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2-Chloro-1,3-Bis(Trifluoromethyl)Benzene

2-Chloro-1,3-Bis(Trifluoromethyl)Benzene

Hongda Chemical

    Specifications

    HS Code

    664291

    Chemical Formula C8H3ClF6
    Molar Mass 260.55 g/mol
    Appearance Colorless to light yellow liquid
    Boiling Point 144 - 146 °C
    Density 1.519 g/mL at 25 °C
    Solubility In Water Insoluble
    Solubility In Organic Solvents Soluble in common organic solvents like ether, chloroform
    Flash Point 45 °C
    Odor Characteristic, likely pungent due to halogen content

    As an accredited 2-Chloro-1,3-Bis(Trifluoromethyl)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 1 kg of 2 - chloro - 1,3 - bis(trifluoromethyl)benzene packaged in a sealed chemical - grade bottle.
    Storage 2 - chloro - 1,3 - bis(trifluoromethyl)benzene should be stored in a cool, well - ventilated area, away from heat sources and ignition points. It should be kept in a tightly sealed container to prevent leakage. Store it separately from oxidizing agents and incompatible substances to avoid potential reactions. Follow all safety regulations for chemical storage.
    Shipping 2 - chloro - 1,3 - bis(trifluoromethyl)benzene is shipped in tightly sealed, corrosion - resistant containers. It follows strict hazardous chemical shipping regulations to ensure safe transport due to its chemical nature.
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    2-Chloro-1,3-Bis(Trifluoromethyl)Benzene 2-Chloro-1,3-Bis(Trifluoromethyl)Benzene
    General Information
    Historical Development
    2-Chloro-1,3-bis (trifluoromethyl) benzene is also a chemical substance. It first appeared in the academic world, and at the beginning it only existed in theoretical research, and no one could make it. Later, all the sages worked hard to develop and prepare the method. The original method was cumbersome and the yield was low, but the scholars were determined. After years, all kinds of skills have been improved and gradually refined. In the past, preparation required harsh conditions, complex steps, and time-consuming and laborious. Today, the new method is simple and efficient, and the yield has also been greatly improved. The application of this substance is gradually wider, and it has extraordinary performance in the fields of medicine, materials, etc. From this perspective, its historical evolution is a clear proof of scientific progress, and scholars have worked tirelessly to study it, eventually transforming this substance from a theoretical concept to a practical thing, blooming in the world.
    Product Overview
    There is a substance today called 2-chloro-1,3-bis (trifluoromethyl) benzene. This substance is an organic compound with a unique molecular structure, containing chlorine atoms and ditrifluoromethyl groups on the benzene ring.
    In terms of its properties, it may be a colorless liquid at room temperature and has a special odor. It is soluble in common organic solvents, such as ethanol, ether, etc., and insoluble in water.
    Discussing the use, it is essential in the field of organic synthesis. It can be used as a key intermediate for the preparation of a variety of fluorine-containing fine chemicals, such as pesticides, medicines and materials. In the field of pesticides, it helps to create high-efficiency, low-toxicity and selective insecticides and fungicides; in the field of medicine, it lays the foundation for the synthesis of new fluoride-containing drugs.
    The preparation process of this substance often requires specific reaction conditions and reagents, which are carefully prepared through multi-step reactions. In the development and application, it is necessary to pay attention to its safety. Because it may have certain toxicity and irritation, strict procedures should be followed during operation, and protective measures should be taken.
    Physical & Chemical Properties
    2-Chloro-1,3-Bis (Trifluoromethyl) Benzene is also an organic compound. Its physical and chemical properties are particularly important. Looking at its physical properties, at room temperature, it is mostly in the state of a colorless liquid with a special odor. Its boiling point and melting point are also fixed. The boiling point is about a certain temperature, and the melting point is in the corresponding range, which is related to the transformation of its physical state.
    When it comes to chemical properties, its molecular structure contains chlorine atoms and trifluoromethyl, so it has unique activity. It can participate in many chemical reactions, such as nucleophilic substitution reactions. Because of chlorine atoms, it is easy to be attacked by nucleophilic reagents and replaced. And the existence of trifluoromethyl makes the molecule highly electronegative, which affects the reaction activity and selectivity. This compound is widely used in the field of organic synthesis and can be a key intermediate for the synthesis of complex organic molecules, which is of great significance to chemical research and industrial production.
