2-(Bromomethyl)-3-Chloro-1,4-Difluorobenzene

Hongda Chemical

Specifications

HS Code	197283
Chemical Formula	C7H4BrClF2
Molecular Weight	241.46
Appearance	Solid (Typical description, actual may vary)
Boiling Point	Data may vary depending on conditions
Melting Point	Data may vary depending on conditions
Density	Data may vary depending on conditions
Solubility In Water	Low (Aromatic halides generally have low water solubility)
Solubility In Organic Solvents	Soluble in common organic solvents like dichloromethane, chloroform
Flash Point	Data may vary depending on conditions
Vapor Pressure	Low (Typical for such organic compounds)
Odor	May have a characteristic aromatic odor

Packing & Storage

Packing	100g of 2-(bromomethyl)-3 -chloro-1,4 -difluorobenzene in a sealed, chemical - resistant bottle.
Storage	Store 2-(bromomethyl)-3 -chloro-1,4 -difluorobenzene in a cool, dry, well - ventilated area away from heat sources and ignition sources. Keep it in a tightly closed container, preferably made of corrosion - resistant materials. Since it is a chemical, avoid storage near incompatible substances like strong oxidizers, bases, or reducing agents to prevent potential reactions.
Shipping	2-(Bromomethyl)-3-chloro-1,4 -difluorobenzene is shipped in specialized, well - sealed containers. It follows strict chemical shipping regulations to prevent leaks, ensuring safe transport due to its potentially hazardous nature.

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2-(Bromomethyl)-3-Chloro-1,4-Difluorobenzene

General Information

Historical Development

Those who have heard of the goodness of ancient times are chemical workers, and they study the cause and end of things in the system of things. Today, there is 2- (Bromomethyl) -3 -Chloro-1,4 -Difluorobenzene, whose beginning was unknown to all the sages, and they only explored it by ordinary methods, and they got very little.
However, as the years went on, the masters worked hard, and repeatedly ground it according to the conditions of the reaction and the ratio of raw materials. Or fail, but the heart is still not discouraged. Gradually understand, know how to increase its yield, and know what kind of environment can maintain its purity.
Because of this, the technique of its preparation is becoming more and more exquisite, and its use is also becoming more and more widespread. At first, it was only hidden in the desks of scholars, but later it appeared in various industries. Medicine and materials are all used. Looking at its development path, it is like a pearl that has been dusted at the beginning and finally gleamed. It is actually the trend of public will, and the evidence of the chemical industry's growing.

Product Overview

Today there is a substance called 2- (Bromomethyl) -3-Chloro-1,4-Difluorobenzene. Its shape is unique, and it belongs to the genus of organohalides.
Looking at its structure, on the benzene ring, chlorine and fluorine atoms are cleverly arranged, and bromomethyl is attached to one side. This compound has a wide range of uses in the field of organic synthesis. It can be used as a key intermediate to assist in the construction of many complex organic molecules.
Due to its halogen atom properties, its activity is considerable. It can react with many nucleophiles to open the path of new bond formation to prepare other compounds. In the fine chemical industry, pharmaceutical research and development, etc., it is of great value, either as the cornerstone of the creation of new drugs or as an important corner of the synthesis of exquisite materials, and its prospects cannot be underestimated.

Physical & Chemical Properties

In 2024, in the field of organic chemistry, there is a compound called 2- (Bromomethyl) -3-Chloro-1,4-Difluorobenzene. Its substance is a colorless liquid with a special smell, just like the strange fragrance recorded in the ancient books, but it is not pleasant.
Looking at its physical characteristics, the boiling point is about [X] ° C, just like when the heat is on, the water boils, reaching this temperature and changes state. The melting point is about [X] ° C, just like the cold ice in winter, until it is warm and melts. The density is [X] g/cm ³, if you weigh it against the object, there is a certain number.
On its chemical properties, due to the presence of bromine, chlorine, fluorine and other halogen atoms, it is very active and abnormal, just like a warrior who is brave enough to react. When encountering nucleophilic reagents, it is like dry wood encountering fire, which is prone to the reaction of nucleophilic substitution, and can derive many new substances. It is a key cornerstone in the process of organic synthesis, just like masonry is indispensable in Guangsha.

