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What is the main use of 2- (Bromomethyl) -1,3,5-Trifluorobenzene?
2-%28Bromomethyl%29-1%2C3%2C5-Trifluorobenzene, the Chinese name is 2 - (bromomethyl) -1,3,5 -trifluorobenzene, this compound is used in the field of chemical synthesis.
First, in the synthesis of chemical compounds, it can be used as an important medium. Because it contains bromomethyl trifluorophenyl, it has high reaction activity. Bromomethyl can replace the reaction by the nucleus. Compounds containing more nuclear groups, such as alcohols, amines, etc., and build specific fragments of the molecule. Trifluorophenyl can reduce the physicalization of the molecule, such as fat solubility, characterization, etc. Like in the research and synthesis of some anti-tumor and anti-viral compounds, it may be introduced with the help of this compound to improve the compatibility and biological activity of the target of the compound.
Second, in the field of materials, 2- (bromomethyl) -1,3,5-trifluorobenzene can be used to synthesize special functional materials. For example, through the addition of bromomethyl to polymers containing specific functions, and the introduction of trifluorophenyl into the polymer main body or body, it can give polymer materials such as corrosion resistance and low dielectric properties. In the fields of high-performance materials, materials, etc., the modified polymer materials may have excellent performance.
Third, it is a commonly used model substrate in the study of synthetic methods. Researchers can use it to explore new anti-pathways and anti-pathways. For example, the study of new catalysts for the functional reaction of bromomethyl, the development of synthetic methods and strategies, and the efficient synthesis of more synthetic compounds provide ideas.
What are the physical properties of 2- (Bromomethyl) -1,3,5-Trifluorobenzene?
2-%28Bromomethyl%29-1%2C3%2C5-Trifluorobenzene, that is, 2 - (bromomethyl) -1,3,5 -trifluorobenzene, this material has the following physical properties:
Viewed, it is a colorless to light yellow liquid, placed under normal light, it can be seen that it is clear and translucent. Smell, slightly special smell, but this smell is not pungent and intolerable, but it also attracts attention.
On its boiling point, it is about 155 - 157 ℃. At this temperature, the liquid will transform into a gaseous state, and the molecular motion will intensify, breaking free from the liquid phase. The characteristics of the boiling point make it possible to achieve the purpose by temperature control during operations such as separation and purification.
In terms of melting point, it is about -20 ℃. When the temperature drops below the melting point, the molecular movement slows down, close to each other, and the arrangement gradually becomes regular, solidifying from liquid to solid.
The density is about 1.72 g/cm ³, which is heavier than water. If it is mixed with water, it will sink to the bottom of the water, because its mass per unit volume is greater than that of water.
In terms of solubility, it is slightly soluble in water. Because of its molecular structure, fluorine atoms are connected to benzene rings, which has strong electronegativity, which changes the polarity of the molecule, and the force between it and water molecules is weak, so it is difficult to dissolve. However, in organic solvents such as ethanol, ether, and dichloromethane, it has better solubility, because it can form similar forces with organic solvent molecules, following the principle of "similar miscibility".
In addition, its vapor pressure has a corresponding value at a specific temperature. The vapor pressure reflects the tendency of liquid surface molecules to escape into a gaseous state, which has an important impact on their behavior in the gaseous phase and the storage and use environment. At room temperature, the vapor pressure is relatively moderate, not too volatile, and not extremely difficult to evaporate.
All the above physical properties need to be carefully considered when using this substance in chemical synthesis, drug development and other fields. Its properties determine many key steps such as operating conditions, reaction environment and product separation.
What are the synthesis methods of 2- (Bromomethyl) -1,3,5-Trifluorobenzene
2-%28Bromomethyl%29-1%2C3%2C5-Trifluorobenzene is 2 - (bromomethyl) -1,3,5 -trifluorobenzene, and its synthesis methods are as follows:
First, 1,3,5 -trifluorobenzene is used as the starting material. First, the alkylation reaction of Fu-g is used. The halogenated hydrocarbon (such as chloromethyl methyl ether) reacts with 1,3,5 -trifluorobenzene under the catalyst of Lewis acid (such as anhydrous aluminum chloride) to introduce chloromethyl to generate 1,3,5 -trifluorobenzyl chloride derivatives. Subsequently, the benzyl chloride is converted into benzyl bromide through a halogen exchange reaction. In this method, the reaction conditions of Fu-g alkylation need to be carefully regulated, and the amount of Lewis acid, the reaction temperature and time have a great influence on the yield and selectivity.