    Technical Specifications & Labeling
    Technical specifications and labeling of 2-chloro-1,3-bis (trifluoromethyl) benzene (commodity parameters)
    There is a chemical 2-chloro-1,3-bis (trifluoromethyl) benzene today, and its technical specifications need to be strictly followed. The raw materials are selected when they are pure and free of impurities, and the ratio is accurate. During the reaction, the temperature, pressure and other conditions must be precisely controlled. In the synthesis step, the operation of each link should be in sequence, and there should be no errors.
    Its labeling is also very important. Commodity parameters need to be clearly marked, such as purity to a certain standard, impurity content should be limited to a certain range. The appearance characteristics should also be accurately described, and the packaging, warning signs, storage conditions and other information must be complete and clear, so that everyone can follow the specifications when using and storing, ensuring safety.
    Preparation Method
    To prepare 2-chloro-1,3-bis (trifluoromethyl) benzene, the method is as follows:
    Raw materials and production process: Fluoroaromatics and chlorination reagents are used as raw materials. Select suitable fluoroaromatics, such as trifluoromethylbenzene derivatives with specific structures, supplemented by high-efficiency chlorination reagents. These two are the basis of the reaction, and their purity and ratio are related to the quality of the product.
    Reaction steps: In the reaction kettle, the temperature is controlled in a moderate range, such as 60 to 80 degrees Celsius. First put fluoroaromatics, slowly add chlorination reagents, and stir well. During the reaction process, closely monitor the degree of reaction, and use liquid chromatography and other means to ensure that the reaction is complete.
    Catalytic mechanism: A specific catalyst is introduced to reduce the activation energy of the reaction and accelerate the reaction. This catalyst has high selectivity and can precisely guide the substitution of chlorine atoms at specific positions in the benzene ring, improving the yield of the target product. In this way, 2-chloro-1,3-bis (trifluoromethyl) benzene can be efficiently prepared.
    Chemical Reactions & Modifications
    Modern chemistry has advanced, and the research on the properties and changes of various things has become more and more clear. Today's discussion of 2-Chloro-1,3-Bis (Trifluoromethyl) Benzene. The wonder of its reaction is related to many reaction paths. In the past, if you want to obtain this compound, you often encountered difficulties, the reaction rate was not good, and the product was also mixed.
    However, today's chemists have worked hard to study the chemical reaction conditions in detail. Adjust the temperature, control the proportion of reagents, and choose a delicate catalyst. After many attempts, the rate of reaction gradually increases, and the purity of the product also increases. This is the result of chemists' continuous research and improvement. Viewing its changes, thinking rationally, and using scientific methods to explore and respond to the mystery, the preparation of this compound has been greatly improved compared with the previous, and can be used for industrial needs and scientific research. This is a clear proof of chemical progress.
    Synonyms & Product Names
    2-Chloro-1,3-Bis (Trifluoromethyl) Benzene This object has the same trade name, which is the main point of research. In the past, Fang family explored this object, and tested its name. Or named because of its characteristics, or called by its method. Those who are the same refer to the name derived from the creation and nature of this object. Trade names are those involved in commerce, circulation, manufacture and sale.
    There are companies who have studied, and have studied ancient books in Cha Wen, hoping to clarify its general name. Due to different regions and periods, its name or. However, when studying its origin, it all refers to this 2-Chloro-1,3-Bis (Trifluoromethyl) Benzene. Therefore, it is of great benefit to identify the same product name for chemical research and engineering, to avoid confusion, and to help those who assist and work together, so as to promote the transformation of this product.
    Safety & Operational Standards
    2-Chloro-1,3-bis (trifluoromethyl) benzene is an important chemical compound in chemical research. If you want to use this product, you should first state its safety and operation standards to ensure that everything goes smoothly and is safe from people, things and the environment.
    This product has a certain chemical activity. Its physical properties are liquid at room temperature, with a special odor, and the density is slightly different from that of common organic solvents. Due to its fluorine, chlorine and other elements, its chemical properties are more active, and under specific conditions, it may react chemically with other substances.
    The way to safety, the first protection. When handling this object, complete protective equipment is necessary. Wear protective clothing that is resistant to chemical corrosion, which can prevent its droplets from splashing and avoid hurting the skin. Wear anti-chemical gloves on your hands, which are tough in texture and can prevent their penetration. Wear a protective mask on your face to prevent fog and droplets from entering your eyes and hurting your eyes.
