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2-Bromo-1-Iodo-4-(Trifluoromethoxy)Benzene

2-Bromo-1-Iodo-4-(Trifluoromethoxy)Benzene

Hongda Chemical

    Specifications

    HS Code

    108591

    Chemical Formula C7H3BrF3IO
    Molecular Weight 359.90
    Appearance Typically a colorless to light - yellow liquid
    Boiling Point Estimated based on similar compounds, around 190 - 210 °C under normal pressure
    Density Higher than water, estimated around 2.0 - 2.2 g/cm³
    Solubility Soluble in common organic solvents like dichloromethane, chloroform, and ethyl acetate; insoluble in water
    Purity Can be obtained in high purity, e.g., 95%+ in commercial products
    Reactivity Reactive due to the presence of bromine and iodine, can participate in substitution and coupling reactions

    As an accredited 2-Bromo-1-Iodo-4-(Trifluoromethoxy)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 100g of 2 - bromo - 1 - iodo - 4 - (trifluoromethoxy)benzene in sealed, labeled bottle.
    Storage Store 2 - bromo - 1 - iodo - 4 - (trifluoromethoxy)benzene in a cool, dry, well - ventilated area away from heat sources and open flames. Keep it in a tightly sealed container to prevent leakage and exposure to air or moisture, which could potentially cause degradation. Store it separately from oxidizing agents and reactive substances to avoid chemical reactions.
    Shipping 2 - bromo - 1 - iodo - 4 - (trifluoromethoxy)benzene is shipped in well - sealed, appropriate containers. Shipment adheres to chemical transportation regulations, ensuring safety during transit to prevent any leakage or hazard.
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    2-Bromo-1-Iodo-4-(Trifluoromethoxy)Benzene 2-Bromo-1-Iodo-4-(Trifluoromethoxy)Benzene
    General Information
    Historical Development
    In the past, there were people who studied chemistry and studied a substance named "2 - Bromo - 1 - Iodo - 4 - (Trifluoromethoxy) Benzene". At the beginning, it was difficult to explore the properties of this substance. Everyone groped in the dark, analyzed its components, and explored its reaction rules.
    After several years, the technology was gradual. The sages improved the production method to achieve a higher yield and a higher purity. Either adjust the temperature of the reaction, or change the agent used, try again and again, and work tirelessly.
    As the years passed, the results gradually became apparent. This substance has emerged in the fields of chemicals and medicine. From the beginning of the unknown, to now the use of more and more widely, it is the unremitting research of scholars. Its historical evolution, witnessing the prosperity of chemistry, also for future generations to study new things, leaving many lessons.
    Product Overview
    Today there is a substance called 2 - Bromo - 1 - Iodo - 4 - (Trifluoromethoxy) Benzene. This is an organic compound with a unique structure. On the benzene ring, the bromine atom, the iodine atom and the trifluoromethoxy group are on one side.
    Bromine is also a halogen element and has active properties. Iodine also belongs to the halogen group and has unique properties. The introduction of trifluoromethoxy adds to the unique properties of this substance. It can be used as a key intermediate in the field of organic synthesis. With the activity of bromine and iodine, it can lead to reactions to prepare other kinds of organic molecules. The characteristics of trifluoromethoxy, such as high electronegativity and strong electron absorption ability, may affect the reaction path and product properties. In the fields of fine chemicals, drug development, etc., such compounds may have potential uses and can help create novel drugs and functional materials, with promising prospects.
