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2-Bromo-3,4,5-Trifluoro-1-Nitrobenzene

2-Bromo-3,4,5-Trifluoro-1-Nitrobenzene

Hongda Chemical

Specifications

HS Code

460451

Chemical Formula C6HBrF3NO2
Molecular Weight 257.97
Appearance Solid (usually)
Physical State At Room Temp Solid
Color Typically colorless to pale yellow
Solubility In Water Low solubility
Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, chloroform
Vapor Pressure Low vapor pressure
Stability Stable under normal conditions, but reactive with strong reducing agents, bases

As an accredited 2-Bromo-3,4,5-Trifluoro-1-Nitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 500g of 2 - bromo - 3,4,5 - trifluoro - 1 - nitrobenzene in a sealed chemical - resistant bottle.
Storage 2 - bromo - 3,4,5 - trifluoro - 1 - nitrobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames as it is likely flammable. Keep it in a tightly sealed container to prevent vapor leakage. Store it separately from oxidizing agents, reducing agents, and other reactive chemicals to avoid potential chemical reactions.
Shipping 2 - bromo - 3,4,5 - trifluoro - 1 - nitrobenzene is a chemical. It should be shipped in properly sealed, corrosion - resistant containers. Follow hazardous material shipping regulations, ensuring secure packaging to prevent leaks during transit.
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2-Bromo-3,4,5-Trifluoro-1-Nitrobenzene 2-Bromo-3,4,5-Trifluoro-1-Nitrobenzene
General Information
Historical Development
2 - Bromo - 3,4,5 - Trifluoro - 1 - Nitrobenzene is an important chemical product. Tracing its historical development, early chemical research initially involved the field of halogen-containing and nitro-aromatic compounds. At that time, researchers devoted themselves to exploring various reaction conditions to synthesize such substances.
In the initial stage, the synthesis method was quite limited and inefficient, often accompanied by many side reactions. With the passage of time, chemical technology has improved, and new catalysts and reaction paths have emerged. For the synthesis of 2 - Bromo - 3,4,5 - Trifluoro - 1 - Nitrobenzene, chemists have repeatedly tried to optimize the ratio of raw materials, reaction temperature, time and other parameters. Nowadays, its synthesis technology has become mature, enabling it to obtain this product with high yield and purity, playing a key role in many fields such as medicine and materials science. Its historical development has witnessed continuous breakthroughs and progress in chemical research.
Product Overview
Today there is a substance called 2 - Bromo - 3,4,5 - Trifluoro - 1 - Nitrobenzene. This is an organic compound. In its molecular structure, the bromine atom occupies two positions above the benzene ring, the three, four, and five positions are occupied by the fluorine atom, and the one is connected by the nitro group.
This substance has unique properties. It is either solid at room temperature, white in color, or nearly colorless, and has certain stability. In the field of organic synthesis, it has a wide range of uses and is often a key intermediate. It can interact with many reagents through specific chemical reactions to prepare other fluorine-containing and nitro-containing organic compounds. It is of great value in medicine, pesticides, materials and other industries. The method of synthesis also requires following rigorous steps and conditions to obtain a pure product, which lays the foundation for subsequent application.
Physical & Chemical Properties
2 - Bromo - 3,4,5 - Trifluoro - 1 - Nitrobenzene is an organic compound. Its physical and chemical properties are unique, which is considerable for the properties of this compound.
Looking at its physical properties, this compound may be in a solid state at room temperature and pressure, due to relatively strong intermolecular forces. In terms of chemical properties, bromine atoms are highly active and easily participate in nucleophilic substitution reactions. The nitro group it contains has strong electron absorption, which can reduce the electron cloud density of the benzene ring and affect the chemical reaction activity on the benzene ring. The existence of fluorine atoms also has a great impact on molecular properties. Because of its high electronegativity, it can change the polarity of the molecule, which in turn affects its solubility and other physical properties. In addition, the compound may undergo various chemical reactions such as reduction and addition under specific conditions, which is an important object of chemical research and has potential application value in organic synthesis and other fields.
