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What are the main uses of 2- (Bromomethyl) -4-Chloro-1- (Trifluoromethyl) Benzene?
2-%28Bromomethyl%29-4-Chloro-1-%28Trifluoromethyl%29Benzene is 2- (bromomethyl) -4 -chloro-1- (trifluoromethyl) benzene, which has a wide range of uses.
In the field of organic synthesis, it is a key intermediate. Due to the unique activities and reaction characteristics of bromomethyl, chlorine atoms and trifluoromethyl in the molecule, it can be used for multiple reactions such as nucleophilic substitution and coupling to construct various complex and high-value-added organic compounds. For example, in pharmaceutical research and development, chemists use this compound to ingeniously adjust reaction conditions and reactants to construct molecular structures with specific pharmacological activities, laying the foundation for the creation of new drugs.
In the field of materials science, 2- (bromomethyl) -4 -chloro-1- (trifluoromethyl) benzene also plays an important role. Because of its trifluoromethyl content, the material is endowed with unique physical and chemical properties, such as excellent chemical resistance and low surface energy. Scientists can use this compound to synthesize polymer materials with special functions, which can be used in high-end fields such as aerospace and electronics to improve the performance and quality of materials.
In addition, in the preparation of fine chemical products, this compound is often used as a starting material or key intermediate. After a series of chemical reactions, it is converted into fine chemicals with specific functions, such as special fragrances, additives, etc., to meet the diverse needs of different industries for fine chemicals.
What are the physical properties of 2- (Bromomethyl) -4-Chloro-1- (Trifluoromethyl) Benzene?
2 - (bromomethyl) -4 -chloro-1 - (trifluoromethyl) benzene, is a kind of organic compound. Its physical properties, first of all, its phase state, under normal temperature and pressure, is mostly colorless to light yellow liquid, clear and transparent, with a special odor. This odor is unique due to the presence of halogen atoms and fluoromethyl groups in the molecular structure.
When it comes to the melting point, its melting point is between -10 ° C and -5 ° C, and the boiling point is in the range of 200 ° C to 210 ° C. The characteristics of this melting point are determined by the intermolecular forces. The presence of bromine, chlorine, and fluorine atoms in the molecule enhances the van der Waals force between molecules, resulting in an increase in the boiling point.
Furthermore, its density is greater than that of water, about 1.6-1.7 g/cm ³, so it sinks to the bottom in water. In terms of solubility, this substance is difficult to dissolve in water, because it is a non-polar or weakly polar molecule, and water is a strongly polar solvent. According to the principle of "similar miscibility", the two are insoluble. However, it is soluble in many organic solvents, such as ether, dichloromethane, toluene, etc. This organic solvent is also non-polar or weakly polar, and it is well miscible with this compound.
Its volatility is moderate, although it has a certain degree of volatilization at room temperature, it is not a very volatile genus. This volatility has a significant impact on its use and storage. When used in poorly ventilated areas, it is necessary to pay attention to the accumulation of volatile gases. In addition, because the molecule contains a variety of halogen atoms, the refractive index is high, and the refraction phenomenon is more significant when light passes through. This property may be useful for analysis and identification.
What is the chemical synthesis method of 2- (Bromomethyl) -4-Chloro-1- (Trifluoromethyl) Benzene?
To prepare 2 - (bromomethyl) -4 - chloro-1 - (trifluoromethyl) benzene, you can do it as follows.
Take 4-chloro-1 - (trifluoromethyl) benzaldehyde as the starting material. Mix it with an appropriate amount of phosphorus tribromide in a suitable reaction vessel, and under low temperature and stirring conditions, the aldehyde group is brominated. In this reaction, phosphorus tribromide acts as a brominating reagent, interacts with the hydroxyl group of the aldehyde group to convert it into a bromine atom, resulting in 4-chloro-1 - (trifluoromethyl) benzoyl bromide. This step requires attention to the control of the reaction temperature to avoid side reactions.
Then, 4-chloro-1- (trifluoromethyl) benzoyl bromide is placed in the reducing system of lithium aluminum hydride. Lithium aluminum hydride is a strong reducing agent, which can reduce the acyl bromide group to methylene, while retaining the chlorine atom and trifluoromethyl on the benzene ring. The reaction needs to be carried out in an anhydrous and low temperature environment, because lithium aluminum hydride is easily decomposed in contact with water, which affects the reaction process. After this step, the crude product of 2 - (bromomethyl) -4 -chloro-1 - (trifluoromethyl) benzene can be obtained.
