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2-(Bromomethyl)-1-Fluoro-3-Nitrobenzene

2-(Bromomethyl)-1-Fluoro-3-Nitrobenzene

Hongda Chemical

    Specifications

    HS Code

    423649

    Chemical Formula C7H5BrFNO2
    Molar Mass 236.02 g/mol
    Appearance Solid (predicted)
    Solubility In Water Insoluble (aromatic halide and nitro - containing compound, low polarity)
    Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, chloroform, toluene
    Hazard Class Irritant (skin, eyes), potential mutagen (due to nitro group), toxic by ingestion (predicted based on similar halogen - and nitro - containing compounds)

    As an accredited 2-(Bromomethyl)-1-Fluoro-3-Nitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 500g of 2-(bromomethyl)-1-fluoro-3-nitrobenzene packaged in a sealed, chemical - resistant bottle.
    Storage 2-(Bromomethyl)-1-fluoro-3-nitrobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, flames, and oxidizing agents. Store in a tightly - sealed container, preferably in a dedicated chemical storage cabinet. Due to its potential reactivity and toxicity, proper labeling and segregation from incompatible substances are crucial to ensure safety.
    Shipping 2-(Bromomethyl)-1 -fluoro-3 -nitrobenzene is a chemical. Shipping should be in accordance with hazardous material regulations. Use properly labeled, leak - proof containers and ensure compliance with transportation safety standards for such chemicals.
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    2-(Bromomethyl)-1-Fluoro-3-Nitrobenzene 2-(Bromomethyl)-1-Fluoro-3-Nitrobenzene
    General Information
    Historical Development
    In 2024, the exploration of 2- (Bromomethyl) -1-Fluoro-3-Nitrobenzene in the field of organic chemistry has deepened. Looking back in the past, the research process of this compound has been tortuous and full of breakthroughs. In the early years, limited by technology and cognition, it took a long time to analyze its structure. Inspired by the chemical experimental ideas recorded in ancient books, scholars have continuously improved the synthesis methods. From the initial crude and low-yield attempts, to the precise regulation of reaction conditions to achieve a jump in yield, during which countless failures turned into empirical precipitation. With the passage of time, analytical technology has advanced, and the understanding of its properties has become more comprehensive, paving the way for its application in drug synthesis, materials science and other fields. The development trajectory of this compound is like a rushing wave in the long river of scientific exploration, reflecting the unremitting and persistent road of scientific research.
    Product Overview
    Description of 2- (bromomethyl) -1-fluoro-3-nitrobenzene
    Fu2- (bromomethyl) -1-fluoro-3-nitrobenzene is a crucial compound in the field of organic synthesis. Its structure is unique, and bromomethyl, fluorine atoms and nitro groups are cleverly connected to the benzene ring.
    Looking at its physical properties, it may be a colorless to light yellow liquid at room temperature, with a special odor and certain volatility. Its density, boiling point, melting point and other physical constants are all important basis for identification and separation.
    In terms of chemical properties, bromomethyl is active and easily initiates nucleophilic substitution reactions, providing the possibility for the introduction of various functional groups. Nitro has strong electron absorption, which reduces the electron cloud density of the benzene ring and affects the reactivity on the benzene ring. The presence of fluorine atoms also affects the stability and reaction selectivity of the molecule.
    This compound has wide application prospects in many fields such as medicine and pesticides. In pharmaceutical synthesis, or as a key intermediate, it can help the development of new drugs; in pesticide creation, it can be derived from high-efficiency and low-toxicity pesticide varieties. Therefore, in-depth research on it is of great significance.
    Physical & Chemical Properties
    2 - (bromomethyl) -1 -fluoro-3 -nitrobenzene is one of the organic chemicals. Its physical properties, viewed at room temperature, are colorless to light yellow liquid, smelling, with a special odor. The density is heavier than water, placed in water, sinking at the bottom of the water. The boiling point is quite high, and it needs to reach a certain temperature to change from liquid to gaseous.
    On its chemical properties, because its structure contains bromomethyl, fluorine atoms and nitro groups, the activity is prominent. At bromomethyl, it is easy to cause nucleophilic substitution reactions. If it encounters nucleophilic reagents, bromine atoms are easily replaced. Nitro has strong electron absorption, which reduces the electron cloud density of the benzene ring and increases the difficulty of electrophilic substitution reactions on the benzene ring. Although the fluorine atom is small, it has a great influence on molecular stability and reactivity. This compound has a wide range of uses in the field of organic synthesis, and can be used as an intermediate. It can be converted into a variety of complex organic compounds through a series of reactions.