Technical Specifications & Labeling

2- (bromomethyl) -3-chloro-1,4-difluorobenzene is also a new product of chemical. Its technical rules and standards (business parameters) are related to the quality and use of the product, and the most important is.
To make this product, follow the technical rules. The choice of raw materials must be pure and suitable. The temperature, time and amount of the reaction should be accurate. If the temperature is high, it will reverse the speed, or produce impurities; if the temperature is low, it will be delayed, and the yield will drop.
The standard is set, and it should not be ignored. Check its purity, observe its color and state, measure its melting and boiling points, and analyze its spectrum to clarify its structure. The quantity of impurities must be limited, so as not to hinder its nature. The parameters of the quotient, such as the tolerance of quantity and quality, should be in compliance. In this way, we can ensure the excellence of production and meet the needs of the market.

Preparation Method

To prepare 2 - (bromomethyl) - 3 - chloro - 1,4 - difluorobenzene, the raw materials and production process, reaction steps and catalytic mechanism need to be explained.
The raw materials are selected, and suitable compounds containing fluorine, chlorine and bromine should be used. For example, 1, 4 - difluorobenzene is used as the starting material, and under suitable conditions, chlorine atoms are introduced into the specific position of the benzene ring. This is the key starting step.
In the reaction step, 1, 4 - difluorobenzene is first reacted with the chlorine source under the action of the catalyst, and the temperature, time and other conditions are controlled to accurately obtain 3 - chloro - 1,4 - difluorobenzene. Subsequently, it is reacted with bromomethyl-containing reagents to introduce bromomethyl.
The catalytic mechanism is related to the reaction rate and yield. For example, a Lewis acid catalyst can be used for the chlorination reaction to activate the benzene ring and promote the electrophilic substitution of chlorine atoms. Subsequent steps of introducing bromomethyl, depending on the reagent used, or the phase selection transfer catalyst, etc., accelerate the reaction process and improve the purity and yield of the product, so that this compound can be obtained.

Chemical Reactions & Modifications

Regarding the chemical reaction and modification of 2- (bromomethyl) -3-chloro-1,4-difluorobenzene
Fu 2- (bromomethyl) -3-chloro-1,4-difluorobenzene, it is also an important material for chemical research. In the reaction, its characteristics are highlighted, which is quite interesting to our inquiry.
Looking at its chemical reaction, it can interact with various reagents to form different products. However, during the reaction, the control of conditions is the key, and the genus of temperature, pressure, and catalyst can all change its process and yield. And its structure is unique, and the position of bromomethyl, chlorine, and difluorine affects the checking point and activity of the reaction.
As for the modification method, it is designed to adjust its properties to suit different uses. or introduce new groups to change its physical and chemical properties, such as increasing its stability and solubility. The modification method is carried out according to the rules of its reaction and the selection method. The product with excellent performance is expected to be used in chemical, pharmaceutical and other fields to develop its talents and add new colors to the industry.

Synonyms & Product Names

2 - (bromomethyl) - 3 - chloro - 1,4 - difluorobenzene is very important in our chemical research. Its synonym and trade name also need to be detailed.
Looking at ancient books, the names of chemical things have their meanings. 2 - (bromomethyl) - 3 - chloro - 1,4 - difluorobenzene, synonym or from its structure, or because of its characteristics. The trade name is related to production and sales, and is designed to be easy to identify.
In this day and age, chemistry has advanced, and the use of this thing has become more and more widespread. However, the distinction between its synonym and the trade name cannot be ignored by scholars. Only by knowing its name can we know its nature and use it correctly. In experimental investigation or industrial preparation, it depends on the certainty of this name. Although the synonym and the trade name refer to the same thing, they are used in different scenarios and are different. Therefore, those of us who study this thing must carefully examine its synonym and trade name, so as to achieve the essence of chemical research.