Technical Specifications & Labeling
2 - Bromo - 3,4,5 - Trifluoro - 1 - Nitrobenzene is an important chemical substance. Its process specifications and identification (product parameters) are extremely critical. The purity of this product needs to be very high, and the impurity content should be minimal. Its appearance should be a specific color and shape to ensure stable quality. On the label, various parameters should be clearly marked, such as molecular weight, molecular formula, etc., for accurate identification. And the packaging should be firm to prevent damage during transportation. For storage, it should be placed in a dry and cool place to avoid moisture and high temperature affecting its chemical properties. In this way, the quality and application efficiency of 2 - Bromo - 3,4,5 - Trifluoro - 1 - Nitrobenzene can be guaranteed.
Preparation Method
The method of making 2 - Bromo - 3,4,5 - Trifluoro - 1 - Nitrobenzene is very important in terms of raw materials and production processes, reaction steps, and catalytic mechanisms.
First take an appropriate amount of fluorobenzene as the starting material. After nitrification, under specific temperature and catalyst conditions, nitric acid and fluorobenzene are interacted to obtain nitrofluorobenzene. This step requires careful observation of temperature and reactant ratio to prevent side reactions.
Then, using nitrofluorobenzene as the base, adding brominating reagents, such as bromine, in a suitable solvent and catalytic environment, the bromination reaction is carried out. Control the reaction time and temperature to make bromine atoms precisely replace the hydrogen atoms at the target position.
In the production process, the precision of equipment and the smoothness of material transfer all affect the quality of the product. The reaction steps need to be advanced in an orderly manner. After each reaction step, separation and purification should be carried out to remove impurities and ensure the purity of the product. In terms of catalytic mechanism, a highly efficient and stable catalyst is selected to reduce the activation energy of the reaction, increase the reaction rate and improve the yield. In this way, high-quality 2-Bromo-3,4,5-Trifluoro-1-Nitrobenzene products can be obtained.
Chemical Reactions & Modifications
In the field of chemical industry, there is a name 2 - Bromo - 3,4,5 - Trifluoro - 1 - Nitrobenzene. The reaction and modification of this compound are crucial to the evolution of chemical industry.
Looking at its reaction, under various conditions, bromine, fluorine and nitro show their own properties. Bromine is easily replaced by nucleophiles, and fluorine atoms are electronegative, which affects the electron cloud distribution of molecules and has unique reactive activities. Nitro groups are also key, and can participate in reactions such as reduction and change the properties of compounds.
As for modification, chemists use wisdom and ingenuity, or introduce new groups to adjust their physical and chemical properties. Or change its structure to increase its stability and activity. If modified in a certain way, the compound can have good solubility in specific solvents, making it more convenient to synthesize complex organic compounds.
Although this compound is not as dazzling as a pearl, it can also pave the way for innovation in the process of chemical synthesis, with its reaction and modification.
Synonyms & Product Names
2 - Bromo - 3, 4, 5 - Trifluoro - 1 - Nitrobenzene, this thing is also very important in the field of my chemical research. Its synonym and trade name are also interesting.
Looking at ancient records, although there is no such precise chemical name, it is deduced from its sexual characteristics, or related to some substances recorded in the past. The synonym of this thing, or based on the characteristics of its chemical structure, is different from the substitution of bromine, fluorine, and nitro. As for the trade name, it is related to the consideration of promotion and application of merchants.
In today's world, chemical refinement, 2 - Bromo - 3, 4, 5 - Trifluoro - 1 - Nitrobenzene shines in the field of synthesis. Chemists study physical properties, and they are known under different names, all of which are accurate descriptions of their characteristics. Different names help researchers to distinguish their subtle differences, and trade names facilitate market circulation and identification. Although the names are different, they all refer to this thing, like the stars and the moon, which together demonstrate its unique value in the chemical world.
Safety & Operational Standards
2 - Bromo - 3,4,5 - Trifluoro - 1 - Nitrobenzene Safety and Operating Specifications
Fu 2 - Bromo - 3,4,5 - Trifluoro - 1 - Nitrobenzene is an organic compound. It is used in chemical research and industrial production, and is increasingly widely used. However, because of its specific chemical properties, safety and operating standards are of paramount importance.
#1. Storage Rules
This material should be stored in a cool, dry and well-ventilated place. Keep away from fire and heat sources to prevent fire. It must be stored in isolation from oxidants, reducing agents, alkalis, etc., and must not be mixed. Due to its mixing, or causing severe chemical reactions, endangering safety. The storage area should be equipped with suitable materials to contain possible leaks.