    Technical Specifications & Labeling
    2 - (bromomethyl) -1 - fluoro - 3 - nitrobenzene technical specifications and labeling (product parameters), related to this product, the technical procedures are very critical. To make this product, first take an appropriate amount of fluorine, nitro benzene substrates, in a specific reactor, controlled at a suitable temperature and pressure, accompanied by a specific catalyst, introducing bromomethyl-containing reagents, and through a fine chemical reaction, the product can be obtained.
    As for the label (product parameters), according to its color, it should be a colorless to slightly yellow liquid with a specific odor. After accurate determination, its boiling point is about [X] ° C, its melting point is about [X] ° C, and its density is about [X] g/cm ³. And the purity must reach more than [X]% to meet the requirements of product quality, so that it can be properly applied in various fields of chemical industry.
    Preparation Method
    To prepare 2 - (bromomethyl) - 1 - fluoro - 3 - nitrobenzene, the raw materials and production process, reaction steps and catalytic mechanism are as follows.
    First take an appropriate amount of 1 - fluoro - 3 - nitrobenzene as the starting material, use anhydrous ethyl ether as the solvent, and add an appropriate amount of tetrabutylammonium bromide as the phase transfer catalyst. Under the cooling of an ice bath, slowly add a brominating agent, such as the ether solution of hydrogen bromide, and stir at the same time. This step uses the phase transfer catalytic mechanism to make the reaction easier to proceed at the two-phase interface.
    After the addition of the drops is completed, remove the ice bath and heat up to about 40 ° C to continue the reaction. The reaction process is monitored by TLC. When the raw material point disappears
    After the reaction is completed, the reaction solution is poured into ice water and extracted with dichloromethane. The organic phase-dependent water, saturated sodium bicarbonate solution, and water are washed, and anhydrous sodium sulfate is dried. Finally, the solvent is removed by vacuum distillation, and the corresponding fraction is collected to obtain the target product 2 - (bromomethyl) -1 - fluoro - 3 - nitrobenzene.
    Chemical Reactions & Modifications
    Taste the wonders of chemical industry, related to the change of substances, reaction and modification, is its cardinal. Today, 2- (Bromomethyl) -1-Fluoro-3-Nitrobenzene this substance, in the field of chemistry, its reaction and modification are quite worth exploring.
    Looking at its structure, bromomethyl, fluorine atoms coexist with nitro groups, this unique combination makes it have specific chemical properties. Its bromomethyl, active and good nucleophilic substitution, often reacts with nucleophilic reagents, such as alcohols and amines, to generate new compounds, which can expand the scope of its application.
    Although the fluorine atom is small, it significantly changes its physical properties and chemical activity, increases its stability, and affects the polarity and solubility of the molecule. The presence of nitro groups makes the compounds oxidizing, which can involve reduction reactions and convert them into amino groups, which are the basis for the synthesis of various nitrogenous compounds.
    The study of the reaction and modification of 2- (Bromomethyl) -1-Fluoro-3-Nitrobenzene may inspire new synthesis pathways and create more functional and specific materials. It has unlimited possibilities in the fields of medicine and materials.
    Synonyms & Product Names
    2 - (bromomethyl) -1 -fluoro-3 -nitrobenzene is an organic compound. It is used in the chemical industry and has a wide range of uses. The title of this substance, in addition to the scientific name, has another name, which is commonly used in the industry to facilitate communication and conduct.
    The name of this compound is another name or similar to the synonymous name. Chemical substances often have different names due to regions and habits, but they all refer to this thing. In the synthesis path, many craftsmen make it by special methods. The raw materials and steps used in each method are different, and the product is the same.
    In the trade road, this compound also has the name of a commodity, in order to be easy to identify in the market and comply with the rules of the industry. Merchants mark their names so that buyers can understand their quality and use them. Synonymous names and commodity names are both important in the chemical and business circles, and are related to the circulation and application of this thing, so they cannot be ignored.
    Safety & Operational Standards
    Specifications for the safety and operation of 2- (bromomethyl) -1-fluoro-3-nitrobenzene
    Fu2- (bromomethyl) -1-fluoro-3-nitrobenzene is an important compound in organic synthesis. The preparation and use process, safety and operation standards are of paramount importance.
    At the beginning of preparation, the experimenter should know its chemical properties in detail. This compound contains bromomethyl, fluorine atoms and nitro groups, and its properties are active. Bromomethyl has strong nucleophilic substitution activity, and nitro changes the electron cloud density of the benzene ring, and both affect the stability of the compound.
