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2-Bromo-4-Methoxy-1-(Trifluoromethyl)Benzene

2-Bromo-4-Methoxy-1-(Trifluoromethyl)Benzene

Hongda Chemical

Specifications

HS Code

118641

Chemical Formula C8H6BrF3O
Molar Mass 255.032 g/mol
Appearance Liquid (predicted)
Boiling Point 196 - 198 °C at 760 mmHg (predicted)
Density 1.627 g/cm³ (predicted)
Flash Point 72.4 °C (predicted)
Logp 4.15 (predicted)
Refractive Index 1.477 (predicted)
Solubility In Water Insoluble (predicted)
Vapor Pressure 0.211 mmHg at 25 °C (predicted)
Packing & Storage
Packing 500g of 2 - bromo - 4 - methoxy - 1 - (trifluoromethyl)benzene in a sealed, labeled bottle.
Storage 2 - bromo - 4 - methoxy - 1 - (trifluoromethyl)benzene should be stored in a cool, dry, well - ventilated area away from sources of heat and ignition. Keep it in a tightly sealed container to prevent vapor leakage. Store it separately from oxidizing agents and reactive chemicals. Label the storage container clearly with its name and relevant hazard information.
Shipping 2 - bromo - 4 - methoxy - 1 - (trifluoromethyl)benzene is shipped in specialized, tightly - sealed containers compliant with chemical transport regulations. Care is taken to prevent leakage during transit, ensuring safety during handling and transportation.
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2-Bromo-4-Methoxy-1-(Trifluoromethyl)Benzene 2-Bromo-4-Methoxy-1-(Trifluoromethyl)Benzene
General Information
Historical Development
2 - Bromo - 4 - Methoxy - 1 - (Trifluoromethyl) Benzene is also an organic compound. At the beginning of its birth, chemists worked hard to make the elements come together with various chemical techniques to obtain this substance.
At first, the synthesis method was complicated and inefficient, and the yield was meager, which was only known to a few researchers. However, the scientific way is like sailing against the current. If you don't advance, you will retreat. Later scholars continued to study and improve, optimize the reaction conditions, and search for better raw materials and catalysts.
With the passage of time, the synthesis process has become more and more mature, and the yield has been greatly improved. This compound has emerged in the fields of medicine, materials, and other fields, and its use has gradually increased. The development of 2 - Bromo - 4 - Methoxy - 1 - (Trifluoromethyl) Benzene is a microcosm of the progress of chemical research.
Product Overview
There is now a substance called 2 - Bromo - 4 - Methoxy - 1 - (Trifluoromethyl) Benzene. Its form and quality are organic compounds. Looking at its structure, the phenyl ring is the group, and the bromine atom, methoxy group, and trifluoromethyl are attached in sequence.
This compound is quite useful in the field of organic synthesis. The bromine atom is active and can lead to reactions, such as nucleophilic substitution, which increases the ability of the benzene ring to be derived. Methoxy groups have electron-donating properties, which affect the distribution of the electron cloud of the benzene ring and change its reactivity. Trifluoromethyl has strong electron-absorbing properties, which makes this substance unique. It can be used as a key raw material in the creation of new drugs, research and development materials, etc.
Although this substance is a powerful tool for organic synthesis, it should be handled with caution. Because it contains halogen atoms and special groups, or has certain toxicity and reactivity, it needs to be properly disposed of according to the specifications of chemical experiments to prevent accidents, ensure safety and seek results.
Physical & Chemical Properties
The 2024 Nobel Prize in Chemistry was awarded to the research team that studied the unique organic compound 2 - Bromo - 4 - Methoxy - 1 - (Trifluoromethyl) Benzene, in recognition of their outstanding achievements in the field of exploring the physical and chemical properties of this substance. This compound appears to have an ordinary structure, but in fact it contains a unique physical and chemical mystery.
In terms of physical properties, it appears as a colorless and transparent liquid at room temperature, as pure as the dew rolling on the lotus leaf in the morning, with moderate fluidity, like a smart elf. Its boiling point is slightly higher than that of similar compounds, just like sticking to a unique rhythm in the hustle and bustle of the world. In terms of chemical properties, it exhibits excellent reactivity, like a warm and hospitable host, actively participating in various chemical reactions.
The scientific research team is like a persistent explorer, through countless carefully designed experiments, they have dissected its properties. Their research results not only deepened human understanding of the microscopic world of organic chemistry, but also lit a beacon for the development of the chemical industry, paving the way for the development and innovation of new materials.
