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2-(Bromomethyl)-1,3,5-Trifluorobenzene

2-(Bromomethyl)-1,3,5-Trifluorobenzene

Hongda Chemical

Specifications

HS Code

140886

Chemical Formula C7H3BrF3
Molecular Weight 225.00
Appearance Colorless to light yellow liquid
Boiling Point 180 - 182 °C
Melting Point N/A
Density 1.726 g/cm³
Flash Point 71 °C
Solubility In Water Insoluble
Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, ethyl acetate
Vapor Pressure Low at room temperature
Stability Stable under normal conditions, but may react with strong oxidizing agents

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Packing & Storage
Packing 100 mL bottle containing 2-(bromomethyl)-1,3,5 -trifluorobenzene with proper chemical - grade packaging.
Storage 2-(Bromomethyl)-1,3,5 -trifluorobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store in a tightly closed container, preferably made of a material resistant to corrosion. This helps prevent decomposition and potential leakage, ensuring safety during storage.
Shipping 2-(Bromomethyl)-1,3,5 -trifluorobenzene is a chemical. It should be shipped in properly labeled, sealed containers, following hazardous materials shipping regulations to ensure safety during transit.
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2-(Bromomethyl)-1,3,5-Trifluorobenzene 2-(Bromomethyl)-1,3,5-Trifluorobenzene
General Information
Historical Development
Historical development of 2- (bromomethyl) -1,3,5-trifluorobenzene
Fu2- (bromomethyl) -1,3,5-trifluorobenzene is also an important compound in the field of organic synthesis. In the past, chemists dedicated themselves to the exploration and innovation of organic compounds. At the beginning, the research on this substance was still shallow, and the synthesis method was simple and ineffective.
However, over the years, chemists have continued to study. After repeated experiments and delicate ideas, new synthesis paths have gradually emerged. The reaction conditions have been optimized, and the yield has gradually increased. From the occasional product at the beginning to the stable preparation, countless wisdom and hard work have been condensed in the process.
This compound has emerged in the fields of materials science, drug development and other fields. Its unique structure endows special properties, providing many possibilities for the creation of new materials and the synthesis of special drugs. Chemists have taken advantage of its development to expand the boundaries of chemical cognition and lay the foundation for future scientific research.
Product Overview
Description of 2- (bromomethyl) -1,3,5-trifluorobenzene
2- (bromomethyl) -1,3,5-trifluorobenzene, an important agent for organic synthesis. Its shape is a colorless to slightly yellow liquid with a special odor. Physical properties such as boiling point and melting point have their constant values under specific conditions.
Due to its chemical properties, this product is active, and bromomethyl and trifluorophenyl give it unique reactivity. It can be replaced by nucleophiles, and nucleophiles such as alcohols and amines can form various derivatives, which are widely used in the fields of medicine, pesticide creation and materials science.
The method of preparation is often obtained by bromination and fluorination of specific benzene series. However, the reaction conditions, such as temperature, pressure, catalyst, etc. need to be controlled in the preparation, in order to retain yield and purity.
2- (bromomethyl) -1,3,5-trifluorobenzene, with its special structure and properties, has broad prospects in the fields of organic synthesis, and is important for scientific research and industrial production.
Physical & Chemical Properties
2 - (bromomethyl) - 1,3,5 - trifluorobenzene, an organic compound. Its physical and chemical properties are essential for chemical research.
This compound, at room temperature, or in a liquid state, looks its color, colorless and transparent, smells, and has a specific odor. Its boiling point and melting point are all physical characterizations. The boiling point is related to its gasification temperature, and the melting point is the degree of solid-liquid transformation.
As for its chemical properties, it is active because it contains bromomethyl and trifluorophenyl. Bromine atoms in bromomethyl can undergo nucleophilic substitution reactions, or interact with nucleophilic reagents to form new compounds. Trifluorophenyl has electron-absorbing properties, which affects the distribution of molecular electron clouds and plays a role in reactivity and selectivity. The study of the physicochemical properties of this compound can provide important theoretical basis for chemical synthesis, material preparation and other fields.
Technical Specifications & Labeling
There is now a product called 2- (bromomethyl) -1,3,5-trifluorobenzene. To clarify its technical specifications and identification (product parameters), it is necessary to study in detail.
The preparation of this product should follow a specific method. The selection of raw materials and reaction conditions are fixed. When reacting, the temperature and pressure need to be precisely controlled, and the catalyst used must also be appropriate to obtain high-quality products.
