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2-Bromo-4-Fluoro-1-Methoxybenzene

2-Bromo-4-Fluoro-1-Methoxybenzene

Hongda Chemical

Specifications

HS Code

177716

Chemical Formula C7H6BrFO
Molar Mass 205.024 g/mol
Appearance Liquid (usually)
Boiling Point Around 195 - 197 °C
Density Data may vary, around 1.5 - 1.6 g/cm³
Solubility In Water Insoluble
Solubility In Organic Solvents Soluble in common organic solvents like ethanol, ether
Vapor Pressure Low at room temperature
Odor Characteristic organic odor

As an accredited 2-Bromo-4-Fluoro-1-Methoxybenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 500g of 2 - bromo - 4 - fluoro - 1 - methoxybenzene packaged in a sealed glass bottle.
Storage 2 - bromo - 4 - fluoro - 1 - methoxybenzene should be stored in a cool, dry, well - ventilated area away from heat sources and open flames. Keep it in a tightly sealed container, preferably made of corrosion - resistant materials. Store it separately from oxidizing agents and reactive chemicals to prevent potential reactions. Ensure proper labeling for easy identification and safety.
Shipping 2 - bromo - 4 - fluoro - 1 - methoxybenzene is shipped in well - sealed, corrosion - resistant containers. It adheres to strict chemical transportation regulations, ensuring secure transit to prevent leakage and maintain product integrity.
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2-Bromo-4-Fluoro-1-Methoxybenzene 2-Bromo-4-Fluoro-1-Methoxybenzene
General Information
Historical Development
2-Bromo-4-Fluoro-1-Methoxybenzene is an important product of organic chemistry. In its historical evolution, at the beginning, chemical ancestors explored the path of organic synthesis and worked tirelessly on this compound. In the past, the synthesis of this product was quite difficult, the raw materials were scarce, and the techniques were not mature.
However, after years, many chemists have worked hard to improve the synthesis method. Find better raw materials, optimize reaction conditions, and improve yield and purity.
Today, the synthesis process of 2-Bromo-4-Fluoro-1-Methoxybenzene is improving day by day, and it has been widely used in medicine, materials and other fields, adding a strong color to the development of chemistry.
Product Overview
Today there is a substance called 2 - Bromo - 4 - Fluoro - 1 - Methoxybenzene. This is an organic compound. In its molecular structure, on the benzene ring, there is one bromine atom, one fluorine atom and one methoxy group. Bromine is also a halogen element, and its activity is active, and it often shows unique chemical properties in compounds. The fluorine atom is also a member of the halogen group. Its electronegativity is very strong, resulting in changes in the polarity and reactivity of the molecule. Methoxy groups have the characteristics of electrons, which have a great influence on the distribution of the electron cloud of molecules.
This substance is widely used in the field of organic synthesis. It can be used as an intermediate to participate in many organic reactions, and can be converted into other compounds with different functions by chemical means. Due to its unique structure, it can provide specific activity checking points for subsequent reactions, or be used to construct more complex organic molecular structures, contributing a lot to the development of organic synthetic chemistry.
Physical & Chemical Properties
2 - Bromo - 4 - Fluoro - 1 - Methoxybenzene is an organic compound. It is a colorless liquid with a special odor. In terms of physical properties, its boiling point and melting point are fixed. The boiling point is about a certain temperature, and the melting point also belongs to the range, which is related to the characteristics of intermolecular forces and structures.
In terms of its chemical properties, it has unique reactivity because it contains functional groups such as bromine, fluorine, and methoxy. Bromine atoms can participate in nucleophilic substitution reactions. Fluorine atoms can affect the molecular electron cloud distribution due to their electronegativity, making the compound unique in specific reactions. Methoxy groups can affect the electron cloud density of benzene rings, making them behave differently in electrophilic substitution reactions. This compound is an important intermediate in the field of organic synthesis, and can be derived from many compounds due to its characteristics, which contribute to chemical research and industrial production.
Technical Specifications & Labeling
Today there is a product called 2 - Bromo - 4 - Fluoro - 1 - Methoxybenzene. In this product, the process specification and identification (commodity parameters) are the key.
Its process specification needs to follow a fine method. From the selection of raw materials, it is necessary to be pure and free of impurities to get a good start. The reaction process, temperature, humidity, duration, etc. need to be precisely controlled. If the reaction temperature, it should be stable at a certain degree, and the quality should not be changed due to a slight difference. The duration should not be tolerated, and it needs enough time to stop before the reaction can be complete.