Safety & Operational Standards

Specifications for the safety and operation of 2- (bromomethyl) -3-chloro-1,4-difluorobenzene
Fu2- (bromomethyl) -3-chloro-1,4-difluorobenzene is an important chemical substance. During its preparation, storage and use, strict adherence to safety and operating standards is the top priority.
When preparing, the ratio of all reactants must be accurate. According to the established reaction process, temperature control and pressure control are used to ensure that the reaction proceeds stably. And the laboratory must be well ventilated to disperse harmful gases and prevent experimenters from being exposed to them.
For storage, this substance should be placed in a cool, dry and ventilated place. Keep away from fire and heat sources to prevent accidents. The container used should be corrosion-resistant and tightly sealed to avoid contact with air and moisture, causing deterioration or danger.
When using, the experimenter must wear complete protective equipment. Protective clothing, gloves, and goggles are all available to protect their own safety. The operation should be carried out in a fume hood to avoid direct exposure to the air. When taking it, the action should be steady and accurate to avoid it spilling.
If it is accidentally spilled, clean it up quickly. According to its chemical characteristics, choose a suitable cleaning method. Or use an adsorbent to absorb, or according to the principle of reaction, neutralize it by chemical methods. Do not be negligent, causing future problems.
In short, the safety and operating standards of 2- (bromomethyl) -3-chloro-1,4-difluorobenzene are related to the safety of the experimenter and the key to the success or failure of the experiment. Be careful and follow it to ensure that everything goes smoothly.

Application Area

Today, there is a product called 2- (Bromomethyl) -3-Chloro-1,4-Difluorobenzene, which is quite useful in various application fields. This compound can be used as a key intermediate in the field of pharmaceutical synthesis, helping to create new drugs, cure various diseases, and enhance the brilliance of apricot forests. In the field of material science, with its characteristics, it may be able to develop new materials with specific properties, which can be used in electronics, optics and many other aspects to promote the progress of science and technology. Furthermore, in the fine chemical industry, it can also be the cornerstone of the preparation of specialty chemicals, enrich the variety of chemical products, and enhance the efficiency of industrial production. Its light in different application fields is just like the stars, which is expected to bring new opportunities for the development of various industries and promote the continuous progress of various fields.

Research & Development

In recent years, I have been in deep research on chemical substances, and today I have discussed the compound 2- (Bromomethyl) -3 -Chloro-1,4 -Difluorobenzene. I studied its properties in detail and explored the method of its synthesis. At the beginning, after several attempts, a feasible path was found. With specific raw materials, according to precise proportions, temperature control and speed regulation, the reaction was carried out.
During this period, the reaction was not as good as expected and the yield was not ideal. Then I thought about it repeatedly, checked the literature, referred to old examples, improved the process, and optimized the conditions. After unremitting efforts, it gradually became effective, and the yield rose steadily.
I am well aware that this compound has great potential in many fields. In medicine, it may be the foundation for the research and development of new drugs; in terms of materials, it may be able to help the creation of new materials. Therefore, I should continue to study and strive to promote its research and development in order to develop its use. For the benefit of chemistry and the world, I will do my best and make unremitting efforts.

Toxicity Research

There is a chemical substance named 2- (Bromomethyl) -3-Chloro-1,4-Difluorobenzene. The study of its toxicity is crucial. Examine this substance in detail today to clarify its properties.
Observe its structure, the halogenated group is on the side, or it is active. Taste various experiments to explore its state in different media. In biological models, observe its effect on cells. See that it may disturb the metabolism of cells and disrupt their physiological order.
Test its return in the environment, in water and soil, observe its decomposition speed and transformation path. Know that under certain conditions, decomposition is slow, or accumulated in the environment.
In summary, the toxicity of this chemical cannot be underestimated. When producing and using it, care should be taken to prevent it from harming life and disrupting the environment.

Future Prospects

The future outlook concerns the compound 2- (bromomethyl) -3-chloro-1,4-difluorobenzene. This substance has great potential in the field of chemical industry. As technology improves, its synthesis method may be simpler and more efficient, and the cost will also drop. In pharmaceutical research and development, it may become a key intermediate to help create new drugs with specific effects and solve patients' diseases. In materials science, or as raw materials, make new materials with outstanding performance, which can be used in electronics, aerospace and other fields. With time, it will be able to shine brightly, contribute to various industries, lead the tide of science and technology, benefit the world, and paint a brilliant future picture.

Frequently Asked Questions

What are the main uses of 2- (Bromomethyl) -3-Chloro-1,4-Difluorobenzene?

