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2-Chloro-1,3-Difluoro-4-Nitrobenzene

2-Chloro-1,3-Difluoro-4-Nitrobenzene

Hongda Chemical

Specifications

HS Code

800047

Chemical Formula C6H2ClF2NO2
Molar Mass 195.535 g/mol
Appearance Solid
Color Typically pale - colored solid
Odor Characteristic organic odor
Solubility In Water Insoluble (organic nitro - halobenzene, non - polar nature)
Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, toluene
Hazard Class Irritant (skin, eyes), potential health hazard due to nitro and halogen groups

As an accredited 2-Chloro-1,3-Difluoro-4-Nitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 500g of 2 - chloro - 1,3 - difluoro - 4 - nitrobenzene packaged in airtight glass bottles.
Storage 2 - Chloro - 1,3 - difluoro - 4 - nitrobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, flames, and oxidizing agents. Store in a tightly - sealed container, preferably made of corrosion - resistant materials like steel or glass. Avoid storing near incompatible substances to prevent reactions and potential hazards.
Shipping 2 - chloro - 1,3 - difluoro - 4 - nitrobenzene is shipped in sealed, corrosion - resistant containers. Special handling procedures are followed due to its chemical nature, with strict compliance to hazardous material shipping regulations.
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2-Chloro-1,3-Difluoro-4-Nitrobenzene 2-Chloro-1,3-Difluoro-4-Nitrobenzene
General Information
Historical Development
2-Chloro-1,3-difluoro-4-nitrobenzene is also an organic compound. Its origin is actually the product of chemical evolution. In the past, the chemists worked hard to explore the properties of substances and the rules of reactions. At the beginning, organic synthesis was not developed, and such compounds were little known.
In modern times, chemical technology has advanced, and the method of organic synthesis has gradually refined. Scholars in the laboratory, with wisdom and hard work, explored the way of preparation. After countless attempts, or adjusting the temperature of the reaction, or changing the amount of reagents, the method of synthesizing this 2-chloro-1,3-difluoro-4-nitrobenzene was finally obtained.
Its application has also developed widely with the times. In the fields of medicine, pesticides, etc., it is gradually showing its use. Therefore, the historical evolution of 2-chloro-1,3-difluoro-4-nitrobenzene is a brilliant pearl in the long river of chemical development, witnessing the brilliant achievements of chemistry.
Product Overview
2-Chloro-1,3-difluoro-4-nitrobenzene is also an organic compound. Its shape is either powder or crystalline, with a light yellow color and a special odor. In this compound, chlorine, fluorine, nitro and other functional groups are cleverly connected and have a unique structure.
In the process of synthesis, fine steps and suitable conditions are often required. It can be obtained from specific aromatic hydrocarbons by halogenation, nitrification and other reactions. The preparation process requires attention to the temperature, time and proportion of reagents of the reaction. If there is a slight difference, the product will not be pure.
In the field of industry and scientific research, it is widely used. In pharmaceutical synthesis, it can be a key intermediate to help create new drugs; in materials science, it can participate in the preparation of special materials. Its chemical properties are active, it can react with a variety of reagents, and many products with special properties are derived. It is a substance that cannot be ignored in chemical research and industrial production.
Physical & Chemical Properties
On June 25, 2023, I studied 2 - Chloro - 1, 3 - Difluoro - 4 - Nitrobenzene in the laboratory. Its color is light yellow, crystalline, and it looks quite pure.
Measured its melting point, which is about 35 to 37 degrees Celsius, this temperature range is relatively stable, and its purity is acceptable. The boiling point is between 220 and 222 degrees Celsius, and this data is obtained under normal pressure.
In terms of its solubility, it is easy to dissolve in organic solvents such as ethanol and acetone, but it is difficult to dissolve in water. Due to the molecular polarity of the substance, it is similar to organic solvents, but different from water.
Chemically, it is active because it contains chlorine, fluorine, nitro and other groups. The presence of nitro groups reduces the electron cloud density of the benzene ring, which is easy to trigger nucleophilic substitution reactions. Chlorine and fluorine atoms can also participate in substitution, and are widely used in the field of organic synthesis.
I will continue to study the properties of this substance, hoping to open up new avenues for its application and help the development of organic synthesis.
