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2-Chloro-1-(Chloromethyl)-4-Fluorobenzene

2-Chloro-1-(Chloromethyl)-4-Fluorobenzene

Hongda Chemical

    Specifications

    HS Code

    841989

    Chemical Formula C7H5Cl2F
    Molecular Weight 181.019
    Appearance Typically a colorless to light - yellow liquid
    Boiling Point Around 200 - 210 °C
    Density Approximately 1.3 - 1.4 g/cm³
    Solubility In Water Insoluble
    Solubility In Organic Solvents Soluble in common organic solvents like ethanol, ether, and chloroform
    Vapor Pressure Low at room temperature
    Flash Point Probably around 80 - 90 °C
    Odor Pungent, characteristic aromatic odor

    As an accredited 2-Chloro-1-(Chloromethyl)-4-Fluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 250 - gram bottle of 2 - chloro - 1-(chloromethyl)-4 - fluorobenzene, well - sealed.
    Storage 2 - chloro - 1 - (chloromethyl)-4 - fluorobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store in a tightly - sealed container to prevent leakage. Due to its potential toxicity and flammability, ensure the storage area is in compliance with safety regulations and is clearly labeled.
    Shipping 2 - chloro - 1 - (chloromethyl)-4 - fluorobenzene is shipped in specialized, tightly - sealed containers. These containers are designed to prevent leakage and are transported following strict chemical shipping regulations to ensure safety during transit.
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    2-Chloro-1-(Chloromethyl)-4-Fluorobenzene 2-Chloro-1-(Chloromethyl)-4-Fluorobenzene
    General Information
    Historical Development
    2-Chloro-1- (chloromethyl) -4-fluorobenzene is also an organic compound. Its initial exploration originated from the pursuit of chemistry by various sages. In the early years, chemists worked hard to explore the properties of substances and find ways to synthesize.
    At that time, the art of chemistry was not as complete as it is today, and the synthesis was difficult. However, the public was not discouraged, with tenacity, after repeated trials and errors, they gradually understood the importance of its synthesis. At the beginning, the yield was very small, and the purity was not perfect.
    After the years passed, science and technology advanced, the instruments gradually refined, and the theory became more and more clear. The deeper the chemist's insight into the reaction mechanism, the better the synthesis technique. The control of conditions is accurate, the yield rises, and the purity is also high. To this day, this compound is widely used in the fields of medicine and materials, adding to the progress of chemistry and becoming one of the benefits of science and technology.
    Product Overview
    2-Chloro-1- (chloromethyl) -4-fluorobenzene is an organic compound. It may be a colorless liquid with a special odor. This substance is widely used in the field of organic synthesis.
    The presence of chlorine atoms and fluorine atoms in its structure gives it unique chemical activity. The part of chloromethyl is also a key check point for its participation in various chemical reactions. Chemists can use its activity to combine with other reagents by ingeniously designing reaction paths to prepare many compounds with special properties.
    It can be used as an intermediate for the synthesis of specific drugs in the process of pharmaceutical research and development; or in the field of materials science, it is an important raw material for the creation of novel functional materials. Although it is widely used, it should also pay attention to its safety when using it, because it contains halogen atoms, or has a potential impact on the environment and human health. It is necessary to follow scientific methods and exercise caution to make the best use of it to avoid harm.
    Physical & Chemical Properties
    2-Chloro-1- (chloromethyl) -4-fluorobenzene, an organic compound. Its state is mostly liquid at room temperature, and its color is close to nothing, with a slightly special gas. Its boiling point is about a specific temperature range, which is related to the intermolecular force, and the structure is affected by halogen atoms.
    In terms of solubility, it is easy to dissolve in organic solvents such as ethanol and ether, but difficult to dissolve in water. This is because of the difference between molecular polarity and water molecular polarity. When it comes to stability, it is relatively stable under general conditions, but it can also change in case of high temperature and strong oxidizing agents.
    This compound is widely used in the field of organic synthesis and can be used as an intermediate to produce a variety of fine chemicals, such as pharmaceuticals, pesticides, etc. Its physical and chemical properties have established its unique position in chemical production, contributing to the development of the chemical industry.
    Technical Specifications & Labeling
    Today there is a product called 2 - Chloro - 1 - (Chloromethyl) -4 - Fluorobenzene. To make this product, it is necessary to specify its technical specifications and identification (product parameters).
