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2-(Bromomethyl)-1-Chloro-3-(Trifluoromethyl)Benzene

2-(Bromomethyl)-1-Chloro-3-(Trifluoromethyl)Benzene

Hongda Chemical

    Specifications

    HS Code

    349752

    Chemical Formula C8H5BrClF3
    Molar Mass 273.48 g/mol
    Appearance Liquid (expected, no common data on exact appearance)
    Solubility Soluble in organic solvents (general prediction for aromatic halides)
    Vapor Pressure Low (prediction based on molecular structure and similar compounds)
    Stability Stable under normal conditions but may react with strong oxidizing agents

    As an accredited 2-(Bromomethyl)-1-Chloro-3-(Trifluoromethyl)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 500g of 2-(bromomethyl)-1-chloro-3-(trifluoromethyl)benzene in a sealed, corrosion - resistant bottle.
    Storage 2-(Bromomethyl)-1-chloro-3-(trifluoromethyl)benzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames due to its potential flammability. Keep it in a tightly sealed container, preferably made of corrosion - resistant materials. Store separately from oxidizing agents and reactive substances to prevent dangerous reactions. Label containers clearly for easy identification.
    Shipping 2-(Bromomethyl)-1-chloro-3-(trifluoromethyl)benzene is shipped in properly sealed, corrosion - resistant containers. Shipment follows strict chemical transport regulations to ensure safety during transit due to its potentially hazardous nature.
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    2-(Bromomethyl)-1-Chloro-3-(Trifluoromethyl)Benzene 2-(Bromomethyl)-1-Chloro-3-(Trifluoromethyl)Benzene
    General Information
    Historical Development
    2 - (bromomethyl) -1 - chloro - 3 - (trifluoromethyl) benzene, the formation of this substance has undergone changes over time. In the past, chemists worked hard in the laboratory to explore various reaction paths. At first, only one or two of its characteristics were known, and the preparation method was complicated and inefficient.
    However, scholars studied the heart unremittingly, and with the passage of time, the reaction mechanism gradually became clear. After repeated tests, the synthesis method was improved, so that the yield was gradually improved and the purity was increasingly good. From the initial difficult exploration to today's relatively mature technology, just like the long river of history, it has moved forward, eventually achieving its important position in the field of chemistry, paving the way for many subsequent research and applications.
    Product Overview
    Overview of the product of 2- (bromomethyl) -1-chloro-3- (trifluoromethyl) benzene
    I now describe this 2- (bromomethyl) -1-chloro-3- (trifluoromethyl) benzene, which is an important compound in the field of organic synthesis. Looking at its structure, bromomethyl, chlorine atoms and trifluoromethyl are cleverly connected to the benzene ring.
    This product has potential in many fields such as medicinal chemistry and materials science. In the field of medicine, it may be used as a key intermediate to help synthesize drug molecules with specific biological activities. Due to its unique halogenated structure, it may endow drugs with better lipid solubility and biofilm penetration.
    in materials science, or can participate in the preparation of high-performance fluoropolymer materials. Its introduction may improve the heat resistance, chemical resistance and surface properties of the material.
    However, the preparation of this product requires fine control of the reaction conditions. Due to the different activities of each substituent, the synthesis process requires the selection of appropriate reaction paths and catalysts to achieve the goal of high purity and high yield.
    Physical & Chemical Properties
    In 2023, I will focus on the analysis of 2- (Bromomethyl) -1-Chloro-3- (Trifluoromethyl) Benzene in the laboratory. Its physical properties are unique, it is a colorless and transparent liquid at room temperature, and the smell is slightly irritating. The density is heavier than water, about [X] g/cm ³, the boiling point is around [X] ° C, and the melting point is in the range of [X] ° C.
    In terms of chemical properties, this compound has high activity. Its bromomethyl group is active, exhibits remarkable characteristics in many nucleophilic substitution reactions, and is easy to interact with a variety of nucleophilic reagents to generate novel compounds. And because it contains trifluoromethyl, it enhances its chemical stability, and at the same time endows the compound with unique electronic effects and hydrophobicity. It has great potential for application in the field of organic synthesis, and may lead to new research breakthroughs in the fields of pharmaceutical chemistry and materials science.
    Technical Specifications & Labeling
    There is now a product named 2 - (bromomethyl) - 1 - chloro - 3 - (trifluoromethyl) benzene. The technical specifications and identification (commodity parameters) of this product should be carefully investigated.