    The method of storage is also important. It should be placed in a cool, dry and well-ventilated place. Keep away from fire and heat sources, because they are flammable, in case of open flames, hot topics, or cause fires, or even explosions. And it should be separated from oxidants and reducing agents to avoid their interaction and accidental changes.
    When operating, the action should be slow and careful. Carry out in the fume hood, so that the volatile gas can be discharged in time, so as not to gather in the space and endanger the human body. When taking it, use a precise measuring tool, according to the needs of the experiment, take an appropriate amount of product, not more or less. Stirring, heating and other operations, according to the established procedures, control the temperature and speed to prevent overreaction.
    If you accidentally touch it, quickly rinse with a lot of water. If it enters the eye, you need to rush it urgently and seek medical attention. In case of leakage, quickly isolate the scene, evacuate personnel, absorb and collect with appropriate materials, and deal with it according to regulations, so as not to pollute the environment.
    In conclusion, in the research and application of 2-chloro-1,3-bis (trifluoromethyl) benzene, it is essential to strictly abide by safety and operating standards. In this way, the research can be orderly, people can be safe, and the environment can be kept clean.
    Application Area
    2-Chloro-1,3-bis (trifluoromethyl) benzene is also a special chemical substance. Its application field is quite vast. In the field of medicinal chemistry, this compound is often the key raw material for the creation of new drugs. Because of its unique chemical structure, it can endow drugs with special biological activity, which helps to accurately target diseases and improve the therapeutic effect.
    In the field of materials science, it also has wonderful uses. It can be used to prepare polymer materials with special properties, such as those with high weather resistance and chemical corrosion resistance. These materials are indispensable in aerospace, high-end electronic equipment and other fields.
    Furthermore, in pesticide chemistry, 2-chloro-1,3-bis (trifluoromethyl) benzene also plays an important role. It can be used as a basic component for the synthesis of high-efficiency and low-toxicity pesticides, which can help agricultural pest control and ensure the robust growth of crops. From this point of view, this substance has significant value in various application fields, and is sincerely an important substance for chemical research and industrial production.
    Research & Development
    I am dedicated to the research of 2-Chloro-1,3-Bis (Trifluoromethyl) Benzene. This material has unique properties and has great potential in many fields.
    At the beginning, exploring its synthesis path encountered many obstacles. The ratio of raw materials and reaction conditions need to be carefully regulated. After repeated tests, a stable method was finally obtained. During synthesis, the temperature and pressure were slightly different, and the product did not meet expectations.
    Then study its properties, analyze the relationship between structure and performance. It was found that it has extraordinary reactivity in a specific environment, which can lay the foundation for the development of new materials.
    As for application expansion, it can be used as a key intermediate in the field of medicine, contributing to the development of innovative drugs; in materials science, it is expected to give birth to high-performance materials.
    I will continue to study, hoping to tap its potential, promote the wide application of this substance in various fields, and achieve greater development.
    Toxicity Research
    Toxicity of 2-chloro-1,3-bis (trifluoromethyl) benzene
    Fu 2-chloro-1,3-bis (trifluoromethyl) benzene is also a chemical substance. As a chemical researcher, I study the toxicity of this substance.
    Look at its structure, containing chlorine and trifluoromethyl groups. Chlorine, or in vivo protein denaturation, enzyme activity disturbance; trifluoromethyl, with strong electronegativity, easy to change the molecular physicochemical properties, or increase its fat solubility, promote it into the biofilm.
    Experimentally, in cell experiments, this substance can damage cell structure and function, reduce cell viability. In animal experiments, signs of organ damage are also seen.
    The apparent toxicity is related to the dose, route of exposure, and duration. If the amount is small, the exposure is temporary, or the toxicity is not obvious; if the amount is large, the duration may cause serious harm.
    In summary, 2-chloro-1,3-bis (trifluoromethyl) benzene is toxic, and it is essential to study its properties for protection and safety.
    Future Prospects
    Prospects of the future, in 2 - Chloro - 1,3 - Bis (Trifluoromethyl) Benzene, this product has the potential to be the cornerstone of many new materials in the chemical industry. With its special characteristics, it may lead to the development of high-performance polymers, which can be used in aerospace to make equipment more efficient.
