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2-(Bromomethyl)-1,3,4-Trifluorobenzene

2-(Bromomethyl)-1,3,4-Trifluorobenzene

Hongda Chemical

Specifications

HS Code

733617

Name 2-(Bromomethyl)-1,3,4-Trifluorobenzene
Molecular Formula C7H4BrF3
Molecular Weight 225.005
Appearance Colorless to light yellow liquid
Boiling Point 184 - 186 °C
Density 1.634 g/mL at 25 °C
Flash Point 65 °C
Solubility Insoluble in water, soluble in organic solvents like ethanol, ether
Purity Typically high - purity products around 97%+
Cas Number 1215555-47-0
Refractive Index 1.4770 - 1.4790

As an accredited 2-(Bromomethyl)-1,3,4-Trifluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 100 - gram vial packaging for 2-(bromomethyl)-1,3,4 - trifluorobenzene chemical.
Storage 2-(Bromomethyl)-1,3,4 -trifluorobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, flames, and oxidizing agents. Store in a tightly sealed container, preferably made of corrosion - resistant materials like glass or certain plastics, to prevent leakage and contact with air or moisture which could potentially cause decomposition or unwanted reactions.
Shipping 2-(Bromomethyl)-1,3,4 -trifluorobenzene is shipped in accordance with strict chemical transport regulations. Packed in suitable, sealed containers, it's transported by specialized carriers to ensure safe handling and delivery.
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2-(Bromomethyl)-1,3,4-Trifluorobenzene 2-(Bromomethyl)-1,3,4-Trifluorobenzene
General Information
Historical Development
In the past, in the field of organic chemistry, people worked tirelessly on novel compounds. "2- (Bromomethyl) -1,3,4-Trifluorobenzene" This compound attracted the attention of many scholars when it first appeared.
At that time, the chemical technology was not as exquisite as it is today, and it was difficult to synthesize this compound. Scholars tried various paths with simple equipment and limited raw materials through trial and error. Despite repeated setbacks, everyone was reluctant to explore with perseverance.
With the passage of time, chemical technology has gradually matured. The discovery of new reaction mechanisms and the advent of efficient catalysts opened up a smooth path for the synthesis of "2- (Bromomethyl) -1,3,4-Trifluorobenzene". The synthesis efficiency has been greatly improved, and the purity has also been significantly improved. This compound has been widely used in medicine, materials and other fields, driving related industries forward. Its historical development has witnessed the great journey of chemical exploration.
Product Overview
Today there is a substance called 2- (Bromomethyl) -1,3,4-Trifluorobenzene. It is an organic compound, what is the shape of it? Looking at it, it is a colorless and transparent liquid, with a special smell.
The structure of this substance is very delicate. On the benzene ring, there are three fluorine atoms, each at 1, 3, and 4 positions, like a list of stars. And at 2 positions, there is a bromomethyl group. This structure gives it unique properties.
It is also widely used. It is an important intermediate in the field of organic synthesis. With its special structure, it can react with many reagents to construct complex organic molecules, providing a key cornerstone for drug development, materials science, and many other aspects. When preparing, it is necessary to follow specific methods and operate strictly to obtain a pure product.
Physical & Chemical Properties
In 2023, the field of organic chemistry will pay more attention to 2- (Bromomethyl) -1,3,4-Trifluorobenzene. Its physical and chemical properties are unique and related to many industrial applications.
Looking at its physical properties, at room temperature, 2- (Bromomethyl) -1,3,4-Trifluorobenzene is a colorless and transparent liquid with a specific odor and volatility. The density is heavier than that of water, and it is difficult to dissolve in water, but it is easily soluble in common organic solvents such as ethanol, ether, etc. This is due to the similar principle of compatibility.
In terms of chemical properties, bromomethyl is abnormally active in its molecular structure. In the case of nucleophiles, nucleophilic substitution reactions often occur, and bromine atoms are easily replaced, and a variety of new compounds are derived. The trifluoro substituent on the benzene ring changes the electron cloud density of the benzene ring, affecting its aromaticity and reactivity. Its stability has specific conditions, and in case of high temperature, strong oxidizing agent, or decomposition and oxidation reactions. In-depth study of the physical and chemical properties of this compound is of key significance for the synthesis of new organic materials and the development of new pharmaceutical products, which can pave a solid way for the development of related fields.