The obtained crude product still needs to go through the purification process. A column chromatography method can be used to select a suitable eluent with a suitable silica gel as the stationary phase. According to the difference in the partition coefficient of each component between the stationary phase and the mobile phase, the separation of the target product and impurities can be achieved. The eluent containing the target product is collected, and the eluent is removed by reduced pressure distillation to obtain pure 2 - (bromomethyl) -4 -chloro-1 - (trifluoromethyl) benzene.
When preparing this compound, the precise control of the reaction conditions at each step is extremely critical. The yield and purity of the product will be affected by the reaction temperature, the amount of reagent, and the anhydrous and anaerobic requirements of the reaction environment.
2- (Bromomethyl) -4-Chloro-1- (Trifluoromethyl) Benzene What to pay attention to when storing and transporting
2-%28Bromomethyl%29-4-Chloro-1-%28Trifluoromethyl%29Benzene is 2- (bromomethyl) -4-chloro-1- (trifluoromethyl) benzene. When storing and transporting this substance, many key matters need to be paid attention to.
When storing, the first choice of environment. When placed in a cool and well-ventilated place, because the substance is quite sensitive to temperature and air, high temperature or lack of air circulation can easily promote its chemical reaction. Keep away from fire and heat sources to prevent it from being heated and causing combustion or explosion. The packaging of this substance must be sealed and must not be in direct contact with air. Because some chemical groups are active, they are easy to react with oxygen, water vapor and other components in the air, causing it to deteriorate.
Furthermore, the storage place should be stored separately from oxidants, acids, alkalis, etc., and must not be mixed. The chemical properties of this compound determine that it encounters the above substances, which is likely to trigger a violent chemical reaction and cause a dangerous situation. Regular inspections of the storage area are required to check whether the packaging is damaged or leaked. Once any abnormalities are found, proper measures should be taken immediately.
When transporting, extreme caution is also required. It is necessary to choose transportation tools that meet safety standards to ensure a smooth transportation process, reduce vibration and collision, and cause material leakage due to violent vibration or collision or packaging damage. Transportation personnel should be familiar with the characteristics of this chemical and emergency treatment methods. If an accident occurs on the way, they can respond quickly and correctly.
The transportation process should strictly follow the specified route, and cannot be changed at will. Avoid densely populated areas and traffic arteries to reduce the harm to the public in the event of an accident. When loading and unloading, the operator must load and unload lightly, and it is strictly forbidden to drop and heavy pressure to prevent damage to the packaging and ensure the safety of the whole transportation process.
What is the market price range for 2- (Bromomethyl) -4-Chloro-1- (Trifluoromethyl) Benzene?
I don't know the market price range of 2- (bromomethyl) -4-chloro-1- (trifluoromethyl) benzene. The price of this compound in the chemical market often varies due to a variety of factors. First, the cost of raw materials has a great impact. If the raw material for preparing this benzene, such as the price of starting materials containing bromine, chlorine and fluorine, rises, the cost of this compound also increases, and the price increases accordingly; conversely, the price of raw materials decreases, and the price may decrease.
Second, the production process also plays a key role. If the process is advanced and the production efficiency is high, the unit production cost can be reduced, and the price may be more competitive; if the process is complex and inefficient, the cost will increase, and the price will be higher.
Third, the market supply and demand relationship is the key factor. If the market demand for this benzene is strong and the supply is limited, the merchant may raise the price due to shortage; if the demand is low and the supply is excessive, the merchant may reduce the price in order to de-stock.
Fourth, the purity of the product also affects the price. High purity of 2- (bromomethyl) -4-chloro-1- (trifluoromethyl) benzene, due to the difficulty of preparation, is suitable for high-end fields, and the price must be higher than that of low purity.
And different regional markets, due to differences in transportation costs, tax policies, market competition, etc., the price will also be different. Therefore, in order to know the exact market price range, it is necessary to carefully investigate the raw material market dynamics, production process details, local supply and demand conditions, and product purity standards, etc., in order to obtain a more accurate price range.