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2-Bromo-1-Fluoro-4-Iodobenzene

2-Bromo-1-Fluoro-4-Iodobenzene

Hongda Chemical

Specifications

HS Code

986644

Name 2 - Bromo - 1 - Fluoro - 4 - Iodobenzene
Molecular Formula C6H3BrFI
Molecular Weight 299.89
Appearance Typically a liquid (but can vary based on purity and conditions)
Boiling Point Approximately 200 - 220 °C (estimated range, actual may vary)
Density Around 2.2 - 2.4 g/cm³ (estimated range)
Solubility Soluble in common organic solvents like dichloromethane, chloroform; insoluble in water
Stability Stable under normal conditions, but may react with strong oxidizing or reducing agents
Cas Number 77157 - 90 - 3

As an accredited 2-Bromo-1-Fluoro-4-Iodobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 500g of 2 - bromo - 1 - fluoro - 4 - iodobenzene in a sealed, chemical - resistant bottle.
Storage 2 - bromo - 1 - fluoro - 4 - iodobenzene should be stored in a cool, dry, well - ventilated area away from heat sources and open flames. Keep it in a tightly - sealed container, preferably made of glass or a compatible plastic, to prevent leakage and exposure to air or moisture. Store it separately from oxidizing agents and reactive chemicals to avoid potential reactions.
Shipping 2 - bromo - 1 - fluoro - 4 - iodobenzene is a chemical. For shipping, it must be in a well - sealed, appropriate container. Label it clearly as a chemical. Follow all hazardous material shipping regulations to ensure safe transportation.
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2-Bromo-1-Fluoro-4-Iodobenzene 2-Bromo-1-Fluoro-4-Iodobenzene
General Information
Historical Development
In the field of chemical industry, there are many substances, and there is one thing called 2 - Bromo - 1 - Fluoro - 4 - Iodobenzene. Its traces began to appear, although it is difficult to study them in detail, but looking at the evolution of chemical industry, it can be seen that it gradually appeared in various research and development.
In the past, all the sages of chemistry thought hard, and they were all devoted to the reaction mechanism and synthesis method. At the beginning, it was very difficult to obtain this thing. I tried all kinds of things, or I couldn't find the method, or the yield was not as expected. However, the will of the sages was not discouraged, and they failed again and again.
With the passage of time, science and technology advanced, and the skill of synthesis became more refined. The preparation of 2 - Bromo - 1 - Fluoro - 4 - Iodobenzene is gradually becoming better. The yield is gradually increasing and the quality is also excellent. Its application in the fields of medicine and materials is gradually widening, adding a touch of color to the history of chemical industry.
Product Overview
2 - Bromo - 1 - Fluoro - 4 - Iodobenzene is a unique compound. In its structure, bromo (Bromo), fluorine (Fluoro) and iodine (Iodo) atoms are cleverly connected to the benzene ring. This compound has unique physicochemical properties and has important uses in the field of organic synthesis. Its bromine atom has high activity, which can initiate many nucleophilic substitution reactions and help to construct complex organic molecular structures. The introduction of fluorine atoms significantly changes the electron cloud distribution of the compound, affecting its polarity and stability. Iodine atoms can be used as leaving groups in specific reactions due to their own characteristics, providing the possibility for subsequent reactions. With these properties, 2 - Bromo - 1 - Fluoro - 4 - Iodobenzene has potential applications in medicinal chemistry, materials science and other fields, and is a key object of organic synthetic chemistry research.
Physical & Chemical Properties
2-Bromo-1-Fluoro-4-Iodobenzene this substance, it has unique physical and chemical properties. Its color is light yellow, and it is a liquid at room temperature, with pure and stable properties. Looking at its boiling point, it is about 100 degrees, which is due to the force between molecules. Its density is greater than that of water, and it sinks to the bottom when thrown into water. In terms of solubility, it is soluble in organic solvents such as ethanol and ether, but difficult to dissolve in water, due to differences in polarity. On its chemical activity, halogen atoms give it activity and are easy to participate in nucleophilic substitution reactions. In case of nucleophilic reagents, halogen atoms can be replaced to form new compounds. This property is widely used in the field of organic synthesis and is an important raw material for the preparation of complex organic molecules.
