2-Bromo-1-fluoro-3- (trifluoromethyl) benzene (2-Bromo-1-Fluoro-3- (Trifluoromethyl) Benzene) and 2-fluoro-6- (trifluoromethyl) bromobenzene (2-Fluoro-6- (Trifluoromethyl) Bromobenzene) are the same substance, and their physical properties are as follows:
Looking at its properties, it is mostly a colorless to light yellow transparent liquid at room temperature, and has a special aromatic smell. The boiling point of the two is about 160-170 ° C. Due to the halogen atom and trifluoromethyl in the molecular structure, their relative density is greater than that of water, about 1.7-1.8 g/cm ³. They are insoluble in water, but can be miscible with common organic solvents such as ether, dichloromethane, toluene, etc. in any ratio.
Regarding the melting point, it is in the range of -20 ° C to -10 ° C. Under certain conditions, the vapor density of the two is greater than that of air. If it leaks into the air, the vapor will diffuse close to the ground.
There are polar covalent bonds in its molecules, such as C-Br and C-F bonds. Due to the high electronegativity of fluorine and bromine, the molecule presents a certain polarity, which affects its physical properties and chemical reactivity.
In addition, the compound has high chemical stability due to its trifluoromethyl, and shows unique chemical behavior under some reaction conditions, which is also related to its physical properties. For example, high stability makes it difficult to decompose under some common conditions, which in turn affects the difficulty of participating in chemical reactions and the reaction path.

2-Bromo-1-fluoro-3- (trifluoromethyl) benzene (2-Bromo-1-Fluoro-3- (Trifluoromethyl) Benzene) and 2-fluoro-6- (trifluoromethyl) bromobenzene (2-Fluoro-6- (Trifluoromethyl) Bromobenzene) are actually the same substance, and they are named based on different nomenclature. These aromatic compounds containing fluorine, bromine and trifluoromethyl are widely used in chemical synthesis.
First, in pharmaceutical research and development, due to its unique electronic effects and spatial structure, it can change the activity, stability and fat solubility of drug molecules. By introducing this structure, the interaction between the drug and the target can be optimized, the curative effect can be improved, or the pharmacokinetic properties can be improved. Like the development of some antibacterial and antiviral drugs, such compounds are used as key intermediates to build complex drug activity structures through subsequent reactions.
Second, in the field of materials science, they can be used as starting materials for the synthesis of special functional materials. Due to the characteristics of fluorine-containing groups, it is helpful to prepare materials with excellent weather resistance, chemical stability, low surface energy and other characteristics. For example, it is used to synthesize high-performance fluoropolymers, which are used in coatings, plastics and other fields to improve the wear resistance, chemical corrosion resistance and water and oil resistance of materials.
Third, in the creation of pesticides, such compounds can be optimized as lead structures. Fluorine and bromine atoms can enhance the biological activity and selectivity of pesticides against pests or pathogens, and develop new pesticide varieties with high efficiency, low toxicity and environmental friendliness, providing strong support for agricultural pest control.

2-Bromo-1-fluoro-3- (trifluoromethyl) benzene (2-Bromo-1-Fluoro-3- (Trifluoromethyl) Benzene) and 2-fluoro-6- (trifluoromethyl) bromobenzene (2-Fluoro-6- (Trifluoromethyl) Bromobenzene) can be prepared by the following ancient techniques:
Arylboronic acid or its ester as the starting material
1. ** Halogenation reaction **: Using aryl boric acid or borate ester containing trifluoromethyl as the starting material, in a suitable reaction vessel, add an appropriate amount of halogenating reagents, such as N-bromosuccinimide (NBS) for introducing bromine atoms, select an appropriate halogenated fluorine reagent (such as Selectfluor, etc.) to introduce fluorine atoms. Using organic solvents such as dichloromethane and toluene as the reaction medium, the reaction is carried out at a certain temperature and in the presence of a catalyst. This process is similar to ancient alchemy, and the ratio of heat to raw materials needs to be precisely controlled. The catalyst can be selected with transition metal salts, such as copper salts, palladium salts, etc., to promote the substitution reaction of halogen atoms. For example, under palladium catalysis, aryl boronic acid reacts with NBS and fluorine reagents in a specific ratio. The reaction temperature is controlled between room temperature and 50 ° C. The reaction takes several hours to achieve the selective substitution of aromatic rings by bromine and fluorine atoms, thereby building the basic skeleton of the target molecule.
2. Modification and optimization of groups **: If trifluoromethyl in the product needs to be further modified, appropriate reagents can be used for the reaction. For example, by using nucleophilic substitution reaction, other functional groups are introduced to fine-tune the surrounding environment of trifluoromethyl to make the product more suitable for expectations. This step is like finely carving the medicinal pill. According to the characteristics of the product and subsequent needs, appropriate reagents and reaction conditions are selected to optimize the molecular structure.
Using halogenated aromatics as raw materials
1. ** Nucleophilic Substitution Reaction **: Select a suitable halogenated aromatic hydrocarbon, which already contains some desired halogen atoms and modifiable check points on its aromatic ring. Use strong bases as activation reagents, such as potassium tert-butyl alcohol, etc., in polar aprotic solvents (such as N, N-dimethylformamide (DMF), dimethylsulfoxide (DMSO)), and react with nucleophiles containing trifluoromethyl. Nucleophilic reagents such as trifluoromethyl copper lithium reagent (CF 🥰 CuLi) can realize the substitution of trifluoromethyl to halogen or other leaving groups on the aromatic ring. The reaction process needs to be carried out gradually at low temperature to room temperature, just like the ancient method of winemaking, you need to wait patiently for the reaction process. Control the reaction temperature and time to prevent overreaction or side reaction.
2. ** Halogen Atom Exchange and Adjustment **: If the position or type of halogen atom in the product does not match the target molecule, it can be adjusted by halogen atom exchange reaction. For example, using a suitable fluoride salt (such as potassium fluoride, etc.), in the presence of a phase transfer catalyst, reacts with bromine or other halogen-containing intermediate products to achieve the exchange of halogen atoms to obtain the desired fluorinated product. This step is like blending a brewed wine, and precisely adjusting the type and position of halogen atoms according to the structure of the target product.
Using aromatic hydrocarbons as the starting material
1. ** Fu-gram reaction and halogenation **: With an aromatic hydrocarbon containing trifluoromethyl as the starting material, first through Fu-gram alkylation or acylation reaction, a suitable substituent is introduced on the aromatic ring to create conditions for the subsequent halogenation reaction. If trifluoromethylbenzene is used as the raw material, under the catalysis of Lewis acid (such as anhydrous aluminum trichloride), it reacts with halogenated hydrocarbons or acyl halides to introduce alkyl or acyl groups at specific positions in the aromatic ring. Subsequently, a halogenation reaction is carried out, and bromination is carried out using a brominating agent (such as liquid bromine) and a catalyst (such as iron powder). Select a suitable fluorination method (such as using a hydrogen fluoride pyridine complex, etc.) for fluorination. This process is similar to the ancient method of processing traditional Chinese medicine, and the multi-step reaction is gradual to build a complex molecular structure.
2. ** Functional group conversion and purification **: After the reaction is completed, the product is transformed into functional groups, and the temporary protective groups introduced in the reaction are removed or other necessary conversions are carried out. Through distillation, recrystallization, column chromatography and other separation and purification methods, just like the ancient method of eluting precious medicinal materials, impurities are removed to obtain high-purity 2-bromo-1-fluoro-3- (trifluoromethyl) benzene and 2-fluoro-6- (trifluoromethyl) bromobenzene.