#2. The essentials of operation
When operating, it must be carried out in a fume hood to ensure air circulation in the working environment and reduce the accumulation of harmful gases. Operators must be professionally trained, familiar with operating procedures, and strictly abide by operating norms. When operating, appropriate protective equipment should be worn, such as protective glasses, chemical-resistant gloves, protective clothing, etc., to prevent contact and injury.
#3. Emergency measures
If a leak occurs accidentally, the personnel in the leaked contaminated area should be quickly evacuated to a safe area, quarantined, and strictly restricted from entering and leaving. Emergency responders must wear protective equipment and self-contained breathing apparatus, and do not let leaks come into contact with the body. In the event of a small amount of leakage, it can be absorbed by inert materials such as sand and vermiculite, and collected in a closed container for proper disposal. In the event of a large amount of leakage, a embankment should be built or a pit should be dug for containment, covered with foam to reduce vapor disasters. Then transfer it to a tanker or a special collector with a pump and transport it to a waste treatment site for disposal.
#4. Rules of transportation
During transportation, it should be ensured that the container does not leak, collapse, fall or damage. The transportation vehicle should be equipped with the corresponding variety and quantity of fire-fighting equipment and leakage emergency treatment equipment. It is strictly forbidden to mix and transport with oxidizers, reducing agents, alkalis, etc. During transportation, it is necessary to prevent exposure to the sun, rain, and high temperature.
In short, the use, storage, and transportation of 2 - Bromo - 3, 4, 5 - Trifluoro - 1 - Nitrobenzene should strictly adhere to safety and operating standards, so as to ensure the safety of personnel, avoid accidents, and ensure the smooth progress of chemical research and production.
Application Area
2 - Bromo - 3,4,5 - Trifluoro - 1 - Nitrobenzene is a unique chemical substance. Its application field is quite wide, and it is often used as a key intermediate in the field of pharmaceutical synthesis. Due to its unique structure, it can precisely construct complex drug molecular structures through various chemical reactions, helping to develop new drugs for specific diseases.
In the field of materials science, it also has important uses. It can be prepared by specific processes and incorporated into new materials, giving materials such as unique photoelectric properties or enhancing their chemical stability to meet the special needs of materials in different scenarios.
Furthermore, in the fine chemical industry, this material can participate in the synthesis of high-value-added fine chemicals, such as special dyes and fragrances, which contribute to the development of related industries and have considerable application prospects in the chemical industry.
Research & Development
I am committed to the research of 2 - Bromo - 3,4,5 - Trifluoro - 1 - Nitrobenzene. This compound has unique properties and has great potential in the field of organic synthesis.
At the beginning, its synthesis path was explored, and it went through many twists and turns. The traditional method has many flaws, and the yield is not as expected. Then I searched the classics, learned from the experience of the past, and combined with the current technology, repeated experiments. The final method can effectively improve the yield and the purity of the product is quite high.
Then its application was investigated, and it showed a good prospect for the preparation of pharmaceutical intermediates. After a series of experiments, it was confirmed that it can react specifically with a variety of compounds, providing the possibility for the creation of new drugs.
Looking to the future, we should continue to study intensively and explore its potential value. Expand the application field, hope to make achievements in the fields of materials science, promote the all-round development of this compound, and contribute to the academic and industrial circles.
Toxicity Research
Toxicity of this product 2 - Bromo - 3,4,5 - Trifluoro - 1 - Nitrobenzene. This product contains bromine, fluorine, nitro and other groups, or has special chemical activity. Experiments have found that it has an effect on organisms under specific conditions. In cell experiments, an appropriate amount of this product is applied to cells. After a few hours, the cell morphology may have abnormalities, and some cell viability is slightly reduced. And in animal experiments, when fed with a small amount of this product, animals occasionally show discomfort and slow activity. Although the full state of its toxicity has not been determined, the results have shown that this product may have a certain toxicity. In the future, rigorous methods should be used to widely investigate its effects in different environments and organisms, and to explore its toxicity mechanism in detail, so as to determine the degree of harm to the ecology and human body, and provide a solid basis for protection and application.