In terms of identification (commodity parameters), its chemical composition, purity geometry, and properties need to be detailed. The chemical composition is established and cannot be confused slightly; the standard of purity must be conclusive; the description of the characteristics should also be true. In this way, the product should be clear and clear before the user, without doubts. The process specifications and labels (commodity parameters) are the foundation of this product and cannot be ignored.
Preparation Method
To prepare 2 - Bromo - 4 - Fluoro - 1 - Methoxybenzene, the raw materials and production process, reaction steps and catalytic mechanism are very critical.
First take an appropriate amount of fluorobenzene as the starting material, add an appropriate amount of brominating reagent, such as bromine, in a specific reactor, and add an appropriate amount of catalyst, such as iron powder, at a certain temperature and stirring rate, initiate a bromination reaction to generate 4 - fluorobenzene. This step requires precise temperature control, about 50 to 60 degrees Celsius, to ensure that the reaction proceeds in the desired direction.
Then, 4-fluorobromobenzene and sodium methoxide are mixed in an organic solvent, heated to 80 to 90 degrees Celsius, and methoxylated. After several hours, the target product 2-Bromo-4-Fluoro-1-Methoxybenzene can be obtained. During the reaction process, the reaction progress needs to be closely monitored and controlled by means of thin layer chromatography to achieve the best yield and purity. In this way, according to this process step, the preparation of this product can be achieved.
Chemical Reactions & Modifications
F 2 - Bromo - 4 - Fluoro - 1 - Methoxybenzene is also an organic compound. In the field of chemical synthesis, its reaction and modification are quite critical.
Looking at its chemical properties, the presence of bromine, fluorine and methoxy groups endows this substance with unique reactivity. Bromine atoms have a tendency to nucleophilic substitution, and can react with many nucleophilic reagents to cause the formation of substitution products. Although fluorine atoms are small, their electronegativity is strong, which can affect the electron cloud distribution of molecules, thereby changing the reactivity and physical properties of compounds. Methoxy groups are the power supply groups, which can enhance the electron cloud density of the benzene ring, making the adjacent and para-sites more prone to electrophilic substitution reactions.
In order to improve its properties, chemists have tried to explore different reaction conditions and reagents. Such as changing the reaction temperature, solvent, or adding a catalyst, which can affect the rate and selectivity of the reaction. After various attempts, a better reaction path has been obtained to improve the purity and yield of the product, and to achieve better applications in materials science, drug development and other fields.
Synonyms & Product Names
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Safety & Operational Standards
2 - Bromo - 4 - Fluoro - 1 - Methoxybenzene Safety and Operating Practices
Fu 2 - Bromo - 4 - Fluoro - 1 - Methoxybenzene is a chemical commonly used in organic synthesis. When using and handling it, it is necessary to strictly observe the safety and operating practices to ensure the safety of people and the environment.
#1. Storage Rules
This chemical should be stored in a cool, dry and well-ventilated place. Keep away from fire and heat sources to prevent accidents. It must be stored separately from oxidants, acids, bases, etc., and must not be mixed to avoid chemical reactions and danger. The storage area should be equipped with suitable materials to contain possible leaks.
#2. The essentials of operation
When operating, the operator must be specially trained and strictly follow the operating procedures. It is recommended that the operator wear a self-priming filter gas mask (half mask), wear chemical safety glasses, wear anti-poison penetration work clothes, and wear rubber gloves. Avoid direct contact with the skin and eyes to prevent inhalation of its vapors. The operating place should ensure good ventilation, and use explosion-proof ventilation systems and equipment. When handling, it should be handled lightly to prevent damage to packaging and containers.
#3. Emergency measures
If you accidentally come into contact with the skin, you should immediately take off the contaminated clothes, rinse with a large amount of flowing water for at least 15 minutes, and then seek medical attention. If you come into contact with the eyes, you should immediately lift the eyelids and rinse thoroughly with a large amount of flowing water or normal saline for at least 15 minutes. You also need to seek medical attention. If you inhale its vapor, you should quickly leave the scene to a fresh air place to keep the respiratory tract unobstructed. If breathing difficulties occur, give oxygen. If breathing stops, immediately perform artificial respiration and seek medical attention. In the event of a leak, personnel from the leaked contaminated area should be quickly evacuated to a safe area and quarantined to strictly restrict access. Cut off the source of fire. It is recommended that emergency personnel wear self-contained positive pressure breathing apparatus and anti-toxic clothing. Cut off the source of Prevent flow into restricted spaces such as sewers and flood drains. Small leaks: Absorb with sand, vermiculite or other inert materials. It can also be scrubbed with emulsions made of non-flammable dispersants, diluted and placed into the wastewater system. Large leaks: build embankments or dig pits for containment. Cover with foam to reduce vapor disasters. Transfer to a tanker or a special collector with a pump, recycle or transport to a waste treatment site for disposal.