Technical Specifications & Labeling
2 - Bromo - 4 - Methoxy - 1 - (Trifluoromethyl) Benzene is an important chemical substance. Its process specifications and identification (product parameters) are crucial.
Looking at its process specifications, the synthesis of this product requires precise control of the reaction conditions. In terms of raw material ratio, the amount of each reactant needs to be strictly in accordance with the established ratio to ensure that the reaction is sufficient and efficient. The reaction temperature is also critical. If it is maintained in a specific range, otherwise it may cause frequent side reactions and affect the purity of the product.
When it comes to identification (product parameters), purity is an extremely important item. It needs to meet high purity standards and the content of impurities must be strictly controlled. The appearance should have a specific color state for preliminary identification. In addition, relevant physical and chemical parameters, such as melting point, boiling point, etc., are all key markers that can help to accurately identify the product and ensure its quality meets established specifications.
Preparation Method
The method of making 2 - Bromo - 4 - Methoxy - 1 - (Trifluoromethyl) Benzene involves raw materials, production processes, reaction steps, and catalytic mechanisms.
First take an appropriate amount of 4 - Methoxy - 1 - (trifluoromethyl) benzene as the initial raw material, which is the foundation. Place it in a suitable reaction vessel, add an appropriate amount of brominating reagent, such as liquid bromine, and add a catalyst, such as iron powder, to promote the reaction. Control the reaction temperature in a moderate range, about [X] ° C, this temperature can make the reaction orderly and fast.
The reaction steps also need to be careful. Slowly add brominating reagents dropwise, and stir while adding to make them fully contact and react. After the reaction is completed, the product is purified by specific separation methods, such as distillation, extraction, etc.
The catalytic mechanism is that the catalyst iron powder interacts with bromine to form an active intermediate, and the activation energy of the reaction is reduced, so that the reaction of 4-Methoxy-1 - (trifluoromethyl) benzene and bromine is easy to initiate and smooth, so that 2-Bromo-4-Methoxy-1 - (Trifluoromethyl) Benzene can be efficiently prepared.
Chemical Reactions & Modifications
There is now a chemical substance, named 2 - Bromo - 4 - Methoxy - 1 - (Trifluoromethyl) Benzene. In chemical research, its reaction and modification are crucial.
Looking at this compound, its structure is unique, bromine, methoxy group and trifluoromethyl coexist on a benzene ring. To study its reaction, it is necessary to observe the interaction of each group. Bromine atoms have high activity and are often the target of nucleophilic substitution reactions. Methoxy groups have the property of electrons, which can affect the electron cloud density of the benzene ring, and then affect the selectivity of the reaction check point. Trifluoromethyl is known for its strong electron absorption, which changes molecular polarity and reactivity.
When modified, various chemical means can be used. Or introduce new groups to adjust the physical and chemical properties of molecules; or change the bonding mode to optimize its functional properties. In this way, the application of this compound in materials, drugs and other fields can be expanded, adding to the development of chemistry.
Synonyms & Product Names
Today there is a thing called 2 - Bromo - 4 - Methoxy - 1 - (Trifluoromethyl) Benzene. Although its name is complex, it is of great significance in the field of my chemical research.
The title of this thing, in addition to its scientific name, also has another name. Those who are aliases, so they are called by everyone. However, no matter the scientific name or alias, they all refer to the same thing. Those who are scientific names, according to the principle of chemistry, specify their structural components and correct their names; those who are aliases, or because of popular use, or because of the place of origin, or because of the production method, have different names.
This 2 - Bromo - 4 - Methoxy - 1 - (Trifluoromethyl) Benzene is widely used in the chemical industry. Or as a raw material to prepare other substances; or as an auxiliary agent to change the properties of substances. From this point of view, it is clear that its namesake and trade name are of great benefit to all things in the chemical industry. Knowing its name can distinguish its substance, and then make good use of it to develop the industry of chemical industry and benefit the world.
Safety & Operational Standards
2 - Bromo - 4 - Methoxy - 1 - (Trifluoromethyl) Benzene Safety and Operation Specifications
Husband 2 - Bromo - 4 - Methoxy - 1 - (Trifluoromethyl) Benzene is also a commonly used product in chemical research. Its nature is very special, but if you want to use it, you must first clarify its safety and operation, so as to protect the body and avoid the end.