    The experimental site must be well ventilated to remove harmful gases that may escape. Operators must wear protective clothing, including lab clothes, gloves and goggles. Gloves should be made of chemically resistant materials, and goggles can prevent liquid splashing and eye damage.
    When using 2- (bromomethyl) -1-fluoro-3-nitrobenzene, use suitable utensils. Due to its solid or liquid form, or volatile and corrosive, the operation should be in a fume hood. If it is a solid, immediately after the spoon is taken, seal the container to avoid long-term contact with the air and deterioration. If it is a liquid, measure it with a dropper or pipette, and do not let the liquid drip.
    During the reaction process, strictly control the temperature, speed and ratio of the reactants. Its active chemistry, reaction or violent, improper conditions can cause danger. When heating, it is advisable to use a mild heating method and do not heat up suddenly.
    After the experiment, properly dispose of the remaining 2- (bromomethyl) -1-fluoro-3-nitrobenzene and waste. The residue is recycled or disposed of according to regulations. The reaction waste containing it cannot be dumped at will. It must be collected uniformly and disposed of according to environmental protection requirements.
    In short, during the preparation and use of 2- (bromomethyl) -1-fluoro-3-nitrobenzene, the experimenter must strictly abide by safety and operating standards to ensure the smooth experiment and avoid accidents.
    Application Area
    Today there is a product called 2- (Bromomethyl) -1-Fluoro-3-Nitrobenzene. This product has its own unique characteristics in various application fields. In the field of pharmaceutical research and development, it can be used as a key intermediate to help the creation of new drugs, which is expected to pave a way for the treatment of difficult diseases. In the field of material research and development, it can use its characteristics to improve the properties of materials, or increase their stability, or add their special reactivity to meet diverse needs. Furthermore, in the fine chemical industry, it is also an indispensable raw material. It can be skillfully synthesized to derive many high-value-added fine chemicals to meet the diverse needs of industry and life. From this perspective, 2- (Bromomethyl) -1-Fluoro-3-Nitrobenzene has broad prospects and extraordinary potential in the application field.
    Research & Development
    In recent years, Yu devoted himself to the research and development of the chemical substance 2- (Bromomethyl) -1-Fluoro-3-Nitrobenzene. This substance has unique characteristics and has great potential in the field of organic synthesis.
    At the beginning, he explored its synthesis path. After various attempts, the ratio of raw materials and reaction conditions were carefully studied. In the face of many obstacles, the reaction yield was not as expected, and the impurities were also difficult to remove. However, he was not discouraged, so he searched the classics and consulted the Fang family, and finally got the optimization method.
    Then, study its reactivity. Interact with a variety of reagents, observe its changes, and record the data in detail. After repeated experiments, the reaction law in different environments was clarified, paving the foundation for its application.
    Looking to the future, we hope to build on this research, expand its application scope, and shine in the fields of medicine, materials, etc., promoting the rapid development of this chemical substance and making modest contributions to academia and industry.
    Toxicity Research
    Today, there is a thing called 2- (Bromomethyl) -1-Fluoro-3-Nitrobenzene, and our generation focuses on its toxicity. The nature of this thing is related to people's health and health, and it cannot be ignored.
    After various investigations, its structure, halogenated hydrocarbons and nitro groups coexist, or have special chemical properties. In the body, it may involve biochemical changes, or disturb cells. Viewed experimentally, touched with various biological samples, and observed their reactions. It can be seen that the state and activity of cells are abnormal.
    Although the research is not complete, the signs of toxicity have emerged. In the future, we should investigate the opportunity in detail, clarify where the harm is, and find ways to protect and avoid use, so as to protect people from danger, so that the benefits of this chemical can be recognized, and the harm can be eliminated.
    Future Prospects
    I have tried to study chemical products, and now look at 2- (Bromomethyl) -1-Fluoro-3-Nitrobenzene this product, and feel that its future is quite promising. This product has a unique structure. The groups of bromine, fluorine and nitro are combined with the benzene ring, giving it a different activity.
    In the field of organic synthesis, it can serve as a key intermediate. With the activity of bromine, it can introduce various functional groups into molecules and expand the synthesis path. Fluorine atoms can increase the stability and biological activity of the product, and nitro can also add variables to the reaction, or lead to the birth of novel compounds.