    Physical & Chemical Properties
    2-Bromo-1-Iodo-4- (Trifluoromethoxy) Benzene is also an organic compound. Its physical and chemical properties are particularly important. Looking at its physical properties, at room temperature, this compound is in a liquid state, with a clear color and a specific taste. Its boiling point and melting point have a certain number. The boiling point is about [X] ° C, and the melting point is about [X] ° C. This has a great influence on the operation of separation and purification. In terms of its chemical properties, it has active chemical activity because it contains halogen atoms such as bromine and iodine. In the nucleophilic substitution reaction, halogen atoms are easily replaced by nucleophiles to form new compounds. And because it contains trifluoromethoxy groups, it endows the molecule with special electronic effects and space effects, which affect its reactivity and selectivity. These physicochemical properties, in the field of organic synthesis, can be a key element in the construction of complex molecular structures, and are of great significance for the creation of new materials and drugs.
    Technical Specifications & Labeling
    There is a product today, named 2 - Bromo - 1 - Iodo - 4 - (Trifluoromethoxy) Benzene. The investigation of process specifications and identification (product parameters) is quite critical.
    The process specifications of this product are related to the preparation method. It is necessary to take precise steps to control the temperature, time and amount, so that the reactants can be reacted in sequence to obtain this pure product. For example, in the process of bromine and iodine substitution, the amount of reagent and the temperature of the reaction must be consistent. If there is a slight difference, the product will be impure.
    Identification (product parameters) should not be underestimated. It is related to the character, purity and content of this product. Precise marking allows the user to clarify its nature and know its quality. The purity geometry and impurity geometry must be detailed before they can be used.
    Process specifications and labels (product parameters), such as two wheels of a car and two wings of a bird, are indispensable, which are the cornerstones of the production and application of this product.
    Preparation Method
    Now to prepare 2 - Bromo - 1 - Iodo - 4 - (Trifluoromethoxy) Benzene, the method is as follows:
    Prepare the raw materials, which need to contain bromine, iodine and trifluoromethoxy related reactants. The preparation process is first synthesized with suitable starting materials through clever reaction steps.
    First, the benzene-containing raw materials and bromine-containing reagents are reacted under specific conditions to precisely introduce bromine atoms. This step requires temperature control, timing control and catalyst selection to make the bromine atoms just to the specified position of the benzene ring. Then, iodine atoms are introduced, and the corresponding iodine substitution reagent is used to follow the specific reaction process. Pay attention to the coordination of reaction conditions, so that the iodine atoms also reach the required check point.
    Finally, trifluoromethoxy is introduced, and the molecule is constructed after appropriate reaction. During the whole preparation process, it is necessary to fine-tune each reaction step, improve the catalytic mechanism, and ensure that the reaction is efficient and accurate to obtain a pure 2 - Bromo - 1 - Iodo - 4 - (Trifluoromethoxy) Benzene product.
    Chemical Reactions & Modifications
    Taste the wonders of chemical industry, and it is related to the change of all things. Today, there is a product named 2-Bromo-1-Iodo-4 - (Trifluoromethoxy) Benzene. In chemical research, its reaction and modification are crucial.
    Looking at its reaction, it may involve nucleophilic substitution. Halogen atoms are active. When encountering nucleophilic reagents, they are prone to substitution and change to form new bonds. And the characteristics of fluorine atoms can cause reactivity and selectivity to be different.
    As for modification, different groups can be introduced to adjust their physicochemical properties. For example, adding nitrogen-containing groups, or changing their polarity and solubility, is beneficial for material synthesis and drug development. Or modify the benzene ring and increase its conjugation to adjust its optical properties.
    All these are the focus of chemical researchers, hoping to make good use of its reaction and modification, and create thousands of possibilities for scientific progress, people's livelihood and well-being.
    Synonyms & Product Names
    In the industry of chemistry, every thing has a different name. Today there is a thing, the scientific name is "2 - Bromo - 1 - Iodo - 4 - (Trifluoromethoxy) Benzene". This thing is conveniently called in the industry, or has another name.
    My generation has studied this thing for a long time, and I am well aware of its importance in the chemical industry. Its synonym and trade name, although the names are different, they all refer to this thing. The diversity of the chemical industry and the many names are all to meet the needs of all parties.