    The method of making this product is that the first raw material is excellent and the ratio is accurate. All raw materials, according to a certain number, are fused and polymerized. When reacting, the temperature and pressure must be appropriate, and do not exceed or exceed. In this way, the reaction can be guaranteed to be smooth and the product is pure.
    As for the label, the characteristics, ingredients and uses of this product should be detailed. So that the viewer can see at a glance what it is and where it can be used. With rigorous technical specifications and clear identification, high-quality 2-Chloro-1- (Chloromethyl) -4-Fluorobenzene can be obtained to meet all requirements.
    Preparation Method
    To prepare 2-chloro-1 - (chloromethyl) - 4-fluorobenzene, the required raw materials and preparation method are as follows:
    The raw material is selected fluorobenzene, supplemented by chloromethyl ether, anhydrous zinc chloride and hydrochloric acid.
    Preparation method: First take an appropriate amount of fluorobenzene, place it in a reactor, and add anhydrous zinc chloride as a catalyst. Then, slowly introduce chloromethyl ether, and control the reaction temperature in a suitable range, about 60 to 80 degrees Celsius. This reaction goes through an electrophilic substitution step. On the benzene ring of fluorobenzene, chloromethyl gradually replaces hydrogen atoms.
    When the reaction is initially completed, cool to room temperature, and pour the reaction mixture into ice water for stratified extraction. Take the organic phase, wash it with dilute alkali solution and water successively, remove impurities and purify it. After distillation operation, collect the specific boiling point fraction to obtain pure 2-chloro-1- (chloromethyl) -4-fluorobenzene. Throughout the preparation process, pay attention to temperature control and raw material ratio adaptation to ensure product purity and yield.
    Chemical Reactions & Modifications
    Nowadays, there is a chemical substance called 2-chloro-1- (chloromethyl) -4-fluorobenzene. In the way of chemical research, reaction and modification are the key.
    The reaction of this compound requires detailed investigation of its molecular structure. The positions of chlorine, fluorine and chloromethyl all affect the trend of the reaction. Its halogen atom is active and can lead to changes in nucleophilic substitution. If you want to modify it, or introduce new groups to make it easier.
    When the nucleophilic reagent meets 2-chloro-1- (chloromethyl) -4-fluorobenzene, the halogen atom can be substituted. If a certain alcohol is used as a reagent, under suitable conditions, chlorine can be changed to alkoxy, changing its polarity and reactivity. This change may also make it useful in organic synthesis. Or by means of metal catalysis, the connection of carbon-carbon bonds is introduced, its molecular framework is expanded, and its complex state is increased, so as to meet the requirements of diversity.
    Synonyms & Product Names
    2-Chloro-1- (chloromethyl) -4-fluorobenzene is also an organic compound. Its synonymous name and the name of the product are related to the identification and cognition of this product.
    In the field of chemistry, the synonymous name is often born to accurately describe its structure and characteristics. Such as 2-chloro-1- (chloromethyl) -4-fluorobenzene, this name depends on the arrangement of its atoms and the location of its functional groups, accurately indicating its chemical structure.
    The name of the product is more commercial. Or take its characteristics, uses, or for marketing convenience. However, it is important to make it easy for the public to remember and recognize this thing.
    The study of chemistry often relies on the name of synonym to identify the substance and avoid confusion. And in the circulation of commerce, the trade name also helps this substance to be known by the market. Although the two are different, they are both of great significance in the development and application of 2-chloro-1- (chloromethyl) -4-fluorobenzene, which complement each other and promote the evolution of this substance in academia and the market.
    Safety & Operational Standards
    2 - Chloro - 1 - (chloromethyl) - 4 - Fluorobenzene Safety and Operating Specifications
    Fu 2 - Chloro - 1 - (chloromethyl) - 4 - Fluorobenzene, the chemical substance is also unique, related to safety and operating standards, must not be ignored.
    ** Storage Regulations **: This substance should be placed in a cool, dry and well ventilated place. Keep away from fire and heat sources to prevent accidents. Because it has certain chemical activity, it can be heated or reactive, endangering safety. It should be stored in a sealed container to avoid contact with air and moisture to avoid deterioration.
    ** How to take it **: When taking it, wear appropriate protective gear, such as gloves, goggles, etc. The operation should be done in the fume hood, so that the volatile gas can be dissipated in time and avoid entering the human body. Measure accurately, according to the needs of the experiment or production, not more or less, so as not to waste or cause the reaction to be unbalanced.
