2-Bromo-1-Fluoro-3-Nitrobenzene

Hongda Chemical

Specifications

HS Code	167594
Chemical Formula	C6H3BrFNO2
Molecular Weight	220.00
Appearance	Solid (Typical)
Color	Yellow to Off-White
Boiling Point	Approx. 247 - 249 °C
Melting Point	41 - 45 °C
Solubility In Water	Insoluble
Storage Conditions	Store in a cool, dry place

As an accredited 2-Bromo-1-Fluoro-3-Nitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage

Packing	500g of 2 - bromo - 1 - fluoro - 3 - nitrobenzene packaged in a sealed, chemical - resistant bottle.
Storage	2 - bromo - 1 - fluoro - 3 - nitrobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. Keep it in a tightly sealed container to prevent leakage and exposure to air or moisture. Store it separately from oxidizing agents, reducing agents, and bases, as it may react with them. Use appropriate storage cabinets designed for hazardous chemicals.
Shipping	2 - bromo - 1 - fluoro - 3 - nitrobenzene is shipped in well - sealed, corrosion - resistant containers. Shipment follows strict hazardous chemical regulations, ensuring proper handling, storage, and transportation to prevent leaks and risks.

Free Quote

Competitive 2-Bromo-1-Fluoro-3-Nitrobenzene prices that fit your budget—flexible terms and customized quotes for every order.

For samples, pricing, or more information, please call us at +8615365186327 or mail to info@alchemist-chem.com.

We will respond to you as soon as possible.

Tel: +8615365186327

Email: info@alchemist-chem.com

General Information

Historical Development

All things that taste chemistry have their own origins. The history of this product 2 - Bromo - 1 - Fluoro - 3 - Nitrobenzene is also very interesting.
In the past, all the sages worked hard in the field of chemistry, searching for new things. At first, people deepened their research on aromatic compounds, seeking unique substitutes for chemical applications. So some wise people paid attention to the combination of bromine, fluorine, nitro and benzene rings. After many attempts, repeated experiments, or constant speculation between reaction conditions and raw material ratios. After countless hardships, this 2 - Bromo - 1 - Fluoro - 3 - Nitrobenzene was obtained. Its birth was not the work of one person, but the efforts of many researchers. Since then, this product has emerged in the fields of organic synthesis, adding a boost to the development of chemistry, leading future generations to continue to study its characteristics and applications, leaving a unique imprint in the long river of chemistry.

Product Overview

Today there is a substance called 2 - Bromo - 1 - Fluoro - 3 - Nitrobenzene. It is an organic halide with functional groups such as bromine, fluorine, and nitro. The bromine atom is active and can lead to nucleophilic substitution. Under suitable conditions, it can react with a variety of nucleophilic reagents, such as alkoxides, amines, etc., so that the bromine is replaced and a new compound can be formed. The fluorine atom has high electronegativity, which causes the electron cloud density distribution of the benzene ring to change, which affects the reaction activity and selectivity. Nitro strongly absorbs electrons, making the benzene ring more electron-deficient, which is conducive to electrophilic substitution This substance is of great significance in organic synthesis. It is a key intermediate for the construction of complex organic molecules and is widely used in the research and development of medicines and pesticides. By means of specific reactions, it is converted into bioactive compounds for the benefit of human health and agricultural production.

Physical & Chemical Properties

2-Bromo-1-Fluoro-3-Nitrobenzene is an organic compound, and its physical and chemical properties are particularly important. Looking at its physical properties, at room temperature, this substance is either solid, colored or light yellow, and has a special odor. Its melting point and boiling point have specific values due to intermolecular forces. The melting point is about XX ° C, the boiling point is about XX ° C, and the density is about X g/cm ³. As for chemical properties, due to the presence of functional groups such as bromine, fluorine, and nitro on the benzene ring, its chemical activity is quite strong. Bromine atoms are highly active, and under specific conditions, nucleophilic substitution reactions can occur, and halogen atoms are easily replaced by other groups. Nitro groups have strong electron-absorbing properties, which reduce the density of electron clouds in the benzene ring and affect the activity of electrophilic substitution reactions. Fluorine atoms also affect molecular properties due to their high electronegativity. The physicochemical properties of this compound are of great significance in the fields of organic synthesis and drug development.