The safety of the husband is more important than Mount Tai. In the operation and use of 2 - Bromo - 4 - Fluoro - 1 - Methoxybenzene, everyone should strictly abide by the norms and not slack, so as to produce safely and without worry.
Application Area
2 - Bromo - 4 - Fluoro - 1 - Methoxybenzene is also an organic compound. Its application field is quite wide. In the field of medicinal chemistry, it is often a key intermediate in the synthesis of many specific drugs. With its unique chemical structure, it can be combined with other compounds through clever reaction paths to obtain a good medicine against specific diseases.
In the field of materials science, this compound also has outstanding performance. It can be used as a precursor to participate in the preparation of high-performance materials. After specific processing, it can endow materials with excellent electrical and optical properties, etc., for the manufacture of advanced electronic devices and optical materials.
Furthermore, in the fine chemical industry, 2 - Bromo - 4 - Fluoro - 1 - Methoxybenzene can be used as an important raw material for the synthesis of special fragrances and dyes. With its structural characteristics, unique products can be prepared to meet the diverse needs of the market. Therefore, this compound has important value in many application fields.
Research & Development
Recently, in my laboratory, I focused on the investigation of 2 - Bromo - 4 - Fluoro - 1 - Methoxybenzene. I investigated its chemical properties and analyzed its molecular structure to understand its activity in various chemical reactions.
After repeated experiments, we explored its reaction path with various reagents, hoping to expand the scope of application of this product. In the process of synthesis, we tried various novel methods to improve its yield and purity.
Looking forward to the future, we hope that through continuous research, the research results of 2 - Bromo - 4 - Fluoro - 1 - Methoxybenzene will be extended to the practical application field. Or in drug research and development, or in materials science, I hope to emerge and contribute to the development of the chemical field, to promote its continuous progress and reach new heights.
Toxicity Research
There is a substance today, called 2 - Bromo - 4 - Fluoro - 1 - Methoxybenzene, in my chemical research, toxicity research is the key.
The toxicity of this substance is related to the safety of the experiment, as well as the advantages and disadvantages of the application. I carefully observe its properties and explore the changes in its contact with other substances. After various experiments, observe its impact on the organism, observe the state of the cell, and test the physiological ability.
The toxicity is affected, or the structure of the cell may be damaged, and the order of metabolism will be disrupted. If it is accidentally touched, the skin will be uncomfortable in the light case, and the viscera will be damaged in the severe case. Therefore, between the research operations, the protective equipment must be comprehensive, and the operation regulations must be strictly observed.
The study of toxicity is not only to avoid harm, but also to make better use of this substance. Only by knowing the degree of its toxicity can it be used in the right way, so that its advantages outweigh the disadvantages, and contribute to the progress of chemistry and the good of life, while preventing it from being a disaster to the world.
Future Prospects
2 - Bromo - 4 - Fluoro - 1 - Methoxybenzene is also a wonder of transformation. Its future prospects can be deeply considered.
In today's world, technology is new, and this compound is expected to be greatly improved in many fields. For research and development, it may become the basis for special effects, and it is extraordinary to eliminate diseases and diseases. In the field of materials, it may also be the characteristics of new materials, and the materials can be used in high-tech equipment with their unique capabilities.
In addition, the synthesis method may also have a refined space. Make the work more efficient, the higher the efficiency, the lower the cost, and the energy can be widely used. Therefore, our researchers should diligently explore the unexplored possibilities of this compound, so as to promote the future development of this compound and benefit the world.
Where to Buy 2-Bromo-4-Fluoro-1-Methoxybenzene in China?
As a trusted 2-Bromo-4-Fluoro-1-Methoxybenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 2-Bromo-4-Fluoro-1-Methoxybenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 2-bromo-4-fluoro-1-methoxybenzene?
2-% hydroxyl-4-ene-1-aminoformylpyridine, although this substance is not explicitly mentioned in "Tiangong Kaiwu", its use can be deduced based on ancient and modern pharmaceutical and chemical knowledge.
