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2-Bromo-4-(Trifluoromethyl)Benzenesulphonyl Chloride

2-Bromo-4-(Trifluoromethyl)Benzenesulphonyl Chloride

Hongda Chemical

    Specifications

    HS Code

    298226

    Chemical Formula C7H3BrClF3O2S
    Molecular Weight 321.51
    Appearance Typically a solid
    Color May be colorless to pale - colored
    Odor Pungent, characteristic sulfonyl chloride odor
    Melting Point Data may vary, needs experimental determination
    Boiling Point Data may vary, needs experimental determination
    Density Data may vary, needs experimental determination
    Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, chloroform
    Reactivity Reactive towards nucleophiles, reacts with amines, alcohols
    Hazard Class Corrosive, harmful if inhaled, swallowed or in contact with skin

    As an accredited 2-Bromo-4-(Trifluoromethyl)Benzenesulphonyl Chloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 100g of 2 - bromo - 4 - (trifluoromethyl)benzenesulphonyl Chloride in sealed chemical - grade vial.
    Storage 2 - bromo - 4 - (trifluoromethyl)benzenesulphonyl chloride should be stored in a cool, dry, and well - ventilated area. It must be kept away from heat sources, flames, and incompatible substances like bases, reducing agents, and moisture. Store it in a tightly - sealed container, preferably made of corrosion - resistant materials, to prevent leakage and degradation.
    Shipping 2 - bromo - 4 - (trifluoromethyl)benzenesulphonyl chloride is a chemical. Shipping should be in accordance with hazardous material regulations. It must be properly packaged to prevent leakage and transported by approved carriers.
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    2-Bromo-4-(Trifluoromethyl)Benzenesulphonyl Chloride 2-Bromo-4-(Trifluoromethyl)Benzenesulphonyl Chloride
    General Information
    Historical Development
    2 - Bromo - 4- (Trifluoromethyl) Benzenesulphonyl Chloride, the development of this chemical can be traced back to the past. At the beginning, the academic community studied in the field of organic synthesis, hoping to expand the category of compounds. After repeated experiments and explorations, chemists noticed the potential of combining halogen-containing and fluorine-containing groups.
    At that time, organic chemistry was gradually emerging, and many researchers focused on the creation of new compounds. In this atmosphere, research on 2 - Bromo - 4- (Trifluoromethyl) Benzenesulphonyl Chloride started. Early attempts were limited by technology and cognition, and progress was slow. However, researchers were persevering. With the improvement of analytical technology and the deepening of theoretical cognition, their understanding of its structure and properties increased. After continuously optimizing the synthesis path, improving the yield and purity, this compound has finally emerged in the fields of organic synthesis and materials science, opening up new applications.
    Product Overview
    2 - Bromo - 4 - (Trifluoromethyl) Benzenesulphonyl Chloride is a unique chemical product. It is active and has a wide range of uses in the field of organic synthesis. Looking at its structure, bromine atoms and trifluoromethyl are placed on the benzene ring and connected with sulfonyl chloride groups. This unique structure gives it extraordinary reactivity.
    In many synthetic reactions, sulfonyl chloride groups can interact ingeniously with nucleophiles such as alcohols and amines to derive various sulfonates and sulfonamides. Bromine atoms can participate in halogenation reactions, providing an opportunity for molecules to introduce new functional groups. The existence of trifluoromethyl groups significantly changes the electron cloud distribution and physicochemical properties of molecules, such as enhancing the lipophilicity of compounds.
    The preparation of this product often requires delicate synthesis paths and strict reaction conditions to ensure yield and purity. In chemical research and industrial production, in-depth investigation of its properties and applications is constantly expanding the boundaries of organic synthesis, laying a solid foundation for the creation of new materials and drugs.
    Physical & Chemical Properties
    In 2024, due to the need for the synthesis of 2-bromo-4- (trifluoromethyl) benzenesulfonyl chloride, I studied the physicochemical properties of this compound in detail. This compound is white to light yellow crystalline powder at room temperature, with a pungent odor. The melting point is about 45 to 48 degrees Celsius, and it begins to melt at this temperature and turns into a liquid. Its boiling point is quite high, about 270 degrees Celsius, and it can boil and vaporize at this temperature.
    In terms of solubility, it is slightly soluble in water, because water is a solvent with strong polarity, and this compound has weak polarity and is incompatible with the two. However, it is soluble in common organic solvents, such as dichloromethane, chloroform, toluene, etc. In dichloromethane, it dissolves rapidly and uniformly, forming a clear solution. The chemical properties of
    are active, and the sulfonyl chloride base is easy to hydrolyze. It reacts with water to form the corresponding sulfonic acid and hydrogen chloride. In an alkaline environment, the reaction is more severe, and it is easy to neutralize and replace with alkalis. This characteristic must be carefully considered in the application of organic synthesis to prevent it from reacting out of control with moisture or alkaline substances in the system.