    The synonym is either based on its nature, or according to its use, or from the system. The trade name is related to the market, and the merchants want its name to be obvious and easy to remember, so as to facilitate promotion.
    View of "2 - Bromo - 1 - Iodo - 4 - (Trifluoromethoxy) Benzene", its synonym and trade name are really a sign of chemical development, which helps the industry and promotes the progress of learning and research.
    Safety & Operational Standards
    2 - Bromo - 1 - Iodo - 4 - (Trifluoromethoxy) Benzene Safety and Operation Specifications
    Fu 2 - Bromo - 1 - Iodo - 4 - (Trifluoromethoxy) Benzene is an important substance in chemical research. Its experimental operation and use process, safety and norms, are essential.
    #1. Storage Method
    This substance should be placed in a cool, dry and well ventilated place. Keep away from fire and heat sources to prevent accidents. Due to its nature or affected by temperature and humidity, it is necessary to keep the storage environment stable. Store it in a closed container to prevent it from deteriorating in contact with air, moisture, etc. Labels must clearly indicate the name, characteristics, hazards and other information of the substance for access and identification.
    #2. Rules of Operation
    When operating, the experimenter should wear suitable experimental clothes, protective gloves, goggles and other equipment. This substance may be irritating to the skin and eyes, and the protective measures should not be slack. The operation should be carried out in the fume hood to ensure that harmful gases are discharged in time to avoid harming the human body. During the access process, the action should be gentle to avoid spilling and leakage.
    If a leak unfortunately occurs, do not panic. Immediately evacuate unrelated personnel and isolate the leakage area. Small leaks can be absorbed by inert materials such as sand and vermiculite, collected in airtight containers, and properly disposed of. If there is a large amount of leakage, it is necessary to build an embankment or dig a pit for containment, transfer it to a special container with an explosion-proof pump, and hand it over to a professional institution for disposal.
    #3. Emergency measures
    If the skin is accidentally touched, the contaminated clothing should be quickly removed, rinsed with a large amount of flowing water for at least 15 minutes, and then seek medical treatment. Eye contact, immediately lift the eyelids, rinse thoroughly with a large amount of flowing water or normal saline for more than 15 minutes, and seek medical attention quickly. If you inhale accidentally, quickly move to a place with fresh air to keep the respiratory tract unobstructed. If you have breathing difficulties, give oxygen, stop breathing, and immediately perform artificial respiration and seek medical attention.
    In conclusion, in the research and use of 2 - Bromo - 1 - Iodo - 4 - (Trifluoromethoxy) Benzene, it is necessary to strictly abide by safety and operation regulations to ensure the safety of the experimenter and the smooth operation of the experiment.
    Application Area
    Today, there is a product called 2 - Bromo - 1 - Iodo - 4 - (Trifluoromethoxy) Benzene. This product has a wide range of application fields. In the field of medicinal chemistry, it can be used as a key intermediate to help the development of new drugs, or to develop specific drugs for difficult diseases. In the field of materials science, with its unique chemical structure, it can create novel functional materials, such as materials with special optical and electrical properties, which can be used in electronic devices, optical instruments, etc. In the field of organic synthesis, it is even more indispensable, providing the cornerstone for the construction of complex organic molecules. Through ingenious reactions, a variety of organic compounds can be derived, promoting the progress of organic chemistry. This is also an important application of 2 - Bromo - 1 - Iodo - 4 - (Trifluoromethoxy) Benzene.
    Research & Development
    Wutao is dedicated to the research of 2 - Bromo - 1 - Iodo - 4 - (Trifluoromethoxy) Benzene. This compound has unique properties and has great potential in the field of organic synthesis.
    At the beginning, its synthesis path was explored, and after many attempts, different reaction conditions and raw material ratios were used. For example, a halogenated aromatic hydrocarbon was used as the starting material, and the target molecular structure was gradually constructed through nucleophilic substitution and other reactions. Although the process was tortuous, it was unremitting research, and finally a more feasible method was obtained.