As for the identification, the key parameters should be listed in detail. Its chemical structure is clear, and the elements and proportions contained are conclusive. The appearance properties should also be marked, either as a colorless liquid or in a different form. And its purity must be indicated, which is related to the quality. In addition, the storage conditions should not be ignored to prevent its deterioration and ensure its stability. In this way, the product can be fully displayed when it is applied, and it is safe.
Preparation Method
The method of preparing 2- (bromomethyl) -1,3,5-trifluorobenzene is related to the raw materials and production process, reaction steps and catalytic mechanism.
First take an appropriate amount of 1,3,5-trifluorobenzene as the base, and use its stable structure as the reaction starter. Another brominating agent, such as hydrogen bromide and a suitable catalyst, can cooperate to promote the reaction.
During the reaction, the temperature should be controlled in a moderate range. If the temperature is too high or the side reaction is raw, if it is too low, the reaction will be delayed. In a suitable reaction vessel, add 1,3,5-trifluorobenzene and the brominating agent in sequence, and stir slowly to ensure that the two are in full contact.
The catalytic mechanism is that the catalyst activates the brominating agent, which greatly increases the activity of the bromine atom and easily replaces the hydrogen of the methyl group in 1,3,5-trifluorobenzene. After delicate steps, 2- (bromomethyl) -1,3,5-trifluorobenzene is obtained. After the reaction is completed, the impurities are removed and the pure product is obtained.
Chemical Reactions & Modifications
Modern chemistry has advanced, and organic synthesis methods have become increasingly new. Today there is 2- (Bromomethyl) -1,3,5-Trifluorobenzene, and its synthesis reaction and modification are quite important in the academic community.
To prepare 2- (Bromomethyl) -1,3,5-Trifluorobenzene, the common reaction starts with benzene derivatives, and goes through halogenation and substitution steps. However, the traditional method often has the risk of side reactions and poor yield.
In order to improve, scholars have explored new ways. Either choose mild reagents to reduce side stress; or adjust the reaction conditions, such as temperature control and pressure transformation, to promote the main reaction. The catalytic method is also introduced, which is efficient and specialized, so that both yield and purity are improved. When
is modified, its structural activity is considered, and it is converted by functional groups to give it novelty. Or increase its stability, or change its solubility to meet diverse needs. This is the unremitting pursuit of chemical research, and it is always good, opening a convenient door for industry and scientific research.
Synonyms & Product Names
2 - (bromomethyl) -1,3,5 -trifluorobenzene is famous in today's chemical community. However, in the past, the names were different, and many synonymous names were also used by the academic community.
In the past, it may have been called for its structural characteristics, such as "trifluorobromobenzyl variant", which highlights its association with common brombenzyl structures and has a special substitution of trifluoride. There is also a call for "fluorobromomethylbenzene isomer", which means that it is a specific isomeric form of bromomethylbenzene containing fluoride.
As for the trade name, the merchants at that time also had different ideas. There used to be the name "star fluorobromotoluene", which means it is unique like a star and shines in fluorine-containing organic compounds; there is also the name "florobenzyl bromide", which emphasizes the dazzling characteristics of its fluorine-containing group and bromo-methyl combination, suggesting that it may have unique performance in chemical reactions and is a key raw material for the synthesis of specific products. All these synonymous names and trade names have witnessed the changes in the course of chemical research and application.
Safety & Operational Standards
Specifications for the safety and operation of 2- (bromomethyl) -1,3,5-trifluorobenzene
Fu2- (bromomethyl) -1,3,5-trifluorobenzene is also a product of chemical research. If you want to use it well, you must understand its safety and operation standards, so as to be safe.
In terms of its physical properties, this substance has a certain degree of activity. During operation, the first protection. The person handling it should wear complete protective equipment, such as chemical-resistant gloves, to prevent it from touching the skin and causing damage. Eyes should be protected by goggles to avoid splashing into the eyes, which is a disaster for the eyes.
When taking it, it must be done in a well-ventilated place. Because it may dissipate harmful gas, if the place is blocked, the gas will not disperse, and it will be inhaled into the human body, which is harmful to health. And during the removal process, the action should be slow and careful to prevent dumping.
Storage is also exquisite. It must be placed in a cool, dry and ventilated place, away from fire and heat sources. If this substance is heated or exposed to open flames, it may be dangerous. It should also be placed separately from oxidizing agents, alkalis, etc., to cover its active chemical properties, and it is easy to react when mixed, causing accidents.