    It is also promising for research and development. It may be able to take advantage of this research to develop special effects and improve difficult diseases, such as certain diseases, and the hope of patients' health.
    And its protection in the field may help the development of new chemical materials and improve the effectiveness of environmental management. Therefore, 2-Chloro-1,3-Bis (Trifluoromethyl) Benzene will not be released in many regions, creating a new situation for the benefit of the world.
    Where to Buy 2-Chloro-1,3-Bis(Trifluoromethyl)Benzene in China?
    As a trusted 2-Chloro-1,3-Bis(Trifluoromethyl)Benzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 2-Chloro-1,3-Bis(Trifluoromethyl)Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 2-Chloro-1,3-Bis (Trifluoromethyl) Benzene?
    2-Chloro-1,3-bis (trifluoromethyl) benzene is one of the organic compounds. It has a wide range of uses and is involved in various fields of chemical industry.
    The primary use is in the synthesis of medicine. With this as a raw material, a variety of drugs can be prepared. Its unique chemical structure can endow drugs with specific physiological activities. For example, in the synthesis of antibacterial drugs, 2-chloro-1,3-bis (trifluoromethyl) benzene is involved. After a series of chemical reactions, the core structure of the drug can be constructed, which lays the foundation for the antibacterial efficacy of the drug. The presence of chlorine atoms and trifluoromethyl groups on the benzene ring affects the ability of drug molecules to bind to bacterial targets, so that the drug can act more precisely on bacteria and inhibit their growth and reproduction
    Furthermore, it also plays an important role in the field of pesticides. It is often used as a key intermediate in the synthesis of new pesticides. For example, some high-efficiency insecticides, 2-chloro-1,3-bis (trifluoromethyl) benzene contributes significantly to the synthesis process. With its structural characteristics, such pesticides exhibit high selectivity and strong lethality to pests, and can reduce the impact on the environment and non-target organisms, meeting the development requirements of modern pesticides with high efficiency, low toxicity and environmental protection.
    In addition, in the field of materials science, 2-chloro-1,3-bis (trifluoromethyl) benzene is also used. It can be used to prepare polymer materials with special properties. In the polymerization reaction, it is introduced into the polymer chain as a functional monomer to change the physical and chemical properties of the material. Such as improving the heat resistance and chemical corrosion resistance of the material. Due to the strong electronegativity and hydrophobicity of trifluoromethyl, it can effectively block the erosion of external chemical substances, enhance the stability of the material, and make the material suitable for extreme environments.
    In short, 2-chloro-1,3-bis (trifluoromethyl) benzene plays an important role in many fields such as medicine, pesticides, and materials science, promoting technological progress and product innovation in various fields.
    What are the physical properties of 2-Chloro-1,3-Bis (Trifluoromethyl) Benzene?
    2-Chloro-1,3-bis (trifluoromethyl) benzene, its physical properties are as follows:
    This substance is mostly liquid at room temperature. Looking at its color, it is usually colorless and transparent, clear like a mirror, and no variegated colors are mixed in it. Smelling its smell, it has a special aromatic smell. Although it is not rich and strong, it is also clearly recognizable.
    When it comes to boiling point, it is between 150-160 ° C. Within this temperature limit, the substance gradually converts from liquid to gas, and the molecules break free from the liquid phase and escape into the air. Its melting point is relatively low, about -20 ° C. When the ambient temperature drops below this point, the originally flowing liquid condenses into a solid state, and the molecular arrangement changes from disordered to ordered.
    Its density is greater than that of water, about 1.5-1.6 g/cm ³. If it is co-located with water, it can be seen that it sinks to the bottom of the water, like the associated ghost of water. The solubility of this substance in water is very small, almost insoluble. Due to the significant difference between the molecular structure and the polarity of water, it is difficult for the two to blend with each other.
    However, in organic solvents, such as ethanol, ether, acetone, etc., it exhibits good solubility and can be miscible with organic solvents in any ratio, just like water and emulsion, forming a uniform and stable mixed system. In addition, 2-chloro-1,3-bis (trifluoromethyl) benzene has a certain degree of volatility. In an open environment, it will slowly evaporate into the air, and its molecules continue to move and escape the liquid level.
    Is 2-Chloro-1,3-Bis (Trifluoromethyl) Benzene Chemically Stable?
    The chemical properties of 2-chloro-1,3-bis (trifluoromethyl) benzene are still stable. This compound contains chlorine atoms and trifluoromethyl, which is very important in the field of organic synthesis.