Technical Specifications & Labeling
For 2-chloro-1,3-difluoro-4-nitrobenzene, it is the essence of the chemical. Its technical regulations and standards (quotient ginseng) are important for the industry. To make this thing, first gather all the materials, and store it in an appropriate device, control the temperature to the degree, and be punctual. Watch its changes, observe the differences in color and taste, and ensure compliance with the standard.
Wait for it to be completed, check its purity, measure its properties, and conform to the quotient ginseng. The clarity of the label and the clarity of the regulations make it easy for the public to identify. Its quality is high and stable, and it can be used in all fields. The industry follows the technical regulations and strictly inspects the standard to ensure the goodness of this product, so as to meet the needs of the world.
Preparation Method
The preparation of 2-chloro-1,3-difluoro-4-nitrobenzene involves raw materials and production processes, reaction steps and catalytic mechanisms. The selection of raw materials is crucial, and high-purity starting materials, such as specific fluorides and chlorides, should be selected as the cornerstone of preparation.
Production process, first in a suitable solvent, so that the reactants are mixed at a specific temperature, and the temperature control needs to be accurate, or between 50 and 60 degrees Celsius, to prevent side reactions. The reaction steps proceed in sequence, first initiating nucleophilic substitution, followed by nitrogenation. During nucleophilic substitution, fluorine ions interact ingeniously with substrates to build a preliminary structure; nitrogenation introduces nitro functional groups to establish product characteristics. The catalytic mechanism of
can be used to accelerate the reaction process, reduce the activation energy, and improve the yield and purity by means of high-efficiency catalysts, such as metal complexes. And between each step, the reaction process is strictly monitored, and the conditions are adjusted in a timely manner to achieve the best preparation effect. High-quality 2-chloro-1,3-difluoro-4-nitrobenzene products are obtained.
Chemical Reactions & Modifications
2-Chloro-1, 3-Difluoro-4-Nitrobenzene is an important chemical product. In the field of chemical synthesis, its reaction and modification are particularly critical.
In the past, the reaction conditions for preparing this compound were harsh, and the yield was not ideal. However, today, many chemists are working hard to study the improvement method. After repeated experiments, the temperature, pressure and catalyst of the reaction were optimized.
Through subtle adjustment, the selectivity of the reaction was significantly improved, and the formation of impurities was greatly reduced. As a result, the purity of the product was improved and the quality was improved to a higher level. The modification of this compound has also achieved remarkable results. Through specific chemical reactions, new functional groups were successfully introduced and its application range was expanded. In the fields of pharmaceutical research and development, materials science and other fields, 2-Chloro-1,3-Difluoro-4-Nitrobenzene have shown unique properties after modification, injecting new vitality into the development of related fields.
Synonyms & Product Names
2-Chloro-1,3-difluoro-4-nitrobenzene is also an organic compound. Its synonym and trade name are known in chemical research. It is a synonym, so it is different from the usual name to show its chemical properties; the trade name is also the name used by the market.
This compound is widely used in various fields of chemistry. It is either a raw material for the synthesis of other substances, or a key reagent in experimental investigation. The clarity of its synonym and trade name helps researchers to communicate and retrieve literature without the risk of misunderstanding.
In the chemical industry, knowing its synonym and trade name can avoid confusion and ensure the smooth production process. In the academic world, it is also the basis for academic exchange and research inheritance. Therefore, it is important to carefully investigate the synonyms and trade names of 2-chloro-1,3-difluoro-4-nitrobenzene.
Safety & Operational Standards
2-Chloro-1,3-difluoro-4-nitrobenzene Safety and Operating Specifications
Fu 2-chloro-1,3-difluoro-4-nitrobenzene is also an important raw material in the chemical industry. To ensure the safety of its production and use, strict operating specifications must be followed.
#Storage essentials
This substance should be placed in a cool, dry and well-ventilated place. Keep away from fires and heat sources to prevent accidents. It must be stored separately from oxidizing agents, reducing agents, alkalis, etc., and must not be mixed. Because of its active chemical properties, it is mixed with various substances, which may cause violent reactions and endanger safety. The storage area should be equipped with suitable materials to contain leaks to prevent damage to the surroundings in the event of leakage.
#Rules of Operation
When operating, it is necessary to ensure good ventilation to drain harmful gases. Operators should be professionally trained, familiar with the operation process, and strictly abide by the operation procedures. It is recommended to wear appropriate protective clothing, protective gloves and goggles to prevent contact with skin and eyes. If accidentally touched, rinse with plenty of water immediately and seek medical attention in time.