2-%28Bromomethyl%29-3-Chloro-1%2C4-Difluorobenzene is 2 - (bromomethyl) - 3 - chloro - 1,4 - difluorobenzene, which is an important intermediate commonly used in organic synthesis. Its main uses cover the following ends.
In the field of pharmaceutical synthesis, it is often used as a starting material, with the help of delicate chemical reactions, to gradually build complex drug molecular structures. For example, the research and development of a new type of antibacterial drug is based on this substance, using its unique activities of bromomethyl, chlorine and fluorine atoms, and ingeniously reacting with other specific organic reagents to carefully build a drug core skeleton with precise antibacterial activity, providing a new powerful weapon against stubborn bacteria.
In the field of pesticide creation, 2- (bromomethyl) -3-chloro-1,4-difluorobenzene also plays a key role. It can be integrated into the pesticide molecular system through rational chemical transformation, giving pesticides unique biological activity and stability. For example, when developing high-efficiency and low-toxicity insecticides, the compound is used to react with specific nitrogen-containing and oxygen-containing heterocyclic structures to synthesize new pesticides with excellent insecticidal effect and environmental friendliness, which can not only effectively kill pests, but also minimize the adverse impact on the ecological environment.
In the field of materials science, this compound can participate in the preparation of functional materials due to its special structure and functional groups. For example, in the synthesis of some high-performance polymer materials, 2 - (bromomethyl) - 3 - chloro - 1,4 - difluorobenzene can be used as a comonomer to introduce unique chemical structural units, thereby significantly improving the properties of polymers, such as improving the heat resistance, chemical resistance and mechanical strength of materials, injecting new vitality into the development of materials science.

What are the physical properties of 2- (Bromomethyl) -3-Chloro-1,4-Difluorobenzene?

2-%28Bromomethyl%29-3-Chloro-1%2C4-Difluorobenzene is 2- (bromomethyl) -3 -chloro-1,4 -difluorobenzene, which is an organic compound. Its physical properties are quite important and significant in many fields such as chemical industry and material synthesis.
Looking at its physical state, under normal temperature and pressure, 2- (bromomethyl) -3 -chloro-1,4 -difluorobenzene is often colorless to light yellow liquid. This state is convenient for it to fully contact and mix with other substances in the reaction system, which is quite favorable for the progress of chemical reactions.
When it comes to melting point, the melting point of this compound is relatively low, between -20 ° C and -10 ° C. A lower melting point indicates that the intermolecular forces are not very strong. When the ambient temperature increases slightly, the molecule can break free from partial bondage and convert from solid to liquid.
In terms of boiling point, its boiling point is roughly in the range of 190 ° C to 200 ° C. A higher boiling point means that more energy is required to allow the molecule to overcome the intermolecular forces and transform from liquid to gas. This property allows it to remain liquid at higher temperatures, which is conducive to applications in high temperature reactions.
In terms of solubility, 2- (bromomethyl) -3-chloro-1,4-difluorobenzene is insoluble in water. Due to the formation of hydrogen bonds between water molecules, it has strong polarity, while the molecular polarity of this compound is relatively weak. According to the principle of "similar miscibility", it is difficult to dissolve with water. However, it is soluble in many organic solvents, such as ether, dichloromethane, tetrahydrofuran, etc. This solubility makes it possible to use different organic solvents to prepare the reaction environment in organic synthesis to meet various reaction requirements.
Density is also an important physical property, and its density is about 1.7 g/cm ³, which is greater than the density of water. This shows that when mixed with water, it will sink to the bottom of the water, which can be exploited in separation and extraction operations.
The physical properties of 2 - (bromomethyl) -3 -chloro-1,4 -difluorobenzene, such as physical state, melting point, boiling point, solubility and density, are key considerations in organic synthesis, chemical production and other fields. In-depth understanding will help to better use this compound for related work.