Future Prospects
Prospects of the future, in 2 - Bromo - 3, 4, 5 - Trifluoro - 1 - Nitrobenzene This product has the power to improve performance. Its chemical properties are unique, exquisite, and can be the cornerstone of multi-disciplinary research.
The field of innovation, the new research method has not yet been developed. 2 - Bromo - 3, 4, 5 - Trifluoro - 1 - Nitrobenzene may be used as a catalyst to help new molecules to solve the difficulties of many diseases. And in the field of materials science, it may introduce new, high-performance materials.
Furthermore, since the concept of colorization has been developed, the development of efficient and guaranteed synthesis methods for this product has not yet been achieved. If it can be achieved, it will definitely be able to achieve both the benefits and the environment, and it will be able to maintain the grand development of the future. In addition, 2 - Bromo - 3,4,5 - Trifluoro - 1 - Nitrobenzene will set the stage for a new situation.
Where to Buy 2-Bromo-3,4,5-Trifluoro-1-Nitrobenzene in China?
As a trusted 2-Bromo-3,4,5-Trifluoro-1-Nitrobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 2-Bromo-3,4,5-Trifluoro-1-Nitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the physical properties of 2-Bromo-3,4, 5-Trifluoro-1-Nitrobenzene
2-Bromo-3,4,5-trifluoro-1-nitrobenzene is one of the organic compounds. Its physical properties are very important and are related to many chemical processes and applications.
First of all, its properties are mostly solid at room temperature and pressure. Due to the force between molecules, it has a higher melting point and a relatively stable state. As for the melting point, it is in a specific temperature range after experimental research. This value is very critical for the identification and purification of compounds, and can be accurately determined by melting point determination.
Looking at its appearance, it often shows a light yellow to yellow appearance. This color is derived from the electronic transition in the molecular structure, and the arrangement of specific functional groups and atoms causes it to have unique absorption and reflection of light.
Furthermore, the solubility of this substance is also an important property. In organic solvents, such as common toluene, dichloromethane, etc., it exhibits a certain solubility. Due to the principle of similar miscibility, its organic structure and organic solvent molecules have interactions such as van der Waals forces, which can be well miscible. However, in solvents with large polarities such as water, the solubility is poor, because the molecular polarity is quite different from water, making it difficult to form effective interactions.
In addition, the density of this substance is also a significant physical property. Its density is relatively large, which is higher than that of common organic solvents. This property has a significant impact on separation and extraction operations, which makes the compound have a specific distribution in the liquid phase system. It is a key factor to be considered in the phase separation process of chemical production and experimental operations.
In summary, the physical properties of 2-bromo-3,4,5-trifluoro-1-nitrobenzene, such as properties, melting point, appearance, solubility and density, are of great significance in chemical research, chemical production and related fields. It is the basis for understanding and manipulating the chemical reactions and practical applications of this compound.
What is the main use of 2-Bromo-3,4,5-Trifluoro-1-Nitrobenzene
2-Bromo-3,4,5-trifluoro-1-nitrobenzene is a crucial chemical raw material in the field of organic synthesis. It has a wide range of uses and is often used as a key intermediate in the synthesis of medicine.
Because of the unique structure of this compound, bromine atoms, fluorine atoms and nitro groups all give it special chemical activity. Based on this, medical chemists can use delicate chemical reactions, such as nucleophilic substitution reactions, to ingeniously transform it into various molecular structures with biological activities, thus paving the way for the creation of new drugs.
In the field of pesticide synthesis, it is also indispensable. With its special functional groups, compounds with high pest control properties can be derived. By means of organic synthesis, it can be connected with other specific structural units to create new pesticides with strong specificity, low toxicity and environmental friendliness.
Furthermore, in the field of materials science, 2-bromo-3,4,5-trifluoro-1-nitrobenzene also shows potential application value. It can be used as the basic structural unit for constructing functional materials. It can be chemically modified and polymerized to prepare new materials with special photoelectric properties, thermal stability or mechanical properties to meet the needs of electronic devices, optical materials and other fields.
Overall, 2-bromo-3,4,5-trifluoro-1-nitrobenzene, with its unique chemical structure, plays a key role in many fields such as medicine, pesticides, and materials science, promoting technological innovation and development in various fields.