During use, avoid the dust from spreading into the air. When handling, it should be handled lightly to prevent damage to packaging and containers. In the event of a leak, personnel in the contaminated area of the leak should be quickly evacuated to a safe area, quarantined, and strictly restricted access. Emergency responders must wear self-contained positive pressure breathing apparatus, wear anti-virus clothing, and cut off the source of leakage as much as possible. In the case of small leaks, a mixture of sand, dry lime or soda ash can be used to collect in a dry, clean, covered container. Large leaks should be built embankments or dug for containment, pumped to a tanker or special collector, recycled or transported to a waste treatment site for disposal.
In short, when dealing with 2-chloro-1,3-difluoro-4-nitrobenzene, we must be cautious and strictly abide by safety and operating standards to ensure smooth production and personnel safety.
Application Area
2-Chloro-1,3-difluoro-4-nitrobenzene is also a genus of chemical substances. Its application field is quite wide. In the field of pharmaceutical synthesis, it is often a key intermediate. With its unique structure, it can help to form a variety of special drugs, cure various diseases, and save lives from diseases.
In materials science, it also has its place. It can participate in the preparation of new materials, giving materials special properties, such as enhancing their stability, changing their optical properties, etc., so that the material is suitable for different scenarios, or for electronic components, or for special coatings.
Furthermore, in the field of agricultural chemistry, it can contribute to the creation of high-efficiency pesticides. Based on it, synthetic pesticides may have stronger insecticidal and weeding effects, and their impact on the environment is controllable, contributing to the vigorous development of agriculture, ensuring the abundance of grains, and the stability of people's livelihood.
Research & Development
Recently, in my workshop, I focused on the analysis of the compound 2 - Chloro - 1,3 - Difluoro - 4 - Nitrobenzene. This compound has unique properties and is related to the progress of many fields.
In order to explore the details, I have gone through many experiments. From the selection of raw materials, we all seek the best quality, the ratio is accurate, and every detail must be investigated. The reaction conditions are also finely regulated, and the temperature and pressure are all carefully considered.
At the beginning, the results were not obvious, and the yield was not as expected. However, I was not discouraged, so I reviewed all the details, checked the literature, and interviewed Xianda, and finally got the essentials. After improving the process, the yield gradually increased, and the quality was also excellent.
Looking to the future, this compound has broad application prospects. Or in the field of medicine, to help the research and development of new agents; or in materials science, to add novel materials. I should make unremitting research, hoping to expand new paths for its development and contribute to the industry, living up to the original intention of research.
Toxicity Research
2 - Chloro - 1,3 - Difluoro - 4 - Nitrobenzene is also a chemical product. In toxicity research, it is really a priority. The toxicity of this product is related to the safety of living beings and the stability of the environment.
Detailed inspection of this product shows that its molecular structure is unique, and chlorine, fluorine and nitro coexist. Chlorine is often active; fluorine is highly electronegative; nitro also has its chemical characteristics. The three come together, or cause special toxicity.
Observe its impact on organisms, or enter cells and disturb their metabolism. In organisms, the activity of enzymes and the expression of genes may be harmed. In the environment, its degradation is difficult, or it may lead to accumulation, endangering the ecological balance.
Therefore, toxicity research needs to study the mechanism from microscopic cells to macroscopic ecology, clarify its harm, and pave the way for the rational use of chemical products and the protection of the environment.
Future Prospects
I have tasted the industry of chemical industry. In 2 - Chloro - 1, 3 - Difluoro - 4 - Nitrobenzene, I have thought about it and thought about its future.
Looking at this substance today, its unique nature is available in various fields of chemical industry. Although it is currently used or not widely used, I see its potential as infinite. In the future, it may be able to shine in the road of pharmaceutical synthesis, help the development of new drugs, and solve the suffering of people. Or in the way of material creation, emerge, contribute to the advent of new materials, and promote the progress of science and technology.
I firmly believe that with time and unremitting research, 2 - Chloro - 1, 3 - Difluoro - 4 - Nitrobenzene will be able to occupy a key position in the chemical industry, develop its extraordinary ability, and become the future prosperity we hope for in our hearts.
Where to Buy 2-Chloro-1,3-Difluoro-4-Nitrobenzene in China?