    ** The essentials of operation **: In the reaction system, temperature control is very critical. This substance participates in the reaction. If the temperature is too high or low, it can affect the quality and quantity of the product, or even cause danger. Mixing evenly to make it fully react is also a priority. And the operation process is focused and attentive, not negligent.
    ** Emergency Policy **: In case of accidental skin contact, quickly rinse with plenty of water, followed by soap. If it enters the eyes, quickly open the eyelids, rinse with flowing water or normal saline, and seek medical attention immediately. In the event of a leak, quickly evacuate unrelated personnel and isolate the scene. Small leaks should be absorbed with inert materials such as sand and vermiculite; large leaks should be contained and properly disposed of.
    All of these are the safety and operation specifications for 2-chloro-1- (chloromethyl) -4-fluorobenzene. Only by following them can we ensure safety.
    Application Area
    2-Chloro-1- (chloromethyl) -4-fluorobenzene is also an organic compound. Its application field is quite wide. In the field of pharmaceutical synthesis, it is often a key intermediary. With its unique structure, it can participate in the construction of a variety of drug molecules, helping to create new drugs and cure various diseases.
    In the field of material science, this compound also has a place. Or it can be used to prepare polymer materials with special properties, increase its stability, weather resistance and other characteristics, and is widely used in aviation, electronics and other industries to meet the needs of high-end materials. In the field of fine chemicals, it can be used as a raw material for the synthesis of fine chemicals such as special fragrances and pigments, adding to the diversity of chemical products and enriching the various colors and textures of our lives.
    Research & Development
    In recent years, I have studied the chemical substance, especially 2 - Chloro - 1 - (Chloromethyl) -4 - Fluorobenzene. The properties of this substance are unique and have potential uses in various fields.
    My initial research focused on its synthesis method. After repeated trials, we can optimize the way, which can increase its yield and reduce the generation of impurities.
    Then observe its physicochemical properties, explain its melting point and dissolution, and know its state in different environments.
    As for the application field, in pharmaceutical chemistry, or as a key raw material for the creation of new agents; in materials science, it is also expected to add new energy to materials.
    My follow-up research can expand its application, making it effective in industrial production and scientific progress, adding to the progress of chemistry and becoming a great cause.
    Toxicity Research
    Today, there is a substance known as 2-chloro-1 - (chloromethyl) -4-fluorobenzene, which is in our chemical research. The investigation of its toxicity is crucial.
    Examine this substance in detail, its molecular structure is unique, containing chlorine, fluorine and other atoms. The properties of such atoms may make this substance toxic. In order to explain its toxicity, we need to use multiple methods.
    First, animal experiments are used to observe its effects on animal physiology, such as feeding, activity, and organ changes. Next, cell experiments are used to investigate its effects on cell growth, metabolism, and apoptosis.
    The study of toxicity is related to the health of the environment and people. If this substance is highly toxic, it will remain in the environment, which may cause harm to the ecology. In humans, it may cause disease. Therefore, we should do our best to study the toxicity of 2-chloro-1- (chloromethyl) -4-fluorobenzene in detail, so as to keep everything in the world safe.
    Future Prospects
    Husband 2 - Chloro - 1 - (Chloromethyl) - 4 - Fluorobenzene, the thing that transforms it is also the thing that transforms it. Today, the prospect of its future development, there is a lot to be done. The way of research and development may become a big problem, and help the power of stone to cure diseases. In the field of material science, it is also expected to be the foundation of new materials, and the extraordinary nature of tools and objects.
    Those who study in my field must study its principles and explore its details. I hope to use the method of intensive research to mine its greatest power. Before it is discovered, I hope to use this material to lead the new realm of science and promote technology. To make this a good thing, to develop it, to be used by the world, to benefit life, and to create undeveloped power. This is what we hope for.
    Where to Buy 2-Chloro-1-(Chloromethyl)-4-Fluorobenzene in China?
    As a trusted 2-Chloro-1-(Chloromethyl)-4-Fluorobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 2-Chloro-1-(Chloromethyl)-4-Fluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 2-Chloro-1- (Chloromethyl) -4-Fluorobenzene?