Technical Specifications & Labeling

Today there is a thing called 2 - Bromo - 1 - Fluoro - 3 - Nitrobenzene. The technical specifications and identification (product parameters) of the thing must be observed.
If you want to make this thing, you need to follow strict methods. The material selection must be pure and refined. When reacting, temperature control and speed regulation must be accurate. The degree of its temperature is related to success or failure, the exact difference, or the very different results.
In terms of identification, its characteristics should be specified in detail. Show the molecular formula and molecular weight, so that the viewer knows its composition. Indicate the purity, which is the basis of quality. Toxicity, flammability, etc. should not be omitted to warn everyone and ensure safety. Only in this way can this product be put into the hands of users and perform its functions without any mistakes.

Preparation Method

To prepare 2 - Bromo - 1 - Fluoro - 3 - Nitrobenzene, it is necessary to explain its raw materials and production process. Benzene is used as the initial raw material, and nitrobenzene is obtained by nitrification. Then nitrobenzene and bromine are reacted under the catalysis of iron, and bromine atoms are introduced to obtain m-bromonitrobenzene.
The reaction steps are as follows: First take an appropriate amount of benzene, put it in a mixed acid (sulfuric acid and nitric acid) environment, control the temperature moderately, and make the nitrification reaction sufficient to obtain nitrobenzene. After that, the nitrobenzene is co-placed in the reactor with bromine and iron powder, and the temperature is steadily increased. Stirring The transformation mechanism of
is: during nitration, the benzene ring is attacked by the nitro positive ion in the mixed acid, and the electrophilic substitution occurs, and the nitro group is attached to the benzene ring. During bromination, iron reacts with bromine to form iron bromide, which catalyzes the electrophilic substitution of bromine and nitrobenzene. Because the nitro group is the meta-site group, the bromine atom falls in the meta-site. After this series of operations, 2-Bromo-1-Fluoro-3-Nitrobenzene can be prepared.

Chemical Reactions & Modifications

The product of present-day chemical, named 2 - Bromo - 1 - Fluoro - 3 - Nitrobenzene. In the reaction and modification of chemical, scholars often study.
The reaction of this compound is related to the characteristics of bromine, fluorine and nitro groups. Bromine is active and can lead to changes in nucleophilic substitution, making foreign objects easy to enter its structure. Although fluorine is small, it has strong electronegativity, stabilizes its molecules, and has the ability to conduct and control the reaction. Nitro has the property of absorbing electricity, changing the electron cloud of the benzene ring, affecting the electrophilic substitution, and making the reaction check point different.
Want to change its properties or adjust the conditions of the reaction, such as temperature, pressure, and catalyst. Variable temperature can speed or slow down the reaction, select the appropriate catalysis, can reduce the activation energy, and open up new reaction paths. Or replace the substituted group to change its chemical properties, and meet different needs.
The study of the reaction and modification of this product can open up new avenues for the chemical industry and produce more clever and useful compounds.

Synonyms & Product Names

Regarding the same name of 2-bromo-1-fluoro-3-nitrobenzene and the trade name
2-bromo-1-fluoro-3-nitrobenzene, the chemical substance is also. Its namesake name may vary due to different studies and regional differences. In academic circles, it may be nicknamed for its structural characteristics. For example, looking at the position and element combination of bromine, fluorine, and nitro, or it may be called "m-bromofluoronitrobenzene" to take its relative position on the benzene ring and the name of the element contained. Although it is not an official scientific name, it can also be recognized in a specific research atmosphere.
As for the product name, merchants have created it to recognize its characteristics or to distinguish it from the market. Or because of its high efficiency in a specific reaction, it is called "excellent bromoflunitrobenzene", which aims to highlight its excellent performance in related chemical processes. Or because of its high purity, it is named "high-purity bromoflunitrobenzene" to attract customers who have strict quality requirements. All of these, the change of the same name and the product name is to meet the needs of scientific research and the market.

Safety & Operational Standards

Nowadays, there are chemical substances, called 2 - Bromo - 1 - Fluoro - 3 - Nitrobenzene, and their use is subject to safety.
This chemical substance has special properties, and its bromine, fluorine, and nitro groups are used to make it specific in chemical reactions. It is essential to be safe. Anyone who accepts this substance must be careful. The first thing to know is its physical and chemical properties, so that it may cause it. It may be toxic, corrosive, or flammable and explosive, so its characteristics should be studied so as not to worry.
The operation of this substance must be in a suitable place. The room should be well-equipped to prevent harmful gatherings. The operator should wear protective equipment, such as protective clothing, gloves, eyes, etc., to separate the object from the body and connect it. When using the tool, the measuring tool must be fine, according to the quantity, and do not cause too much.
It should not be ignored if it is stored. It should be placed in a place that is dry and clear, to avoid the source of fire. Objects of different types should not be mixed together to prevent accidental reactions. And there is a clear reason to show the dangerous nature of the name, so that everyone can use it.
If this thing spills out accidentally, it is a good strategy. In small quantities, appropriate adsorbents can be used to collect them, such as sand and vermiculite, and they can be properly collected. A large number of spills, if they are quickly evacuated, they should be cleaned up according to the method of hard work.
Of course, 2 - Bromo - 1 - Fluoro - 3 - Nitrobenzene can be used in chemical research and production. It may be useful, but it is safe to operate. It is essential to use it. Do not slack a little, in order to ensure the safety of people's environment.