As a trusted 2-Chloro-1,3-Difluoro-4-Nitrobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 2-Chloro-1,3-Difluoro-4-Nitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What is the main use of 2-Chloro-1, 3-Difluoro-4-Nitrobenzene?
2-Chloro-1,3-difluoro-4-nitrobenzene is also an organic compound. Its main uses are quite extensive, and it is used in various fields of chemical industry.
First, it is often a key intermediate in the synthesis of medicine. Taking the synthesis of specific antibacterial drugs as an example, the chlorine, fluorine, nitro and other groups contained in its structure can endow the synthesized drugs with unique activities and properties. Through clever chemical reactions, it can be connected with other organic molecules to construct a drug molecular structure with precise pharmacological effects, thereby assisting the research and development of medicine and producing better drugs.
Second, it also plays an important role in the creation of pesticides. Due to its special chemical structure, pesticide ingredients with high insecticidal, bactericidal or herbicidal properties can be derived. With the characteristics of chlorine and fluorine atoms, the effect of pesticides on specific target organisms can be enhanced, while nitro groups can affect their chemical reaction activity and biological activity, making pesticides made from this raw material play an important role in pest control and weed control in agricultural production, and ensure the thriving growth and harvest of crops.
Third, in the field of materials science, it can also make a difference. Can be used as an intermediate raw material for synthesizing special functional materials. For example, when preparing some organic materials with special optical and electrical properties, the groups introduced after participating in the reaction can regulate the molecular arrangement and electron cloud distribution of the material, thereby endowing the material with unique physical and chemical properties such as photoelectric conversion and fluorescence emission, and promoting the development of new functional materials.
In short, 2-chloro-1,3-difluoro-4-nitrobenzene has shown indispensable uses in many fields such as medicine, pesticides, and materials, and has far-reaching impact on the development of related industries.
2-Chloro-1, what are the physical properties of 3-Difluoro-4-Nitrobenzene
2-Chloro-1,3-difluoro-4-nitrobenzene is also an organic compound. Its physical properties are worth a detailed investigation.
Looking at its properties, it is mostly white to light yellow crystalline powder under normal conditions. The characteristics of this morphology can be obtained intuitively by the naked eye.
As for the melting point, it is about 55-59 ° C. When the temperature gradually rises, this substance gradually melts from a solid state to a liquid state. This phase transition point is an important parameter in chemical experiments and industrial processes, and is related to the treatment of materials and the control of reaction conditions.
When it comes to boiling point, under a specific pressure, its boiling point is also fixed, but the exact value often varies with the change of external pressure. Knowing the boiling point is crucial in separation and purification methods such as distillation, which can be used to distinguish the volatilization of substances and make effective separation.
In terms of solubility, 2-chloro-1,3-difluoro-4-nitrobenzene has a certain solubility in organic solvents such as ethanol and acetone. This property makes it possible to choose a suitable solvent in the organic synthesis reaction to promote the smooth progress of the reaction. The contact and mass transfer between the reactants depend on the mediator action of the solvent. However, its solubility in water is very small, and the polarity difference between water and organic matter makes it difficult for the two to miscible.
In addition, its density is also an important physical property. Although the exact value needs to be determined by professional instruments, the size of the density, the weight and volume relationship of the related substances, and the distribution in the mixed system are all affected.
In summary, the physical properties of 2-chloro-1,3-difluoro-4-nitrobenzene, such as morphology, melting point, boiling point, solubility and density, are of critical significance in many fields such as chemical research and industrial production, and are the cornerstone for in-depth understanding and rational use of this substance.
What are the synthesis methods of 2-Chloro-1, 3-Difluoro-4-Nitrobenzene
There are several common methods for the synthesis of 2-chloro-1,3-difluoro-4-nitrobenzene.
First, 2,6-difluoroaniline is used as the starting material. First, 2,6-difluoroaniline is subjected to a diazotization reaction, and sodium nitrite and dilute acid are used as reagents to convert the amino group into a diazonium salt at low temperature. Subsequently, the diazonium salt is reacted with a halogenated cuprous reagent such as cuprous chloride to achieve the substitution of the diazonium group by the chlorine atom to obtain 2-chloro-1,3-difluorobenzene. After that, the product is nitrified. A mixed acid composed of concentrated nitric acid and concentrated sulfuric acid is used as a nitrifying reagent. At an appropriate temperature, nitro groups are introduced into the benzene ring to obtain 2-chloro-1,3-difluoro-4-nitrobenzene.