    2-Chloro-1- (chloromethyl) -4-fluorobenzene is also an organic compound. It has a wide range of uses and is important in the field of organic synthesis.
    First, it can be used as a pharmaceutical intermediate. In the preparation process of many drugs, this compound can be used as a key starting material. Taking a certain type of antibacterial drug as an example, through a specific chemical reaction, its structure can be ingeniously modified to introduce other functional groups, and then construct a complex molecular structure with specific pharmacological activities, opening up a path for pharmaceutical research and development.
    Second, it is also useful in pesticide synthesis. It can be used as an important building block for the synthesis of new pesticides. After chemical transformation, compounds with high insecticidal, bactericidal or herbicidal properties can be derived. In response to the needs of agriculture for green and high-efficiency pesticides, research and development based on this is expected to create environmentally friendly and high-performance pesticide varieties.
    Third, it has made its mark in the field of materials science. Or it can participate in the synthesis of functional materials, giving the materials unique physical and chemical properties. For example, in the preparation of some optoelectronic materials, the introduction of this compound structural unit can adjust the electronic transport properties and optical properties of the materials, providing the possibility for the development of new optoelectronic materials.
    In conclusion, 2-chloro-1- (chloromethyl) -4-fluorobenzene has important application value in many fields such as medicine, pesticides and materials, providing an indispensable foundation for the innovation and development of related industries.
    What are the physical properties of 2-Chloro-1- (Chloromethyl) -4-Fluorobenzene?
    2-Chloro-1- (chloromethyl) -4-fluorobenzene is one of the organic compounds. Its physical properties are quite important, and it has many applications in chemical industry.
    Looking at its properties, at room temperature, this substance is mostly colorless to light yellow liquid, and its appearance is bright, occasionally with a little special smell. Although this smell is not pungent and intolerable, it should also be paid attention to, because it may be slightly irritating to human senses.
    When it comes to melting point and boiling point, the melting point value is low, causing it to be liquid in room temperature environment. The boiling point is relatively moderate, and this property is of great significance in chemical processes such as separation and purification. In a specific temperature range, by means of heating, it can be converted from liquid to gaseous state, and then the purpose of separation from other substances can be achieved.
    In addition to density, its density is greater than that of water. If this substance is poured into water, it can be seen that it sinks to the bottom of the water. This property is of great reference value when it comes to the operation of liquid-liquid separation.
    In terms of solubility, this substance dissolves well in organic solvents such as ethanol and ether. However, its solubility in water is poor and only slightly soluble. This property makes the selection of organic solvents extremely critical when chemical synthesis and reaction system construction.
    In addition, the volatility of 2-chloro-1- (chloromethyl) -4-fluorobenzene is also a key consideration. It has a certain degree of volatility and can slowly evaporate into the air in an open environment. Therefore, when storing and using, it is necessary to pay attention to closed operation to prevent its dissipation, and pay attention to ventilation and ventilation to ensure environmental safety.
    The above physical properties are interrelated and affect each other. They are an indispensable basis for many links such as chemical synthesis, product preparation, storage and transportation. Practitioners must study them carefully and use them carefully.
    Is 2-Chloro-1- (Chloromethyl) -4-Fluorobenzene Chemically Stable?
    2-Chloro-1- (chloromethyl) -4-fluorobenzene is also an organic compound. The stability of its chemical properties needs to be analyzed in detail.
    The stability of this substance depends on its molecular structure. The benzene ring has a conjugated system, which endows the molecule with a certain stability. However, the chlorine atom, chloromethyl and fluorine atoms connected to the benzene ring also have a significant impact on its stability. The chlorine atom and the fluorine atom have a large electronegativity and have an electron-absorbing induction effect, which can reduce the electron cloud density of the benzene ring. In the chlorine methyl group, the electron-absorbing action of the chlorine atom coexists with the electron-giving action of the methyl group and interacts with each
    Under normal conditions, 2-chloro-1- (chloromethyl) -4-fluorobenzene is relatively stable. When exposed to high temperature, strong light or specific chemical reagents, the stability will change. Under high temperature and strong light, the energy of chemical bonds in molecules increases, which may cause bond breakage. Such as carbon-chlorine bonds in chloromethyl groups, or cracking due to energy excitation, resulting in structural changes of compounds.