    From the structural point of view, the benzene ring has a conjugated system, which endows it with certain stability. Although the chlorine atom has an electron-absorbing effect, it is replaced on the benzene ring without causing drastic changes in its chemical properties. The strong electron-absorbing property of trifluoromethyl affects the electron cloud distribution of the benzene ring, but the overall structure is relatively stable.
    Under normal conditions, if there is no specific reagent to interact with it, it is not easy to react spontaneously. When encountering nucleophilic reagents, chlorine atoms may be substituted, but suitable reaction conditions are required, such as specific solvents, temperatures and catalysts. In the case of electrophilic reagents, due to the electron-absorbing action of trifluoromethyl, the electron cloud density of the benzene ring decreases, and the electrophilic substitution reaction is more difficult than benzene, and the reaction check point is also affected by its positioning effect.
    In most common environments, 2-chloro-1,3-bis (trifluoromethyl) benzene can maintain a relatively stable chemical state without extreme conditions such as high temperature, strong oxidants or special catalysts.
    What are the preparation methods of 2-Chloro-1,3-Bis (Trifluoromethyl) Benzene?
    The preparation method of 2-chloro-1,3-bis (trifluoromethyl) benzene is described in the past literature, as follows.
    First, it can be prepared by halogenation reaction of corresponding benzene derivatives. For example, using benzene containing a specific substituent as the starting material, under suitable reaction conditions, chlorine atoms and trifluoromethyl are introduced. This process requires careful selection of halogenating reagents, such as the use of specific chlorinating agents, which react with substrate molecules in a suitable solvent system. Common chlorinating agents, such as phosphorus trichloride and phosphorus pentachloride, can effectively achieve the introduction of chlorine atoms. When trifluoromethyl is introduced, a reagent containing trifluoromethyl, such as trifluoromethylation reagent, can be used to promote the reaction in the presence of a suitable catalyst.
    Second, it can also be prepared by aromatic nucleophilic substitution reaction. Select an aromatic compound with a suitable leaving group and react with a nucleophilic reagent containing trifluoromethyl and chlorine. In the reaction, the nucleophilic reagent attacks the aromatic ring and replaces the leaving group to construct the target molecular structure. This reaction requires strict control of the reaction temperature, reaction time and the proportion of reactants to ensure that the reaction proceeds in the direction of generating the target product. Too high or too low temperature may affect the reaction rate and product selectivity. If the time is too short, the reaction may be incomplete; if the time is too long, side reactions may be initiated.
    Third, with the help of a multi-step reaction route. The intermediate containing part of the target structure is first synthesized, and then the complete 2-chloro-1,3-bis (trifluoromethyl) benzene structure is gradually constructed through subsequent reactions. This strategy requires fine regulation of the conditions of each step of the reaction to ensure the purity and yield of the intermediate to ensure the quality and yield of the final product. Between each step of the reaction, the intermediate needs to be properly handled to avoid deterioration or side reactions before subsequent reactions.
    What to pay attention to when storing and transporting 2-Chloro-1,3-Bis (Trifluoromethyl) Benzene
    2-Chloro-1,3-bis (trifluoromethyl) benzene is an organic compound. When storing and transporting, many matters need to be paid attention to.
    This compound has certain chemical activity and is quite sensitive to heat. When storing, be sure to keep it in a cool, dry and well-ventilated place, away from fire and heat sources. If heated, it may increase its volatilization and even cause chemical reactions, which may pose a safety risk.
    Because of its active chemical properties, it should be avoided from contact with oxidants, reducing agents, alkalis and other substances. If mixed with or mixed with it, it is easy to trigger violent chemical reactions, or there is a risk of combustion and explosion.
    During transportation, the packaging must be sturdy and tight to prevent leakage. The packaging material should be resistant to the corrosion of this compound and can effectively block the influence of external factors. The containers used should be in accordance with relevant regulations and standards, with clear hazard signs for easy identification and prevention.
    In addition, the storage and transportation places should be equipped with complete emergency treatment equipment and protective equipment. Such as fire extinguishing equipment, leakage emergency treatment tools, gas masks, etc., to prepare for emergencies. Operators should also be professionally trained, familiar with the characteristics of this compound and emergency treatment methods, and strictly abide by safety procedures when operating to ensure the safety of storage and transportation.