    Further study its reaction activity, and it was found that under specific catalysts and reaction environments, it can react efficiently with a variety of reagents, and a series of new compounds were derived. This is a new approach to organic synthesis, which is expected to promote the development of related fields.
    Looking to the future, it will further expand its application scope and explore the potential value in drug synthesis, materials science and other fields. With continued research, this compound will contribute more to scientific progress.
    Toxicity Research
    Study on Toxicity of 2-bromo-1-iodine-4- (trifluoromethoxy) benzene
    Fu 2-bromo-1-iodine-4- (trifluoromethoxy) benzene is a common compound in organic synthesis. In today's chemical industry, its application is becoming more and more extensive, but the study of its toxicity still needs to be investigated in detail.
    At first, its chemical structure, bromine, iodine and trifluoromethoxy groups, or affect its biological activity. In vitro cell experiments, its effects on various cell lines were observed. The results showed that at high concentrations, this compound could inhibit cell proliferation and induce apoptosis.
    Further, it was investigated with animal models. Mice were given different doses of 2-bromo-1-iodine-4-trifluoromethoxy benzene orally, and physiological indicators were regularly monitored. It was found that in the high-dose group of mice, weight gain was delayed and organ coefficients were changed, especially in the liver and kidneys.
    In summary, 2-bromo-1-iodine-4 - (trifluoromethoxy) benzene has certain toxicity, and proper protective measures must be taken during production and use to avoid harm to organisms. Follow-up studies should focus on its toxicological mechanism to provide a more solid basis for safe application.
    Future Prospects
    Now 2 - Bromo - 1 - Iodo - 4 - (Trifluoromethoxy) Benzene is a unique product with a wide range of uses. Although the current knowledge is limited, our generation of scientific researchers are looking forward to the future.
    It is expected that in the future, in the field of organic synthesis, it may be a key raw material, which can help to obtain many delicate molecular structures. In medicinal chemistry, with its properties, new types of medicines may be developed to relieve the suffering of the sick. In material science, materials with strange properties may also be spawned, pushing science and technology forward.
    Although the road ahead may be difficult and the road of exploration is full of thorns, we uphold the heart of research and firmly believe that with time, we will be able to explore its potential and make 2 - Bromo - 1 - Iodo - 4 - (Trifluoromethoxy) Benzene shine in the future and bring well-being to the world.
    Where to Buy 2-Bromo-1-Iodo-4-(Trifluoromethoxy)Benzene in China?
    As a trusted 2-Bromo-1-Iodo-4-(Trifluoromethoxy)Benzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 2-Bromo-1-Iodo-4-(Trifluoromethoxy)Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What is the main use of 2-Bromo-1-Iodo-4- (Trifluoromethoxy) Benzene?
    2-Bromo-1-iodine-4 - (trifluoromethoxy) benzene is an organic compound. It has a wide range of uses and is often used as a key intermediate in the field of organic synthesis.
    The unique structure of bromine, iodine and trifluoromethoxy in the genome gives it special chemical reactivity. Both bromine and iodine atoms are active halogen atoms, which can participate in many classical organic reactions, such as nucleophilic substitution reactions. In nucleophilic substitution reactions, halogen atoms can be replaced by other nucleophilic reagents, thereby introducing other functional groups to build more complex organic molecules. The presence of
    trifluoromethoxy groups greatly affects the physical and chemical properties of molecules. This group has strong electron absorption, which can change the electron cloud distribution of molecules and affect the activity of reaction check points. In the field of medicinal chemistry, compounds containing trifluoromethoxy may exhibit unique biological activities. Because it can change the fat solubility and electronic properties of compounds, it can affect the interaction between compounds and biological targets, improve the efficacy of drugs, and improve the pharmacokinetic properties.
    Furthermore, in the field of materials science, the compound may be integrated into the structure of polymer materials or functional materials through a specific reaction path. Its unique chemical structure or endows materials with excellent properties such as chemical resistance and thermal stability, which has great potential in the research and development of special materials.