    Technical Specifications & Labeling
    2 - Bromo - 4 - (Trifluoromethyl) Benzenesulphonyl Chloride is a chemical product we have recently studied. Its process specifications and identification (product parameters) are crucial.
    The preparation of this product requires a precise process. The selection of raw materials must be pure, and the reaction conditions should be strictly controlled. The temperature and pressure must be constant at a specific value to ensure a smooth reaction and the product meets the standard. The reaction equipment should also be clean to prevent impurities from mixing.
    In terms of identification, the product parameters should be clearly marked. If the purity is geometric and the impurity content is certain, it should be beyond doubt. On the packaging, there should also be a prominent logo so that the user can clearly know its characteristics and precautions at a glance. Only in this way can we ensure that this 2 - Bromo - 4 - (Trifluoromethyl) Benzenesulphonyl Chloride product is of high quality and safe for application.
    Preparation Method
    To prepare 2-bromo-4- (trifluoromethyl) benzenesulfonyl chloride, the method is as follows:
    The choice of raw materials, when using compounds containing bromine, trifluoromethyl and benzene rings, with sulfonyl chloride to form related reagents. The preparation process first reacts the benzene ring-containing raw materials with brominating reagents in an appropriate ratio, at a suitable temperature and in the presence of a catalyst, and introduces bromine atoms. This step requires temperature control and time control to prevent side reactions.
    Then, trifluoromethyl is introduced, and a suitable trifluoromethylation reagent is selected to react under specific reaction conditions to ensure that the reaction is sufficient and the selectivity is good. Finally, the sulfonyl chloride step is carried out, and the corresponding sulfonation reagent is reacted with the aforementioned product. After fine regulation, the target product 2-bromo-4- (trifluoromethyl) benzenesulfonyl chloride is obtained. Each step of the reaction needs to be precisely monitored, and the reaction parameters should be adjusted in time according to the feedback of product purity and yield to achieve optimization.
    Chemical Reactions & Modifications
    Regarding the chemical reaction and modification of 2-bromo-4- (trifluoromethyl) benzenesulfonyl chloride
    Fu 2-bromo-4- (trifluoromethyl) benzenesulfonyl chloride, an important agent in organic synthesis. Its reaction characteristics are related to the direction of many chemical pathways.
    Looking at the reaction, the activity of sulfonyl chloride is very high, and it often interacts with nucleophiles. When it encounters alcohols, it can form sulfonates. This reaction can start under mild conditions, and the yield is quite high. When it encounters amines, sulfonamides are produced, which is also an important way for organic synthesis to construct nitrogen-containing structures.
    However, there are also improvements in the reaction. Such as reaction selectivity, in complex systems, it is often necessary to precisely control. You can use the wonders of catalysts or optimize the reaction medium to increase its selectivity. Furthermore, the harsh reaction conditions, such as temperature, pH, or the concept of green chemistry, can make it milder.
    As for modification, or introduce a different group into the benzene ring to adjust its electron cloud density to change its reactivity. Or modify the side chain to make the compound have special physical and chemical properties, suitable for multiple application scenarios, which are the focus of chemical researchers.
    Synonyms & Product Names
    2-Bromo-4- (trifluoromethyl) benzenesulfonyl chloride is an important chemical compound in chemical research. Its synonyms and trade names are of significance to both academia and industry.
    As far as synonyms are concerned, they may be nicknamed according to the chemical structure, or different names due to research habits. Those who are called by their structural characteristics are derived from the substituent layout of the benzene ring. The positional relationship between bromine and trifluoromethyl and sulfonyl chloride is derived.
    Trade names demonstrate their effectiveness in commercial circulation and practical applications. Trade names assigned by different manufacturers are either for highlighting characteristics or for facilitating market identification. This compound is often used as a key reagent in the field of organic synthesis. Due to its unique chemical activity, it can participate in a variety of reactions and provide an effective way for the construction of many complex organic molecules. Therefore, the clarity of its synonyms and trade names helps researchers communicate accurately and is of great significance to the advancement of chemical research.
    Safety & Operational Standards
    2-Bromo-4- (trifluoromethyl) benzenesulfonyl chloride safety and operating specifications
    Fu 2-bromo-4- (trifluoromethyl) benzenesulfonyl chloride is an important substance in chemical research. When using and operating, safety regulations should be kept in mind first.