Technical Specifications & Labeling
The technical specifications and labeling (product parameters) of 2- (bromomethyl) -1,3,4-trifluorobenzene are crucial to the regulation and labeling of this product. In the technical specifications, the raw materials must be carefully selected, and the preparation process should be strictly followed. From the ratio of starting materials to the control of reaction conditions, all must be accurate. The reaction temperature should be constant in a specific range, and the duration should be customized to ensure the purity and quality of the product.
As for the labeling, the name of the product should be stated, that is, 2- (bromomethyl) -1,3,4-trifluorobenzene, and its physical and chemical properties should be detailed, such as properties, melting point, boiling point and other parameters. On the packaging, a warning should also be clearly marked to inform the user of the possible risks of this item, so that the operation can be carried out with extra caution to ensure safety.
Preparation Method
If you want to make 2 - (bromomethyl) -1,3,4 -trifluorobenzene, you need to study its preparation method in detail. Its raw materials and production process are essential. First select the appropriate raw materials, you can find compounds containing trifluorobenzene structure and reagents containing bromomethyl.
Reaction steps should be carried out with caution. In the environment of temperature and pressure, the raw materials should be combined. Shilling trifluorobenzene and bromomethylation reagents should be put into the reaction kettle according to a specific ratio. The power of the catalyst can be used to promote the rapid reaction. The choice of this catalyst is related to the effect of the reaction and needs to be carefully observed.
Control the reaction process, and each step must be accurate. If the temperature is controlled, according to the needs of the reaction, either the temperature is raised to urge it, or the temperature is cooled to stabilize it. After the reaction is completed, the product is purified to remove its impurities and obtain pure 2- (bromomethyl) -1,3,4-trifluorobenzene. In this way, scientific rules can be followed to produce good products.
Chemical Reactions & Modifications
Nowadays, there are chemical substances, named 2- (Bromomethyl) -1,3,4-Trifluorobenzene, whose transformation and transformation should be investigated by our generation.
To observe the transformation of this substance, its conditions, rate, and the genus of products are all important to explore. To make it conform and efficient, various factors such as temperature, pressure, and catalyst must be adjusted. Temperature can be increased or increased, but there is also a risk of side effects; pressure change is also related to the collision of molecules, which has an impact on the direction of response.
As for the change of its transformation, the change of structure can be caused. Increasing or decreasing the group, adjusting the distribution of its electron cloud, can change its activities. or affinity with other things, or change isomerism.
As chemical researchers, we should carefully investigate its application, and seek the rules of chemical adaptation and chemical change, so as to optimize its use and benefit the development of the world.
Synonyms & Product Names
2 - (bromomethyl) - 1,3,4 -trifluorobenzene, in the field of my chemical research, its synonyms and trade names are all well studied by us. In ancient Chinese, this thing has various names. Either from its structural characteristics, or because of past research, it has different names. As for the trade name, merchants are different things from the city, and they also take a unique name to mark it.
In the process of research, knowing its synonyms can show its origin and rheology. Many scholars have different names, but they all refer to this thing. The trade name is related to the operation of the market, and the names given by different trade names are all designed to show their characteristics and attract the attention of businesspeople.
This 2- (bromomethyl) -1,3,4-trifluorobenzene, in the way of chemistry, the study of its synonyms and trade names is an important way to understand its status in the academic and business circles.
Safety & Operational Standards
2 - (bromomethyl) - 1,3,4 -trifluorobenzene, also a chemical product. During its experimental preparation and application, safety and operating standards are of paramount importance and cannot be ignored.
Where this substance is involved, the experimental site should be well ventilated to remove harmful gases. The operator must wear protective gear, such as protective clothing, gloves, goggles, etc., to avoid contact with the skin and eyes to prevent inadvertent injuries.
When taking it, the action should be slow and careful to avoid its spillage. When weighing, measure accurately and follow the instructions. If there is any spillage, clean it up in an appropriate way quickly, and do not keep it, which will pollute the environment and endanger safety.
There are also rules for storing this thing. It should be placed in a cool, dry and ventilated place, away from fire and heat sources, and away from direct sunlight. It must also be separated from oxidizing agents, alkalis, etc., and should not be mixed to prevent unexpected reactions.