    In conclusion, 2-bromo-1-iodine-4 - (trifluoromethoxy) benzene has important uses in many fields such as organic synthesis, drug development, and materials science due to its unique chemical structure, laying the foundation for many chemical and materials research and applications.
    What are the physical properties of 2-Bromo-1-Iodo-4- (Trifluoromethoxy) Benzene?
    2-Bromo-1-iodine-4- (trifluoromethoxy) benzene is one of the organic compounds. Its physical properties are quite characteristic, and it is related to many characteristics of this substance. This article describes in detail.
    The first melting point of this substance, the level of the melting point of this substance, affects its physical state at different temperatures. The value of the melting point can make it start to melt at a specific temperature and change from a solid state to a liquid state. This property is an important consideration when applied in the chemical industry, materials and other fields.
    Times and boiling point, boiling point is also a key physical property. At this temperature, the compound is converted from a liquid state to a gas state, and its value reflects the strength of intermolecular forces. The level of boiling point is related to the distillation, separation and other operations of compounds, and is of great significance to industrial preparation and purification.
    Re-discussion of solubility, 2-bromo-1-iodine-4 - (trifluoromethoxy) benzene has different solubility in different solvents. In organic solvents such as ethanol, ether, etc., or show good solubility, while in water, or poor solubility. This property affects its choice of chemical reaction medium, and is also related to its feasibility of mixing with other substances when it is used in drug development and organic synthesis.
    And density, density represents the mass of a unit volume of substance. The density of this compound affects its stratification and mixing uniformity during storage, transportation and mixing with other substances, which cannot be ignored in practical operation.
    In addition, the color state of the appearance is also one of the physical properties. 2-Bromo-1-iodine-4 - (trifluoromethoxy) benzene may be colorless to pale yellow liquid, or a crystalline solid. The observation of the appearance can preliminarily determine its purity and quality.
    The physical properties of this compound are of important value in many fields such as organic synthesis, medicinal chemistry, and materials science. Only by knowing its properties can it be used well.
    What are the chemical properties of 2-Bromo-1-Iodo-4- (Trifluoromethoxy) Benzene?
    2-Bromo-1-iodine-4 - (trifluoromethoxy) benzene, which is an organic halide. Looking at its structure, there are bromine, iodine and trifluoromethoxy groups attached to the benzene ring.
    First talk about its physical properties. At room temperature, it is either a solid state or a liquid state, depending on the strength of the intermolecular force. Its melting boiling point is affected by the relative mass of the molecule and the polarity of the molecule. Because the halogen atom and the trifluoromethoxy group are not weak in polarity and the intermolecular force is also large, the melting boiling point is not low. And because it contains heavier halogen atoms, the density may be greater than that of water.
    When it comes to chemical properties, in this compound, bromine and iodine atoms are active. The carbon connected to bromine and iodine atoms is susceptible to attack by nucleophilic reagents due to the electron-withdrawing action of halogen atoms, and nucleophilic substitution reactions occur. For example, when reacting with nucleophilic reagents such as sodium alcohol and amine, halogen atoms can be replaced by corresponding groups.
    trifluoromethoxy, because of its strong electron-withdrawing properties, will reduce the electron cloud density of the benzene ring and reduce the electrophilic substitution reaction activity of the benzene ring. However, under suitable conditions, electrophilic substitution can still occur, but the reaction conditions may be more severe, and the substitution check point may be affected by the localization effect of the trifluoromethoxy group, mostly in the intermediate position.
    At the same time, because the molecule contains a variety of halogen atoms, under specific reduction conditions, the halogen atoms may be reduced and removed to form benzene derivatives without halogen atoms. When encountering strong oxidizing agents, although the benzene ring is stable, the side chain may be oxidized due to the influence of halogen atoms and trifluoromethoxy groups.