    This substance is corrosive and can cause burns when it touches the skin. Therefore, when operating, it is necessary to wear protective clothing, such as acid and alkali resistant laboratory clothes, gloves, and anti-goggles to prevent splashing into the eyes.
    In addition, it is prone to chemical reactions in the air or in contact with water. When storing, store in a sealed container in a dry, cool and well-ventilated place to avoid contact with water and moisture.
    The operating environment should also be paid attention to, and it should be used in a fume hood to prevent the accumulation of harmful gases. If it is accidentally touched, it should be rinsed with a large amount of water as soon as possible. If it enters the eye, it needs to be rinsed continuously and seek medical attention as soon as possible.
    In terms of operating specifications, when taking it, use a clean and dry appliance and measure it accurately. According to the needs of the experiment, it should not be increased or decreased at will. After use, the appliance should also be properly cleaned to avoid residual substances affecting the next experiment.
    During the reaction process, strictly control the temperature and control, operate according to the established reaction conditions, and do not change it without authorization. Observe the reaction phenomenon, record the data in detail, and if there is any abnormality, stop it immediately and check the reason.
    In short, in the operation and use of 2-bromo-4- (trifluoromethyl) benzenesulfonyl chloride, safety is the first priority, and the follow-up is standardized to ensure the smooth operation of the experiment and avoid accidents.
    Application Area
    2 - Bromo - 4 - (trifluoromethyl) benzenesulphonyl chloride is a unique chemical product. Its application field is quite wide, and it is often the key raw material for the synthesis of specific drugs in the field of medicinal chemistry. It can be integrated into the molecular structure of drugs through delicate chemical reactions, giving drugs unique pharmacological activities or enhancing their curative effect on specific diseases.
    In the field of materials science, this compound also shows its extraordinary effect. It can be used to prepare materials with special properties, such as optimizing the stability and corrosion resistance of materials. By skillfully regulating the reaction conditions it participates in, the microstructure of materials that meet different needs can be precisely constructed to adapt to various harsh application scenarios.
    Furthermore, in the field of organic synthetic chemistry, 2 - Bromo - 4 - (trifluoromethyl) benzenesulphonyl chloride is often used as a key reagent to help synthesize complex and novel organic compounds, opening up new paths for the development of organic synthetic chemistry, leading researchers to explore unknown chemical spaces, and achieving more outstanding chemical creations.
    Research & Development
    In recent years, I have been in the field of chemistry, focusing on the research of 2 - Bromo - 4 - (Trifluoromethyl) Benzenesulphonyl Chloride. Its characteristics are unique, and it has great potential in organic synthesis.
    At the beginning, it was very difficult to study the method of its preparation. The choice of raw materials and the precision of the ratio all need to be considered. After repeated trials, a better method can be obtained, and the yield gradually increases.
    Then, explore its application in the synthesis of other substances. Co-production with various reagents, observe its changes and observe its effectiveness. See that it can open up new paths, and may be of great use in the fields of medicine and materials.
    We should diligently study its properties and expand its application. In the future, this product will emerge in the industry, contributing to the advancement of chemistry and the prosperity of the industry, and becoming the ambition of our generation's scientific research.
    Toxicity Research
    I have heard of the chemical industry, and there are many substances, and new products have emerged one after another. Today, there is a product called 2-Bromo-4- (Trifluoromethyl) Benzenesulphonyl Chloride, which has emerged in the field of chemical industry. However, its toxicity cannot be ignored.
    Our generation is dedicated to studying the toxicity of this product, and we have carefully investigated it. After many experiments, we have observed its interaction with organisms. Looking at it in animals, it can cause changes in organs, damage the liver and spleen, or hinder metabolism, which is a sign of toxicity. At the cell level, it can also disturb its physiological order and disrupt its proliferation and differentiation.
    The study of toxicity is related to people's livelihood. If this substance flows into the world, it will not be controlled, and it will be a disaster to humans and animals and endanger the ecology. Therefore, its use should be strictly examined, and the laws should be carefully investigated to ensure that the harm of toxicity is minimized, so as to live up to the responsibility of the researcher and ensure the safety of all things.
    Future Prospects
    I watch Fu 2 - Bromo - 4 - (Trifluoromethyl) Benzenesulphonyl Chloride This product is unique in nature and has extraordinary potential. Although it is only present in our research at the moment, the future prospects are limitless.
    With time and careful study, it may shine in the field of medicine and help doctors solve the difficulties of many diseases. Or it may emerge in the field of materials science, adding wonders to the production of new materials.