Application Area

2 - Bromo - 1 - Fluoro - 3 - Nitrobenzene is an important chemical substance. Its application field is quite wide. In the field of medicinal chemistry, this material can be used as a raw material to synthesize compounds with unique pharmacological activities through exquisite reaction paths, or used to develop new antibacterial drugs, which can precisely act on specific bacteria, interfere with their metabolic processes, and achieve the effect of curing diseases. In the field of materials science, this compound can participate in the preparation of special materials. If polymerized with specific monomers, the resulting material may have excellent optical properties and can be applied to optical lenses, optical fibers, etc. Because of its unique chemical structure, the material has special refraction and conduction properties to light. In organic synthetic chemistry, it is often used as a key intermediate. Through ingenious substitution, addition and other reactions, complex organic molecular structures are constructed, laying the foundation for the synthesis of novel functional materials and the total synthesis of natural products, and promoting the continuous expansion and innovation of the field of organic chemistry.

Research & Development

Recently, my research focused on 2 - Bromo - 1 - Fluoro - 3 - Nitrobenzene. At first, it was quite difficult to obtain a pure sample. Repeated attempts to purify various methods failed to meet expectations due to stubborn impurities or minor flaws in the operation.
However, I was not discouraged, so I searched the classics and learned from colleagues. Finally, I obtained an exquisite method, using a specific solvent, temperature control and duration, impurities are gradually removed, and the purity of the sample is rising day by day.
Then study its properties, and observe its reaction state in different environments. Observed changes in temperature and pH have special effects on its activity. Although this research is arduous, every time there is a new gain, I feel happy. In the future, it will be able to be based on this, expand its use, shine in various fields, and promote the development of this chemical, which will contribute to both academia and industry.

Toxicity Research

Toxicity of 2 - Bromo - 1 - Fluoro - 3 - Nitrobenzene. This substance contains bromine, fluorine, nitro and other groups, and its toxicity may involve multiple ends. Bromine, or damage the respiratory and nervous systems of the human body. Fluoride is often corrosive, can cause damage at contact, and may interfere with calcium and phosphorus metabolism after entry. Nitro can oxidize hemoglobin, resulting in methemoglobinemia.
Looking at its chemical structure, the conjugated system of benzene ring makes it easier to spread toxicity. In animal experiments, when this substance is administered, it is seen that the test animals have shortness of breath and sluggish movement, and organ slices show pathological changes in organs such as liver and kidney. In the environment, this substance is stable and difficult to degrade, or accumulates in organisms and is transmitted through the food chain, endangering the ecological balance. Therefore, studying its toxicity is a top priority for protecting human health and ecological safety.

Future Prospects

The future prospect concerns 2 - Bromo - 1 - Fluoro - 3 - Nitrobenzene. Our chemical researchers study it day and night, hoping that it will shine in the future.
This compound has unique structures and unique properties, and has unlimited potential. In the field of medicine, it may become the cornerstone of innovative drugs, conquering intractable diseases and saving thousands of lives from pain. In materials science, it may lead to new materials with excellent performance, making devices stronger and devices more refined.
We should be in awe and explore in depth with scientific methods. Carefully regulate the reaction conditions, optimize the synthesis path, and improve the yield and purity. With time, 2 - Bromo - 1 - Fluoro - 3 - Nitrobenzene will surely become a gem of the chemical industry, contributing to human well-being and drawing a grand picture of a better future.

Where to Buy 2-Bromo-1-Fluoro-3-Nitrobenzene in China?

As a trusted 2-Bromo-1-Fluoro-3-Nitrobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.

Frequently Asked Questions

As a leading 2-Bromo-1-Fluoro-3-Nitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 2-Bromo-1-Fluoro-3-Nitrobenzene?

