2-Bromo-5-fluorobenzenesulfonyl chloride is an important compound in organic chemistry. Its physical properties are unique and it has a wide range of uses in the field of organic synthesis.
Looking at its appearance, 2-bromo-5-fluorobenzenesulfonyl chloride is usually in a colorless to pale yellow liquid state at room temperature and pressure. This substance has a higher density, is heavier than water, and has good fluidity in liquid state. Its odor is pungent and highly irritating, so extra caution should be taken when handling, and beware of inhalation or contact with skin and eyes.
When it comes to melting point, the melting point of 2-bromo-5-fluorobenzenesulfonyl chloride is relatively low, resulting in its liquid state at room temperature. This property provides convenient conditions for some reactions that need to be carried out at lower temperatures. Because of its liquid state, it is easier to mix with other reactants, thereby promoting the reaction.
In terms of boiling point, the compound has a high boiling point, which indicates that it has good thermal stability. In a certain temperature range, even when heated, 2-bromo-5-fluorobenzenesulfonyl chloride is not volatile, which helps to maintain the stability of the reaction system. When some reactions require heating, its higher boiling point can ensure that the substance will not evaporate a lot at the required temperature of the reaction, ensuring the smooth development of the reaction.
In terms of solubility, 2-bromo-5-fluorobenzenesulfonyl chloride has good solubility in most organic solvents, such as dichloromethane, chloroform, ether, etc. This property makes it easy to interact with various organic reagents in organic synthesis. In solution, the chance of collision between molecules increases, and the reaction rate increases. However, it has poor solubility in water and will react with water. When exposed to water, its sulfonyl chloride group is easily hydrolyzed to form the corresponding sulfonic acid and hydrogen chloride. This hydrolysis reaction is an exothermic reaction and will lead to increased acidity of the system.
The vapor pressure of 2-bromo-5-fluorobenzenesulfonyl chloride is low, indicating that its volatilization rate is slow at room temperature. However, it should be noted that although the volatilization rate is slow, its vapor may still accumulate in a poorly ventilated environment, causing harm to the human body. Therefore, good ventilation is essential when handling this compound.
In conclusion, the physical properties of 2-bromo-5-fluorobenzenesulfonyl chloride, such as appearance, density, melting point, boiling point, solubility, and vapor pressure, have a profound impact on its application in organic synthesis and related fields. Only by understanding and mastering these properties can this compound be used rationally in practical operations, achieve the desired synthetic goals, and ensure the safety of experimental operations.

2-Bromo-5-fluorobenzenesulfonyl chloride is a crucial chemical reagent in the field of organic synthesis. It has a wide range of uses and has shown key value in many fields.
First, in the field of pharmaceutical synthesis, this reagent is often used as a key intermediate. It can participate in the construction of molecular structures with specific biological activities through a series of chemical reactions. For example, when developing new antibacterial drugs or anti-tumor drugs, 2-bromo-5-fluorobenzenesulfonyl chloride can be substituted with other nitrogenous and oxygen-containing nucleophiles, and specific functional groups can be ingeniously introduced to carefully design and synthesize compounds with ideal pharmacological activities. By precisely adjusting the reaction conditions and the proportion of reactants, the target product can be precisely prepared to meet the needs of medicine, providing an indispensable material basis for the development of new drugs.
Second, in the field of materials science, 2-bromo-5-fluorobenzenesulfonyl chloride also plays an important role. For example, in the preparation of high-performance polymer materials, it can participate in the polymerization reaction as a functional monomer. Its special chemical structure can give the polymer unique properties, such as improving the heat resistance, corrosion resistance and mechanical properties of the polymer. By copolymerizing with different types of monomers, polymer materials with diverse properties can be flexibly designed and synthesized to meet the strict requirements of high-end fields such as aerospace, electronics and electrical appliances for special properties of materials.
Third, in the synthesis of pesticides, the reagent also has important applications. It can be used to synthesize new pesticides by introducing specific benzenesulfonyl chloride structures to enhance the affinity and biological activity of pesticide molecules to target organisms. For example, when developing high-efficiency and low-toxicity insecticides or herbicides, 2-bromo-5-fluorobenzenesulfonyl chloride can be used as a key starting material to construct pesticide molecules with unique mechanisms through multi-step reactions, providing more effective means for agricultural pest control and weed control.