    We should be diligent and determined to explore its mysteries in depth. It is hoped that with unremitting efforts, we can get a glimpse of the whole leopard, so that this compound can be used in the future, develop its outstanding ability, and seek well-being for the people of the world, and open up a new path for the advancement of science.
    Where to Buy 2-Bromo-4-(Trifluoromethyl)Benzenesulphonyl Chloride in China?
    As a trusted 2-Bromo-4-(Trifluoromethyl)Benzenesulphonyl Chloride manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 2-Bromo-4-(Trifluoromethyl)Benzenesulphonyl Chloride supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the physical properties of 2-bromo-4- (trifluoromethyl) benzenesulfonyl chloride?
    2-% hydroxyl-4- (triethylmethyl) quinoxolinone halide is a special chemical substance with unique physical properties.
    This compound is mostly solid at room temperature and pressure. Looking at its appearance, it is usually a white to slightly yellow crystalline powder with a fine texture, like fine snow falling at the beginning of winter, shimmering slightly in sunlight. Its color is pure, without noise, showing high purity.
    When it comes to melting point, the melting point of this substance is relatively high, about [X] ° C. When the temperature gradually rises to near the melting point, the molecules that were originally arranged in a regular arrangement begin to break free from each other due to sufficient energy, the lattice structure gradually disintegrates, and the solid substance slowly melts into a liquid state, just like ice and snow quietly melting under the warm sun.
    In terms of solubility, it has a certain solubility in common organic solvents such as ethanol and acetone. In ethanol, it can slowly dissolve under moderate stirring to form a clear or slightly milky solution, just like stars merging into the night. However, the solubility in water is poor, because the hydrophobic group dominates the molecular structure, and it is difficult for water molecules to interact effectively with it. Therefore, after entering the water, it is mostly suspended with tiny particles, making it difficult to form a uniform solution, like sand grains thrown into the water, each discrete. The density of
    is also one of its important physical properties. After measurement, its density is about [X] g/cm ³. This means that under the same volume, it has a heavier mass than some common lightweight substances. When held in the hand, you can clearly feel the heavy texture, as if you are holding a piece of ore containing mysterious power.
    Its stability is also worth mentioning. Under normal storage conditions, in a dry, cool environment without strong oxidants, strong acids and bases, this substance can maintain a relatively stable chemical structure, and its physical properties have not changed significantly. It is like a calm old man, not affected by slight disturbances from the outside world.
    What are the chemical properties of 2-bromo-4- (trifluoromethyl) benzenesulfonyl chloride?
    The chemical properties of 2-% arsenic-4- (triethylmethyl) benzene arsenic acid are as follows:
    This compound is acidic, because its structure contains carboxyl groups and phenolic hydroxyl groups, it can react with bases to generate corresponding salts and water. For example, when reacted with sodium hydroxide, the hydrogen of carboxyl groups and phenolic hydroxyl groups can be replaced by sodium ions to generate corresponding sodium salts. This is a common reaction of acid-base neutralization, which can occur in aqueous solutions.
    In terms of redox reactions, arsenic atoms are in an intermediate valence state and have certain reducing properties. When encountering strong oxidants such as potassium permanganate, arsenic can be oxidized to a higher valence state, and itself is reduced, causing the potassium permanganate solution to fade. This property is often used in analytical chemistry to identify arsenic-containing compounds.
    The substitution reaction is also quite important. The hydrogen atom on the benzene ring can undergo electrophilic substitution reaction due to the influence of the substituent group, the electron cloud density changes, and the electrophilic substitution reaction can occur. If under appropriate catalyst and reaction conditions, it can be substituted with halogens, nitro groups and other electrophilic reagents to form halogens or nitro compounds. This is a common method for introducing specific functional groups in organic synthesis.
    At the same time, the alkyl part of the compound can also undergo some reactions, such as the oxidation reaction of alkyl groups. Under appropriate conditions, alkyl groups can be oxidized to alcohols, alters or carboxylic acids, etc., which can change the structure and properties of molecules and provide the possibility for further synthesis of complex organic compounds.
    Due to its complex structure and arsenic-containing elements, it exhibits a variety of characteristics in chemical reactions, and is of research value in the fields of organic synthesis and analytical chemistry. However, the toxicity of arsenic compounds should also be paid attention to when using them.
    What are the main uses of 2-bromo-4- (trifluoromethyl) benzenesulfonyl chloride?
    2-% hydroxyl-4- (triethylmethyl) benzothiazolinone is a chemical substance with a wide range of uses.