    Furthermore, in the research and development of medicine, it may become a potential star. After reasonable modification, it is expected to obtain molecules with unique pharmacological activities, paving the way for the creation of new drugs. In material science, or with its characteristics, to help the emergence of new functional materials. With time and careful study, this product will shine in various fields and have an endless future.
    Where to Buy 2-(Bromomethyl)-1-Fluoro-3-Nitrobenzene in China?
    As a trusted 2-(Bromomethyl)-1-Fluoro-3-Nitrobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 2-(Bromomethyl)-1-Fluoro-3-Nitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the physical properties of 2- (Bromomethyl) -1-Fluoro-3-Nitrobenzene?
    2-%28Bromomethyl%29-1-Fluoro-3-Nitrobenzene, the Chinese name is 2 - (bromomethyl) -1 -fluoro-3 -nitrobenzene. This substance is a compound with special physical properties.
    Its outer surface is often solid, and it is mostly white or white crystals. This is due to the presence of bromomethyl, fluorine atoms and nitro groups in the molecule, resulting in a specific mode of molecular force, so it is often solid.
    < and melting, because it contains bromomethyl, fluorine atoms, nitro and other groups, the molecular properties are low, and the molecular force is large, so the melting and boiling phase is not low. Generally speaking, the melting effect is specific, but due to different degrees and fixed parts, the precision value may be wavy.
    In terms of solubility, it is soluble in solution. For example, in diethyl ether and dichloromethane, it can dissolve well. Due to its molecular properties, it can be dissolved by the interaction of molecular forces. However, the solubility in water is not good. Due to the solubility of water, it can be dissolved by the force of the molecule to match.
    Density is also an important physical property. Due to the specific atom and mesh of the molecule, its density has a specific value, which is related to the common atom, or due to the heavy atom characteristics of the bromine atom, the density may be higher.
    In addition, this substance may have certain properties, which are not limited by the force of the molecule. Its physical rationality is determined by its own molecules, and its use in the synthesis and chemical reaction is of great importance. Those who work on it need to properly operate and preserve its physical properties.
    What are the main uses of 2- (Bromomethyl) -1-Fluoro-3-Nitrobenzene
    2-%28Bromomethyl%29-1-Fluoro-3-Nitrobenzene is 2 - (bromomethyl) -1 -fluoro-3 -nitrobenzene, which has a wide range of uses and is often used as a key intermediate in the field of organic synthesis.
    First, it can be used to construct complex fluorine-containing and nitro-containing organic compounds. Because its structure contains both bromomethyl, fluorine atoms and nitro groups, bromomethyl is very active and prone to nucleophilic substitution. Through nucleophilic substitution, various functional groups can be introduced, such as alcohol hydroxyl groups, amino groups, etc., and then many compounds with different structures and functions can be derived.
    Second, in the field of medicinal chemistry, it may have potential value. Compounds containing fluorine and nitro groups often perform well in terms of pharmaceutical activity. Using this substance as a starting material, through a series of reactions, drug molecules with specific pharmacological activities can be prepared for the prevention and treatment of diseases.
    Third, in the field of materials science, or can participate in the synthesis of new functional materials. For example, through a specific reaction path, it is integrated into the polymer material structure, endowing the material with special optical, electrical or thermal properties, and expanding the application scene of the material.
    Fourth, in the field of fine chemical synthesis, it can be used to prepare special dyes, fragrances, etc. Using its unique structure and appropriate chemical transformation to generate fine chemicals with unique colors or odors to meet specific industrial and consumer needs.
    What is the synthesis method of 2- (Bromomethyl) -1-Fluoro-3-Nitrobenzene
    To prepare 2 - (bromomethyl) - 1 - fluoro - 3 - nitrobenzene, you can follow the following method. First take 1 - fluoro - 3 - nitrobenzene as the starting material, which is the key substrate. Put an appropriate amount of 1 - fluoro - 3 - nitrobenzene into a reactor with a stirring, condensing device and thermometer, and use an appropriate amount of carbon tetrachloride as a solvent to fully dissolve it to create a homogeneous reaction environment.
    Then, slowly add N - bromosuccinimide (NBS), which is a bromine-derived reagent. The dosage needs to be precisely controlled, usually according to the stoichiometric ratio of the reaction and a slight excess to ensure the completion of the reaction. At the same time, a small amount of benzoyl peroxide is added as an initiator to initiate a free radical reaction. During the reaction, the temperature should be closely monitored to maintain it between 50 and 60 ° C. This temperature range is conducive to the smooth progress of the reaction and can avoid the excessive occurrence of side reactions.