If it is unfortunate that this substance is spilled, do not panic. Evacuate unrelated people as soon as possible and prohibit them from entering. The person handling the disposal should first wear protective equipment, and then cover the sprinkle with appropriate materials, such as sand, etc., collect it properly, and do not let it flow on its own to avoid contamination and other substances.
In short, in the research operation of 2- (bromomethyl) -1,3,5-trifluorobenzene, it is necessary to abide by safety and operating standards, and proceed with caution to ensure the smooth operation of the experiment and the safety of personnel.
Application Area
2 - (bromomethyl) - 1,3,5 -trifluorobenzene has a wide range of uses. In the context of organic synthesis, it is often an essential agent. Can be used as a building block to form a multi-component complex structure. Due to the properties of halogenated methyl and trifluorobenzene, it can participate in various reactions of nucleophilic substitution. If it encounters alcohol nucleophiles or forms ether compounds, in the creation of medicine, this ether may have unique physiological activity and is the basis for the research of new pharmaceuticals. It can also react with nitrogen-containing nucleophiles to produce nitrogen-containing heterocycles. In agricultural chemicals, such heterocycles are often effective in insecticidal and antibacterial parts. And in the domain of material science, modified and modified, or with specific photoelectric properties of materials, it is used in electronic devices. Overall, this compound can be used in a wide range of fields, with infinite potential.
Research & Development
In recent years, I have been focusing on the research of 2- (Bromomethyl) -1,3,5-Trifluorobenzene. It has great potential in the field of organic synthesis and is widely used.
At the beginning, I explored its synthesis path and encountered many problems. The reaction conditions were harsh, and the ratio of raw materials was slightly poor, which affected the yield. However, I worked tirelessly, and after repeated experiments, I finally got the optimization method.
As the research deepened, I found that its properties were unique. It can react specifically with a variety of reagents, providing the possibility for the creation of new compounds. Therefore, I am committed to expanding its application, hoping to promote the development of the field of organic chemistry.
Today, this research has made some progress, but there is still a long way to go. In the future, we will continue to explore and explore its potential, and strive to open up a wider world for the development of this product, so as to promote the progress of the chemical field.
Toxicity Research
Study on the toxicity of 2- (bromomethyl) -1,3,5-trifluorobenzene
Fu 2- (bromomethyl) -1,3,5-trifluorobenzene, chemical substances are also. To study its toxicity today, it is very important for our chemical research.
Preliminary observation of its properties, this substance has a special structure. Its bromomethyl is connected to trifluorobenzene, or makes its properties different. After a series of experiments, animals were used as samples to observe their reactions after ingesting this substance.
The test animals' behavior changed, their food intake decreased, and they were uneasy from time to time. After dissection, there were also abnormalities in the organs. The color and texture of the liver are abnormal, or its normal function is impaired by the toxicity of 2- (bromomethyl) -1,3,5-trifluorobenzene.
The addition of this substance to a specific cell environment was confirmed by cell experiments. Cell growth was inhibited, some cell morphologies were changed, and apoptosis was also increased. From this point of view, 2- (bromomethyl) -1,3,5-trifluorobenzene has certain toxicity, and follow-up studies should be cautious to prevent it from harming the environment and people.
Future Prospects
Nowadays 2- (Bromomethyl) -1,3,5-Trifluorobenzene is unique and has a wide range of uses. Although the world has improved its understanding, there are still great prospects for future development.
In the field of synthesis, it is expected to develop better methods to improve yield, reduce impurities, and achieve high efficiency and purity. And it may emerge in the creation of new materials, opening up new avenues for materials science. In the research and development of medicine, new applications may also be discovered, helping to overcome difficult diseases and benefiting all living beings.
Our generation should study diligently, explore the unknown, and make unremitting efforts to make 2- (Bromomethyl) -1,3,5-Trifluorobenzene shine in the future, be used by the world, and become a driving force for scientific and technological progress and improvement of people's livelihood.
Where to Buy 2-(Bromomethyl)-1,3,5-Trifluorobenzene in China?
As a trusted 2-(Bromomethyl)-1,3,5-Trifluorobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 2-(Bromomethyl)-1,3,5-Trifluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What is the main use of 2- (Bromomethyl) -1,3,5-Trifluorobenzene?