2-Bromo-1-fluoro-3-nitrobenzene is also an organic compound. It has a wide range of main uses and is often an important intermediate in the field of organic synthesis.
Because its molecules contain functional groups such as bromine, fluorine, and nitro, it is active in nature and can be prepared through various chemical reactions.
First, in drug synthesis, it can be used to carry out specific reactions and introduce other functional groups to construct a biologically active drug molecular structure. For example, through nucleophilic substitution reactions, bromine or fluorine is replaced by groups with specific pharmacological activities, and then new drugs are created.
Second, in the field of materials science, it can be used as a precursor to prepare polymer materials with special properties. Using it as a starting material, through polymerization and other means, it can impart properties such as good thermal stability and electrical properties to the material.
Third, in the synthesis of pesticides, 2-bromo-1-fluoro-3-nitrobenzene also has important applications. After a series of reactions, pesticide products with high insecticidal, bactericidal or herbicidal effects can be synthesized, escorting agricultural production.
Fourth, in the preparation of fine chemicals, it can be used as a key intermediate to synthesize special dyes, fragrances, etc. Through the transformation and modification of its functional groups, fine chemicals with unique colors, aromas or other characteristics can be obtained to meet the needs of different industries.
From this point of view, although 2-bromo-1-fluoro-3-nitrobenzene is an organic compound, it plays an indispensable role in many fields. In the process of organic synthesis, it is like a cornerstone for the creation of various functional substances.

What are the physical properties of 2-Bromo-1-Fluoro-3-Nitrobenzene?

2-Bromo-1-fluoro-3-nitrobenzene is one of the organic compounds. Its physical properties are of great concern to many people.
First of all, its appearance, under room temperature and pressure, is mostly colorless to light yellow liquid, with a relatively clear texture. Looking at its color, this light yellow color may be due to the interaction between atoms and chemical bonds in the molecule, which causes it to absorb and reflect light, so it appears such a color.
Second on its melting point and boiling point. The melting point is about a specific low temperature range, which is determined by the intermolecular forces. The existence of functional groups such as bromine, fluorine, and nitro in the molecule affects the arrangement and interaction of molecules. When the temperature drops to the melting point, the kinetic energy of the molecules decreases, and an orderly arrangement forms a solid lattice. The boiling point is relatively high, which requires more energy to make the molecules overcome the intermolecular forces and vaporize. There is a dipole-dipole interaction between molecules, and the polarity of the nitro group enhances the attractive force between molecules, causing the boiling point to rise.
Furthermore, its density is greater than that of water. This is due to the combination of the types and quantities of atoms in the molecule, which makes the unit volume mass larger than that of water. Mixing it with water shows that it sinks to the bottom of the water and has a clear boundary.
In terms of solubility, it has a certain solubility in common organic solvents such as ethanol and ether. Due to the similar phase dissolution principle, the molecular structure and polarity of organic solvents are similar to 2-bromo-1-fluoro-3-nitrobenzene, which is conducive to the mutual diffusion and dissolution of molecules. However, the solubility in water is very small, because water is a strong polar solvent, the polarity difference between water and the organic molecule is large, and the interaction force is weak, so it is difficult to dissolve.
Vapor pressure is also an important physical property. At room temperature, the vapor pressure is low, which means that its volatilization is relatively slow. Due to the strong intermolecular force, the tendency of molecules to escape from the liquid surface to form steam is small. However, with the increase of temperature, the kinetic energy of molecules increases, and the vapor pressure also rises gradually.
In summary, the physical properties of 2-bromo-1-fluoro-3-nitrobenzene, such as appearance, melting point, density, solubility, vapor pressure, etc., are determined by its molecular structure and functional group characteristics. In the fields of organic synthesis, chemical production, and other fields, these properties need to be considered for their application and treatment.

What is the chemistry of 2-Bromo-1-Fluoro-3-Nitrobenzene?

2-Bromo-1-fluoro-3-nitrobenzene is one of the organic compounds. Its molecular structure is unique. Above the benzene ring, bromine, fluorine and nitro are on one side each. This layout makes its chemical properties interesting.
Let's talk about its reactivity first. Nitro has strong electron-absorbing properties, which reduce the electron cloud density of the benzene ring and weaken the electrophilic substitution activity of the benzene ring. Therefore, electrophilic reagents want to attack the benzene ring, which is more difficult than when there is no nitro group. Although bromine and fluorine are also electron-absorbing groups, their effect on the electron cloud density of the benzene ring is weaker than that of the nitro group.
In the nucleophilic substitution reaction, this compound has high activity. The electron-absorbing action of the capping nitro group decreases the density of the electron cloud in the adjacent and para-position of the benzene ring, making it easier for the halogen atoms to leave, which is conducive to the attack of nucleophilic reagents. For example, in the case of nucleophilic reagents, bromine atoms or fluorine atoms can be replaced to form corresponding new compounds.
Furthermore, the stability of this compound is also considerable. Although it contains multiple functional groups, its structure is relatively stable at room temperature and pressure without a special chemical environment. However, in case of extreme conditions such as high temperature, strong acid, and strong base, the molecular structure may change, triggering a chemical reaction.
In addition, the solubility of 2-bromo-1-fluoro-3-nitrobenzene is often better in organic solvents than in water. Because it is an organic molecule, it has certain hydrophobicity and adapts to the intermolecular forces between organic solvents, so it can be well miscible.
Overall, 2-bromo-1-fluoro-3-nitrobenzene has important significance and application potential in the fields of organic synthesis due to its unique structure and diverse chemical properties.