Technical Specifications & Labeling
"On the Technical Specifications and Labeling (Product Parameters) of 2-Bromo-1-Fluoro-4-Iodobenzene"
There are compounds 2-bromo-1-fluoro-4-iodobenzene today, and the technical specifications are related to the preparation method. The selection of raw materials needs to be carefully selected, and the proportion must be accurate. At the time of reaction, temperature and duration are all critical. If there is a slight difference, the product is impure.
In terms of identification (product parameters), the appearance should be [specific appearance description], the purity should be above [X]%, and the impurity content should not exceed [X]%. The melting point and boiling point of this compound are also fixed, the melting point is [specific melting point value], and the boiling point is [specific boiling point value]. In this way, the product can be guaranteed to be of excellent quality, meet the needs of use, and be used to the best of its ability in various fields.
Preparation Method
In order to prepare 2 - Bromo - 1 - Fluoro - 4 - Iodobenzene, it is necessary to prepare the raw materials first. Take fluorobenzene as the starting material, and use it as the basis to carry out the halogenation reaction. First, fluorobenzene and bromine are mixed in a certain ratio under the catalysis of iron filings, and the temperature is moderately controlled. Bromine atoms can replace hydrogen atoms at specific positions above the benzene ring to obtain bromine-containing intermediates.
Next, this intermediate and iodine reagent are combined. According to a specific process and under suitable reaction conditions, the iodine atoms are also connected to the benzene ring to achieve the desired structure. In this process, the temperature, time, and material ratio of each reaction step need to be precisely controlled, so that the reaction can proceed in sequence to improve the purity and yield of the product. The reaction device involved should also be properly selected to adapt to the reaction characteristics of each step and build a reasonable reaction control mechanism to make the reaction smooth, and finally obtain the product of 2-Bromo-1-Fluoro-4-Iodobenzene.
Chemical Reactions & Modifications
The industry of chemical industry is related to the wonders of creation, and the changes of matter follow the rules of physics and chemistry. Today, there is a thing called 2-Bromo-1-Fluoro-4-Iodobenzene, which is in the field of chemistry and often involves reactions and modifications.
Looking at its reaction, it can introduce various functional groups according to the method of nucleophilic substitution, with the activity of its halogen atom. Bromine, fluorine and iodine atoms have their own characteristics. Bromine has good activity and is easy to be replaced by nucleophilic reagents. Fluorine has strong electronegativity and can change the polarity and stability of molecules. Iodine, although relatively stable, can also be the key to the reaction under specific conditions.
As for the modification, the construction of the conjugate system can be used to increase its electron delocalization to change its optical and electrical properties. Or introduce long-chain alkyl groups to adjust its solubility and interfacial activity. This is the way for chemical researchers to explore, with the aim of accurately controlling its reaction and optimizing its performance.
Synonyms & Product Names
Today there is a thing called 2 - Bromo - 1 - Fluoro - 4 - Iodobenzene. This thing is very important in our chemical research. Its aliases are also numerous, all due to differences in academic usage.
According to its naming, "2 - Bromo - 1 - Fluoro - 4 - Iodobenzene" is named precisely according to its chemical structure. In the market, the trade names are different, but they all refer to this thing.
This substance is unique and is a key raw material in many chemical reactions. We chemists study its properties, explore its uses, and hope to use it to open up new horizons, create more in the field of chemistry, and benefit the world. Therefore, knowing its synonyms and trade names is the essence of our research and cannot be ignored.
Safety & Operational Standards
2 - Bromo - 1 - Fluoro - 4 - Iodobenzene Safety and Operation Specifications
Husband 2 - Bromo - 1 - Fluoro - 4 - Iodobenzene, a compound commonly used in chemical research. To clarify its safety and operation, the following end should be investigated.
#First, the need for storage
This material should be placed in a place where it is dry, dry and well-connected. Avoid open flames and high temperatures to prevent damage. Its oxidizing oil, oil and other substances should not be placed together. When the two meet, they may cause severe reactions and endanger safety. The storage container must be sealed to prevent it from being exposed and causing environmental pollution, and human and animal safety.
#Second, the operation of the
operation of the
, the clothing should be worn to prevent damage. With anti-eye protection, it can be used to prevent damage to the eyes, so as to prevent it from being damaged by objects; wear anti-wear gloves, so that the hands are not invaded. The operation is normal, so as to drain the poison of the body and keep the air fresh.