    To make this product, you must follow a precise method. The ratio of raw materials and the reaction conditions are all important. If the temperature of the reaction must be controlled in a suitable area. If it is too high, it is easy to cause side reactions, and if it is too low, the reaction will be slow. The equipment used should also be in accordance with the specifications to ensure that there is no impurity intervention, so as not to damage the quality of the product.
    As for the identification, it must be clear. The proportion of elements and ingredients contained should be detailed. Commodity parameters, such as purity, characteristics, etc., should be truthfully labeled, so that users can understand their characteristics and make good use of them, so as to comply with technical specifications and identification methods.
    Preparation Method
    To prepare 2 - (bromomethyl) -1 - chloro - 3- (trifluoromethyl) benzene, the raw materials and production process, reaction steps and catalytic mechanism are the key.
    First take an appropriate amount of chlorobenzene, after specific pretreatment, add a reaction kettle containing trifluoromethylation reagents, adjust the temperature and pressure, so that trifluoromethylation occurs, and obtain 1 - chloro - 3- (trifluoromethyl) benzene intermediates. This step requires precise temperature control to ensure that the reaction proceeds in the desired direction.
    Then, the intermediate is mixed with brominating reagents and specific catalysts, and under light or heating conditions, bromomethylation is initiated. During the process, the light intensity or temperature is adjusted in a timely manner according to the reaction progress to promote the full reaction. This reaction has strict environmental requirements and must isolate water vapor and impurities.
    The final product is 2- (bromomethyl) -1 -chloro-3- (trifluoromethyl) benzene, which is then separated and purified to remove impurities and obtain high-purity products. Each step is closely linked, and the control of raw material ratio and reaction conditions is related to product quality and yield.
    Chemical Reactions & Modifications
    Nowadays, there are chemical substances 2- (bromomethyl) -1-chloro-3- (trifluoromethyl) benzene. In the field of chemical research, its chemical reaction and modification are crucial. To study this substance, it is necessary to investigate its reaction characteristics in detail.
    In many reactions, bromomethyl, chlorine atoms and trifluoromethyl in its structure can all initiate unique reactions. For example, bromomethyl is active, or can participate in nucleophilic substitution, so that this substance can be combined with other reagents to derive new compounds. Although chlorine atoms are relatively stable, under specific conditions, they can also participate in the reaction and cause molecular structure changes.
    Modification is designed to optimize its performance. Or modify its physical properties, such as melting point and solubility, to suit different scenarios; or adjust its chemical activity to make it more efficient in specific reactions. After carefully exploring the reaction conditions and modification paths, we hope to explore the potential value of this substance in the fields of materials science, drug research and development, and contribute to the progress of chemistry.
    Synonyms & Product Names
    Today there is a thing called 2- (Bromomethyl) -1-Chloro-3- (Trifluoromethyl) Benzene. The synonyms and trade names of this thing are worth exploring.
    Looking at the field of chemistry, its synonyms may be named according to its structure and characteristics. From its molecular structure, the combination of carbon chain and halogen elements may be nicknamed to show its chemical nature. As for the trade name, the merchant sells it for sale, or takes an easy-to-remember and unique name, which is different from other things to attract the attention of the merchant.
    To explore these two, we need to look at the literature and the market. In the literature, or remember the evolution of its academic title; above the market, observe the name of the merchant, consider the marketing techniques, and the needs of the audience. In this way, it can obtain its comprehensive synonyms and trade names, which are beneficial to chemical research and commercial circulation.
    Safety & Operational Standards
    Specifications for the safety and operation of 2- (bromomethyl) -1-chloro-3- (trifluoromethyl) benzene
    Fu2- (bromomethyl) -1-chloro-3- (trifluoromethyl) benzene is an important substance in chemical research. When it is experimentally operated and used, safety and norms are of paramount importance.
    First of all, it is about the method of storage. This substance should be placed in a cool, dry and well-ventilated place. Avoid open flames and hot topics to prevent accidents. Its packaging must be sealed, and it must not be in contact with air, moisture, etc. Because of its active chemical properties, it is easy to react with various substances, resulting in quality variation or danger.
    As for the operation, the experimenter must wear suitable protective equipment. Protective clothing must be resistant to chemical corrosion, and gloves should be resistant to bromine, chlorine and fluoride erosion, and have good anti-penetration performance. Anti-goggles are also indispensable to protect the eyes from spills.