During the preparation process, the temperature, time, material ratio, etc. of the reaction should be strictly followed. The reaction equipment must be intact, running normally, and equipped with safety devices, such as explosion-proof and leak-proof.
In the event of an emergency, such as leakage, fire, etc., the operator should be calm and follow the emergency plan. In the event of a leak, quickly cut off the fire source, evacuate everyone, set up warning signs, and then take proper measures to remove the leak. In the event of a fire, choose an appropriate fire extinguisher as appropriate, try your best to put it out, and report it to the relevant departments at the same time.
In short, the operation of 2- (bromomethyl) -1,3,4-trifluorobenzene is based on safety, and compliance with regulations can ensure the smooth operation of the experiment, the safety of personnel, and the cleanliness of the environment.
Application Area
2 - (bromomethyl) - 1,3,4 -trifluorobenzene, organic compounds are also. Its application field is quite wide. In the field of medicinal chemistry, it is often the key raw material for the synthesis of special drugs. With its special chemical structure, it can prepare drugs with targeted curative effect on specific diseases, helping to overcome difficult diseases and relieve the suffering of patients.
In the field of materials science, this compound is also wonderfully useful. It can participate in the preparation of high-performance functional materials, such as special optical materials or conductive materials. Based on it, it can endow materials with unique physical and chemical properties, expand the boundaries of material application, and demonstrate its effectiveness in high-tech products. In fact, it is a compound with extraordinary potential in the fields of medicine and materials.
Research & Development
In recent years, I have been in the field of organic synthesis, focusing on the study of 2- (Bromomethyl) -1,3,4-Trifluorobenzene. Its unique properties, in medicine and materials, have a wide range of applications.
At the beginning, the synthesis of thorns. The ratio of raw materials and reaction conditions need to be fine-tuned. After several tests, a suitable method can be obtained. With a specific halogenating agent, the temperature is controlled in a certain range, and after several steps of reaction, this compound can be obtained.
However, the yield and purity are still problems to be solved. Then the reaction mechanism was re-studied to optimize the process. After improvement, the yield gradually increased and the purity reached excellent grade.
Looking to the future, it will expand its application scope. Join hands with colleagues to explore the possibility of new drug research and development, and also hope to emerge in the preparation of high-end materials to promote the development of this compound and add new color to the industry.
Toxicity Research
I recently focused on the toxicity study of 2- (Bromomethyl) -1,3,4-Trifluorobenzene. This compound may have applications in the chemical industry, but its toxicity cannot be underestimated.
After multi-party experimental investigation, various organisms were used as samples to observe the effects of this compound. The interference on the physiological functions of organisms is reflected in behavioral disorders, organ damage, etc. At the cellular level, it can also be seen that it destroys cell structure and function.
From this, it can be seen that 2- (Bromomethyl) -1,3,4-Trifluorobenzene is quite toxic. During its production and use, strict protection measures must be set up to prevent its escape and damage. This study is expected to provide a solid basis for the safe application of this compound and the prevention and control of hazards in the future, so as to ensure the safety of the environment and people.
Future Prospects
The future of the future is especially important for chemical substances. Today, there is 2- (Bromomethyl) -1,3,4-Trifluorobenzene, which has not yet been developed and can be fully developed.
This compound has special properties, or can be used in new research. In research, we seek high-efficiency and low-toxicity substances. The properties of 2- (Bromomethyl) -1,3,4-Trifluorobenzene may be new and new.
In addition, in the field of materials, it may also be useful. New materials require special compounds to determine their properties. The properties of this compound may help the material to have better properties, such as quality and characterization.
And technology is improving, and the analysis method is also more refined. In the future, the knowledge of 2- (Bromomethyl) -1,3,4-Trifluorobenzene will be more in-depth, and its uses will also be expanded. In the fields of technology, materials, etc., it will be a great display of color and a step forward for the world.
Where to Buy 2-(Bromomethyl)-1,3,4-Trifluorobenzene in China?
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Frequently Asked Questions

As a leading 2-(Bromomethyl)-1,3,4-Trifluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 2- (Bromomethyl) -1,3,4-Trifluorobenzene?