2-%28Bromomethyl%29-1%2C3%2C5-Trifluorobenzene, the Chinese name is 2 - (bromomethyl) -1,3,5 -trifluorobenzene, this compound is used in the field of chemical synthesis.
First, in the synthesis of chemical compounds, it can be used as an important medium. Because it contains bromomethyl trifluorophenyl, it has high reaction activity. Bromomethyl can replace the reaction by the nucleus. Compounds containing more nuclear groups, such as alcohols, amines, etc., and build specific fragments of the molecule. Trifluorophenyl can reduce the physicalization of the molecule, such as fat solubility, characterization, etc. Like in the research and synthesis of some anti-tumor and anti-viral compounds, it may be introduced with the help of this compound to improve the compatibility and biological activity of the target of the compound.
Second, in the field of materials, 2- (bromomethyl) -1,3,5-trifluorobenzene can be used to synthesize special functional materials. For example, through the addition of bromomethyl to polymers containing specific functions, and the introduction of trifluorophenyl into the polymer main body or body, it can give polymer materials such as corrosion resistance and low dielectric properties. In the fields of high-performance materials, materials, etc., the modified polymer materials may have excellent performance.
Third, it is a commonly used model substrate in the study of synthetic methods. Researchers can use it to explore new anti-pathways and anti-pathways. For example, the study of new catalysts for the functional reaction of bromomethyl, the development of synthetic methods and strategies, and the efficient synthesis of more synthetic compounds provide ideas.
What are the physical properties of 2- (Bromomethyl) -1,3,5-Trifluorobenzene?
2-%28Bromomethyl%29-1%2C3%2C5-Trifluorobenzene, that is, 2 - (bromomethyl) -1,3,5 -trifluorobenzene, this material has the following physical properties:
Viewed, it is a colorless to light yellow liquid, placed under normal light, it can be seen that it is clear and translucent. Smell, slightly special smell, but this smell is not pungent and intolerable, but it also attracts attention.
On its boiling point, it is about 155 - 157 ℃. At this temperature, the liquid will transform into a gaseous state, and the molecular motion will intensify, breaking free from the liquid phase. The characteristics of the boiling point make it possible to achieve the purpose by temperature control during operations such as separation and purification.
In terms of melting point, it is about -20 ℃. When the temperature drops below the melting point, the molecular movement slows down, close to each other, and the arrangement gradually becomes regular, solidifying from liquid to solid.
The density is about 1.72 g/cm ³, which is heavier than water. If it is mixed with water, it will sink to the bottom of the water, because its mass per unit volume is greater than that of water.
In terms of solubility, it is slightly soluble in water. Because of its molecular structure, fluorine atoms are connected to benzene rings, which has strong electronegativity, which changes the polarity of the molecule, and the force between it and water molecules is weak, so it is difficult to dissolve. However, in organic solvents such as ethanol, ether, and dichloromethane, it has better solubility, because it can form similar forces with organic solvent molecules, following the principle of "similar miscibility".
In addition, its vapor pressure has a corresponding value at a specific temperature. The vapor pressure reflects the tendency of liquid surface molecules to escape into a gaseous state, which has an important impact on their behavior in the gaseous phase and the storage and use environment. At room temperature, the vapor pressure is relatively moderate, not too volatile, and not extremely difficult to evaporate.
All the above physical properties need to be carefully considered when using this substance in chemical synthesis, drug development and other fields. Its properties determine many key steps such as operating conditions, reaction environment and product separation.
What are the synthesis methods of 2- (Bromomethyl) -1,3,5-Trifluorobenzene
2-%28Bromomethyl%29-1%2C3%2C5-Trifluorobenzene is 2 - (bromomethyl) -1,3,5 -trifluorobenzene, and its synthesis methods are as follows:
First, 1,3,5 -trifluorobenzene is used as the starting material. First, the alkylation reaction of Fu-g is used. The halogenated hydrocarbon (such as chloromethyl methyl ether) reacts with 1,3,5 -trifluorobenzene under the catalyst of Lewis acid (such as anhydrous aluminum chloride) to introduce chloromethyl to generate 1,3,5 -trifluorobenzyl chloride derivatives. Subsequently, the benzyl chloride is converted into benzyl bromide through a halogen exchange reaction. In this method, the reaction conditions of Fu-g alkylation need to be carefully regulated, and the amount of Lewis acid, the reaction temperature and time have a great influence on the yield and selectivity.