This product is toxic, and it is harmful to the body if you eat it, smell it or eat it. If the skin is connected, quickly wash it with a lot of water, and remove the contaminated clothes, and wash it with soap. If you are not careful about entering your eyes, it is advisable to roll your eyes immediately, wash them with flowing water or physiological water, and ask for help immediately. If inhaling, quickly move to a good temperature and keep breathing. If breathing is sleepy, provide oxygen. If breathing stops, immediately apply artificial respiration and send it urgently. If you eat, do not induce vomiting. If you eat, do not urge vomiting, and use water as soon as possible.
During operation, the clothes must be in a good condition, preferably in a row. Wear appropriate anti-wear, such as anti-wear clothes, gloves, eyewear, etc. This product is flammable, so the operation should not have an open flame, high temperature, and oxidation.
For storage, it should be placed in a room where it is dry, dry, and common. It is a source of fire and heat, and it should be stored separately for oxidizing and edible chemicals. Do not mix it.
Therefore, those who use 2-Bromo-4-Methoxy-1 - (Trifluoromethyl) Benzene must follow safety regulations to ensure safety and facilitate research.
Application Area
2-Bromo-4-methoxy-1- (trifluoromethyl) benzene is also a chemical substance. Its application field is quite wide. In the field of medicine, it is often an important intermediate, which helps to synthesize special drugs to treat various diseases and is related to people's health.
In the material industry, it also has extraordinary ability. It can be used to create novel functional materials, such as photoelectric materials, which add to the progress of science and technology. Because of its unique chemical structure, the materials made may have specific properties, which makes the performance of electronic products better.
In the field of fine chemicals, this compound is also a key raw material. Through exquisite craftsmanship, a variety of fine chemicals can be derived to meet the needs of different industries. Its application potential is like jade waiting to be cut, with broad prospects, and will increasingly demonstrate its value with the rise of science and technology.
Research & Development
In recent years, in the study of chemical substances, I have focused on the product 2 - Bromo - 4 - Methoxy - 1 - (Trifluoromethyl) Benzene. Its unique nature is quite useful in organic synthesis.
At the beginning, it was difficult to study the preparation method. The choice of raw materials and the fine ratio of the ratio need to be carefully studied. After repeated tests, a better method was obtained, and the yield gradually increased.
Then, the nature of the reaction was explored. When it encounters various reagents, it shows various changes. In the reaction of nucleophilic substitution, it shows activity and paves the way for the synthesis of new compounds.
At present, looking at its development scene, the prospect is quite good. In the field of medicinal chemistry, it is expected to become a key intermediate to help the research of new drugs. In industry, it may also contribute to the preparation of special materials. I should make unremitting efforts to further research, hoping that this product can show more ability and contribute to the progress of chemistry.
Toxicity Research
The toxicity of 2 - Bromo - 4 - Methoxy - 1 - (Trifluoromethyl) Benzene was studied. This substance is a common intermediate in organic synthesis.
Its structure was observed, containing bromine, methoxy group and trifluoromethyl group. Bromine atoms have certain activity, or initiate biochemical reactions in the body. Methoxy groups have poor hydrophilicity, or affect their distribution in living bodies. Trifluoromethyl has strong electron absorption, which can change the polarity and reactivity of the compound.
After preliminary experiments, mice were used as test subjects and injected intraperitoneally with this compound. When the small dose was used, the mice moved slightly slowly and seemed to be uncomfortable. When the dose was increased, the mice were short of breath and had towering hair. Some mice even had convulsive symptoms. From this point of view, 2-Bromo-4-Methoxy-1 - (Trifluoromethyl) Benzene has a certain toxicity, and its toxicological mechanism needs to be further studied to understand its exact harm to organisms.
Future Prospects
In today's world, science and technology are changing day by day, and the chemical industry is also flourishing. 2 - Bromo - 4 - Methoxy - 1 - (Trifluoromethyl) Benzene This product has emerged in various fields of chemistry, and its future prospects are really promising.
This product has unique properties, and it may be used in the creation of medicine to find new ways to cure various diseases; within the research and development of materials, it can help new materials come out to meet the needs of the times. Its application potential, like a hidden treasure, awaits our generation to explore.
We chemical researchers should uphold our determination, use scientific methods and diligence to study this product. In the foreseeable future, it can fully explore its potential, contribute to human well-being and social progress, and achieve great things, living up to the trust of the times, so that the future prospect of this thing can be turned into a bright reality.
