2-%28Bromomethyl%29-1%2C3-Difluorobenzene is 2- (bromomethyl) -1,3-difluorobenzene, which has a wide range of uses. In the field of organic synthesis, it is often used as a key intermediate. Because its structure contains active bromomethyl and difluorobenzene rings, it can react with nucleophilic reagents such as alcohols, amines, and mercaptans through various chemical reactions, such as nucleophilic substitution reactions, to generate many organic compounds with special properties and uses, such as the preparation of fluorinated drugs, pesticides, and functional materials.
In the field of pharmaceutical chemistry, it can be used as a starting material to construct many molecular frameworks of fluorinated drugs. The introduction of fluorine atoms can significantly change the physical and chemical properties and biological activities of drug molecules, such as improving drug fat solubility, facilitating transmembrane transport, and enhancing bioavailability. At the same time, fluorinated drugs often have higher metabolic stability and selectivity, which can improve drug efficacy and reduce side effects. Therefore, 2- (bromomethyl) -1,3-difluorobenzene plays an important role in the research and development and production of new fluorinated drugs.
In the field of materials science, it also plays an important role. After chemical reaction, its structure can be introduced into the main chain or side chain of polymer materials, giving the material special properties, such as improving the material's heat resistance, chemical corrosion resistance, and electrical properties. For example, in the preparation of fluoropolymer materials, 2- (bromomethyl) -1,3-difluorobenzene can be used as a functional monomer to participate in the polymerization reaction, resulting in fluorine-containing polymer materials with excellent performance, which are widely used in high-end fields such as electronics and aerospace.
In pesticide chemistry, it can be used to synthesize fluorinated pesticides. The presence of fluorine atoms can enhance the toxic effect of pesticides on pests and pathogens, improve the shelf life and environmental adaptability of pesticides, and provide efficient, low-toxic and environmentally friendly pesticide products for agricultural production. Overall, the unique structure and reactivity of 2- (bromomethyl) -1,3-difluorobenzene play a key role in many fields such as organic synthesis, medicine, materials and pesticides, and promote technological progress and industrial development in related fields.

2-%28Bromomethyl%29-1%2C3-Difluorobenzene is 2- (bromomethyl) -1,3-difluorobenzene, which is an organic compound with special physical properties.
Looking at its properties, it may be a colorless to light yellow liquid at room temperature, and it may smell or have a special odor. Its boiling point is related to the intermolecular force and the relative molecular mass. Because it contains bromine and fluorine atoms, the molecular polarity is large, and the boiling point is relatively high. However, the specific value needs to be accurately determined by experiments.
When it comes to the melting point, the regularity of the molecular structure and the intermolecular force are about. The structure of this compound may be underregular, and the intermolecular force caused by the introduction of bromine and fluorine atoms is complex, and the melting point may not be very high.
In terms of solubility, according to the principle of "similar miscibility", it is an organic compound. It may have good solubility in organic solvents such as ethanol, ether, and dichloromethane. In water, it has strong non-polarity and poor solubility.
Density is also an important physical property. Because it contains bromine atoms with relatively large atomic mass, its density may be greater than that of common organic solvents.
In addition, the vapor pressure of 2- (bromomethyl) -1,3-difluorobenzene is greatly affected by temperature. The temperature increases and the vapor pressure increases. This property needs to be carefully considered during storage and use to prevent potential safety hazards caused by vapor accumulation.
In summary, the physical properties of 2- (bromomethyl) -1,3-difluorobenzene have far-reaching influence in the fields of organic synthesis and chemical production, and in-depth understanding of it is helpful for rational use and safe operation.