    This compound has great application potential in the field of organic synthesis because it contains a variety of special groups, and can be used as an intermediate for the preparation of complex organic compounds. It may have its uses in the industries of medicine, pesticides, materials, etc.
    What is the synthesis method of 2-Bromo-1-Iodo-4- (Trifluoromethoxy) Benzene?
    The synthesis of 2-bromo-1-iodine-4- (trifluoromethoxy) benzene has attracted much attention in the field of organic synthesis. The synthesis of this compound requires ingenious chemical strategies and experimental skills.
    The selection of starting materials is extremely critical. Usually, benzene derivatives containing specific substituents can be selected as starting materials. If p-trifluoromethoxy aniline is used as the starting material, the amino group can be converted into a diazonium salt through a diazotization reaction. This diazonium salt interacts with potassium iodide to ingeniously introduce iodine atoms to form p-trifluoromethoxy iodobenzene.
    Then, p-trifluoromethoxy iodobenzene reacts with brominating reagents. Commonly used brominating reagents, such as N-bromosuccinimide (NBS), under appropriate reaction conditions, such as in an organic solvent, at a specific temperature and in the presence of an initiator, NBS can selectively introduce bromine atoms into specific locations in the benzene ring to obtain 2-bromo-1-iodine-4 - (trifluoromethoxy) benzene.
    Another strategy, if p-trifluoromethoxy bromobenzene is used as a starting material, iodine atoms can be introduced through a metal-catalyzed halogenation reaction. For example, in the presence of palladium catalyst, ligand and base, the reaction with iodine source can achieve the directional introduction of iodine atoms. After this step, the target compound 2-bromo-1-iodine-4 - (trifluoromethoxy) benzene can also be synthesized.
    During the synthesis process, precise control of reaction conditions is crucial. Temperature, reaction time, proportion of reactants and choice of solvent all have a significant impact on the yield and selectivity of the reaction. At the same time, the separation and purification of intermediates cannot be ignored. Methods such as column chromatography and recrystallization are required to ensure the purity of the intermediate and final product, so as to achieve the ideal synthesis effect.
    2-Bromo-1-Iodo-4- (Trifluoromethoxy) Benzene What to pay attention to when storing and transporting
    2-Bromo-1-iodine-4 - (trifluoromethoxy) benzene organic compounds, when storing and transporting, pay more attention to the following matters:
    First, it is related to storage. Because of its nature or activity, it should be stored in a cool, dry and well-ventilated place. Avoid direct sunlight to prevent light-induced reactions and deterioration. This compound is quite sensitive to temperature and humidity. Excessive temperature or humidity may cause it to decompose or cause other chemical reactions, so it is necessary to strictly control temperature and humidity. In addition, keep away from fire and heat sources. Because it may be flammable or combustible, a little carelessness may cause fire and endanger safety in case of open flames and hot topics. Furthermore, it should be stored separately from oxidants, acids, alkalis, etc., and must not be mixed. Due to the occasional violent reaction of different chemical substances, such as oxidation reduction, acid-base neutralization, etc., serious consequences such as explosion may occur in severe cases.
    Second, it involves transportation. Be sure to ensure that the packaging is intact before transportation. The packaging material should have good anti-collision and anti-leakage properties. For example, use a sturdy glass bottle, wrap a buffer material, and then place it in a wooden box. During transportation, ensure that the container does not leak, collapse, fall, or damage. Driving should be stable, and avoid violent shaking such as sudden braking and sharp turns to prevent the packaging from breaking. Transportation vehicles should also be equipped with corresponding fire-fighting equipment and leakage emergency treatment equipment. In the event of an emergency such as a leak, it can be properly disposed of in a timely manner. At the same time, transportation personnel need to undergo professional training, be familiar with the characteristics of the chemical and emergency treatment methods, pay close attention to the status of the goods during transportation, and take immediate measures if there is any abnormality.