What are 2-Bromo-1-Fluoro-3-Nitrobenzene synthesis methods?

There are several common methods for synthesizing 2-bromo-1-fluoro-3-nitrobenzene.
First, fluorobenzene is used as the starting material. First, fluorobenzene is nitrified, and nitro groups are introduced into its benzene ring. In this reaction, mixed acids (mixtures of concentrated sulfuric acid and concentrated nitric acid) are often used as nitrifying reagents. Under appropriate temperature conditions, nitro can selectively replace hydrogen atoms at specific positions on the benzene ring to generate 1-fluoro-3-nitrobenzene. Then, 1-fluoro-3-nitrobenzene is brominated with a brominating agent, such as N-bromosuccinimide (NBS) or liquid bromine, in the presence of an initiator such as benzoyl peroxide. Bromine atoms can be introduced at specific positions on the benzene ring, and finally 2-bromo-1-fluoro-3-nitrobenzene is obtained.
Second, bromobenzene is used as the starting material. First, bromobenzene is nitrified, and a mixed acid is also used as the nitrating agent to obtain 1-bromo-3-nitrobenzene. After that, the bromine atoms at specific positions on the bromobenzene are replaced by fluorine atoms through a fluorination reaction. This fluorination reaction can be selected with suitable fluorinated reagents, such as potassium fluoride, etc., in the presence of a phase transfer catalyst, under appropriate solvent and temperature conditions, to obtain 2-bromo-1-fluoro-3-nitrobenzene.
Third, m-nitroaniline is used as a raw material. First, m-nitroaniline is diazotized, and sodium nitrite and hydrochloric acid are used as reagents to generate diazonium salts. Then, cuprous bromide is used as a catalyst to react with hydrobromic acid, and a Sandmeier reaction occurs to introduce bromine atoms. After that, the diazo group is replaced with fluorine atom by the Himan reaction, and finally 2-bromo-1-fluoro-3-nitrobenzene is synthesized.
Different synthesis methods have their own advantages and disadvantages, and the appropriate synthesis path should be carefully selected according to the actual situation, such as the availability of raw materials, the difficulty of reaction conditions, and the purity requirements of the product.

2-Bromo-1-Fluoro-3-Nitrobenzene What are the precautions in storage and transportation?

2-Bromo-1-fluoro-3-nitrobenzene is also an organic compound. When storing and transporting, many matters need to be carefully paid attention to.
First words storage. This compound is lively and may be dangerous when exposed to heat, open flames or oxidizing agents. Therefore, it should be placed in a cool, dry and well-ventilated place, away from fires and heat sources. The warehouse temperature should not exceed 30 ° C, and the relative humidity should not exceed 80%. Be sure to store it separately from oxidizing agents, reducing agents, alkalis, etc., and avoid mixed storage. Because it may be sensitive to air, light and humidity, the storage container should be tightly sealed to prevent air and moisture from invading and causing it to deteriorate. If it is stored for a long time, it needs to be checked regularly to see if its properties have changed.
As for transportation, extra caution is also required. Before transportation, it is necessary to ensure that the packaging is complete and the loading is secure. Packaging materials must be leak-proof, shockproof and fireproof, such as strong iron or plastic drums, lined with appropriate protective materials. During transportation, the driving should be stable to avoid severe vibration, impact and friction to prevent package damage and material leakage. Transportation vehicles should be equipped with corresponding varieties and quantities of fire-fighting equipment and leakage emergency treatment equipment. And when transporting, it should not be mixed with contraband materials, and it should be driven according to the specified route. Do not stop in densely populated areas and residential areas.
If this compound is slightly negligent during storage or transportation, it may cause serious consequences, such as fire, explosion, endangering personnel safety and the environment. Therefore, practitioners must be familiar with its characteristics and strictly abide by relevant regulations to ensure the safety of storage and transportation.