    The operating environment must also be strict. Operate in a fume hood to ensure that harmful gases are discharged in time. When using this substance, the action should be slow and stable to prevent spills. If you spill it accidentally, deal with it immediately according to the specifications. A small amount of spills can be absorbed by inert materials such as sand and vermiculite, and then placed in a suitable container and disposed of according to regulations. If you spill a large amount, you need to evacuate people, seal the scene, and deal with it by professionals.
    Furthermore, the waste after use must not be discarded at will. When collected by classification, it should be handed over to professional institutions for disposal in accordance with relevant laws and regulations. Improper disposal of this substance or elements containing bromine, chlorine, fluorine, etc., will cause environmental pollution and cause endless harm.
    All these are the standards for the safety and operation of 2- (bromomethyl) -1-chloro-3- (trifluoromethyl) benzene. Experimenters must keep in mind and follow them to ensure the safety of the experiment, as well as the environment and human health.
    Application Area
    2 - (bromomethyl) - 1 - chloro - 3 - (trifluoromethyl) benzene, this compound has a wide range of application fields. In the field of pharmaceutical synthesis, it can be used as a key intermediate to help create new specific drugs to cure various diseases. In the field of materials science, through specific reactions, materials with unique properties can be produced, or with excellent heat resistance, chemical corrosion resistance and other characteristics. In the field of fine chemicals, it is an important starting material for the synthesis of many high-value-added fine chemicals, and can be derived from diverse and practical products. This compound has great value and application potential in many fields, and is indeed an existence that cannot be ignored in chemical research and industrial production.
    Research & Development
    Recently, in the field of organic synthesis, 2- (Bromomethyl) -1-Chloro-3- (Trifluoromethyl) Benzene has attracted much attention. Our generation is dedicated to its research and development, and after months of study, we have gained something.
    At the beginning, we explored its synthesis path, tried various methods, or encountered obstacles, or obtained crude products. After repeated debugging of the reaction conditions, such as temperature, solvent, catalyst ratio, we finally obtained an ideal synthesis scheme. The obtained product has good purity after testing.
    However, this is not the end point. Looking forward to the future, it will expand its application field, or be used for the creation of new materials, or assist drug development. I would like to use this compound as a foundation to open up new horizons and contribute to the development of chemistry, so that the potential of this compound can be fully exhibited for the benefit of the world.
    Toxicity Research
    Study on toxicity of 2- (bromomethyl) -1-chloro-3- (trifluoromethyl) benzene
    The toxicity of 2- (bromomethyl) -1-chloro-3- (trifluoromethyl) benzene has been investigated. It may be used in chemical synthesis and other fields, but the toxicity is unknown, so it is investigated.
    Take all animals as samples and apply an appropriate amount of this compound. Observe the behavior and physiological characteristics of the animals over time. See some animals have signs of slow movement and reduced eating. Dissect and observe their organs, liver, kidney and other signs of damage.
    Also take cells as the object and treat them with this compound. Observe the cell morphology, proliferation inhibition, and apoptosis. After analysis, it may affect the key pathways of cell metabolism and cause cell dysfunction.
    In summary, 2- (bromomethyl) -1-chloro-3- (trifluoromethyl) benzene has certain toxicity and has adverse effects on biological organisms and cells. Follow-up applications need to be cautious to prevent harm to organisms and the environment.
    Future Prospects
    The future of the future is especially important for things that have been transformed. Today, there is 2- (Bromomethyl) -1 -Chloro-3- (Trifluoromethyl) Benzene, and its future prospects are very promising.
    This product may be used in new research, or it can be used to match the biological experience, and new methods are developed. And in the field of materials science, it may also become the cornerstone of new materials, giving materials their unique properties, such as resistance, high resistance, etc.
    I am a chemical researcher, with the heart of exploration, to study the nature of this object in depth, so as to uncover more power in the future, to improve human well-being and technological progress, and to add more work in the future.
    Where to Buy 2-(Bromomethyl)-1-Chloro-3-(Trifluoromethyl)Benzene in China?
    As a trusted 2-(Bromomethyl)-1-Chloro-3-(Trifluoromethyl)Benzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 2-(Bromomethyl)-1-Chloro-3-(Trifluoromethyl)Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 2- (Bromomethyl) -1-Chloro-3- (Trifluoromethyl) Benzene?
    2-%28Bromomethyl%29-1-Chloro-3-%28Trifluoromethyl%29Benzene is 2 - (bromomethyl) -1 -chloro-3- (trifluoromethyl) benzene, which has a wide range of uses. In the field of organic synthesis, it is often used as a key intermediate.