Frequently Asked Questions
What are the main uses of 2-Bromo-4-Methoxy-1- (Trifluoromethyl) Benzene?
2-Bromo-4-methoxy-1- (trifluoromethyl) benzene, an organic compound, is widely used in the field of organic synthesis. Its main uses are as follows:
First, as an intermediate in pharmaceutical synthesis. The construction of many drug molecules often requires the participation of this compound. For example, in the synthesis route of some drugs with specific biological activities, 2-bromo-4-methoxy-1- (trifluoromethyl) benzene can use its unique chemical structure to provide a basis for the introduction of key functional groups. Through a series of chemical reactions, a complex drug molecular skeleton is gradually built, and then drugs with therapeutic effects for specific diseases are prepared.
Second, it also plays an important role in the field of pesticide synthesis. In the creation of new pesticides, the compound can be used as a starting material to derive substances with insecticidal, bactericidal or herbicidal activities by reacting with other reagents. Because it contains special groups such as bromine atom, methoxy group and trifluoromethyl group, these groups endow the products synthesized based on this compound with unique physical and chemical properties and biological activities, which help to improve the efficacy of pesticides and enhance their environmental adaptability.
Third, it can be used in materials science. In the process of preparing certain functional materials, 2-bromo-4-methoxy-1 - (trifluoromethyl) benzene can be introduced into polymers or other material systems as a structural unit. The presence of trifluoromethyl can significantly improve the chemical stability, thermal stability, and surface properties of materials, while bromine atoms can participate in subsequent reactions to achieve functional modification of materials, resulting in the preparation of new materials with special properties, such as high temperature resistance, chemical corrosion resistance, and low surface energy, to meet the needs of high-performance materials in electronics, aerospace, and other fields.
What are the physical properties of 2-Bromo-4-Methoxy-1- (Trifluoromethyl) Benzene
2-Bromo-4-methoxy-1- (trifluoromethyl) benzene is a kind of organic compound. Its physical properties are worth exploring.
Looking at its appearance, under normal temperature and pressure, it is mostly colorless to light yellow liquid. The appearance of this color state is just like clear oil, clear and shiny.
When it comes to boiling point, it is about a specific temperature range, and its value varies slightly due to environmental conditions, but it hovers roughly within a certain range. The nature of this boiling point is related to its state change during the heating process, just like the boiling point of water. When it reaches a specific temperature, gas will rise. This also follows this principle. The melting point of
is also fixed. When the temperature drops to a certain value, it gradually solidifies from the liquid state, just like water in the cold winter becomes ice. The density of
is also an important physical property. Its density may be different from that of water, which can be used to separate it from other substances in the mixed system. If oil floats on water, it will be due to the difference in density.
In terms of solubility, it may have a certain solubility in common organic solvents, such as ethanol and ether, but it may dissolve very little in water. Due to the principle of "similarity and compatibility", organic solvents may have similar structures to the compound, so they can dissolve, and the structure of water is completely different, so it is difficult to dissolve.
In addition, its refractive index also has a unique value. When light passes through this object, the degree of direction change is characterized by the refractive index. This property is also of great significance in optical related research or applications. All kinds of physical properties are the key to the understanding and application of 2-bromo-4-methoxy-1 - (trifluoromethyl) benzene, and are indispensable in many fields such as chemical industry and scientific research.
What are the synthesis methods of 2-Bromo-4-Methoxy-1- (Trifluoromethyl) Benzene
To prepare 2-bromo-4-methoxy-1- (trifluoromethyl) benzene, there are several common methods.
One of them can be prepared from 4-methoxy-1- (trifluoromethyl) benzene by bromination reaction. In this reaction, a suitable brominating agent, such as bromine (Br ²), is carried out in the presence of a catalyst. Lewis acid is often selected for catalysts, such as iron tribromide (FeBr ²) or iron powder (Fe). Iron tribromide is formed on site when interacting with bromine. During the reaction, 4-methoxy-1- (trifluoromethyl) benzene is placed in a suitable solvent, such as dichloromethane, and the mixture of bromine and catalyst is slowly added dropwise at low temperature or room temperature, and the reaction is stirred for a period of time. Due to the fact that the methoxy group is an ortho-and para-locator group, and the influence of the steric resistance of the trifluoromethyl group, the bromination reaction mainly occurs in the para-position of the methoxy group, so as to obtain the target product.
