzene compounds containing iodine and other substituents that can be converted into chlorine and fluorine through reaction, and react with suitable fluorine and chlorine sources. Fluorine sources such as potassium fluoride and chlorine sources such as chlorination reagents can achieve precise substitution of fluorine and chlorine atoms for the original substituents under specific solvents and reaction conditions. This method requires strict reaction conditions, and the choice of solvent is crucial to ensure that it can dissolve the reactants without interfering with the normal progress of the halogen exchange reaction. At the same time, the pH of the reaction system, reaction time and other factors have a great impact on the reaction process and product purity, and need to be finely adjusted to efficiently prepare 2-chloro-1-fluoro-4-iodobenzene.
    What 2-Chloro-1-Fluoro-4-Iodobenzene need to pay attention to when storing and transporting
    2-Chloro-1-fluoro-4-iodobenzene is an organic compound. When storing and transporting, many aspects need to be paid attention to.
    Safety first. This compound may be toxic, irritating, and even flammable and explosive. The storage place must be cool, dry and well ventilated, away from fire, heat and oxidants. Because it may react violently with oxidants, it is dangerous to ignite and explode. And it should be stored separately from acids, alkalis and other substances to prevent chemical reactions.
    When transporting, the packaging must be tight and meet relevant safety standards. Use a specific container to ensure that there is no leakage during transportation. Transportation personnel should be professionally trained to be familiar with its hazards and emergency treatment methods.
    Furthermore, pay attention to stability. 2-Chloro-1-fluoro-4-iodobenzene is sensitive to light, heat or. Brown bottles should be used for storage, protected from light and dark places to slow down decomposition and deterioration. During transportation, sun exposure and high temperature environments should also be protected.
    Also pay attention to its environmental impact. If leakage occurs, it may cause pollution to soil, water bodies or. Emergency measures for leakage should be taken during storage and transportation, such as preparing adsorption materials, so that they can be dealt with in time.
    When storing and transporting 2-chloro-1-fluoro-4-iodobenzene, safety, stability and environmental factors should not be underestimated, and it must be operated in strict accordance with regulations to ensure the safety of personnel, the environment and property.
    2-Chloro-1-Fluoro-4-Iodobenzene safety precautions
    2-Chloro-1-fluoro-4-iodobenzene is an organic compound, which is widely used in the chemical synthesis field. However, it has certain hazards, and many safety precautions need to be paid attention to during operation.
    First word toxicity. This compound may be toxic and can cause harm to the human body through inhalation, ingestion or skin contact. When operating, be sure to wear appropriate protective equipment, such as gas masks, protective gloves and protective clothing, to avoid direct contact with it. After the operation, the contact area should be washed in time to prevent residual substances from damaging the body.
    Times and explosion risk. Although its flammability data may vary depending on specific conditions, many organic halides have certain fire hazards. Fireworks should be strictly prohibited in the workplace, and fire sources should be properly managed. At the same time, suitable fire extinguishing equipment, such as dry powder fire extinguishers, carbon dioxide fire extinguishers, etc. should be prepared for emergencies.
    Furthermore, this compound may also be harmful to the environment. During use, it is crucial to prevent its leakage to the environment. In the event of a leak, emergency measures should be taken immediately. When a small amount of leakage occurs, try to try to absorb inert adsorption materials such as sand and vermiculite; if a large amount of leakage needs to be contained and collected, and then handed over to professional institutions for treatment. It must not be discharged at will to avoid polluting soil, water sources and other environmental elements.
    Storage is also exquisite. 2-Chloro-1-fluoro-4-iodobenzene should be stored in a cool and well-ventilated place, away from fire and heat sources. At the same time, it should be stored separately from oxidants, alkalis, etc., and should not be mixed to prevent chemical reactions from causing danger. The storage area should be equipped with suitable materials to contain possible leaks.
    When operating, attention should also be paid to ventilation. Try to carry out relevant operations in the fume hood to ensure air circulation in the workplace, discharge volatile harmful gases in time, reduce the concentration of harmful substances in the air, and ensure the health of operators.
    In addition, for the use, storage and transportation of 2-chloro-1-fluoro-4-iodobenzene, relevant laws and regulations and safety standards must be strictly followed. Operators need to be professionally trained and familiar with its nature and safety operating procedures before operating, so as to ensure the safety of the entire process.