2-Bromo-1-fluoro-3- (trifluoromethyl) benzene and 2-fluoro-6- (trifluoromethyl) bromobenzene are both chemical substances. During storage and transportation, many matters need to be paid attention to.
First, the storage place must be dry and cool. Due to humid gas and high temperature, the chemical substance can react, causing its properties to change and affecting its quality. These two are quite sensitive to water vapor, moisture invasion, or cause reactions such as hydrolysis, which damage its purity. High temperature will also accelerate the rate of chemical reactions and cause the material to deteriorate. Therefore, the storage place should have good ventilation and temperature control facilities to keep the environment dry and cool.
Second, these two need to be kept away from fire sources and oxidants. Because of its certain chemical activity, it is easy to cause violent combustion or even explosion when exposed to fire or oxidants. Oxidants can promote oxidation reactions, while fire sources provide energy, trigger chemical reactions, and cause dangerous accidents. Fireworks are strictly prohibited in storage and transportation places, and dangerous items such as oxidants should be stored in isolation.
Third, packaging must be tight. Proper packaging can avoid its leakage and prevent external substances from mixing in. Leakage not only wastes resources, but also pollutes the environment and endangers the safety of personnel. Packaging materials need to be resistant to corrosion of this substance, and can withstand certain pressure and vibration to ensure that the transportation process is intact.
Fourth, relevant regulations must be followed during transportation. The transportation of such chemical substances requires the corresponding qualification permits. Transport personnel should be professionally trained and familiar with their characteristics and emergency treatment methods. Transport vehicles need to be equipped with necessary safety equipment and protective equipment, such as fire extinguishers, leakage emergency treatment tools, etc.
In short, store and transport 2-bromo-1-fluoro-3 - (trifluoromethyl) benzene and 2-fluoro-6 - (trifluoromethyl) bromobenzene in a dry and cool place, away from fire-source oxidants, ensure tight packaging, and strictly follow regulations, so as to ensure safety and avoid accidents.

2 - Bromo - 1 - fluoro - 3 - (trifluoromethyl) benzene (2 - Bromo - 1 - Fluoro - 3 - (Trifluoromethyl) Benzene) and 2 - fluoro - 6 - (trifluoromethyl) bromobenzene (2 - Fluoro - 6 - (Trifluoromethyl) Bromobenzene) are the same substance, both are organohalogenated aromatics, and are widely used in chemical, pharmaceutical, materials and other fields.
However, its market price range is difficult to accurately determine. The reason is affected by multiple factors, one of which is market supply and demand. If the industry's demand for fluorobenzene compounds surges, and production and supply are difficult to keep up in time, its price will rise; on the contrary, if the supply exceeds the demand, the price may fall. The second is production costs, changes in costs such as raw materials, energy consumption, equipment and labor, all affect the final selling price. If the scarcity of raw materials causes the cost to rise, the price of the product will also rise. The third is about product purity and quality. High-purity products have complex preparation processes, high costs and high prices; ordinary purity products are relatively inexpensive. The fourth is the market competition situation. When there are many manufacturers and the competition is fierce, the manufacturers may reduce the price in order to seize the market; conversely, under the monopoly or oligopoly situation, the price may be controlled at a higher level.
According to past market conditions and price fluctuations of similar compounds, the price of this compound may range from tens to thousands of yuan per kilogram. If it is ordinary purity, mass production and sufficient market supply, or in the low price range, tens to hundreds of yuan per kilogram; if the purity requirements are strict, the production process is complicated, and the output is limited, the price may reach thousands of yuan per kilogram. However, this is only a rough estimate. The real-time price still needs to be accurately known by consulting chemical product suppliers, consulting professional market reports or inquiring on chemical trading platforms.