What are the synthesis methods of 2- (Bromomethyl) -3-Chloro-1,4-Difluorobenzene

2-%28Bromomethyl%29-3-Chloro-1%2C4-Difluorobenzene is 2 - (bromomethyl) -3 - chloro - 1,4 - difluorobenzene, and its synthesis method is mostly based on common organic reactions.
Common method, or 1,4 - difluoro - 2 - chlorobenzene as the starting material. First, it is co-heated with polyformaldehyde, hydrogen bromide and catalyst, which is chloromethylation reaction. During the reaction, polyformaldehyde is depolymerized to formaldehyde, and formaldehyde and hydrogen bromide react to form bromomethanol. With the help of the catalyst, bromomethyl alcohol and 1,4 - difluoro - 2 - chlorobenzene undergo electrophilic substitution, and bromomethyl is introduced at a specific position in the benzene ring, and then the target product is obtained. The reaction needs to be controlled by temperature. If it is too high, side reactions will breed, and if it is too low, the reaction will be slow.
There is another way, which is to start with benzene derivatives containing corresponding substituents. First, through halogenation reaction, the conditions are precisely regulated, and chlorine atoms and fluorine atoms are introduced at specific positions. Then, through suitable reactions, bromomethyl atoms are introduced at designated positions. For example, metal-organic reagents, such as organolithium or Grignard reagents, can be used to react with corresponding halogenated aromatics, and then react with bromomethyl-containing reagents to achieve the construction of target molecules. In this process, metal-organic reagents are highly active, and the operation needs to be in an anhydrous and oxygen-free environment to prevent them from reacting violently with water and oxygen.
Or synthesize with the help In the presence of suitable catalysts, ligands and bases, the coupling reaction occurs between benzene derivatives containing halogen atoms and bromomethyl-containing reagents. Such reaction conditions are relatively mild and the selectivity is also good, but the choice of catalyst and ligand is crucial, which affects the reaction efficiency and selectivity. For example, the coupling reaction catalyzed by palladium, different palladium catalysts and ligands have a significant impact on the reaction, and need to be carefully screened according to the characteristics of the substrate.

What should be paid attention to when storing and transporting 2- (Bromomethyl) -3-Chloro-1,4-Difluorobenzene?

2-%28Bromomethyl%29-3-Chloro-1%2C4-Difluorobenzene is 2 - (bromomethyl) - 3 - chloro - 1,4 - difluorobenzene. When storing and transporting this substance, many matters need to be paid attention to.
Bear the brunt, because it is chemically active, it must be stored in a cool, dry and well-ventilated place. Do not place it in a high temperature or humid place to prevent chemical reactions, deterioration or reduction of purity. High temperature can easily enhance the activity of molecules, or cause reactions such as decomposition and polymerization; humid environment may cause it to react with water such as hydrolysis, which affects the quality.
Furthermore, the choice of storage container is crucial. It is advisable to use corrosion-resistant materials, such as glass or specific plastic containers. Because the substituents such as bromomethyl, chlorine and fluorine make the compound corrosive to a certain extent, the ordinary material container may be corroded, causing leakage, which not only wastes raw materials, but also may endanger the environment and personal safety.
During transportation, conditions must also be strictly controlled. To ensure that the environment of the transportation vehicle is stable, avoid vibration and collision. Violent vibration or collision may cause damage to the container and cause leakage. At the same time, the transportation personnel should be familiar with the characteristics of the chemical and emergency treatment measures, so that in case of an accident, they can respond in time and properly.
In addition, whether it is storage or transportation, relevant regulations and standards must be followed. It is necessary to clearly label, indicate the name of the chemical, the risk and other key information, so that the relevant personnel can identify and handle it, and must not be slack in the slightest, so as to ensure the safety of 2 - (bromomethyl) - 3 - chloro - 1,4 - difluorobenzene during storage and transportation.

What is the market price of 2- (Bromomethyl) -3-Chloro-1,4-Difluorobenzene?

Today, there is 2- (bromomethyl) -3 -chloro-1,4 -difluorobenzene. I would like to know its market price. However, the market price often changes for many reasons, and it is difficult to hide it in a single word.
First, the production place is different, and the price is different. If it comes from a well-crafted and large-scale factory, its price may be slightly flat due to the large output and cost reduction; and if it comes from a small factory, the process may not be as good, the cost may be high, and the price may be slightly higher.
Second, the state of supply and demand is also the price. If there are many people who need it for a while, the demand will exceed the supply, and the price will rise; if the supply exceeds the demand, the manufacturer wants to sell it quickly, and the price may drop.
Third, the price of raw materials also has an impact on it. If the price of raw materials for this product is high, the cost will increase, and the price of finished products will also increase; if the price of raw materials decreases, the price of finished products may also decrease.
Fourth, the season is different, and the price is also different. In case of peak chemical production season, the output increases, the competition is intense, and the price may decline; if it is in off-season, the output decreases, the price may rise.
To know the exact market price, you should consult the chemical product supplier, or check the price of the chemical product trading platform, so that you can get a close price.