There are many different methods for synthesizing 2- (bromomethyl) -1,3-difluorobenzene. One method is to take 1,3-difluorobenzene first, blend it with polyformaldehyde and hydrobromic acid, add an appropriate amount of catalyst, such as zinc salt or iron salt, and react at a specific temperature. This reaction needs to be carried out in a suitable reaction vessel under stirring to make the reactants fully contact and improve the reaction efficiency. Temperature control is very critical. If it is too high, side reactions will be easy to occur, and if it is too low, the reaction rate will be slow.
In another method, the corresponding benzyl alcohol derivative can be prepared from 1,3-difluorobenzene first, and then the benzyl alcohol hydroxyl group can be replaced with a bromine atom with an appropriate brominating agent, such as phosphorus tribromide or a mixture of hydrobromic acid and sulfuric acid. When preparing benzyl alcohol derivatives, the corresponding halogenated hydrocarbons and metallic magnesium can be used to make Grignard reagents, and then react with formaldehyde to obtain benzyl alcohol.
In another method, 1,3-difluorobenzene is reacted with benzyl triphenyl phosphonium bromide under the action of a base. The choice of base is very important, and the commonly used bases such as potassium tert-butanol and sodium hydride need to be selected according to the specific conditions of the reaction This reaction is carried out in organic solvents, such as tetrahydrofuran, toluene, etc. At a certain temperature and time, the target product 2- (bromomethyl) -1,3-difluorobenzene can be obtained. However, each method has its advantages and disadvantages. It is necessary to consider the reaction conditions, yield, cost and many other factors according to actual needs, and choose the appropriate one.

2-%28Bromomethyl%29-1%2C3-Difluorobenzene is 2- (bromomethyl) -1,3-difluorobenzene. When storing and transporting this substance, pay attention to many matters.
Looking at its chemical properties, 2- (bromomethyl) -1,3-difluorobenzene has a certain activity, and bromomethyl is prone to nucleophilic substitution. Therefore, when storing, it should be placed in a cool, dry and well-ventilated place, away from fires and heat sources. Because it encounters open flames, hot topics or can cause combustion explosions, it is essential to strictly prohibit fireworks.
Furthermore, this substance also has requirements for packaging. Packaging must be sealed to prevent it from deteriorating in contact with air. The packaging materials used should be chemically resistant, and suitable glass bottles or metal drums lined with special materials can be selected. During transportation, it is also necessary to ensure that the packaging is intact to avoid bumps and collisions that cause the packaging to break and cause material leakage.
From a toxicity point of view, although the exact toxicity is not known in detail, it may be toxic and irritating as an organic halide. Storage and transportation personnel should take protective measures, such as wearing suitable protective gloves, protective glasses and gas masks, to prevent physical damage caused by contact or inhalation.
In addition, the storage area should be stored separately from oxidants, strong bases, etc., because 2- (methyl bromide) -1,3-difluorobenzene may react violently with it. Do not mix with such substances during transportation. At the same time, warehouses and transportation vehicles should be equipped with corresponding fire fighting equipment and leakage emergency treatment equipment. If there is a leak, it can be responded to in time. Relevant training should be provided to warehousing and transportation personnel to familiarize them with the characteristics of the substance and emergency treatment methods to ensure the safety of warehousing and transportation.

2-%28Bromomethyl%29-1%2C3-Difluorobenzene that is 2- (bromomethyl) -1,3-difluorobenzene, the market price range of this substance is difficult to say in a word. The price of this substance is often changed due to multiple factors, which cannot be ignored.
First, the market supply and demand trend has a great impact on its price. If there are many people who need it, and the supply is small, the price will rise; conversely, if the supply exceeds the demand, the price will drop. Second, the difficulty of preparation also affects its price. The synthesis process of this substance may require exquisite craftsmanship and rare raw materials, so the cost is high and the price is also high; if the preparation is easier, the cost will decrease and the price will also decrease. Third, the fluctuation of raw material prices is also related to its price. If the price of the raw materials required for preparation fluctuates, the price of this substance also fluctuates. Fourth, the prices charged by different suppliers vary. Those with a strong reputation and large scale may have higher prices due to their excellent quality and good after-sales service; while those who are new to the market or have a small scale may compete for a share, and the price may be lower.
Looking at the market conditions, the price of 2- (bromomethyl) -1,3-difluorobenzene per gram may range from tens of yuan to hundreds of yuan. For small-scale scientific research trials, the purchase quantity is small, and the unit price may increase, reaching more than 100 yuan per gram, or even hundreds of yuan. If it is a large-scale industrial purchase, due to large quantities, suppliers may have discounts, and the price per gram may be reduced to tens of yuan. However, this is only an approximate price, and the actual transaction price still needs to be discussed in detail according to the market conditions and trading conditions at that time.