    In the case of nucleophiles, the electron cloud density of the benzene ring is uneven due to the influence of substituents, and nucleophiles are prone to attack parts with lower electron cloud density. The chlorine atom and the carbon atom near the fluorine atom may become the check point of the nucleophilic substitution reaction, which then destroys the original structure of the compound and causes its stability to be lost.
    Re-discussion on the redox environment. Strong oxidants or reducing agents may react with 2-chloro-1- (chloromethyl) -4-fluorobenzene. Oxidants or some of the groups can be oxidized, such as chloromethyl or oxidized to carboxyl groups; reducing agents or reducing reactions such as hydrogenation of benzene rings can change their stability. Therefore, the stability of 2-chloro-1- (chloromethyl) -4-fluorobenzene is not absolutely unchanged, and it is actually influenced by many external conditions and chemical environments, which need to be considered according to the specific situation.
    What are the synthesis methods of 2-Chloro-1- (Chloromethyl) -4-Fluorobenzene?
    The synthesis of 2-chloro-1- (chloromethyl) -4-fluorobenzene is an important research direction in the field of organic synthesis. To synthesize this substance, there are several common methods as follows.
    First, it can be started from a specific fluorobenzene derivative. First, the fluorobenzene interacts with the halomethylating reagent under suitable reaction conditions. In this process, the selection of halomethylating reagents is crucial, usually such as chloromethylating reagents. In a suitable catalyst and reaction environment, the substitution reaction of fluorobenzene is promoted, and chloromethyl is introduced at a specific position in the benzene ring. Then, chlorine atoms are introduced into another specific position through halogenation reaction to achieve the synthesis of 2-chloro-1- (chloromethyl) -4-fluorobenzene. However, in this method, precise control of reaction conditions is extremely important, such as temperature, reaction time and catalyst dosage, which will have a significant impact on the yield and selectivity of the reaction.
    Second, benzene ring compounds containing chlorine and fluorine can also be used as starting materials. First, the functional groups are converted and modified, and the desired molecular structure is gradually constructed through a series of organic reactions, such as nucleophilic substitution and elimination reactions. This process requires a deep understanding of the mechanism of each step of the reaction in order to ingeniously design the reaction route and improve the efficiency and success rate of the synthesis.
    Third, the reaction path catalyzed by transition metals can also be used. Transition metal catalysts often play a unique catalytic role in such reactions, which can effectively promote the formation and fracture of carbon-halogen bonds. For example, the selection of appropriate transition metal catalysts and specific ligands can promote the orderly reaction of the substituents on the benzene ring to achieve the formation of the target product. Although this method can exhibit high reactivity and selectivity, the cost of transition metal catalysts is often high, and the post-reaction treatment may be relatively complex, which needs to be properly considered.
    All the above synthesis methods have their own advantages and disadvantages. In practical application, the appropriate synthesis path should be carefully selected according to many factors such as specific experimental conditions, availability of raw materials and cost considerations.
    What should be paid attention to when storing and transporting 2-Chloro-1- (Chloromethyl) -4-Fluorobenzene?
    2-Chloro-1- (chloromethyl) -4-fluorobenzene is an organic chemical. When storing and transporting, many matters need to be paid careful attention.
    This chemical has certain toxicity and irritation. The storage place must be well ventilated to prevent the accumulation of harmful gases, poisoning or other hazards. And it should be kept away from fire and heat sources, because it may be flammable, in case of open flames and hot topics, it is easy to cause combustion and explosion, resulting in catastrophe.
    Store strictly sealed to prevent contact with air and moisture. Due to the chemical reaction of the substance or with oxygen and moisture in the air, it will deteriorate, affect the quality and performance, and even generate dangerous products.
    In terms of transportation, suitable packaging materials and containers must be selected in accordance with relevant regulations. The packaging should be solid and firm to ensure that it will not be damaged or leaked during transportation. During the handling process, the operator must handle it with care to avoid collisions and falls to prevent package damage and material leakage.
    Transportation vehicles must also meet safety requirements and be equipped with corresponding fire fighting equipment and emergency treatment equipment. In the event of an accident such as leakage, emergency treatment can be carried out immediately to reduce hazards. At the same time, the transportation process should strictly follow the established route and time, and stay away from densely populated areas and important facilities.
    When storing and transporting 2-chloro-1- (chloromethyl) -4-fluorobenzene, safety is the primary consideration, and all links should be operated in accordance with regulations and treated with caution to ensure the safety of personnel and the environment from pollution.