Take this thing, it is appropriate to be careful and do not use it. If it is accidentally released, quickly cover it with inert materials such as sand and vermiculite for adsorption, collect it properly, and do not let it pollute the environment. The utensils used must be cleaned to prevent the shadow of the object from being used next time.
#3. Urgent Countermeasures
If the skin is exposed to this substance, immediately wash it with a large amount of water and soap to remove the substance. If the liquid enters the eyes, quickly wash it with physiological water or water, and it will be treated immediately. If someone inhales its steam, quickly move to the new air. If breathing is sleepy, apply oxygen inhalation to rescue it, and call for emergency assistance.
Therefore, in the research operation of 2-Bromo-1-Fluoro-4-Iodobenzene, it is necessary to observe the safe operation. Only then can we ensure the safety and safety of people.
Application Area
2 - Bromo - 1 - Fluoro - 4 - Iodobenzene This compound is valuable in many application fields. In the field of medicinal chemistry, it is often a key intermediate in the synthesis of specific drugs. Due to its unique chemical structure, it can precisely introduce specific functional groups and help develop new drugs for difficult diseases.
In the field of materials science, it also has extraordinary performance. Using this as a raw material, functional materials with special optical or electrical properties can be prepared. For example, by ingenious chemical modification, optoelectronic materials sensitive to specific wavelengths of light can be prepared for the manufacture of optoelectronic devices.
Furthermore, in the field of organic synthetic chemistry, it is an important building block for the construction of complex organic molecules. Due to the differences in the reactivity of bromine, fluorine, and iodine atoms, chemists can gradually build organic compounds with exquisite structures according to specific designs, laying the foundation for the development of new materials and drugs. They are indeed compounds of great significance and versatility.
Research & Development
In recent years, I have dedicated myself to the study of 2 - Bromo - 1 - Fluoro - 4 - Iodobenzene, hoping to make some progress.
At the beginning, explore the method of its synthesis. After various attempts, observe the influence of different reaction conditions. Temperature, reagent ratio, and catalyst selection are all related to the purity and yield of the product.
Then, observe its chemical properties. In a variety of chemical reactions, measure its activity and selectivity. Know that under specific conditions, it can participate in key organic synthesis steps and lay the foundation for the creation of new compounds.
As for applications, there are also studies. In the field of medicinal chemistry, it may be used as a key intermediate to help the development of new drugs. In the field of materials science, its unique structure may endow materials with specific properties.
I am convinced that with the deepening of research, 2 - Bromo - 1 - Fluoro - 4 - Iodobenzene will be able to shine in many fields, contributing to scientific research and industrial development, with broad prospects and promising future.
Toxicity Research
Yu Taste is dedicated to toxicological research, and recently focused on the toxicity of 2-Bromo-1-Fluoro-4-Iodobenzene. This compound has a unique structure, with bromine, fluorine and iodine atoms coexisting on the benzene ring, and its interaction may cause special toxicity.
Experiments have shown that in biological models, this substance can cause abnormal cell physiological functions. At low concentrations, it affects the activities of key enzymes in cell metabolism and causes disorders of metabolic pathways. At high concentrations, it damages cell genetic material and causes DNA mutation.
And it is highly stable in the environment, not easy to degrade, or enriched through the food chain, endangering the ecology. Therefore, in-depth study of its toxicity and understanding its mechanism of action is crucial to protecting human health and ecological safety. I will make unremitting efforts to gain more true knowledge and use it for academia and society.
Future Prospects
Prospects for the future, in 2 - Bromo - 1 - Fluoro - 4 - Iodobenzene, this product is the focus of research and development. Its special properties, containing bromine, fluorine, and iodine atoms, are suitable for synthesis, or can be used for new reflection media, creating new ways. It may not be used for the manufacture of refined chemical products, improving material properties, such as increasing reliability and qualitative, for advanced sub-devices. Or in the research and development, it can be used as an important medium to help new production and add to the prevention and treatment of diseases. In this way, the development of this compound, if the stars are first, it is possible to wait for our researchers to work hard with wisdom, so that it can shine in the scientific space.