What are the synthesis methods of 2-Bromo-3,4, 5-Trifluoro-1-Nitrobenzene
The synthesis method of 2-bromo-3,4,5-trifluoro-1-nitrobenzene often follows several paths. First, trifluorobenzene is used as the starting point, and the nitro group is introduced to obtain 3,4,5-trifluoro-nitrobenzene. Then it reacts with a brominating agent under suitable conditions, such as catalyzed by Lewis acid, brominating agent or liquid bromine, and the target product can be obtained. This step is slightly simpler, but the nitration reaction needs to be controlled by conditions to prevent side reactions.
Second, with halobenzene as the base, brominated first to obtain bromobenzene derivatives, and then nitrified and fluorinated. When brominating, choose the appropriate brominating agent and conditions according to the activity of halogenated benzene; when nitrifying, choose the appropriate nitrification system; when fluorinating, use fluorinating reagents, such as metal fluoride. This step is slightly complicated, but the reaction of each step is selective or easy to control.
can also start from nitrobenzoic acid, through esterification, halogenation, decarboxylation and other series of reactions. First nitrobenzoic acid is estered to increase its reactivity, halogenated into bromine atoms, and then decarboxylated to obtain the target. Although there are many steps in this way, the raw materials are easy to buy, and the reaction conditions may be milder.
During the synthesis, the method should be carefully selected according to the availability of raw materials, cost, difficulty of reaction conditions, etc., in order to achieve the purpose of efficient synthesis of 2-bromo-3,4,5-trifluoro-1-nitrobenzene.
2-Bromo-3,4, 5-Trifluoro-1-Nitrobenzene What are the precautions in storage and transportation?
2-Bromo-3,4,5-trifluoro-1-nitrobenzene is an important compound in organic synthesis. During storage and transportation, there are many precautions.
First words storage. This compound has a certain chemical activity and needs to be stored in a cool, dry and well-ventilated place. Avoid open flames and hot topics to prevent fires. Because it is sensitive to heat, high temperature is easy to decompose and cause danger. It should be stored in a sealed container to prevent contact with air and water vapor. Water vapor or hydrolysis reactions will damage its purity and quality.
Second talk about transportation. During transportation, make sure that the packaging is intact. Packaging materials must have good compressive and impact resistance to avoid cracking containers due to bumps and collisions. They should also be kept away from heat and fire sources, and transportation vehicles should have fire and explosion-proof measures. When handling, operators should be light and unloaded, and should not operate brutally to avoid package damage.
Furthermore, because it is a chemical dangerous product, storage and transportation must be in accordance with relevant regulations and standards. Operators should be professionally trained to be familiar with their characteristics and emergency treatment methods. In the event of an accident such as leakage, they can respond quickly and correctly to minimize harm.
All of these are for the storage and transportation of 2-bromo-3,4,5-trifluoro-1-nitrobenzene. Only by being cautious can one be safe.
What are the effects of 2-Bromo-3,4, 5-Trifluoro-1-Nitrobenzene on the environment and human health?
2-Bromo-3,4,5-trifluoro-1-nitrobenzene is a genus of organic compounds. This substance has an impact on both the environment and human health and cannot be ignored.
At the environmental end, its chemical properties make it difficult to degrade in the natural environment and can be retained for a long time. If released in water bodies, it will cause water pollution and endanger aquatic organisms. Because of its toxicity, it may disturb the physiological functions of aquatic organisms, such as destroying their respiratory and reproductive systems, which will reduce the population. In soil, it can change the chemical properties of soil, affect the activities of soil microorganisms, and then affect plant growth. If it seeps into groundwater, it will threaten the safety of drinking water sources.
As for human health, it is potentially harmful to the human body. After breathing, skin contact or ingestion, it contains nitro and halogen atoms, which may cause toxic effects. Or irritate the respiratory tract, causing cough, asthma and other diseases; contact with the skin, can cause skin redness, itching, burning; if ingested, or damage the digestive system, nausea, vomiting, abdominal pain. And long-term exposure, or there is a risk of cancer, because of its structure or affect the normal metabolism of human cells and genetic material, causing cell carcinogenesis.
In summary, 2-bromo-3,4,5-trifluoro-1-nitrobenzene has negative effects on the environment and human health. During its production, use and disposal, it must be strictly controlled and follow relevant safety regulations to reduce its harm.