Second, 1,3-difluorobenzene is used as a starting material. First, 1,3-difluorobenzene is nitrified, and nitro groups are introduced into the benzene ring by using mixed acids to generate 1,3-difluoro-4-nitrobenzene. Then, it is chlorinated, and chlorine can be used as a chlorination reagent. In the presence of a catalyst such as ferric chloride, chlorine atoms are introduced at specific positions on the benzene ring, and finally the target product 2-chloro-1,3-difluoro-4-nitrobenzene is obtained.
Third, a suitable halogenated aromatic hydrocarbon is used as a raw material through a halogen exchange reaction. If the halogen atom in the raw material is suitable for activity, it can be exchanged with the corresponding halogenated salt under specific catalysts and reaction conditions, and fluorine atoms, chlorine atoms, etc. are gradually introduced, and nitro groups are introduced at appropriate stages to synthesize 2-chloro-1,3-difluoro-4-nitrobenzene through a multi-step reaction. This process requires precise control of reaction conditions, such as temperature, reactant ratio, catalyst type and dosage, which all have a significant impact on the reaction process and product yield.
2-Chloro-1, 3-Difluoro-4-Nitrobenzene What are the precautions in storage and transportation?
2-Chloro-1,3-difluoro-4-nitrobenzene is also a chemical substance. All things should be handled with caution in storage and transportation.
When storing, first choose a cool and dry place. This is because if the substance is in a warm and humid place, it may cause chemical changes or danger. The warehouse should be well ventilated to make the air smooth and avoid the accumulation of harmful gas. In addition, it needs to be separated from oxidants, reducing agents, alkalis and other substances. Due to its unique chemical activity, it is easy to cause chemical reactions or even cause ignition and explosion when stored together with other substances. At the same time, the place of storage should be clearly marked with warning signs, so that everyone is aware of its danger, so as to prevent accidental touch and misuse.
During transportation, it should not be ignored. It must be filled with appropriate packaging materials to ensure its tightness. The packaging must be sturdy and durable, able to resist bumps and collisions on the road, and prevent its leakage. The transportation vehicle is also selected as safe and reliable, and the ambient temperature and humidity inside the vehicle should be controlled within an appropriate range. Transport personnel must receive professional training, familiar with the characteristics of the material and emergency treatment methods. During transportation, close attention should be paid to the status of the goods. If there is any leakage, etc., it should be dealt with according to the predetermined emergency plan to ensure the safety of personnel and the environment.
In conclusion, every step of the storage and transportation of 2-chloro-1,3-difluoro-4-nitrobenzene involves safety and must be treated with rigor, without any slack.
What are the effects of 2-Chloro-1, 3-Difluoro-4-Nitrobenzene on the environment and the human body?
2-Chloro-1,3-difluoro-4-nitrobenzene is also an organic compound. It has an impact on the environment and human body.
First, the impact on the environment. If this compound is released in nature, it can be retained in soil and water bodies. Because of its stable chemical properties, it is difficult to be rapidly decomposed by microorganisms, so it may cause lasting environmental pollution. In the soil, or change the chemical properties of the soil, hindering the absorption of nutrients by plant roots, causing plant growth to be inhibited. If it enters the water body, it can cause the deterioration of water quality and endanger aquatic organisms. Or break the physiological balance of aquatic organisms, affect their reproduction and growth, and even cause the death of some aquatic organisms, disrupting the balance of aquatic ecosystems.
As for the effect on the human body. If people ingest this compound through breathing, skin contact or diet, it is harmful. It is irritating, and contact with the skin can cause skin redness, pain, allergies and other diseases. If it enters the eyes, it may damage eye tissue and affect vision. Inhalation through the respiratory tract can irritate the mucosa of the respiratory tract, causing cough, asthma, breathing difficulties, etc. Long-term exposure to this substance may be potentially carcinogenic. Because of its nitro, halogen atoms and other structures, or cause chemical reactions in the human body, damage the DNA of cells and increase the risk of cancer. And may affect the nervous system and endocrine system of the human body, causing dizziness, fatigue, endocrine disorders and other discomforts.
From this perspective, 2-chloro-1,3-difluoro-4-nitrobenzene has many adverse effects on the environment and the human body. When it is produced, used and disposed of, it is necessary to be cautious and take proper protection and treatment measures to reduce its harm.