In the field of medicine, it may have antibacterial and anti-inflammatory properties. Many compounds containing similar structures often exhibit inhibitory effects on the growth of microorganisms such as bacteria and fungi. Such as pyridine ring and alkenyl group, aminoformyl group, etc., can be embedded in the activity check point of key metabolic enzymes of bacteria, hinder their normal metabolism, achieve antibacterial effect, or can be used to treat infectious diseases.
Furthermore, it can be used as a drug synthesis intermediate. Due to its unique chemical structure, it can undergo various chemical reactions and combine with other functional groups to build complex drug molecular structures. In modern drug research and development, such pyridine derivatives containing specific functional groups are often important synthetic blocks, helping chemists create new drugs with better efficacy and fewer side effects.
In the chemical industry, or can participate in the synthesis of polymer materials. Alkenyl groups can undergo polymerization reactions and copolymerize with other monomers, giving polymer materials special properties, such as improving the mechanical strength, thermal stability or improving their solubility, etc., or used in the manufacture of engineering plastics, fibers, etc.
In addition, there may be applications in the field of pesticides. Some compounds with pyridine structure have repellent and poisoning effects on pests, and 2-hydroxy- 4-ene-1-aminoformylpyridine or due to its own structure, has biological activity on some pests, and is developed as a new type of pesticide for agricultural pest control to ensure crop yield and quality.
What are the physical properties of 2-bromo-4-fluoro-1-methoxybenzene?
The physical properties of 2-% hydroxyl-4-ether-1-aminophenyl are as follows:
The color state of this substance is usually white to slightly yellow crystalline powder, which is quite stable at room temperature and pressure. Looking at its appearance, it is fine and uniform in texture, without obvious agglomeration or impurities.
When it comes to solubility, its solubility in water is limited, but it shows good solubility in some organic solvents, such as ethanol and acetone. This property allows for the selection of suitable solvents according to needs to achieve the purpose of dissolution in a specific chemical process or preparation.
Its melting point is also one of the important physical properties. After measurement, it is within a certain temperature range. This melting point characteristic helps to play a key role in the purification, identification and quality control of substances. The purity and authenticity of the substance can be judged by melting point measurement.
Furthermore, its density has a fixed value under specific conditions. This value reflects the mass of the substance per unit volume. It is of great significance in terms of material measurement, mixing ratio calculation, and compatibility with other substances. It can accurately control the dosage and ratio of the reaction material.
As for its stability, under normal storage conditions, it can be stored for a long time in a dry, cool and well-ventilated place without significant chemical changes. However, exposure to strong light, high temperatures, or high humidity may cause changes in its physical or chemical properties, which in turn affect its effectiveness.
What are the chemical properties of 2-bromo-4-fluoro-1-methoxybenzene?
2-% hydroxyl-4-ene-1-aminoformyl pyridine, this is an organic compound with unique chemical properties. In its structure, the hydroxyl group coexists with the alkenyl group and the aminoformyl group, and affects each other, giving the substance a variety of chemical activities.
In terms of reactivity, the hydroxyl group at the 2 position has a certain nucleophilicity. Due to the strong electronegativity of the oxygen atom, the oxygen-hydrogen bond electron pair in the hydroxyl group is biased towards oxygen, making hydrogen acidic to a certain extent and can participate in acid-base reactions. In the case of strongly basic substances, the hydrogen of the hydroxyl group is easily taken away, generating corresponding negative ions, and then participating in nucleophilic substitution or addition reactions. For example, when it encounters halogenated hydrocarbons, hydroxyl negative ions can attack the carbon atoms of halogenated hydrocarbons. When the halogen atoms leave, a nucleophilic substitution reaction occurs, forming a new carbon-oxygen bond and deriving ether compounds. The alkenyl group at the
4 position is an electron-rich system with high reactivity. The carbon-carbon double bond in the alkenyl group contains a π electron cloud, which is vulnerable to attack by electrophilic reagents. Common electrophilic reagents such as halogens and hydrogen halides can undergo electrophilic addition reactions with alkenyl groups. Take bromine as an example. When the bromine molecule is close to the alkenyl group, it is polarized by the π electron cloud, and the positively charged end is close to the alkenyl group to form a ternary cyclic bromide ion intermediate. Then the negative bromine ion attacks from The alkenyl group can also participate in the Diels-Alder reaction. As a diene or dienophile, it reacts with suitable conjugated dienes or dienophiles to construct complex cyclic structures, which are widely used in organic synthesis. The aminoformyl group at the
1 position affects the stability and reaction selectivity of the molecule. The nitrogen atom in the aminoformyl group has a lone pair of electrons, which can form a conjugation effect with the surrounding atoms, which makes the molecular electron cloud distribution more uniform and enhances the stability. At the same time, this conjugation effect also affects the electron cloud density of other parts of the molecule, which in turn affects the reaction activity and selectivity. For example, in some electrophilic substitution reactions, the aminoformyl group can guide the electrophilic reagent to attack a specific location through the con
2-Hydroxy-4-ene-1-aminoformylpyridine exhibits rich chemical properties due to the interaction of various functional groups, and has potential application value in organic synthesis, medicinal chemistry and other fields. It can be used as an important intermediate for the synthesis of compounds with complex structures and unique functions.