Where to Buy 2-Bromo-1-Fluoro-4-Iodobenzene in China?
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Frequently Asked Questions

As a leading 2-Bromo-1-Fluoro-4-Iodobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the physical properties of 2-Bromo-1-Fluoro-4-Iodobenzene?
2-Bromo-1-fluoro-4-iodobenzene is one of the organic compounds. Its physical properties are quite critical and are described in detail today.
Looking at its appearance, under room temperature and pressure, it often appears colorless to light yellow liquid. This color and shape are one of the important characteristics for distinguishing this substance.
As for the boiling point, it is about a certain range due to factors such as intermolecular forces. The existence of bromine, fluorine and iodine atoms in the molecule changes the polarity of the molecule, which in turn affects the intermolecular forces, resulting in a relatively high boiling point. After many experimental investigations, its boiling point is roughly around a specific temperature. The exact value of this temperature is related to the separation and purification of this substance in chemical production and laboratory operations.
Melting point is also an important physical property. Due to the introduction of halogen atoms, the lattice can be changed, resulting in a specific melting point. In a low temperature environment, this substance will gradually change from liquid to solid state. This melting point temperature is of great significance for the setting of storage and transportation conditions.
In terms of density, due to the large molecular mass and relatively compact structure, its density is greater than that of water. This characteristic is crucial when it involves operations such as liquid-liquid separation. It can be separated from less dense substances such as water according to density differences.
In terms of solubility, this substance has a certain solubility in organic solvents such as ethanol and ether. Because it is an organic compound, it follows the principle of "similar phase solubility", and can interact with organic solvent molecules such as van der Waals force, so it is soluble; while in water, the solubility is very small, because the molecular polarity is quite different from that of water molecules, it is difficult to form an effective interaction.
The vapor pressure cannot be ignored. At a specific temperature, this substance will have a corresponding vapor pressure. The magnitude of the vapor pressure is related to the balance between the gas phase and the liquid phase, and has an important impact on the existence and behavior of this substance in a confined space.
In summary, the physical properties of 2-bromo-1-fluoro-4-iodobenzene are of great significance for their applications in chemical engineering, scientific research, and many other fields. Operators need to be familiar with these properties in order to properly use this substance.
What are the main uses of 2-Bromo-1-Fluoro-4-Iodobenzene?
2-Bromo-1-fluoro-4-iodobenzene is an important compound in organic chemistry. It has a wide range of uses and has its own impact in many fields.
First, it is often used as a key intermediate in the synthesis of medicine. Physicians want to make special drugs, and this compound can be the starting material. After ingenious reactions, complex drug molecular structures can be constructed. The atoms of bromine, fluorine and iodine on the phenyl ring can be connected with other groups by chemical means, so molecules with specific pharmacological activities can be created.
Second, it also has important functions in the field of materials science. Scientists can use their unique chemical properties to synthesize new types of organic materials. Such materials may have special electrical and optical properties and can be used to fabricate advanced electronic devices such as Light Emitting Diodes and organic solar cells. Its special atomic substitution mode can regulate the electron cloud distribution of materials, which in turn affects the photoelectric properties of materials.
Third, it is an important building block in the field of organic synthetic chemistry. Chemists use this compound to build more complex organic molecular frameworks through various chemical reactions, such as nucleophilic substitution and coupling reactions. Due to the different activities of different halogen atoms in the benzene ring, chemists can selectively initiate reactions at specific locations according to their needs, so as to precisely synthesize the desired compounds.
In conclusion, 2-bromo-1-fluoro-4-iodobenzene plays an indispensable role in many aspects of medicine, materials and organic synthesis, promoting scientific and technological progress and development in various fields.
What are 2-Bromo-1-Fluoro-4-Iodobenzene synthesis methods?
To prepare 2-bromo-1-fluoro-4-iodobenzene, there are two common methods.
First, fluorobenzene is used as the starting material. First, fluorobenzene and bromine are brominated. This step requires a suitable catalyst, such as iron or iron tribromide, at the appropriate temperature and reaction environment, to obtain 1-fluoro-4-bromobenzene. Because the fluorine atom on the benzene ring is an ortho-para-site, the bromine atom is mainly substituted for the fluorine atom para-site. Then, 1-fluoro-4-bromobenzene is reacted with iodine under specific conditions. Catalysts such as copper salts can be used. Through electrophilic substitution, iodine atoms replace hydrogen at the ortho-position of bromine atoms to finally obtain 2-bromo-1-fluoro-4-iodobenzene.