    Under stirring conditions, the reaction lasts for several hours, during which time samples are taken regularly, and the reaction progress is monitored by thin layer chromatography (TLC). When the raw material point is basically eliminated, it indicates that the reaction has reached the expected level. After the reaction is completed, the reaction solution is cooled to room temperature, and then the post-treatment is carried out. The reaction solution is first washed with an appropriate amount of water to remove unreacted water-soluble impurities, and the organic phase is separated. Then the organic phase is dried with anhydrous sodium sulfate to remove residual moisture. Afterwards, the solvent carbon tetrachloride is removed by reduced pressure distillation to obtain the crude product.
    The crude product is further purified by column chromatography, and the eluent is prepared with petroleum ether and ethyl acetate in an appropriate ratio. The fraction containing the target product is collected, and after removing the solvent, a pure 2- (bromomethyl) -1-fluoro-3-nitrobenzene can be obtained. In this way, the synthesis of this compound can be achieved through the above steps.
    2- (Bromomethyl) -1-Fluoro-3-Nitrobenzene What are the precautions in storage and transportation
    2 - (bromomethyl) -1 -fluoro-3 -nitrobenzene is an organic compound, and many matters need to be paid attention to during storage and transportation.
    First of all, storage, because it has a certain chemical activity, the first storage environment is dry. Moisture can easily lead to chemical reactions such as hydrolysis, resulting in quality damage, so it should be placed in a dry, well-ventilated place, away from water sources and high humidity. Furthermore, protection from light is also key. This compound is sensitive to light, and light or its structure changes should be stored in dark containers such as brown bottles, protected from direct light. In addition, the substance may be toxic and corrosive, and should be stored separately from oxidants, reducing agents, acids, alkalis, etc., and must not be mixed in storage to avoid violent reactions and safety accidents.
    As for transportation, the packaging must be tight. Select appropriate packaging materials to ensure that there is no leakage during transportation. Transportation vehicles should be equipped with corresponding fire equipment and leakage emergency treatment equipment to prevent accidents. The transportation process should be carried according to the specified route, avoiding densely populated areas and busy traffic sections. And transportation personnel should be professionally trained, familiar with its nature and emergency treatment methods, pay close attention to the status of the goods during transportation, and deal with any abnormalities immediately. In this way, the safety of storage and transportation of 2 - (bromomethyl) - 1 - fluoro - 3 - nitrobenzene can be guaranteed.
    2- (Bromomethyl) -1-Fluoro-3-Nitrobenzene market prospects
    2 - (bromomethyl) -1 -fluoro-3 -nitrobenzene is also an organic compound. Its prospects in the market can be viewed from several angles.
    First of all, the field of this compound is involved. In the field of organic synthesis, it is an important intermediate. Because its structure contains bromomethyl, fluorine atoms and nitro groups, all of which have active chemical properties and can be derived through various chemical reactions. Compounds with special properties and uses. Therefore, in the fields of medicinal chemistry, materials science and other fields, it has its application.
    In the field of medicinal chemistry, the development of new drugs often requires the construction of compounds with novel structures and specific biological activities. 2 - (bromomethyl) -1 -fluoro-3 -nitrobenzene, due to its unique functional group, can be used as a key starting material to synthesize drug molecules targeting specific disease targets through a series of reactions. Such as drug development for certain cancer and inflammation-related diseases, this compound may play an important role. Therefore, with the increasing global demand for innovative drugs, it is expected to gain more attention and demand in the drug synthesis raw material market.
    Looking at materials science again. With the vigorous rise of high-tech industries, the need for special performance materials is also increasing day by day. 2 - (bromomethyl) -1 -fluoro-3 -nitrobenzene can be reacted into the structure of polymer materials, giving the materials such as excellent heat resistance, chemical corrosion resistance or special optical properties. Such as in high-end fields such as electronic materials and aerospace materials, the demand for materials with such special properties is quite eager. Therefore, from the perspective of material synthesis intermediates, its market prospects are also considerable.
    However, it should also be noted that it faces challenges. The process or storage complexity of synthesizing this compound is high and the cost is not easy to control. If you want to expand the market, you need to develop more efficient, economical and environmentally friendly synthesis routes. And market competition should not be underestimated, and there may be congeneric products or substitutes in the relevant industries. Therefore, in order to occupy a place in the market, in addition to optimizing the synthesis process, it is also necessary to pay attention to product quality improvement and cost control, in order to emerge in the highly competitive market and seek a good prospect.