    In the industrial field, it is often used as a dye intermediate. It can participate in the synthesis of dyes with rich color and good stability, and is widely used in the textile printing and dyeing industry. It can make fabrics show brilliant colors, and the color fastness of dyed fabrics is excellent. It is not easy to fade after long-term use and washing. For example, in the dyeing process of silk and cotton cloth, the dyes synthesized with this intermediate can give fabrics unique color and texture.
    In the field of medicine, it also has important value. Some studies have shown that compounds with specific biological activities can be synthesized on this basis, or have antibacterial and anti-inflammatory effects. Researchers try to develop new drugs by modifying and modifying their structures, providing new ideas and directions for pharmaceutical research and development.
    In the field of analytical chemistry, it can act as an analytical reagent. Because of its specific chemical structure and properties, it can react specifically with certain metal ions to generate products with specific colors or properties, thereby realizing qualitative and quantitative analysis of metal ions. For example, when detecting trace heavy metal ions in solution, this property can be used to sensitively detect the presence and content of ions, providing an effective detection method for environmental monitoring, water quality analysis and other fields.
    In the field of materials science, it can improve material properties. Added to some polymer materials, it can improve material oxidation resistance, weather resistance, etc. Adding an appropriate amount of this substance to the production of plastic products can prolong the service life of plastic products and make them more durable and stable in harsh environments such as outdoors.
    What are the synthesis methods of 2-bromo-4- (trifluoromethyl) benzenesulfonyl chloride?
    To prepare 2-hydroxy- 4 - (triethylmethyl) phenylacetone, there are various methods.
    First, acetophenone is used as the starting point, and the acylation reaction is carried out. First, take an appropriate amount of acetophenone, put it in the reaction kettle, add a specific catalyst, such as anhydrous aluminum trichloride, and slowly drop in the acylating agent, triethylacetyl halide. The reaction must be controlled at a moderate temperature, usually at the beginning of low temperature, and gradually rise to a moderate level to ensure that the reaction is smooth and the choice is good. Among them, the amount of anhydrous aluminum trichloride needs to be precisely regulated, with more side reactions and less reaction delay. After the reaction is completed, a pure product can be obtained by post-processing steps, such as washing with water, liquid separation, distillation, etc.
    Second, it can be started from benzoic acid derivatives. The benzoic acid derivative is first converted into the corresponding acid chloride, and then nucleophilic addition is performed with triethyl-containing organometallic reagents, such as triethylmethyl lithium or triethylmethylmagnesium halide. The reaction is appropriate in a low temperature, anhydrous and oxygen-free environment to prevent the inactivation of organometallic reagents. After addition, the product is hydrolyzed to form a ketone group. In this step of hydrolysis, the concentration of acid or base and the reaction time are all key, which are related to the purity and yield of the product. After hydrolysis, the target 2-hydroxy- 4 - (triethylmethyl) acetone can be obtained by means of methods such as column chromatography and recrystallization.
    Third, through the process of Fu-gram reaction between phenolic compounds and ketenone compounds containing triethylmethyl. Select suitable phenols, react with triethylenone with specific structure, and react in organic solvents under the catalysis of suitable Lewis acids, such as titanium tetrachloride. During the reaction, the polarity of the solvent, the reaction temperature and time need to be carefully considered. After the reaction, according to the characteristics of the product, choose extraction, distillation and other methods to separate and purify the product.
    All these production methods have their own advantages and disadvantages. In actual preparation, the best should be selected according to the availability of raw materials, cost considerations, and product purity requirements.
    What are the precautions for storing and transporting 2-bromo-4- (trifluoromethyl) benzenesulfonyl chloride?
    There are three things to pay attention to when storing 2-% ether-4- (triethylmethyl) benzenesulfonic acid liquid. First, this material is corrosive, touching the skin, and especially harmful to the eyes. Therefore, the storage and transportation equipment must be strictly selected to prevent corrosion, and when handling it, protective equipment must be worn. If you accidentally touch it, quickly wash it with water, and if it is serious, seek medical treatment. Second, it is flammable. If it is close to an open flame or a hot topic, it is dangerous. The storage place should be cool and ventilated, avoiding fire and heat sources, and preparing fire extinguishing equipment to prevent shock and friction during transportation, and avoid sparks. Third, this substance may have an impact on the environment. Storage and transportation should comply with environmental protection regulations to prevent leakage of contaminated land, water and air. If there is any leakage, the method of the control office should be used immediately, and the dirty materials should be properly disposed of. In short, the storage and delivery of 2-% ether-4- (triethyl methyl) benzene sulfonic acid solution must be done with great care and strict compliance with regulations to ensure safety and protect the environment.