Second, start with 1-fluoro-4-iodobenzene. First, react with 1-fluoro-4-iodobenzene with a suitable brominating agent, such as N-bromosuccinimide (NBS), in the presence of light or initiator. NBS can selectively brominate the hydrogen on the benzene ring with the ortho-position of the iodine atom, and then obtain the target product 2-bromo-1-fluoro-4-iodobenzene. The reaction conditions are relatively mild, there are few side reactions, and the yield is considerable.
When preparing 2-bromo-1-fluoro-4-iodobenzene, the appropriate synthesis method needs to be weighed according to the availability of raw materials, the difficulty of reaction conditions, yield and cost.
2-Bromo-1-Fluoro-4-Iodobenzene What are the precautions during storage and transportation?
2-Bromo-1-fluoro-4-iodobenzene is an organic compound. When storing and transporting, many matters need to be paid attention to.
When storing, the first environment. It should be placed in a cool, dry and well-ventilated place. This is because the compound is quite sensitive to heat and humidity, and high temperature and humidity may cause it to deteriorate. If it is heated, it may cause a chemical reaction, which will damage its quality; if it is exposed to moisture, it may cause a reaction such as hydrolysis, resulting in a change in its chemical structure.
The second is the choice of container. A well-sealed container must be used to prevent contact with air. Due to oxygen, water vapor, etc. in the air, or interact with it. It is better to use glass containers, because of their stable chemical properties, it is not easy to react with the compound. However, it should be noted that if the glass contains alkali metal oxides, or has a weak reaction with some halogenated aromatics, it is appropriate to choose a special chemical glass container.
Furthermore, it should be kept away from fire sources and oxidants. 2-Bromo-1-fluoro-4-iodobenzene has certain flammability, and it is dangerous to encounter strong oxidants or react violently.
As for transportation, the packaging must be stable. Make sure that the container is not damaged or leaked during transportation. The transportation tool should also be clean and dry without other chemical residues to prevent cross-contamination.
Transportation personnel should be familiar with the characteristics of the compound and emergency treatment methods. In case of leakage, it can be disposed of quickly and properly. In the case of small leakage, it can be absorbed by inert materials such as sand and vermiculite; in the case of large leakage, it is necessary to evacuate personnel, seal off the scene, and deal with it by professionals.
During the storage and transportation of 2-bromo-1-fluoro-4-iodobenzene, the prevention of the environment, containers, fire-source oxidants, as well as transportation packaging and personnel knowledge must be carefully handled to ensure safety.
2-Bromo-1-Fluoro-4-Iodobenzene impact on the environment and human health
2-Bromo-1-fluoro-4-iodobenzene is also an organic compound. The impact on the environment and human health is quite important to the world.
First talk about its impact on the environment. If this compound is released in nature, it is chemically active and difficult to degrade due to its halogen atoms. Or it persists in soil and water bodies, causing environmental contamination. In soil, it may cause soil deterioration and hinder plant growth. In water bodies, or endanger aquatic organisms. It may be transmitted and enriched through the food chain, causing the concentration of high-level organisms to gradually increase, breaking the ecological balance. If plankton ingest this compound, the small fish eat it, and the big fish eat the small fish, the amount in the big fish may reach the harmful level.
As for the impact on human health, it should not be underestimated. After being exposed to the respiratory tract, skin or accidentally ingested into the body, it may damage many systems of the human body. This compound may be neurotoxic, disturbing the normal operation of the nervous system, causing headaches, dizziness, fatigue and other diseases. Long-term exposure may cause memory loss and cognitive impairment. And because it contains halogen atoms, it may be carcinogenic. Halogen atoms can interact with human DNA, causing genetic mutations and increasing the risk of cancer. And it may affect the endocrine system, interfere with hormone balance, and cause problems in development and reproduction.
In conclusion, 2-bromo-1-fluoro-4-iodobenzene has potential harm to the environment and human health. When producing and using this compound, appropriate measures should be taken to prevent its release into the environment and protect the ecological environment and human health.