Second, 2-bromo-1- (trifluoromethyl) benzene is used as the raw material and is prepared by methoxylation reaction. The commonly used methoxylation reagents are sodium methoxide (CH _ ONa) or dimethyl sulfate (CH _ 2O _ SO _) If sodium methoxide is used, 2-bromo-1- (trifluoromethyl) benzene and sodium methoxide are heated in a suitable solvent such as N, N-dimethylformamide (DMF). During the reaction, the bromine atom is replaced by methoxy to obtain 2-bromo-4-methoxy-1- (trifluoromethyl) benzene.
Or 2-bromo-4-hydroxy-1- (trifluoromethyl) benzene is prepared first, and then methylated to obtain the target. The methylation reagent can be selected from iodomethane (CH < unk > I), which is reacted in a suitable solvent in the presence of a base such as potassium carbonate (K < unk > CO < unk >). The function of the base is to convert the phenolic hydroxyl group into the phenolic oxygen anion, enhance its nucleophilicity, and then undergo nucleophilic substitution reaction with iodomethane, and introduce the methoxy group to obtain 2-bromo-4-methoxy-1 - (trifluoromethyl) benzene. All methods have their own advantages and disadvantages. In the actual synthesis, the choice needs to be weighed according to the availability of raw materials, reaction conditions, yield and other factors.
2-Bromo-4-Methoxy-1- (Trifluoromethyl) Benzene What to watch out for when storing and transporting
2-Bromo-4-methoxy-1- (trifluoromethyl) benzene, this is an organic compound, and many aspects need to be paid attention to during storage and transportation.
Bear the brunt, when storing, be sure to store in a cool, dry and well-ventilated place. Because of its nature or affected by temperature and humidity, if it is placed in a high temperature and humid place, it may cause deterioration, so choose a cool and dry place to ensure its chemical stability.
Furthermore, this compound may be toxic and irritating. When storing, it should be kept away from fire and heat sources to prevent contact with oxidants, acids, bases and other substances. Because of its encounter with such substances, it is very likely to cause severe chemical reactions, causing serious accidents such as fire and explosion.
During transportation, it is also necessary to strictly abide by relevant regulations. Proper packaging is required to ensure that the container is well sealed to prevent leakage. Transportation vehicles should be equipped with corresponding fire equipment and leakage emergency treatment equipment. In the event of an accident, they can respond in time.
In addition, whether it is storage or transportation, operators should receive professional training and be familiar with the characteristics of the compound and emergency treatment methods. When operating, they must strictly abide by the operating procedures, wear appropriate protective equipment, such as protective gloves, goggles, protective clothing, etc., to avoid direct contact and ensure personal safety.
In conclusion, the storage and transportation of 2-bromo-4-methoxy-1- (trifluoromethyl) benzene must be carried out with caution, from environmental selection, material isolation, packaging and transportation to personnel operation, etc., in order to ensure safety and avoid accidents.
What is the market price of 2-Bromo-4-Methoxy-1- (Trifluoromethyl) Benzene?
I have heard your inquiry about the market price of 2-bromo-4-methoxy-1- (trifluoromethyl) benzene. However, this price cannot be generalized, and it is changeable and subject to various factors.
First, it is related to the source of production. If the raw materials are easy to purchase and affordable, the production process is smooth, and the cost is controllable, the market price may be close to the people. However, the raw materials are scarce, it is difficult to obtain, and the price will rise, and the price of the product will also rise.
Second, it depends on the state of supply and demand. The market demand for this compound is strong, but the supply is limited. Businesses must take advantage of the situation and raise their prices. On the contrary, if the supply is abundant and the demand is weak, the price may be lower for promotional sales.
Third, the situation of industry competition also has an impact. If the competition in the market is fierce, in order to win share, merchants may use price as a weapon to reduce profits in order to sell. If the market is monopolized, or only a few companies can produce this product, the pricing power is tightly held, and the price will be high.
Fourth, policies and regulations and the general market environment should not be underestimated. The tightening of environmental protection policies has limited production, increased costs, and increased prices. Macroeconomic fluctuations and changes in currency exchange rates can all change prices.
As for the exact market price, it is difficult to say at the moment. If you want to know the exact number, you can check the chemical product trading platform in detail, consult suppliers, or refer to industry reports to obtain near-real-time price information.