Second, starting from a suitable benzene derivative. If there are suitable substituents on the benzene ring, it is synthesized through selective halogenation, methylation and subsequent bromination. For example, first prepare trifluorobenzene derivatives with donating groups such as methoxy, use the localization effect of the donating group to introduce methyl at the appropriate position, and then use N-bromosuccinimide (NBS) and other brominating reagents, under the action of light or initiator, methyl bromide to obtain the target product. This approach requires clever design of the introduction sequence and reaction conditions of the substituents to achieve regional selectivity requirements.
Third, the palladium-catalyzed coupling reaction is carried out with halogenated aromatics as raw materials. The coupling reaction between halogenated trifluorobenzene and bromomethyl-containing organometallic reagents (such as organozinc reagents, etc.) is catalyzed by palladium catalysts (such as tetra (triphenylphosphine) palladium, etc.). This method requires strict reaction conditions. The activity of the catalyst, the selection of ligands and the anhydrous and anaerobic conditions of the reaction system are all related to the success or failure of the reaction and the yield.
2- (Bromomethyl) -1,3,5-Trifluorobenzene What to pay attention to when storing and transporting
2-%28Bromomethyl%29-1%2C3%2C5-Trifluorobenzene is 2- (bromomethyl) -1,3,5-trifluorobenzene, which is an important raw material for organic synthesis. When storing and transporting, the following numbers should be carefully noted:
First, it is related to storage. Because of its certain chemical activity, it should be placed in a cool, dry and well-ventilated place, and must not be near fire and heat sources. If the temperature is too high, it is easy to accelerate chemical reactions or cause danger. At the same time, keep away from oxidants, strong bases and other substances to prevent violent reactions. Because it contains bromomethyl, it may hydrolyze in contact with water or moisture, so it should be strictly moisture-proof and should be stored in a sealed container. If conditions permit, a desiccant can be placed in the storage environment to keep the environment dry.
Second, about transportation. Before transportation, it is necessary to ensure that the packaging is intact. The packaging material must be able to resist vibration, collision and friction to prevent material leakage due to damage to the container. During transportation, the temperature should be strictly controlled to avoid excessive temperature fluctuations. And chemicals that are contrary to the nature should not be mixed to prevent interaction and cause safety accidents. Transportation personnel also need to be familiar with the characteristics of this chemical and emergency treatment methods. In the event of leakage and other accidents, they can be disposed of quickly and properly. In short, whether it is storing or transporting 2- (bromomethyl) -1,3,5-trifluorobenzene, relevant safety regulations and operating guidelines must be strictly followed to ensure the safety of personnel and the environment.
What are the effects of 2- (Bromomethyl) -1,3,5-Trifluorobenzene on the environment and the human body?
2-%28Bromomethyl%29-1%2C3%2C5-Trifluorobenzene is 2 - (bromomethyl) -1,3,5 -trifluorobenzene. The effects of this substance on the environment and the human body are detailed as follows:
At the end of the environment, it has a certain chemical activity. If released into the atmosphere, it will be driven by factors such as light, participate in complex photochemical reactions, or cause the formation of secondary pollutants, such as ozone, which disturbs the quality of the atmosphere. Once it flows into the water body, it will settle to the bottom of the water due to its hydrophobicity, or adsorbed on suspended particles, and persist in the sediment, endangering the aquatic ecology. If aquatic organisms come into contact, they may cause abnormal physiological functions, such as stunted development and suppressed reproduction. It is also difficult to degrade in soil, will accumulate in soil, affect the structure and function of soil microbial community, and then impact plant growth, causing damage to vegetation health and biodiversity loss.
As for the human body, it can be ingested through breathing, skin contact or accidental ingestion. Respiratory contact, or irritation of the nose, throat and lungs, causing cough, asthma, breathing difficulties and other symptoms. Skin contact, or cause allergies, redness, swelling, pain and other irritation reactions. If accidentally ingested, it will damage the digestive system, such as nausea, vomiting, abdominal pain, etc. And this substance may be potentially carcinogenic and genotoxic. Long-term exposure will increase the risk of cancer, damage genetic material, and affect the health of future generations. During metabolism in the body, it may interfere with normal physiological and biochemical processes, involve important organs such as liver and kidney, weaken organ function, and endanger human health.
Therefore, the use and emission of 2- (bromomethyl) -1,3,5-trifluorobenzene should be strictly controlled to reduce its harm to the environment and human body.