2-%28Bromomethyl%29-1%2C3%2C4-Trifluorobenzene is 2- (bromomethyl) -1,3,4-trifluorobenzene, which has a wide range of uses. In the field of organic synthesis, it is often used as a key intermediate. The special structure of bromomethyl and trifluorobenzene in the molecule gives it unique reactivity.
can be replaced by nucleophilic substitution, and the bromine atom of bromomethyl is easily replaced by various nucleophilic reagents. For example, when reacted with alcohol nucleophilic reagents, ether compounds can be formed, which is an important means to construct specific structural units in pharmaceutical chemistry and materials science. In the field of materials science, fluoroether compounds prepared by such reactions may have unique electrical and optical properties and can be used to prepare new electronic materials.
In the field of drug synthesis, it also plays an important role. Because of its fluorine-containing atoms, the introduction of drug molecules can significantly change the physical and chemical properties of compounds, such as improving fat solubility, thereby enhancing the ability of drugs to pass through biofilms and improving bioavailability. For example, through multi-step reactions, it can be connected to a specific drug skeleton to develop new drugs with higher activity and selectivity.
In addition, in the field of pesticide chemistry, fluorinated organic compounds often have the characteristics of high efficiency, low toxicity, and environmental friendliness. 2- (bromomethyl) -1,3,4-trifluorobenzene can be used as an important raw material for the synthesis of new fluorinated pesticides. After a series of reactions, pesticide products with high-efficiency control effects against specific pests and diseases can be prepared. Overall, 2- (bromomethyl) -1,3,4-trifluorobenzene has important applications in many fields such as organic synthesis, medicinal chemistry, materials science, and pesticide chemistry due to its special structure.
What are the physical properties of 2- (Bromomethyl) -1,3,4-Trifluorobenzene?
2-%28Bromomethyl%29-1%2C3%2C4-Trifluorobenzene, the Chinese name is 2 - (bromomethyl) - 1,3,4 - trifluorobenzene. This physical property is very special, let me explain.
Its outer color is usually yellow to light color liquid, and it has flow properties, such as clear spring water. Smell it, or have a special smell, but this taste is not pungent, and it also has the smell of ordinary things. Smell it, you can feel the special taste of its chemical substances.
Its melting temperature, melting temperature is low, and it is often low in the liquid, and the boiling temperature depends on its chemical characteristics, usually at a certain degree. This boiling is affected by the molecular force. Because the molecules contain bromine, fluorine and other atoms, the molecular force has its own characteristics, so the boiling force also has a specific value.
In terms of solubility, 2- (bromomethyl) -1,3,4-trifluorobenzene has good solubility in soluble materials, such as ether and toluene. However, in water, its solubility is very poor. Because of the hydrophobicity of the molecules and the harmony of water molecules, it is mostly oil floating on the water surface in water.
In addition, its density is also special, and the phase density is higher than that of water. When it drops into water, it can sink in the bottom of the water, such as stone. This density characteristic also refers to the amount of bromine and fluorine atoms in the molecule and the density of the phase.
Its chemical activity is low. Due to the existence of bromomethyl in the molecule, it is easy to generate nuclear substitution inverse. This inverse property makes it valuable in the synthetic field, and can be used as an important synthetic material for the identification of various compounds. And the introduction of fluorine atoms gives it special chemical and physical properties, so that the materials synthesized from this raw material may have special biological activity, resistance and other characteristics, and have a promising future in many fields such as engineering and materials.
What are the synthesis methods of 2- (Bromomethyl) -1,3,4-Trifluorobenzene
2-%28Bromomethyl%29-1%2C3%2C4-Trifluorobenzene is 2- (bromomethyl) -1,3,4-trifluorobenzene, and its synthesis method is as follows:
First, 1,3,4-trifluorobenzene is used as the starting material. First, through the Fu-gram alkylation reaction, under the catalysis of Lewis acid such as anhydrous aluminum trichloride, react with chloromethyl methyl ether, and stir at a suitable temperature such as 0-5 ° C for a certain period of time to generate 2- (chloromethyl) -1,3,4-trifluorobenzene. This step of the reaction needs to be carried out in an anhydrous and anaerobic environment to ensure the smooth reaction. Subsequently, 2 - (chloromethyl) - 1,3,4 - trifluorobenzene and sodium bromide are heated and refluxed in acetone solution, and the target product 2 - (bromomethyl) - 1,3,4 - trifluorobenzene can be obtained through halogen exchange reaction. During this process, attention should be paid to controlling the reaction temperature and time to ensure a higher yield.
