2-Bromo-5-fluoro-1-iodobenzene is an important compound in organic chemistry. Its main uses cover the following ends.
First, it is a key intermediate in the field of drug synthesis. Many drug molecules with specific biological activities need to use 2-bromo-5-fluoro-1-iodobenzene to build their core structures. Because the halogen atoms such as bromine, fluorine, and iodine attached to the benzene ring have active chemical properties, they can be combined with other organic fragments through many organic reactions, such as nucleophilic substitution reactions, metal-catalyzed coupling reactions, etc., to build complex and functional drug skeletons.
Second, in the field of materials science, it also has important applications. It can be used as a starting material for the preparation of new organic optoelectronic materials. After appropriate chemical modification and synthesis steps, it can endow materials with unique optical and electrical properties, such as good fluorescence emission characteristics, charge transport capabilities, etc., and then applied to organic Light Emitting Diode (OLED), organic solar cells and other optoelectronic devices.
Furthermore, in the study of organic synthesis methodology, 2-bromo-5-fluoro-1-iodobenzene is often used as a model substrate. By studying various chemical reactions in which it participates, researchers explore new reaction paths and optimize reaction conditions to improve the efficiency and selectivity of organic synthesis, and provide new methods and strategies for the development of organic chemistry.
Overall, 2-bromo-5-fluoro-1-iodobenzene plays an indispensable role in drug synthesis, materials science and organic synthesis methodology, and is of great significance to promote the progress and development of related fields.

2-Bromo-5-fluoro-1-iodobenzene, this is an organohalogenated aromatic hydrocarbon. It has special physical properties and is very important for organic synthesis chemistry.
When it comes to appearance, under room temperature and pressure, 2-bromo-5-fluoro-1-iodobenzene is often in the state of colorless to light yellow liquid. Those with pure quality are light in color, and the influence of impurities may make the color slightly darker. Looking at its fluidity, it looks like an ordinary liquid with low viscosity and can flow smoothly.
Smell it, it has a special odor, but it is not strongly pungent. The characteristics of organic halide odor can be detected slightly. This odor can be used as a basis for preliminary identification in chemical experiments and industrial production.
In terms of boiling point, due to the introduction of bromine, fluorine and iodine atoms into the molecule, the relative molecular weight increases, the intermolecular force is enhanced, and the boiling point is higher. About 200 ° C - 250 ° C, the exact value varies slightly with the experimental conditions. Such a high boiling point requires specific temperature conditions for separation and purification.
The melting point is also affected by the influence of halogen atoms, usually in the lower temperature range, about - 20 ° C - 0 ° C, depending on the purity of the substance. Low temperature melting point makes storage and transportation or temperature control measures are required.
In terms of solubility, 2-bromo-5-fluoro-1-iodobenzene is insoluble in water, because it is a non-polar organic matter, and water is a polar solvent. According to the principle of "similar miscibility", the two are insoluble. However, it is soluble in many organic solvents, such as ether, dichloromethane, chloroform, etc. In organic synthesis reactions, this solubility is convenient for selecting a suitable solvent to promote the reaction.
The density is greater than that of water. If placed in water, it will sink to the bottom. This property has important applications in liquid-liquid separation operations. Due to density differences, it can be separated from water by means of liquid separation.

The synthesis method of 2-bromo-5-fluoro-1-iodobenzene, as described in ancient books, probably has several paths. First, halogenated aromatic hydrocarbons are used as starting materials and prepared by halogenation reaction. Select the appropriate aromatic hydrocarbon substrate and introduce bromine, fluorine and iodine atoms into the aromatic ring one after another under specific reaction conditions. The key here is to precisely control the reaction conditions and reagent dosage to achieve high selectivity and yield of the target product. For example, bromine atoms are introduced into the aromatic ring with a brominating reagent under the action of an appropriate solvent and catalyst, and then fluorine and iodine atoms are introduced in sequence through similar steps.
Second, cross-coupling reaction catalyzed by palladium. In the presence of palladium catalysts, ligands and bases, carbon-halogen bonds are often coupled using bromine and fluorine-containing aromatic halides and iodine substitutes as raw materials. This method requires careful selection of palladium catalysts and ligands, optimization of reaction temperature, time and solvent conditions, in order to promote the efficient coupling reaction and obtain pure 2-bromo-5-fluoro-1-iodobenzene.
Third, there is also a method of conversion and synthesis by functional group with benzene ring derivatives as starting materials. First, the benzene ring is modified, and it can be converted into functional groups, and then it is gradually converted into bromine, fluorine and iodine atoms through a series of reactions. This approach requires a good understanding of the reaction mechanism at each step, and precise regulation of the reaction process to ensure the quality and yield of the final product.
All synthesis methods have their own advantages and disadvantages. In practical applications, the choice needs to be weighed according to factors such as raw material availability, cost, reaction conditions and purity of the target product.