What are the synthesis methods of 2-bromo-4-fluoro-1-methoxybenzene?
To prepare 2-hydroxy-4-ether-1-aminoformylbenzene, there are various methods.
First, benzene can be used as the starting point. First, by halogenation, halogen atoms are introduced into the benzene ring, and suitable halogenating agents, such as halogen elemental substances, are selected in the catalytic environment to make them electrophilically substituted with benzene to obtain halogenated benzene. After etherification, suitable alcohols and bases are selected, and halogenated benzene reacts with alcohol to form corresponding ethers. Then hydroxylation is performed, and the hydroxyl groups on the benzene ring are increased by specific reagents and conditions. Finally, the method of carbamylation is used, and the carbamylation reagent, such as phosgene derivatives, is used to react with the precursor to obtain 2-hydroxyl-4-ether-1-aminoformylbenzene.
Second, it can also be started from benzene derivatives with specific substituents. If the starting material contains some of the desired substituents, it can be converted by functional group. If there is a benzene derivative containing an ether group first, it can be hydroxylated to make ortho or para-hydroxyl groups. Then, by the method of carbamylation, the amino formyl group can be introduced, which can also achieve the goal.
Or, using a compound containing a polyfunctional group as a raw material, it can be gradually broken and bonded. For example, a phenyl ring containing convertible functional groups, by hydrolysis, condensation and other reactions, the functional groups are converted in sequence, and the structure of 2-hydroxy- 4-ether-1-aminoformylbenzene is gradually constructed.
The method of preparing this substance is not the same. It should be carefully selected according to the availability of raw materials, the difficulty of reaction, the high cost and many other factors to achieve efficient, economical and environmentally friendly synthesis.
What are the precautions for storing and transporting 2-bromo-4-fluoro-1-methoxybenzene?
For 2-% cyanogen-4-alkyne-1-methoxybenzene, many key matters must be paid attention to during storage and transportation.
Safety is the top priority. Because of its special chemical properties, it is a dangerous chemical, and safety regulations must be strictly observed during storage and transportation. Storage should be in a well-ventilated, cool and dry place, and away from fire sources, heat sources and all kinds of flammable and explosive materials to prevent the risk of fire and explosion. During transportation, proper protective measures should also be taken to ensure that the means of transportation are in good condition to prevent leakage.
Furthermore, there are strict requirements for packaging. Packaging must be tight and sealed to prevent leakage. The packaging materials used must be resistant to the corrosion of the substance, and can withstand certain pressure and vibration to ensure stability during transportation and storage. On the packaging, warning signs should be clearly marked, such as dangerous goods labels, toxicity labels, etc., so that the contact person can see at a glance and dispose of it with caution.
At the same time, the professional quality of storage and transportation personnel should not be underestimated. The relevant workers, when professionally trained, are familiar with the characteristics, hazards and emergency treatment methods of 2-% cyanogen-4-alkyne-1-methoxybenzene. In case of emergencies, such as leaks, they can respond quickly and correctly to minimize the harm.
In addition, relevant records cannot be ignored. During the storage process, the time, quantity, batch and other information of entering and leaving the warehouse should be recorded in detail; when transporting, the transportation route, time, handling personnel and other records should also be kept. Such records not only help to trace the flow of the product, but also provide an important basis for investigation and handling in the event of an accident.
In short, 2-% cyanogen-4-alkyne-1-methoxybenzene needs to be treated with caution in terms of safety, packaging, personnel quality and records during storage and transportation, and must not be sloppy at all to ensure the safety of the whole process.