2-Chloro-1- (3-fluorobenzoxy) -4-nitrobenzene is an important compound in the field of organic synthesis. Its main uses are extensive, involving many fields such as medicinal chemistry and materials science.
In the field of medicinal chemistry, such compounds are often used as key intermediates to prepare drug molecules with specific biological activities. The presence of chlorine atoms, fluorobenzoxy groups and nitro groups in its structure endows the molecule with unique physical and chemical properties and reactivity. It can be modified and transformed by a series of organic reactions, such as nucleophilic substitution and reduction, to build a complex and biologically active drug skeleton. For example, through nucleophilic substitution reactions, chlorine atoms can be replaced with groups containing heteroatoms such as nitrogen and oxygen, thereby improving the interaction between drugs and targets, enhancing drug efficacy and selectivity.
In the field of materials science, 2-chloro-1- (3-fluorobenzoxy) -4-nitrobenzene can be used to synthesize functional polymer materials. Due to its special structure, it can participate in polymerization reactions, introduce specific functional groups into high molecular chains, and endow materials with special properties such as fluorescence and conductivity. For example, by polymerizing it with suitable monomers, polymers with specific photoelectric properties can be obtained, which are expected to be used in organic Light Emitting Diodes, sensors and other fields.
In addition, in the methodological research of organic synthetic chemistry, this compound is also often used as a substrate to explore new reaction pathways and catalytic systems. Through the study of its reaction properties, it helps to expand the methods and strategies of organic synthesis and promote the development of organic chemistry.

The synthesis of 2-chloro-1- (3-fluorobenzoxy) -4-nitrobenzene involves a variety of methods. One of the methods is to take 3-fluorobenzyl alcohol first, add an appropriate amount of alkali, such as potassium carbonate, to a suitable reaction vessel, and then add a halogenated agent, such as sulfoxide chloride, to react to obtain 3-fluorobenzyl halide. This halide is active and can react with 2-chloro-4-nitrophenol in a suitable solvent, such as N, N-dimethylformamide, under heating and alkali catalysis conditions. The alkali can assist in the deprotonation of phenolic hydroxyl groups and enhance their nucleophilicity, so that the nucleophilic substitution reaction occurs with 3-fluorobenzyl halide to form the target product 2-chloro-1- (3-fluorobenzyl oxide) -4-nitrobenzene.
Another way can be to prepare 2-chloro-4-nitrobenzyl ether first. Using it as a raw material, at low temperature, in an appropriate solvent such as dichloromethane, strong Lewis acid, such as aluminum trichloride, etc., demethylates the methoxyl group to generate 2-chloro-4-nitrophenol. Then, 3-fluorobenzyl halide is reacted with the phenol, and the target product can also be obtained under the catalysis of alkali. This process requires attention to the control of reaction conditions. Temperature, ratio of reactants and reaction time all affect the yield. If the temperature is too high, it may cause more side reactions; if the ratio is improper, it is difficult to achieve the ideal yield. After the reaction, the product needs to be separated and purified by extraction, column chromatography and other means to obtain pure 2-chloro-1 - (3-fluorobenzoxy) -4-nitrobenzene.

2-Chloro-1- (3-fluorobenzoxy) -4-nitrobenzene is one of the organic compounds. Its physical properties are quite important and have an impact on both scientific research and chemical industry.
The first word melting point, the measurement of the melting point of this compound can help to distinguish its purity and crystalline characteristics. When covering the compound of different purity, the melting point is often different. With high purity, the melting point is relatively fixed and sharp; if there are many impurities, the melting point is reduced and the melting range is widened.
The boiling point reflects the temperature of the substance changing from liquid to gas under a specific pressure. This property is of great significance in the separation and purification process, such as distillation, which can separate the mixture according to the difference in boiling point, so as to obtain pure 2-chloro-1- (3-fluorobenzoxy) -4-nitrobenzene.
The other is density, which is related to the relationship between the mass and volume of the substance. In the study and operation of liquid mixtures, the density difference can be used for stratification separation and other means. Understanding the density of this compound is helpful for the design and optimization of chemical processes.
The solubility cannot be ignored, and the solubility of 2-chloro-1- (3-fluorobenzoxy) -4-nitrobenzene varies in different solvents. In organic solvents, such as ethanol and ether, it may have a certain solubility, but its solubility in water may be limited. This property is considered in the selection of reaction media, product separation and pharmaceutical preparations.
In terms of appearance, it usually appears as a solid or liquid of a specific color and shape. Intuitive appearance characteristics can preliminarily judge the state and purity of the substance.
The above physical properties are related and affect each other. It is an indispensable factor in the research, production and application of 2-chloro-1- (3-fluorobenzoxy) -4-nitrobenzene.

2-Chloro-1- (3-fluorobenzoxy) -4-nitrobenzene, this is an organic compound with specific chemical properties.
In terms of physical properties, the normal state or solid, the melting point and boiling point depend on the intermolecular forces and structural characteristics. Functional groups such as chlorine, fluorine, nitro and benzoxy affect the polarity of molecules, which in turn affects the solubility. In polar solvents, nitro and water can form hydrogen bonds, or have a certain solubility; in non-polar solvents, benzoxy and other non-polar parts make it soluble.
Chemically, chlorine atoms have high reactivity and can undergo nucleophilic substitution reactions. Nucleophilic reagents such as sodium alcohols and amines can attack chlorine atoms to connect to carbon atoms, and chlorine atoms leave to form new compounds. This reaction is of great significance for the preparation of ether and amine derivatives in organic synthesis.
Nitro is a strong electron-absorbing group, which decreases the electron cloud density of the benzene ring and causes the activity of the electrophilic substitution reaction of the benzene ring to decrease. The electron cloud density of the meta-relative neighbor and para-position is slightly higher, and the electrophilic substitution reaction is prone to occur in the meta-position. At the same time, the nitro group can be reduced, such as under suitable reducing agents and conditions, it can be converted into an amino group, which is used in the synthesis of amino-containing compounds and is widely used in the fields of medicine and dye synthesis.
3 -fluorobenzoxy moiety, fluorine atoms have strong electronegativity, which has an effect on the electron cloud distribution of benzoxy groups, or changes the reactivity of benzoxy groups. The oxygen atoms in benzoxy groups contain lone pairs of electrons, which can participate in reactions as nucleophilic check points, or form coordination bonds with metal ions.
In short, 2-chloro-1- (3-fluorobenzoxy) -4-nitrobenzene contains functional groups with diverse chemical properties. It plays an important role in the field of organic synthesis chemistry and provides the possibility for the preparation of complex organic compounds.

I have not been able to confirm the price range of 2-chloro-1- (3-fluorobenzyloxy) -4-nitrobenzene in the market. The price of this product is easily influenced by many factors, such as the price of raw materials, difficulty in preparation, supply and demand, quality specifications and market competition.
If the price of raw materials is high, or the preparation requires complex processes and high-cost equipment, the price will increase. Supply and demand are also key. If demand exceeds supply, the price will rise; if supply exceeds demand, the price will be depressed. Differences in quality specifications also lead to different prices. Those with high purity are more expensive. The market competition is fierce, and merchants may lower prices to compete for a share.
For the exact price range, you can consult chemical product suppliers, distributors, or check the quotation information of chemical product trading platforms. You can also look at industry reports and market surveys to understand the market price dynamics of the product. However, the price changes rapidly, and the actual transaction price should be subject to real-time inquiry.