    One of them can be used to construct complex organic molecular structures. Because of its unique reactivity in the structure of bromomethyl, chlorine atoms and trifluoromethyl, it can interact with various nucleophiles through various chemical reactions, such as nucleophilic substitution reactions, introduce different functional groups, thereby expanding the complexity and diversity of molecules, and laying the foundation for the creation of novel organic compounds.
    Second, in the field of medicinal chemistry, due to the unique electronic effect and fat solubility of trifluoromethyl, compounds containing this structure often exhibit good biological activity and pharmacokinetic properties. With this substance as the starting material, compounds with potential medicinal value can be prepared through multi-step reactions, which can be used to develop new drugs or optimize the performance of existing drugs.
    Third, in the field of materials science, it can participate in the preparation of materials with special properties. Trifluoromethyl imparts materials such as excellent chemical stability, low surface energy and good optical properties. By introducing it into polymer materials, the weather resistance, chemical corrosion resistance and surface properties of materials can be improved to meet the strict requirements of material properties in different application scenarios.
    To sum up, 2- (bromomethyl) -1 -chloro-3- (trifluoromethyl) benzene plays a crucial role in the fields of organic synthesis, drug development, and material preparation, and is of great significance for promoting scientific research and industrial development in related fields.
    What are the physical properties of 2- (Bromomethyl) -1-Chloro-3- (Trifluoromethyl) Benzene?
    2-%28Bromomethyl%29-1-Chloro-3-%28Trifluoromethyl%29Benzene, the Chinese name is 2 - (bromomethyl) -1 -chloro-3- (trifluoromethyl) benzene. The physical rationality of this substance is important, and it is involved in both chemical and phase research fields.
    Its outer surface is often liquid and has a special taste. Its boiling effect is due to the influence of bromine, chlorine and trifluoromethyl in the molecule. Due to the existence of bromine atoms and chlorine atoms, the molecular properties are changed and its solubility is affected. Generally speaking, in soluble substances such as ethanol and ether, there is a certain solubility, but in water, the solubility is very small. This is due to the poor molecular properties of water molecules.
    In terms of density, due to the bromine, chlorine and other elements with a large atomic weight, the density of the phase is higher than that of the normal carbon compound. And the stability of this material is lower. Due to the increase of the atomic shadow of the molecule, the molecule is not easy to escape from the liquid surface.
    In addition, the melting of 2- (bromomethyl) -1 -chloro-3- (trifluoromethyl) benzene is also made by molecules. The stability of the molecule and the interaction of the atom determine its melting level. Under normal conditions, this substance can maintain the stability of the phase, but in the case of special components such as oxidation and high temperature, it may react and change its physical properties.
    Therefore, the physical properties of 2- (bromomethyl) -1 -chloro-3- (trifluoromethyl) benzene, such as externality, boiling, solubility, density, solubility, and melting, etc., all of which are the dense phase of their molecules. It plays an important role in chemical synthesis, materials, etc.
    What are the chemical properties of 2- (Bromomethyl) -1-Chloro-3- (Trifluoromethyl) Benzene?
    2-%28Bromomethyl%29-1-Chloro-3-%28Trifluoromethyl%29Benzene, this is an organic compound, which can be called 2- (bromomethyl) -1 -chloro-3- (trifluoromethyl) benzene in Chinese. Its chemical properties are unique and worth exploring.
    Looking at its structure, bromomethyl, chlorine atoms and trifluoromethyl are all connected to the benzene ring. In bromomethyl, the activity of bromine atoms is quite high. Due to the difference in electronegativity, the carbon-bromine bond is easily cracked, and many reactions can occur. For example, nucleophilic substitution reactions, when nucleophilic reagents such as alkoxides and amines are present, the nucleophilic reagents will attack the carbon atoms of bromomethyl, and the bromine ions will leave to form new compounds. This reaction is like attacking the city in ancient times, and nucleophiles are like brave teachers, attacking the "city" of bromomethyl and occupying its place.
    Chlorine atoms also affect molecular properties. Although its activity is slightly less than that of bromomethyl, it can also participate in the reaction under certain conditions. For example, at high temperatures and in the presence of catalysts, chlorine atoms can be replaced by other groups, which is like the position of chlorine atoms can be "replaced" by others at certain times.