2-Bromo-5-fluoro-1-iodobenzene is an organic compound. When storing and transporting, the following matters should be paid attention to:
** Storage aspects **:
First, because of its chemical activity, it should be stored in a cool, dry and well-ventilated place. High temperature or humid environment may cause chemical reactions to occur, affecting quality. If placed in a high temperature environment, the compound may decompose due to heat and change its chemical structure; in a humid environment, moisture may participate in the reaction and form impurities.
Second, keep away from fire, heat and oxidants. This compound may be flammable. In case of open flame and high heat energy, it may cause combustion. Contact with oxidants may also react violently and even explode.
Third, it should be stored in a sealed container to prevent volatilization and contact with air. 2-Bromo-5-fluoro-1-iodobenzene is volatile. Sealed storage can prevent it from escaping into the air, and components such as oxygen and water vapor in the air or react with it. Sealing can reduce such risks.
Fourth, the storage area should be clearly marked to remind personnel that it is potentially dangerous, and non-professionals should not enter.
** Transportation **:
First, the transportation container must be strong and well sealed. Vibration and collision are inevitable during transportation, and strong containers can prevent leakage; sealing can prevent reactions from contact with external substances.
Secondly, transportation tools need to be equipped with fire and explosion-proof facilities. In view of the potential flammability of the compound, it is easy to be dangerous in case of open flames and hot topics. Necessary fire and explosion-proof facilities can reduce the risk.
Furthermore, transportation personnel should be professionally trained and familiar with the characteristics of 2-bromo-5-fluoro-1-iodobenzene and emergency treatment methods. If there is an accident such as leakage during transportation, it can be handled in a timely and correct manner to reduce the harm.
Finally, the transportation process should strictly follow relevant regulations and standards to ensure transportation safety compliance.

The market price of 2-bromo-5-fluoro-1-iodobenzene is difficult to determine. Although this compound is not as frequently traded as common bulk chemicals in the chemical industry, it has critical uses in specific fine chemicals, pharmaceutical synthesis and other fields.
In the past, its price was constrained by multiple factors. The first to bear the brunt is the price and availability of raw materials. If the supply of bromine, fluorine, iodine and other element-related raw materials is tight, or the price fluctuates due to the situation of origin or policy regulation, it will definitely affect the cost of 2-bromo-5-fluoro-1-iodobenzene. And the difficulty of the synthesis process is also a major factor. The complex synthesis path requires high-end equipment, exquisite technology, and many steps. Side reactions occur frequently, and the cost will rise, which will affect the price.
Furthermore, the market supply and demand relationship determines its price. If pharmaceutical R & D institutions suddenly have a large demand for intermediates containing this compound, and manufacturers are difficult to expand production capacity for a while, prices will rise. On the contrary, if demand is low and production is excessive, prices will also decline.
As far as the current market is concerned, there is no exact unified pricing. Different suppliers have different quotations due to differences in production scale, technical level, and sales strategies. In some small chemical raw material trading platforms, the selling price may be high due to small quantities; while large chemical enterprises, by virtue of the scale effect, if they purchase in large quantities, they may be able to give relatively favorable prices. Based on various factors, the price per gram may range from tens to hundreds of yuan, but this is only a rough estimate. The actual price still needs to be consulted with each supplier in detail and determined comprehensively according to the specific purchase volume and delivery conditions.