The method of preparing 2-bromo-5-fluorobenzene sulfonyl chloride often follows the following path.
First, 2-bromo-5-fluorobenzene is used as the starting material, and the sulfonic acid group is introduced through the sulfonation reaction. In this step, fuming sulfuric acid or concentrated sulfuric acid is mostly used as the sulfonation reagent. Under the appropriate reaction temperature and duration, 2-bromo-5-fluorobenzene and the sulfonating reagent are fully reacted. Generally speaking, the reaction temperature may need to be controlled in a specific range, and the duration also depends on the reaction process. In the reaction system, the ratio of materials is very critical, and precise regulation is required to ensure the efficient progress of the sulfonation reaction.
After the sulfonation product is formed, the chlorination reaction is continued to convert the sulfonic acid group into a sulfonyl chloride group. Commonly used chlorination reagents include phosphorus pentachloride, sulfoxide chloride, etc. Taking sulfoxide chloride as an example, it reacts with the sulfonation product under appropriate conditions. During the reaction process, an appropriate amount of catalyst may be added to accelerate the reaction. Temperature control cannot be ignored. Usually, the reaction needs to be carried out smoothly under the condition of heating and reflux. The amount of sulfoxide chloride should be reasonably determined according to the amount of sulfonation product to ensure the complete chlorination reaction.
After the reaction is completed, a series of post-treatment steps, such as reduced pressure distillation, extraction, recrystallization, etc., are used to purify the product. Vacuum distillation can separate unreacted raw materials and by-products, extraction can further purify the target product, and recrystallization can obtain high-purity 2-bromo-5-fluorobenzenesulfonyl chloride. All steps require strict control of conditions to obtain satisfactory yield and purity.

2-Bromo-5-fluorobenzenesulfonyl chloride is a commonly used reagent in organic synthesis. When storing, many things must be paid attention to.
The first one to bear the brunt is the temperature of the storage environment. This compound is more sensitive to heat, and high temperature can easily cause it to decompose and deteriorate. Therefore, it should be stored in a cool place. Generally speaking, the temperature should be maintained at 2-8 ° C. This is like the ancient people's storage in a cool cellar to protect its quality.
Second, the humidity should not be underestimated. It is easy to react with water, and it will hydrolyze when exposed to water, which will affect its quality. The place where it is stored must be kept dry, and it can be placed in a dryer, just like the ancients used lime and other substances to absorb moisture and protect items from moisture.
Furthermore, light will also have an effect on it. 2-Bromo-5-fluorobenzenesulfonyl chloride may cause photochemical reactions and cause structural changes after being exposed to light. Therefore, it should be stored in a place protected from light, such as in a brown bottle and placed in a dark place, just like the ancients preserved precious paintings and calligraphy in the dark.
In addition, 2-bromo-5-fluorobenzenesulfonyl chloride is corrosive and irritating, and should be stored to avoid contact with skin, eyes, etc. When storing, it should be separated from other chemical substances, especially not with alkaline substances, water and other substances that can react with it in the same room to prevent accidents, just like the ancients separated the incompatible substances.
In short, the proper storage of 2-bromo-5-fluorobenzenesulfonyl chloride needs to be in a cool, dry, dark place, and isolated from incompatible substances, so as to ensure its quality and stability for subsequent organic synthesis.

The market price range of 2-bromo-5-fluorobenzenesulfonyl chloride is difficult to determine. Because the market price changes, it often varies for many reasons.
First, the price of raw materials has a very close relationship. If the price of bromide, fluoride and other raw materials required for the synthesis of this product rises and falls, the price of 2-bromo-5-fluorobenzenesulfonyl chloride will also fluctuate. If the price of raw materials is high, the cost will decrease, and its market price may also decrease; conversely, the price of raw materials will rise due to scarcity and high costs.
Second, the situation of supply and demand affects the market. If at a certain time, many industry players need this product, and the demand exceeds the supply, the price will rise; if the demand is weak and the supply exceeds the demand, the price may be in a downward state.
Third, the preparation technique also has an impact. If the new technique can increase the yield and reduce the cost, the impact on the price will be significant, or the price will be reduced to compete for the market.
Fourth, the difference in region is also a factor. Different places have different prices due to different taxes, freight and local supply and demand. If the cost increases due to long-distance transportation, the local selling price may be higher than elsewhere.
Looking at the changes in the market in the past, the price of such fine chemicals may range from tens to hundreds of yuan per kilogram. However, this is only an approximate number, and the actual price should be based on the current market conditions. For the exact price, you can consult chemical raw material suppliers, industry trading platforms, or market survey agencies to get real-time accurate prices.