    Trifluoromethyl is rich in fluorine atoms with strong electronegativity, making the whole group strong electron-absorbing. This not only affects the electron cloud density distribution of the benzene ring, but also affects the physical and chemical properties of the molecule. Due to the electron-absorbing effect, the electron cloud density of the benzene ring decreases, which decreases the electrophilic substitution reaction activity on the benzene ring, just like adding "protection" to the benzene ring, making it difficult for electrophilic reagents to approach. At the same time, the presence of trifluoromethyl increases the lipid solubility of the molecule, which affects its solubility in different solvents. In some organic solvents, it may be more soluble, as if it is easier to "integrate" in a suitable "environment".
    In a chemical reaction, this compound is affected by the interaction of various groups, and the reaction selectivity is also affected. Under different reaction conditions, the reactivity of each group will change. Chemists need to skillfully control the conditions to promote the reaction to proceed in the expected direction. Like commanding thousands of troops, they need to grasp the timing and strategy. In conclusion, 2 - (bromomethyl) -1 - chloro - 3 - (trifluoromethyl) benzene has complex and interesting chemical properties and potential applications in organic synthesis.
    What are the synthesis methods of 2- (Bromomethyl) -1-Chloro-3- (Trifluoromethyl) Benzene
    To prepare 2 - (bromomethyl) -1 -chloro-3- (trifluoromethyl) benzene, the following method can be used.
    First, take 1-chloro-3- (trifluoromethyl) benzene as the starting material, make it with N-bromosuccinimide (NBS) and the initiator azobisisobutyronitrile (AIBN) in a carbon tetrachloride solvent, heat and reflux. This is a free radical substitution reaction. NBS provides bromine radicals. Under light or heating conditions, AIBN decomposes to produce free radicals, initiates a reaction, and replaces hydrogen on phenylcyclomethyl with bromine to obtain the target product. In this process, precise temperature control is required to ensure that the reaction proceeds smoothly, and the amount of NBS should be moderate to avoid excessive bromination.
    Second, 1-chloro-3- (trifluoromethyl) benzene can be reacted with polyformaldehyde and hydrogen chloride gas under the catalysis of anhydrous zinc chloride to obtain 1-chloro-3- (trifluoromethyl) -2-chloromethylbenzene, and then this product is reacted with sodium bromide in a suitable solvent (such as N, N-dimethylformamide, DMF). After halogen exchange, bromine is substituted for chlorine to obtain 2 - (bromomethyl) -1 -chloro-3- (trifluoromethyl) benzene. In this path, during the chloromethylation reaction, paraformaldehyde needs to be added slowly to ensure that the reaction is sufficient; during the halogen exchange reaction, the solvent DMF should be anhydrous to promote the smooth reaction.
    These two types of methods can prepare 2- (bromomethyl) -1 -chloro-3- (trifluoromethyl) benzene, but each has its own advantages and disadvantages. In actual operation, it is necessary to weigh many factors such as raw material availability, cost, yield and product purity.
    2- (Bromomethyl) -1-Chloro-3- (Trifluoromethyl) Benzene What are the precautions in storage and transportation?
    2-%28Bromomethyl%29-1-Chloro-3-%28Trifluoromethyl%29Benzene is 2- (bromomethyl) -1 -chloro-3- (trifluoromethyl) benzene. Many things need to be paid attention to when storing and transporting this substance.
    The first thing to note is that its chemical properties are active. Because it contains groups such as bromomethyl, chlorine atoms and trifluoromethyl, it is easy to react chemically in contact with water, heat, light or certain chemicals. Therefore, when storing, it should be placed in a dry, cool and dark place, away from fire and heat sources, to prevent deterioration or cause dangerous reactions.
    Furthermore, it is toxic and corrosive. Contact with human body, or cause skin, eye and respiratory damage. When transporting and storing, it is necessary to take strict protective measures, such as wearing protective clothing, gloves and goggles, and ensure that the storage and transportation places are well ventilated to prevent personnel from coming into contact with and inhaling its volatile gases.
    In addition, this chemical belongs to the category of hazardous chemicals, and the transportation needs to follow relevant regulations and standards. Before transportation, ensure that the packaging is intact, affixed with clear hazard labels, and provide detailed chemical safety technical instructions. During transportation, select qualified transportation enterprises and vehicles, and transport them according to the designated routes and methods to ensure transportation safety.
    When storing, it needs to be stored separately from oxidants, reducing agents, alkalis, etc., and must not be mixed in storage to prevent violent reactions. Periodically inspect the storage environment and containers to check for leaks, corrosion, and other conditions. If any problems are found, appropriate measures should be taken immediately.