Second, 1,3,4 - trifluorobenzoic acid is used as the starting material. First, it is esterified with methanol catalyzed by concentrated sulfuric acid, and heated and refluxed for several hours to obtain 1,3,4 - methyl trifluorobenzoate. Next, lithium aluminum hydride is used to reduce it, and tetrahydrofuran solution of lithium aluminum hydride is slowly added at low temperature such as 0 ° C. After the reaction, it is hydrolyzed to obtain 1,3,4-trifluorobenzyl alcohol. Then react 1,3,4-trifluorobenzyl alcohol with phosphorus tribromide at low temperature to obtain 2- (bromomethyl) -1,3,4-trifluorobenzene. There are many steps in this route, but the reaction conditions of each step are relatively mild. Pay attention to the removal of impurities and separation operations after each step of the reaction to improve the purity of the product.
When synthesizing 2- (bromomethyl) -1,3,4-trifluorobenzene, it is necessary to carefully select the appropriate synthesis route according to the actual needs and conditions, and strictly control the reaction conditions to achieve the ideal synthesis effect.
2- (Bromomethyl) -1,3,4-Trifluorobenzene What to pay attention to when storing and transporting
2 - (bromomethyl) - 1,3,4 - trifluorobenzene is an organic compound, which has certain special properties. When storing and transporting, many aspects must be paid attention to.
First words storage. Because of its chemical activity, it needs to be placed in a cool, dry and well-ventilated place. This is to prevent it from reacting with water vapor, oxygen and other components in the air. If the environment is humid, water vapor or reactions such as hydrolysis of compounds will damage its purity and quality; poor ventilation, volatile gases or accumulation of compounds will cause safety hazards.
Furthermore, it should be kept away from fire and heat sources. 2 - (bromomethyl) - 1,3,4 - trifluorobenzene or flammable, in case of open flame, hot topic or cause combustion or even explosion, so the storage place is strictly prohibited fireworks, electrical equipment must also have explosion-proof function.
At the same time, it should be stored separately from oxidants and strong bases, and must not be mixed. Due to its chemical structure characteristics, contact with oxidants or severe oxidation reactions; encounters with strong bases, or reactions such as alkali hydrolysis, can cause dangerous conditions, such as fire, explosion, or the formation of harmful products.
Storage containers are also crucial, and suitable materials should be selected. Corrosion-resistant glass bottles or specific plastic bottles should be used to ensure that the containers are well sealed to prevent leakage. Because the compound may be toxic and corrosive, once it leaks, it not only pollutes the environment, but also threatens human health.
As for transportation, relevant regulations and standards must be strictly adhered to. Transportation vehicles must have corresponding safety signs and protective facilities, such as fire extinguishers, leakage emergency treatment equipment, etc. During transportation, it should be protected from exposure to the sun and rain to avoid the impact of high temperature and humid environment on the compound. When loading and unloading, operators should be careful to prevent leakage caused by damage to the container. If a leak occurs during transportation, emergency measures should be taken immediately to evacuate the crowd, seal the site, and properly handle it according to the characteristics of the compound.
What are the environmental effects of 2- (Bromomethyl) -1,3,4-Trifluorobenzene?
2-%28Bromomethyl%29-1%2C3%2C4-Trifluorobenzene is 2- (bromomethyl) -1,3,4-trifluorobenzene, the impact of this substance on the environment should not be underestimated.
It has certain toxicity. If released in the environment, or diffused by water, soil, and air. In the aquatic environment, it may cause poisoning to aquatic organisms and interfere with their normal physiological functions, such as hindering fish respiration, affecting reproduction, and long-term population decline. In the soil, or absorbed by plant roots, it affects plant growth and development, and even passes through the food chain, endangering organisms that feed on plants.
In addition, its chemical properties are active, in the atmosphere or participate in photochemical reactions, affect air quality, generate harmful secondary pollutants, such as ozone, etc., damage human health and affect atmospheric visibility. And because it is difficult to degrade, it can exist in the environment for a long time, accumulate continuously, and cause more lasting and extensive harm.
When manufacturing, using and handling products containing 2- (bromomethyl) -1,3,4-trifluorobenzene, proper protective measures should be taken to avoid its leakage to the environment. Once leaked, effective cleaning measures should be taken quickly to reduce the harm to the environment.