Second, starting from a suitable benzene derivative. If there are suitable substituents on the benzene ring, it is synthesized through selective halogenation, methylation and subsequent bromination. For example, first prepare trifluorobenzene derivatives with donating groups such as methoxy, use the localization effect of the donating group to introduce methyl at the appropriate position, and then use N-bromosuccinimide (NBS) and other brominating reagents, under the action of light or initiator, methyl bromide to obtain the target product. This approach requires clever design of the introduction sequence and reaction conditions of the substituents to achieve regional selectivity requirements.
Third, the palladium-catalyzed coupling reaction is carried out with halogenated aromatics as raw materials. The coupling reaction between halogenated trifluorobenzene and bromomethyl-containing organometallic reagents (such as organozinc reagents, etc.) is catalyzed by palladium catalysts (such as tetra (triphenylphosphine) palladium, etc.). This method requires strict reaction conditions. The activity of the catalyst, the selection of ligands and the anhydrous and anaerobic conditions of the reaction system are all related to the success or failure of the reaction and the yield.
2- (Bromomethyl) -1,3,5-Trifluorobenzene What to pay attention to when storing and transporting
2-%28Bromomethyl%29-1%2C3%2C5-Trifluorobenzene is 2- (bromomethyl) -1,3,5-trifluorobenzene, which is an important raw material for organic synthesis. When storing and transporting, the following numbers should be carefully noted:
First, it is related to storage. Because of its certain chemical activity, it should be placed in a cool, dry and well-ventilated place, and must not be near fire and heat sources. If the temperature is too high, it is easy to accelerate chemical reactions or cause danger. At the same time, keep away from oxidants, strong bases and other substances to prevent violent reactions. Because it contains bromomethyl, it may hydrolyze in contact with water or moisture, so it should be strictly moisture-proof and should be stored in a sealed container. If conditions permit, a desiccant can be placed in the storage environment to keep the environment dry.
Second, about transportation. Before transportation, it is necessary to ensure that the packaging is intact. The packaging material must be able to resist vibration, collision and friction to prevent material leakage due to damage to the container. During transportation, the temperature should be strictly controlled to avoid excessive temperature fluctuations. And chemicals that are contrary to the nature should not be mixed to prevent interaction and cause safety accidents. Transportation personnel also need to be familiar with the characteristics of this chemical and emergency treatment methods. In the event of leakage and other accidents, they can be disposed of quickly and properly. In short, whether it is storing or transporting 2- (bromomethyl) -1,3,5-trifluorobenzene, relevant safety regulations and operating guidelines must be strictly followed to ensure the safety of personnel and the environment.
What are the effects of 2- (Bromomethyl) -1,3,5-Trifluorobenzene on the environment and the human body?
2-%28Bromomethyl%29-1%2C3%2C5-Trifluorobenzene is 2 - (bromomethyl) -1,3,5 -trifluorobenzene. The effects of this substance on the environment and the human body are detailed as follows:
At the end of the environment, it has a certain chemical activity. If released into the atmosphere, it will be driven by factors such as light, participate in complex photochemical reactions, or cause the formation of secondary pollutants, such as ozone, which disturbs the quality of the atmosphere. Once it flows into the water body, it will settle to the bottom of the water due to its hydrophobicity, or adsorbed on suspended particles, and persist in the sediment, endangering the aquatic ecology. If aquatic organisms come into contact, they may cause abnormal physiological functions, such as stunted development and suppressed reproduction. It is also difficult to degrade in soil, will accumulate in soil, affect the structure and function of soil microbial community, and then impact plant growth, causing damage to vegetation health and biodiversity loss.
As for the human body, it can be ingested through breathing, skin contact or accidental ingestion. Respiratory contact, or irritation of the nose, throat and lungs, causing cough, asthma, breathing difficulties and other symptoms. Skin contact, or cause allergies, redness, swelling, pain and other irritation reactions. If accidentally ingested, it will damage the digestive system, such as nausea, vomiting, abdominal pain, etc. And this substance may be potentially carcinogenic and genotoxic. Long-term exposure will increase the risk of cancer, damage genetic material, and affect the health of future generations. During metabolism in the body, it may interfere with normal physiological and biochemical processes, involve important organs such as liver and kidney, weaken organ function, and endanger human health.
Therefore, the use and emission of 2- (bromomethyl) -1,3,5-trifluorobenzene should be strictly controlled to reduce its harm to the environment and human body.